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Journals Journal of the Neurological Sc...

Journal of the Neurological Sciences

https://read.qxmd.com/read/37774562/axial-symptoms-as-main-predictors-of-short-term-subthalamic-stimulation-outcome-in-parkinson-s-disease
#1
JOURNAL ARTICLE
Carlo Alberto Artusi, Claudia Ledda, Domiziana Rinaldi, Elisa Montanaro, Alberto Romagnolo, Gabriele Imbalzano, Mario Giorgio Rizzone, Maurizio Zibetti, Leonardo Lopiano, Marco Bozzali
Deep brain stimulation (DBS) is an established therapeutic option for Parkinson's disease (PD) patients; however, a clear-cut definition of subthalamic (STN) DBS predictors in PD is lacking. We analyzed a cohort of 181 STN-treated PD patients and compared pre- vs. 1-year post-surgical motor, dyskinesia, Off time, and daily-life activities (ADL) scores. A multivariate linear regression analysis was used to evaluate the association between clinical/demographic characteristics and the extent of STN-DBS response for outcomes proving a significant change after surgery...
September 26, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37774561/dopaminergic-dysfunction-role-for-genetic-epigenetic-testing-in-the-new-psychiatry
#2
JOURNAL ARTICLE
Kenneth Blum, J Wesson Ashford, Babak Kateb, Daniel Sipple, Eric Braverman, Catherine A Dennen, David Baron, Rajendra Badgaiyan, Igor Elman, Jean Lud Cadet, Panayotis K Thanos, Colin Hanna, Abdalla Bowirrat, Edward J Modestino, Vicky Yamamoto, Ashim Gupta, Thomas McLaughlin, Mlan Makale, Mark S Gold
Reward Deficiency Syndrome (RDS), particularly linked to addictive disorders, costs billions of dollars globally and has resulted in over one million deaths in the United States (US). Illicit substance use has been steadily rising and in 2021 approximately 21.9% (61.2 million) of individuals living in the US aged 12 or older had used illicit drugs in the past year. However, only 1.5% (4.1 million) of these individuals had received any substance use treatment. This increase in use and failure to adequately treat or provide treatment to these individuals resulted in 106,699 overdose deaths in 2021 and increased in 2022...
September 23, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37776718/deep-learning-analysis-of-uplc-ms-ms-based-metabolomics-data-to-predict-alzheimer-s-disease
#3
JOURNAL ARTICLE
Kesheng Wang, Laurie A Theeke, Christopher Liao, Nianyang Wang, Yongke Lu, Danqing Xiao, Chun Xu
OBJECTIVE: Metabolic biomarkers can potentially inform disease progression in Alzheimer's disease (AD). The purpose of this study is to identify and describe a new set of diagnostic biomarkers for developing deep learning (DL) tools to predict AD using Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS/MS)-based metabolomics data. METHODS: A total of 177 individuals, including 78 with AD and 99 with cognitive normal (CN), were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort along with 150 metabolomic biomarkers...
September 22, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37757638/clinical-characteristics-of-pathological-confirmed-prodromal-dementia-with-lewy-bodies
#4
JOURNAL ARTICLE
Simon Kang Seng Ting, Seyed Ehsan Saffari, Shahul Hameed, Hui Jin Chiew, Kok Pin Ng, Adeline Sl Ng
INTRODUCTION: Misdiagnosis rate of Dementia with Lewy Bodies (DLB) remains high despite being second most common cause of neurodegenerative dementia. To date, understanding of clinical profile of pathologically confirmed prodromal DLB remains limited. The main objective of this study was to describe and compare it with pathologically confirmed Alzheimer's disease (AD). METHODS: We accessed the National Alzheimer's Coordinating Center database from 2005 to December 2022 data freeze and included 111 and 501 prodromal DLB and AD patients respectively...
September 21, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37757637/cost-of-treatment-failure-medicare-spending-on-stroke-for-atrial-fibrillation-patients-not-receiving-anticoagulation
#5
JOURNAL ARTICLE
Steven D Culler, W Frank Peacock, April W Simon
BACKGROUND: It is well known that atrial fibrillation (AF) patients not receiving anticoagulants are at higher risk of Ischemic Stroke (IS). OBJECTIVE: Our objective is to estimate how much the Medicare program spends during one-year treating a Medicare beneficiary (MB) with AF who were not being anticoagulated prior to or during their IS hospitalization. METHODS: This cross-sectional study population consisted of all MBs in the fee-for-service program who were discharged from a hospitalization for IS having AF during 2018...
September 19, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37742348/a-novel-mri-based-volumetric-index-for-monitoring-the-motor-symptoms-in-parkinson-s-disease
#6
JOURNAL ARTICLE
Anupa A Vijayakumari, Nymisha Mandava, Olivia Hogue, Hubert H Fernandez, Benjamin L Walter
BACKGROUND: Conventional MRI scans have limited usefulness in monitoring Parkinson's disease as they typically do not show any disease-specific brain abnormalities. This study aimed to identify an imaging biomarker for tracking motor symptom progression by using a multivariate statistical approach that can combine gray matter volume information from multiple brain regions into a single score specific to each PD patient. METHODS: A cohort of 150 patients underwent MRI at baseline and had their motor symptoms tracked for up to 10 years using MDS-UPDRS-III, with motor symptoms focused on total and subscores, including rigidity, bradykinesia, postural instability, and gait disturbances, resting tremor, and postural-kinetic tremor...
