Leonard Y M Cheung, Lucy Menage, Karine Rizzoti, Greg Hamilton, Typhanie Dumontet, Kaitlin Basham, Alexandre Z Daly, Michelle L Brinkmeier, Bailey E Masser, Mathias Treier, John Cobb, Alessio Delogu, Robin Lovell-Badge, Gary D Hammer, Sally A Camper
The pituitary gland regulates growth, metabolism, reproduction, the stress response, uterine contractions, lactation, and water retention. It secretes hormones in response to hypothalamic input, end organ feedback, and diurnal cues. The mechanisms by which pituitary stem cells are recruited to proliferate, maintain quiescence or differentiate into specific cell types, especially thyrotropes, are not well understood. We utilized single-cell RNA sequencing in juvenile P7 mouse pituitary cells to identify novel factors in pituitary cell populations, with a focus on thyrotropes and rare subtypes...
May 15, 2023: Endocrinology