Journals Journal of the Neurological Sc...

Journal of the Neurological Sciences
Arenn F Carlos, Jonathan Graff-Radford, Brian A Crum, Mary M Machulda, Nha Trang Thu Pham, Val J Lowe, Jennifer L Whitwell, Keith A Josephs
No abstract text is available yet for this article.
March 17, 2023: Journal of the Neurological Sciences
Pauline Jakubina, Alexandre Meloux, Gauthier Duloquin, Serge Aho, Catherine Vergely, Yannick Béjot
BACKGROUND: Identifying biological markers of ischemic stroke (IS) is an important research approach to develop innovative therapeutic strategies. This study aimed to assess the association between plasma Growth Differentiation Factor-8 (GDF-8)/Myostatin levels and outcome of IS patients. METHODS: Consecutive patients with acute IS treated with either intravenous thrombolysis and/or mechanical thrombectomy at Dijon University Hospital, France were prospectively included...
March 16, 2023: Journal of the Neurological Sciences
Rong Zhou, Yanyu Wang, Ling Gao, Liangjun Dang, Suhang Shang, Ningwei Hu, Wei Peng, Yi Zhao, Shan Wei, Ye Yuan, Fan Gao, Jin Wang, Qiumin Qu
OBJECTIVES: It has been known that pulse pressure (PP) is a risk factor for cardiovascular disease and stroke, however, the relationship between PP and cognitive impairment is unclear. METHODS: This was a community-based cohort study. Participates were followed-up for 4 years and new-onset cognitive impairment was diagnosed. Multivariable logistic regression and restricted cubic spline (RCS) were used to investigate the relationship between PP and cognitive impairment...
March 11, 2023: Journal of the Neurological Sciences
Ayano Shima, Kenji Sakai, Fumio Yamashita, Tsuyoshi Hamaguchi, Tetsuyuki Kitamoto, Makoto Sasaki, Masahito Yamada, Kenjiro Ono
BACKGROUND: Radiological features in patients with sporadic Creutzfeldt-Jakob disease (sCJD) are hyperintensity of the cerebral cortex and the basal ganglia displayed by diffusion-weighted magnetic resonance imaging (DW-MRI). We performed a quantitative study on neuropathological and radiological findings. METHODS: Patient 1 received a definite diagnosis of MM1-type sCJD, while patient 2 received a definite diagnosis of MM1 + 2-type sCJD. Two DW-MRI scans were performed on each patient...
March 6, 2023: Journal of the Neurological Sciences
Eirini Papadopoulou, Georgia Pepe, Spiridon Konitsiotis, Maria Chondrogiorgi, Nikolaos Grigoriadis, Vasilios K Kimiskidis, Georgios Tsivgoulis, Dimos D Mitsikostas, Elisabeth Chroni, Eleni Domouzoglou, Georgios Tsaousis, Georgios Nasioulas
Technological advancements have facilitated the availability of reliable and thorough genetic analysis in many medical fields, including neurology. In this review, we focus on the importance of selecting the appropriate genetic test to aid in the accurate identification of disease utilizing currently employed technologies for analyzing monogenic neurological disorders. Moreover, the applicability of comprehensive analysis via NGS for various genetically heterogeneous neurological disorders is reviewed, revealing its efficiency in clarifying a frequently cloudy diagnostic picture and delivering a conclusive and solid diagnosis that is essential for the proper management of the patient...
March 5, 2023: Journal of the Neurological Sciences
Yeonggeun Choi, Yerim Kim, Sung Eun Kim, Ju-Hun Lee
BACKGROUND AND PURPOSE: Although supraventricular ectopic beats (SVE), including premature atrial contractions (PACs) and non-sustained atrial tachycardia (NSAT), are frequent in the general population, some study results indicate that they are pathologic. SVE may predict undiagnosed atrial fibrillation or be associated with the embolic pattern of ischemic stroke. The aim of this study was to identify the indicators most associated with embolic stroke among the parameters that suggest the burden of SVE...
March 5, 2023: Journal of the Neurological Sciences
Xinran Hu, Yusuke Fukui, Tian Feng, Zhihong Bian, Haibo Yu, Ryuta Morihara, Xiao Hu, Yuting Bian, Hongming Sun, Mami Takemoto, Yumiko Nakano, Taijun Yunoki, Koji Abe, Toru Yamashita
Carnosine (β-alanyl-L-histidine) is a natural dipeptide with multiple neuroprotective properties. Previous studies have advertised that carnosine scavenges free radicals and displays anti-inflammatory activity. However, the underlying mechanism and the efficacies of its pleiotropic effect on prevention remained obscure. In this study, we aimed to investigate the anti-oxidative, anti-inflammative, and anti-pyroptotic effects of carnosine in the transient middle cerebral artery occlusion (tMCAO) mouse model...
