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Journal of the Neurological Sciences

Nobuhito Nakajima, Masayuki Ueda
No abstract text is available yet for this article.
February 16, 2019: Journal of the Neurological Sciences
Doug King, Patria A Hume, Natalie Hardaker, Alan Pearce, Cloe Cummins, Trevor Clark
AIM: To provide epidemiological data and related costs to the national health insurance scheme for traumatic brain injury (TBI) in New Zealand. METHOD: A retrospective analytical review utilising detailed descriptive minor and moderate-to-severe epidemiological TBI data obtained from the Accident Compensation Corporation (ACC) for 2012-2016. Injuries were analysed by three levels of increasing severity: moderate, moderate-to-serious (MSC) and severe claims categories...
February 12, 2019: Journal of the Neurological Sciences
Yen-Ting Chen, Shengai Li, Ping Zhou, Sheng Li
Reticulospinal (RS) hyperexcitability is observed in stroke survivors with spastic hemiparesis. Habituated startle acoustic stimuli (SAS) can be used to stimulate the RS pathways non-reflexively. However, the role of RS pathways in motor function and its interactions with the corticospinal system after stroke still remain unclear. Therefore, the purpose of this study was to investigate the effects of conditioning SAS on the corticospinal system in healthy subjects and in stroke subjects with spastic hemiparesis...
February 11, 2019: Journal of the Neurological Sciences
Mohammad Hossein Panahi
No abstract text is available yet for this article.
February 11, 2019: Journal of the Neurological Sciences
Tetsuya Kanai, Akiyuki Uzawa, Satoshi Kuwabara
No abstract text is available yet for this article.
February 11, 2019: Journal of the Neurological Sciences
Vibhash D Sharma, Kelly E Lyons, Jules M Nazzaro, Rajesh Pahwa
INTRODUCTION: Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease (PD). However, its effect in older patients is not extensively studied, as they are often excluded from DBS surgery due to concerns of complications or reduced benefit. We assessed clinical outcomes after subthalamic nucleus (STN) DBS in older patients (age > 75 years) with PD. METHODS: All PD patients above 75 years who underwent STN-DBS between 1999 and 2015 were included...
February 11, 2019: Journal of the Neurological Sciences
W H Jost, A Schramm, M Müngersdorf, A Stenner, P Schwingenschuh, P Maisonobe, M Koch, B Haslinger
AbobotulinumtoxinA (aboBoNT-A; Dysport®) is an effective treatment for cervical dystonia (CD) with a well-established safety profile. In this prospective, multicentre, non-interventional study (NCT01840462) the primary objective was effectiveness (Tsui score) of aboBoNT-A in botulinum neurotoxin type A (BoNT-A) treatment-naïve and previously-treated (>2 yrs) patients after two injection cycles (at visit 3). Secondary objectives included the effectiveness of aboBoNT-A overall visits and quality of life (CDQ-24) in different CD subtypes...
February 10, 2019: Journal of the Neurological Sciences
Tiago Gregorio, Inês Albuquerque, Vasco Neves, Rui Reinas, Sara Pipa, Luís Azevedo, Paulo Castro Chaves
BACKGROUND: Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic peptides, frequently used in the management of heart failure, have been shown to correlate with disease severity and prognosis in brain disorders. The aim of this study was to test the hypothesis that NT-pro-BNP correlates with disease severity and is an independent prognostic marker for non-traumatic ICH patients. METHODS: A consecutive sample of 201 non-traumatic ICH patients, who were non-comatose on admission and medically treated in a stroke unit, were evaluated for in-hospital mortality and three-month functional dependency (modified Rankin Scale >2)...
February 8, 2019: Journal of the Neurological Sciences
Ewelina Marciniewicz, Przemysław Podgórski, Tomasz Pawłowski, Krzysztof Małyszczak, Katarzyna Fleischer-Stępniewska, Brygida Knysz, Marta Waliszewska-Prosół, Agnieszka Żelwetro, Weronika Rymer, Małgorzata Inglot, Maria Ejma, Marek Sąsiadek, Joanna Bladowska
The study was performed to evaluate cerebral volume changes in HCV-infected subjects before and after interferon-free therapy with direct-acting antiviral agents (DAA). We aimed also to estimate the impact of successful DAA therapy on the neuropsychological state of patients. Eleven HCV genotype 1 (GT1) patients treated with ombitasvir/paritaprevir (boosted with ritonavir) and dasabuvir, with or without ribavirin underwent brain magnetic resonance (MR) before and 24 weeks after completion of therapy. All patients achieved sustained viral response...
February 7, 2019: Journal of the Neurological Sciences
Ece Bayram, Brent Bluett, Xiaowei Zhuang, Dietmar Cordes, Denise R LaBelle, Sarah J Banks
OBJECTIVE: Cognitive decline is common in Parkinson's disease (PD), but changes can occur in a variety of cognitive domains. The lack of a single cognitive phenotype complicates diagnosis and tracking. In an earlier study we used a data-driven approach to identify distinct cognitive phenotypes of early PD. Here we identify the morphometric brain differences between those different phenotypes compared with cognitively normal PD participants. METHODS: Six different cognitive classes were included (Weak, Typical, Weak-Visuospatial/Strong-Memory, Weak-Visuospatial, Amnestic, Strong)...
