Rupak Thapa, Logan Druessel, Liang Ma, Donald S Torry, Brent M Bany
During the secretory phase of the menstrual cycle, elongated fibroblast-like mesenchymal cells in the uterine endometrium begin to trans-differentiate into polygonal epithelioid-like (decidual) cells. This decidualization process continues more broadly during early pregnancy, and the resulting decidual tissue supports successful embryo implantation and placental development. This study was carried out to determine if atonal basic helix-loop-helix transcription factor 8 (ATOH8) plays a role in human endometrial stromal fibroblast (ESF) decidualization...
December 7, 2023: Endocrinology
Nadia Saadat, Joseph Ciarelli, Brooke Pallas, Vasantha Padmanabhan, Arpita Kalla Vyas
Gestational hyperandrogenism adversely impacts offspring health. Using an ovine model, we found prenatal testosterone (T) excess adversely affects growth and cardiometabolic outcomes in female offspring and sex-specific effects on fetal myocardium. Since lipids are essential to cardiometabolic function, we hypothesized that prenatal T excess will lead to sex-specific disruptions in lipid metabolism at birth. Shotgun lipidomics was performed on the plasma samples collected 48 hours after birth from female (F) and male (M) lambs of control (C) and (T) sheep (CF=4, TF=7, CM=5, TM=10) and data analyzed by univariate analysis, multivariate dimensionality reduction modeling followed by functional enrichment and pathway analyses...
December 7, 2023: Endocrinology
Juan Pablo Robles, Magdalena Zamora, Jose F Garcia-Rodrigo, Alma Lorena Perez, Thomas Bertsch, Gonzalo Martinez de la Escalera, Jakob Triebel, Carmen Clapp
Vasoinhibin is a proteolytic fragment of the hormone prolactin that inhibits blood vessel growth (angiogenesis) and permeability, stimulates the apoptosis and inflammation of endothelial cells and promotes fibrinolysis. The antiangiogenic and antivasopermeability properties of vasoinhibin were recently traced to the HGR motif located in residues 46 to 48, allowing the development of potent, orally active, HGR-containing vasoinhibin analogs for therapeutic use against angiogenesis-dependent diseases. However, whether the HGR motif is also responsible for the apoptotic, inflammatory, and fibrinolytic properties of vasoinhibin has not been addressed...
December 6, 2023: Endocrinology
Tianzhichao Hou, Qi Wang, Huajie Dai, Yanan Hou, Jie Zheng, Tiange Wang, Hong Lin, Shuangyuan Wang, Mian Li, Zhiyun Zhao, Yuhong Chen, Yu Xu, Jieli Lu, Ruixin Liu, Guang Ning, Weiqing Wang, Min Xu, Yufang Bi
CONTEXT: The association between the gut microbiota and thyroid cancer remains controversial. OBJECTIVE: We aimed to systematically investigate the interactive causal relationships between the abundance and metabolism pathways of gut microbiota and thyroid cancer. METHODS: We leveraged genome-wide association studies for the abundance of 211 microbiota taxa from the MiBioGen study (N = 18,340), 205 microbiota metabolism pathways from the Dutch Microbiome Project (N = 7738), and thyroid cancer from the Global Biobank Meta-analysis Initiative (N cases = 6699 and N participants = 1,620,354)...
December 5, 2023: Endocrinology
Katherine Kim, Mita Varghese, Haijing Sun, Simin Abrishami, Emily Bowers, Dave Bridges, Jennifer L Meijer, Kanakadurga Singer, Brigid Gregg
Obesity and metabolic diseases are rising in women of reproductive age, increasing offspring metabolic risk. Maternal nutritional interventions during lactation present an opportunity to modify offspring outcomes. We previously demonstrated in mice that adult male offspring have metabolic impairments and increased adipose tissue macrophages (ATM) when dams are fed high fat diet (HFD) during the postnatal lactation window (HFD PN). We sought to understand the effect of HFD during lactation on early life inflammation...