September 19, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37757639/switching-between-anti-calcitonin-gene-related-peptide-monoclonal-antibodies-a-comparison-of-monthly-and-quarterly-dosing
#7
JOURNAL ARTICLE
Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Naoki Miyazaki, Ryo Takemura, Satoko Hori, Jin Nakahara, Tsubasa Takizawa
BACKGROUND: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) have dramatically changed preventive treatment options for patients with migraine. Although there is emerging real-world evidence on the use of CGRPmAbs globally, the change in efficacy and safety after switching between CGRPmAbs owing to patients' frequency of hospital visits preference remains unknown. METHODS: We conducted a single-centre, retrospective, real-world study of patients with migraine who first received galcanezumab for 3 or 4 months and then switched to fremanezumab at Keio University Hospital...
September 16, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37742349/invoking-ai-for-diagnosis-art-at-the-cutting-edge-of-science
#8
EDITORIAL
Pulikottil Wilson Vinny
No abstract text is available yet for this article.
September 16, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37741773/does-gpt-4-have-neurophobia-localization-and-diagnostic-accuracy-of-an-artificial-intelligence-powered-chatbot-in-clinical-vignettes
#9
JOURNAL ARTICLE
Kristin Galetta, Ethan Meltzer
BACKGROUND AND OBJECTIVES: This is an observational study of the performance of an artificial intelligence-powered chatbot tasked with solving unknown neurologic case vignettes. The primary objective of the study is to assess the current capabilities of widely-accessible artificial intelligence within the field of clinical neurology in order to determine how this technology can be deployed in clinical practice, and what insights can be learned from its performance and translated to clinical education...
September 15, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37742350/resumption-of-oral-anticoagulation-in-patients-with-non-valvular-atrial-fibrillation-after-intracerebral-hemorrhage-a-sub-analysis-of-the-pasta-registry-study
#10
JOURNAL ARTICLE
Satoshi Suda, Yasuyuki Iguchi, Yoshiki Yagita, Takao Kanzawa, Seiji Okubo, Shigeru Fujimoto, Yu Kono, Kazumi Kimura
PURPOSE: To investigate the rate and timing of oral anticoagulant (OAC) resumption and its safety in patients after intracerebral hemorrhage (ICH) in current clinical practice in Japan. METHODS: We conducted a sub-analysis of the PASTA registry, an observational, multicenter registry of 1043 patients with stroke receiving OACs in Japan, by including patients with ICH on OAC treatment for non-valvular atrial fibrillation (NVAF). The clinical characteristics of the patients in the resumption and non-resumption groups, rate and timing of OAC resumption, its safety, and switching of OACs after ICH were investigated...
September 14, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37729754/characteristics-and-outcomes-of-unknown-onset-stroke-the-japan-stroke-data-bank
#11
JOURNAL ARTICLE
Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Masatoshi Koga
BACKGROUND: Clinical outcomes of unknown onset stroke (UOS) are influenced by the enlargement of the therapeutic time window for reperfusion therapy. This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS. METHODS: Patients with acute ischemic stroke (AIS) who were admitted within 24 h of their last known well time, from January 2017 to December 2020, were included. Data were obtained from a long-lasting nationwide hospital-based multicenter prospective registry: the Japan Stroke Data Bank...
September 14, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37722232/automated-pupillometry-and-optic-nerve-sheath-diameter-ultrasound-to-define-tuberculous-meningitis-disease-severity-and-prognosis
#12
JOURNAL ARTICLE
Flora Casey, Hoang Minh Tu Van, Joseph Donovan, Ho Dang Trung Nghia, Pham Kieu Nguyet Oanh, C Louise Thwaites, Nguyen Hoan Phu, Guy E Thwaites
BACKGROUND: Tuberculous meningitis (TBM) causes high mortality and morbidity, in part due to raised intracranial pressure (ICP). Automated pupillometry (NPi) and optic nerve sheath diameter (ONSD) are both low-cost, easy-to-use and non-invasive techniques that correlate with ICP and neurological status. However, it is uncertain how to apply these techniques in the management of TBM. METHODS: We conducted a pilot study enrolling 20 adults with TBM in the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam...
September 13, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37717279/clinical-narratives-as-a-predictor-for-prognosticating-functional-outcomes-after-intracerebral-hemorrhage
#13
JOURNAL ARTICLE
Ling-Chien Hung, Ying-Ying Su, Jui-Ming Sun, Wan-Ting Huang, Sheng-Feng Sung
BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke type that causes high mortality rates and severe disability among survivors. Many prognostic models are available for prognosticating patients with ICH. This study aimed to investigate whether clinical narratives can improve the performance for predicting functional outcomes after ICH. METHODS: This study used data from the hospital stroke registry and electronic health records. The study population (n = 1363) was randomly divided into a training set (75%, n = 1023) and a holdout test set (25%, n = 340)...