March 4, 2023: Journal of the Neurological Sciences
Abhi Pandhi, Rahul Chandra, Mohammad A Abdulrazzak, Anas Alrohimi, Ashutosh Mahapatra, Mark Bain, Nina Moore, M Shazam Hussain, Jennifer Bullen, Gabor Toth
BACKGROUND: Multiple trials have shown that mechanical thrombectomy (MT) is superior to medical therapy. However, no robust evidence is available regarding MT beyond 24 h. In this study, we aimed to determine the safety and efficacy of endovascular stroke therapy in this late window. METHODS: We conducted a retrospective study of prospectively collected data of patients who met extended window trial criteria, but underwent MT beyond 24 h. Safety and efficacy outcomes included symptomatic intracerebral hemorrhage (sICH), procedural complications, number of passes, successful recanalization (mTICI 2b - 3), delta (Δ) NIHSS (baseline-discharge), and favorable outcomes (mRS 0-2 at 90 days)...
March 2, 2023: Journal of the Neurological Sciences
A Salvalaggio, M Cacciavillani, C Tiengo, A Cipriani, L Frizziero, M Fedrigo, S Rizzo, A Angelini, R Gasparotti, C Briani
No abstract text is available yet for this article.
February 28, 2023: Journal of the Neurological Sciences
Peter Fusdahl, Jeffrey Cummings, Clive Ballard, Miguel Germán Borda, Dag Aarsland
No abstract text is available yet for this article.
February 28, 2023: Journal of the Neurological Sciences
Mukesh Kumar, Sherry Hu, Steven Beyea, Noreen Kamal
Neuroimaging, including CT and MRI, is integral to ischemic stroke (IS) treatment, management, and prevention. However, the use of MRI for IS patients is limited despite its potential to provide high-quality images that yield definitive information related to the management of IS. MRI is beneficial when the information provided by CT is insufficient for decisions related to the diagnosis, etiology, or treatment of IS. In the emergency setting, MRI can improve the diagnostic accuracy of CT-negative acute ischemic strokes (AIS) and ensure a better selection of patients for reperfusion therapies with thrombolysis and/or thrombectomy...
February 18, 2023: Journal of the Neurological Sciences
William K Page, David W Sulon, Charles J Duffy
Navigation gets us from place to place, creating a path to arrive at a goal. We trained a monkey to steer a motorized cart in a large room, beginning at its trial-by-trial start location and ending at a trial-by-trial cued goal location. While the monkey steered its autonomously chosen path to its goal, we recorded neural activity simultaneously in both the hippocampus (HPC) and medial superior temporal (MST) cortex. Local field potentials (LFPs) in these sites show similar patterns of activity with the 15-30 Hz band highlighting specific room locations...
February 17, 2023: Journal of the Neurological Sciences
Lize C Jiskoot, Lucy L Russell, Georgia Peakman, Rhian S Convery, Caroline V Greaves, Martina Bocchetta, Jackie M Poos, Harro Seelaar, Lucia A A Giannini, John C van Swieten, Rick van Minkelen, Yolande A L Pijnenburg, James B Rowe, Barbara Borroni, Daniela Galimberti, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Chris R Butler, Caroline Graff, Robert Laforce, Raquel Sanchez-Valle, Alexandre de Mendonça, Fermin Moreno, Matthias Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle le Ber, Johannes Levin, Markus Otto, Florence Pasquier, Isabel Santana, David M Cash, David Thomas, Jonathan D Rohrer
OBJECTIVE: Sensitive cognitive markers are still needed for frontotemporal dementia (FTD). The Benson Complex Figure Test (BCFT) is an interesting candidate test, as it assesses visuospatial, visual memory, and executive abilities, allowing the detection of multiple mechanisms of cognitive impairment. To investigate differences in BCFT Copy, Recall and Recognition in presymptomatic and symptomatic FTD mutation carriers, and to explore its cognitive and neuroimaging correlates. METHOD: We included cross-sectional data from 332 presymptomatic and 136 symptomatic mutation carriers (GRN, MAPT or C9orf72 mutations), and 290 controls in the GENFI consortium...
February 16, 2023: Journal of the Neurological Sciences
Angelo Torrente, Paolo Alonge, Vincenzo Di Stefano, Roberta Baschi, Raffaele Ornello, Edvige Correnti, Antonino Lupica, Cecilia Camarda, Gabriella Farinella, Vincenzo Raieli, Simona Sacco, Roberto Monastero, Filippo Brighina
OBJECTIVE: To describe the characteristics of patients with new-onset headache following SARS-CoV-2 infection. BACKGROUND: SARS-CoV-2 infection leads to several neurological manifestations, and headache is a frequent and disabling symptom, both exacerbating pre-existing headache syndromes and causing new-onset ones. METHODS: Patients with new-onset headache after SARS-CoV-2 infection with consent to participate were included, while those ones with previous headaches were excluded...