December 4, 2023: Endocrinology
Masamichi Fujita, Takashi Miyazawa, Keiichiro Uchida, Naohiro Uchida, Shojiro Haji, Seiichi Yano, Norifusa Iwahashi, Tomomi Hatayama, Shunsuke Katsuhara, Shintaro Nakamura, Yukina Takeichi, Maki Yokomoto-Umakoshi, Yasutaka Miyachi, Ryuichi Sakamoto, Yoichiro Iwakura, Yoshihiro Ogawa
Pancreatic islet inflammation plays a crucial role in the etiology of type 2 diabetes (T2D). Macrophages residing in pancreatic islets have emerged as key players in islet inflammation. Macrophages express a plethora of innate immune receptors that bind to environmental and metabolic cues and integrate these signals to trigger an inflammatory response that contributes to the development of islet inflammation. One such receptor, Dectin-2, has been identified within pancreatic islets; however, its role in glucose metabolism remains largely unknown...
December 1, 2023: Endocrinology
Rosa I Luna-Ramirez, Amy C Kelly, Miranda J Anderson, Christopher A Bidwell, Ravi Goyal, Sean W Limesand
Prevailing hypoxemia and hypoglycemia in near-term fetuses with placental insufficiency-induced intrauterine growth restriction (IUGR) chronically increases norepinephrine concentrations, which lowers adrenergic sensitivity and lipid mobilization postnatally, indicating a predisposition for adiposity. To determine adrenergic-induced responses, we examined the perirenal adipose tissue transcriptome from IUGR fetuses with or without hypercatecholaminemia. IUGR was induced in sheep with maternal hyperthermia, and hypercatecholaminemia in IUGR was prevented with bilateral adrenal demedullation...
November 30, 2023: Endocrinology
Julia N C Toews, Tristan J Philippe, Matthew Dordevic, Lesley A Hill, Geoffrey L Hammond, Victor Viau
Produced by the liver, corticosteroid-binding globulin (CBG) regulates the plasma distribution and actions of glucocorticoids. A sex difference in pituitary growth hormone secretion patterns established during puberty in rats results in increased hepatic CBG production and two-fold higher plasma corticosterone levels in females. Glucocorticoids control hepatic development and metabolic activities, and we have therefore examined how disrupting the SerpinA6 gene encoding CBG influences plasma corticosterone dynamics, as well as liver gene expression in male and female rats before and after puberty...
November 28, 2023: Endocrinology
Sebastian A Pace, Brent Myers
Hindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to physical and psychological challenges. Neurons that synthesize adrenaline and noradrenaline target hypothalamic structures to modulate endocrine responses while descending spinal projections regulate sympathetic function. Furthermore, these neurons respond to diverse stress-related metabolic, autonomic, and psychosocial challenges. Accordingly, adrenergic and noradrenergic nuclei are integrative hubs that promote physiological adaptation to maintain homeostasis...
November 28, 2023: Endocrinology
Chandler S Callaway, Lila M Mouchantat, Benjamin G Bitler, Andrea Bonetto
Cancer-associated cachexia occurs in 50-80% of cancer patients and is responsible for 20-30% of cancer-related deaths. Cachexia limits survival and treatment outcomes, and is a major contributor to morbidity and mortality during cancer. Ovarian cancer is one of the leading causes of cancer-related deaths in women and recent studies have begun to highlight the prevalence and clinical impact of cachexia in this population. Here, we review the existing understanding of cachexia pathophysiology and summarize relevant studies assessing ovarian cancer-associated cachexia in clinical and pre-clinical studies...
November 19, 2023: Endocrinology
Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
BACKGROUND: Catecholamine-stimulated lipolysis is reduced with aging, which may promote adiposity and insulin resistance. Organic cation transporter 3 (OCT3), which is inhibited by estradiol (E2), mediates catecholamine transport into adipocytes for degradation, thus decreasing lipolysis. In this study, we investigate the association between OCT3 mRNA levels in subcutaneous adipose tissue (SAT) from women with aging and markers of insulin resistance. METHODS: SAT biopsies were obtained from 66 women with or without T2D (19/47 respectively, 22-76 years old, 20...