February 7, 2019: Journal of the Neurological Sciences
Aleksandra Radojicic, Vlasta Vukovic-Cvetkovic, Tatjana Pekmezovic, Goran Trajkovic, Jasna Zidverc-Trajkovic, Rigmor Højland Jensen
BACKGROUND: The aim of the study was to evaluate the presenting symptoms and signs of idiopathic intracranial hypertension (IIH) in a large cohort of patients and to estimate their possible role in establishing the diagnosis of IIH. METHODS: This prospective cohort study in two tertiary centers, the Danish Headache Center in Rigshospitalet-Glostrup and the Neurology Clinic of the Clinical Center of Serbia, included 286 patients referred by attending specialists for possible IIH evaluation...
February 6, 2019: Journal of the Neurological Sciences
D Tolomeo, A Rubegni, M Severino, F Pochiero, C Bruno, D Cassandrini, A Madeo, S Doccini, M Pedemonte, A Rossi, F D'Amore, M A Donati, M Di Rocco, F M Santorelli, C Nesti
Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relatively common etiology of Leigh-like syndrome (LS). With a few exceptions, descriptions of the clinical spectrum of specific mutations in CI are scarce. We here present three unrelated Italian children who harbored the homoplasmic m...
February 6, 2019: Journal of the Neurological Sciences
Chien-Hao Wu, Chang-Mu Chen, Po-Wen Cheng, Yi-Ho Young
OBJECTIVE: This study reviewed our experience in treating patients with vestibular schwannoma (VS) who had acute sensorineural hearing loss (ASHL) early after radiosurgery. PATIENTS AND METHODS: Seventy VS patients underwent cyberknife radiosurgery. Of them, 6 patients had ASHL early (<6 m) after radiosurgery (Group A), accounting for 8.6% prevalence. The remaining 64 patients without ASHL were assigned to Group B. Another 10 VS patients with tiny tumor and serviceable hearing adopted observation policy (Group C)...
February 6, 2019: Journal of the Neurological Sciences
Ran Li, Poornima Venkat, Michael Chopp, Qiang Zhang, Tao Yan, Jieli Chen
Subarachnoid hemorrhage (SAH) results in neurological damage, acute cardiac damage and has a high mortality rate. Immunoresponse in the acute phase after SAH plays a key role in mediating vasospasm, edema, inflammation and neuronal damage. The S1P/S1PR pathway impacts multiple cellular functions, exerts anti-inflammatory and anti-apoptotic effects, promotes remyelination, and improves outcome in several central nervous system (CNS) diseases. RP001 hydrochloride is a novel S1PR agonist, which sequesters lymphocytes within their secondary tissues and prevents infiltration of immune cells into the CNS thereby reducing immune response...
February 5, 2019: Journal of the Neurological Sciences
Shin C Beh
No abstract text is available yet for this article.
February 5, 2019: Journal of the Neurological Sciences
Liis Sabre, Amelia Evoli, Anna Rostedt Punga
Recent reports on cognitive dysfunction, in addition to skeletal muscle fatigue, in muscle-specific tyrosine kinase antibody seropositive (MuSK+) myasthenia gravis (MG) patients led us to study cognition in mice with MuSK+ passive transfer MG (PTMG). Twelve 7-week-old female wild-type C57BL/6J mice were passively immunized with IgG from MuSK+ MG patients and 12 control mice received intraperitoneal saline injections. Mice were evaluated with clinical, neurophysiological and behavioral tests (Barnes maze (BM) and novel object recognition (NOR)), and the muscles were immunostained to evaluate the neuromuscular junction in the end of the study...
February 4, 2019: Journal of the Neurological Sciences
Tsuyoshi Hamaguchi, Junji Komatsu, Kenji Sakai, Moeko Noguchi-Shinohara, Satoshi Aoki, Takeshi Ikeuchi, Masahito Yamada
No abstract text is available yet for this article.
February 1, 2019: Journal of the Neurological Sciences
William F Wright, Casey N Pinto, Kathryn Palisoc, Salim Baghli
Viral meningitis is an inflammation of the meninges associated with acute onset of meningeal symptoms and fever, pleocytosis of the cerebrospinal fluid, and no growth on routine bacterial culture. It is sometimes associated with viral encephalitis and meningoencephalitis. Viruses reach the central nervous system (CNS) hematogenously or in a retrograde manner from nerve endings. The viral etiology varies according to age and country. Molecular diagnostics technology has helped improve the rate of pathogen detection reducing unnecessary antibiotic use and length of hospitalization...
January 31, 2019: Journal of the Neurological Sciences
A-Ching Chao, Ke Han, Sheng-Feng Lin, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Han-Hwa Hu, Chyi-Huey Bai
BACKGROUND AND PURPOSE: The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6 mg/kg) and standard-dose (0.9 mg/kg) alteplase for varying severity of Asian geriatric stroke patients. METHODS: The favorable functional outcome on day 90 after stroke onset, and the symptomatic intracranial hemorrhage (SICH) rate following 24-36 h of intravenous alteplase were measured...
January 29, 2019: Journal of the Neurological Sciences
Christian Roth, Andreas Ferbert, Johannes Matthaei, Stefanie Kaestner, Holger Engel, Markus Gehling
BACKGROUND: Clinical investigations of brain death are supposed to prove absence of cerebral perfusion. However, only limited data are available documenting intracranial pressure (ICP) and cerebral perfusion pressure (CPP) during the development of brain death. Our study presents additional data to understand the course of ICP and CPP in patients developing brain death. MATERIAL AND METHODS: We analyzed retrospective data of 18 patients with ICP monitoring during the development of brain death due to primary brain lesions...
January 29, 2019: Journal of the Neurological Sciences
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