September 13, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37741123/prevalence-of-pineal-cysts-in-healthy-individuals-emphasis-on-size-morphology-and-pineal-recess-crowding
#14
JOURNAL ARTICLE
Bogna Warsza, Pernille Due-Tønnessen, Paulina Due-Tønnessen, Are Pripp, Geir Ringstad, Per K Eide
The present study aimed to determine prevalence of non-hydrocephalic pineal cysts of different size and morphology in healthy individuals. In a cohort of healthy individuals who as part of research volunteered to undergo magnetic resonance imaging (MRI) of the brain, we performed a systematic search for occurrence of pineal cysts of different sizes, morphology and evidence of crowding of the pineal recess. Degree of crowding in the pineal recess was estimated by the imaging biomarkers anterior-posterior diameter and cyst-tectum-splenium (CTS) ratio at midsagittal MRI...
September 12, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37741122/the-impact-of-off-hour-mechanical-thrombectomy-therapy-on-outcomes-for-acute-ischemic-stroke-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Sherief Ghozy, Alireza Hasanzadeh, Hassan Kobeissi, Mariam Abdelghaffar, Mahan Shafie, Zahra Beizavi, Amir Hassankhani, Ahmed Y Azzam, Adam A Dmytriw, Ramanathan Kadirvel, David F Kallmes
BACKGROUND: The impact of off-hours and on-hours mechanical thrombectomy (MT) treatment for acute ischemic stroke (AIS) is not well understood. We conducted a systematic review and met-analysis comparing outcomes between patients undergoing off-hours MT versus on-hours MT. METHODS: This study is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses recommendations. A systematic literature review of the English language literature was conducted using Web of Science, Embase, Scopus, and PubMed databases...
September 12, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37717280/effect-of-edaravone-on-symptomatic-intracranial-hemorrhage-in-patients-with-acute-large-vessel-occlusion-on-apixaban-for-non-valvular-atrial-fibrillation
#16
JOURNAL ARTICLE
Takuya Saito, Fumihiro Sakakibara, Kazutaka Uchida, Shinichi Yoshimura, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Takeshi Morimoto
BACKGROUND: Edaravone administration was associated with lower incidence of symptomatic intracranial hemorrhage (sICH) in patients with acute large vessel occlusion (LVO). However, its protective effect on sICH in patients with LVO who receive direct oral anticoagulants for non-valvular atrial fibrillation (NVAF) is uncertain. OBJECTIVES: To explore the effect of edaravone administration on the incidence of sICH in patients with acute LVO receiving apixaban for NVAF...
September 12, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37716237/plasma-p-tau181-as-a-promising-non-invasive-biomarker-of-alzheimer-s-disease-pathology-in-subjective-cognitive-decline-and-mild-cognitive-impairment
#17
JOURNAL ARTICLE
Giulia Giacomucci, Salvatore Mazzeo, Chiara Crucitti, Assunta Ingannato, Silvia Bagnoli, Sonia Padiglioni, Giulia Galdo, Filippo Emiliani, Daniele Frigerio, Valentina Moschini, Carmen Morinelli, Sandro Sorbi, Valentina Bessi, Benedetta Nacmias
INTRODUCTION: The aim of this study is to investigate the role of plasma phosphorylated tau (p-tau) 181 as a potential biomarker for Alzheimer's Disease (AD) pathology in the early stages of the disease, as a valuable marker for tauopathy. MATERIALS AND METHODS: Thirty-three Subjective Cognitive Decline (SCD), 32 Mild Cognitive Impairment (MCI) and 14 AD demented (AD-d) patients underwent plasma p-tau181 analysis with SiMoA assay. Twenty-six SCD, 32 MCI and 14 AD-d patients also underwent CSF biomarkers analysis (Aβ1-42, Aβ1-42/1-40, p-tau, t-tau) and were classified as carriers of AD pathology (AP+) when A+ was associated with T+ (regardless of N), or non-carriers (AP-) when they were A- (regardless of T and N), or A+/T-/N-, or A+/T-/N+ according to the A/T(N) system...
September 12, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37713951/in-memoriam-paula-coutinho-1941-2022-a-pioneer-in-neurogenetics
#18
LETTER
Jorge Sequeiros, José Leal Loureiro, José Barros
No abstract text is available yet for this article.
September 9, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37703708/acute-onset-of-adult-alexander-disease-and-the-concept-of-gfap-toxicity
#19
LETTER
Filipe Godinho, Carolina Guerreiro, João Parente Freixo, Jorge Oliveira, José Lourenço Rosa
No abstract text is available yet for this article.
September 9, 2023: Journal of the Neurological Sciences
https://read.qxmd.com/read/37703705/looking-for-inconsistency-combining-distraction-with-spirography-for-diagnosis-of-functional-tremor
#20
LETTER
Saad Moughal, Andreas Christou, Mark Edwards, Jan Coebergh
No abstract text is available yet for this article.
September 9, 2023: Journal of the Neurological Sciences
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