February 16, 2023: Journal of the Neurological Sciences
Tomáš Veverka, Pavel Hok, Markéta Trnečková, Pavel Otruba, Jana Zapletalová, Zbyněk Tüdös, Martin Lotze, Petr Kaňovský, Petr Hluštík
In post-stroke spasticity (PSS), effective treatment with botulinum neurotoxin (BoNT) is associated with transient decrease in activation of the ipsilesional superior parietal lobule (SPL) and intraparietal sulcus (IPS). We hypothesized that this would be reflected in changes in resting-state functional connectivity (rsFC) of the SPL/IPS. Our aim was therefore to assess rsFC of the ipsilesional SPL/IPS in chronic stroke patients with hemiparesis both with and without PSS and to explore the relationship between SPL/IPS rsFC and PSS severity...
February 15, 2023: Journal of the Neurological Sciences
Yuichiro Ohya, Ryu Matsuo, Noriko Sato, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono
BACKGROUND AND PURPOSE: This study examined the association between age and clinical outcomes after ischemic stroke, and whether the effect of age on post-stroke outcomes can be modified by various factors. METHODS: We included 12,171 patients with acute ischemic stroke, who were functionally independent before stroke onset, in a multicenter hospital-based study conducted in Fukuoka, Japan. Patients were categorized into six groups according to age: ≤ 45, 46-55, 56-65, 66-75, 76-85, and > 85 years...
February 15, 2023: Journal of the Neurological Sciences
Tadashi Kanamoto, Yohei Tateishi, Kairi Yamashita, Kanako Furuta, Daishi Torimura, Yuki Tomita, Takuro Hirayama, Tomoaki Shima, Atsushi Nagaoka, Shunsuke Yoshimura, Teiichiro Miyazaki, Reiko Ideguchi, Minoru Morikawa, Yoichi Morofuji, Nobutaka Horie, Tsuyoshi Izumo, Akira Tsujino
BACKGROUND AND PURPOSE: We aimed to investigate the relationship between arterial recanalization following endovascular therapy and the susceptibility vessel sign (SVS) length and width on susceptibility-weighted imaging. METHODS: We retrospectively evaluated consecutive patients with anterior circulation ischemic stroke who underwent magnetic resonance imaging preceded endovascular therapy, and measured the SVS length and width. Successful recanalization was defined as expanded thrombolysis in cerebral infarction grade of 2b to 3...
February 12, 2023: Journal of the Neurological Sciences
Hyein Cho, Giuseppina Pilloni, Raisa Tahsin, Pamela Best, Lauren Krupp, Cheongeun Oh, Leigh Charvet
OBJECTIVES: Intra-individual variability (IIV), measured across repeated response times (RT) during continuous psychomotor tasks, is an early marker of cognitive change in the context of neurodegeneration. To advance IIV towards broader application in clinical research, we evaluated IIV from a commercial cognitive testing platform and compared it to the calculation approaches used in experimental cognitive studies. METHODS: Cognitive assessment was administered in participants with multiple sclerosis (MS) during the baseline of an unrelated study...
February 12, 2023: Journal of the Neurological Sciences
Paula Nurminen, Johan Marjamaa, Mika Niemelä, Tiina Sairanen
BACKGROUND: Hemifacial spasm (HFS) is a movement disorder of facial muscles innervated by the facial nerve. This condition often demands regular utilization of healthcare resources. However, knowledge of the incidence and prevalence of this condition is based on scarce studies. This research aimed to identify the incidence and prevalence of HFS in Finland's largest hospital district. METHODS: This retrospective study was conducted in the largest hospital district in Finland (Helsinki and Uusimaa)...
February 12, 2023: Journal of the Neurological Sciences
Jonas L Isaksen, Jonas Ghouse, Morten W Skov, Morten S Olesen, Anders G Holst, Adrian Pietersen, Jonas B Nielsen, Anja Maier, Claus Graff, Thomas A Gerds, Ruth Frikke-Schmidt, Jørgen K Kanters
OBJECTIVE: The association between common electrocardiogram (ECG) markers and Alzheimer's disease has been scarcely investigated, and it is unknown if ECG markers can improve risk prediction. Thus, we aimed to examine the association between common ECG markers and Alzheimer's disease in a large population. METHODS: We studied the association between ECG markers and Alzheimer's disease using Cox models with adjustment for age, sex, and comorbidities using a large primary care population of patients aged 60 years or more...
February 9, 2023: Journal of the Neurological Sciences
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