November 16, 2023: Endocrinology
Daniel Salamon, Dorina Ujvari, Anton Hellberg, Angelica Lindén Hirschberg
Interleukin 33 (IL-33) signaling regulates most of the key processes of pregnancy, including decidualization, trophoblast proliferation and invasion, vascular remodeling, and placental growth. Accordingly, dysregulation of IL-33, its membrane bound receptor (ST2L, transducer of IL-33 signaling) and its soluble decoy receptor (sST2, inhibitor of IL-33 signaling) has been linked to a wide range of adverse pregnancy outcomes that are common in women with obesity and polycystic ovary syndrome, i.e., conditions associated with hyperandrogenism, insulin resistance and compensatory hyperinsulinemia...
November 16, 2023: Endocrinology
Christian A Unger, Marion C Hope, Ahmed K Aladhami, William E Cotham, Cassidy E Socia, Barton C Rice, Deborah J Clegg, Kandy T Velázquez, Holly A LaVoie, Fiona Hollis, Reilly T Enos
AIMS: Serum sex steroid levels fluctuate throughout the reproductive cycle. However, the degree to which sex steroid tissue content mimics circulating content is unknown. Understanding the flux and physiological quantity of tissue steroid content is imperative for targeted hormonal therapy development. METHODS: Utilizing a gold-standard ultrasensitive liquid chromatography-mass spectrometry method (LC/MS) we determined sex steroid (17β-Estradiol (E2), testosterone, androstenedione, and progesterone) fluctuations in serum and in 15 tissues throughout the murine estrous cycle (proestrus, estrus, and diestrus I) and in ovariectomized (OVX) mice...
November 15, 2023: Endocrinology
Bo Ahrén
Recently impressive weight loss has been reported for novel incretin therapies based on dual and triple hormone receptor coagonists. These agents have potential as being positioned as early therapeutics for metabolic diseases where weight loss is preferred, such as type 2 diabetes, obesity, cardiovascular diseases and non-alcoholic liver disease. This development will change the landscape of future therapy and also place weight reduction at the centerpiece for therapy of metabolic diseases.
November 10, 2023: Endocrinology
Ricardo Augusto Leoni De Sousa, Ricardo Cardoso Cassilhas
No abstract text is available yet for this article.
November 10, 2023: Endocrinology
Wei Zhao, Yue Wang, Juan Liu, Qianying Yang, Shuai Zhang, Xiao Hu, Zhicheng Shi, Zhenni Zhang, Jianhui Tian, Dapeng Chu, Lei An
Decidualization is a progesterone-dependent cellular differentiation process that is essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization is remarkable, but their developmental functions remain largely unknown. Herein, we identify that endometrial lactate production plays a critical role in establishing local histone lactylation, a newly identified histone modification, and is important for ensuring normal decidualization. Enhanced endometrial glycolysis is the hallmark metabolic change and is tightly coupled with H4K12la during decidualization...
November 10, 2023: Endocrinology
Yifan Wu, Yuan Zeng, Yaolin Ren, Jie Yu, Qian Zhang, Xinhua Xiao
The incidence of glucose and lipid metabolism diseases, including type 2 diabetes, obesity, metabolic syndrome, and nonalcoholic fatty liver disease is rising, which places an enormous burden on people around the world. However, the mechanism behind these disorders remains incompletely understood. N6-methyladenosine (m6A) is one type of posttranscriptional RNA modification and research has shown that it plays a crucial role in several metabolic diseases. m6A methylation is reversibly and dynamically regulated by methyltransferases (writers), demethylases (erasers) and m6A binding proteins (readers)...
November 9, 2023: Endocrinology
Cheryl Cero, Weiguo Shu, Amy L Reese, Diana Douglas, Michael Maddox, Ajeet P Singh, Sahara L Ali, Alexander R Zhu, Jacqueline M Katz, Anne E Pierce, Kelly T Long, Naris Nilubol, Raymond H Cypess, Jonathan L Jacobs, Fang Tian, Aaron M Cypess
Functional human brown and white adipose tissue (BAT and WAT) are vital for thermoregulation and nutritional homeostasis, while obesity and other stressors lead, respectively, to cold intolerance and metabolic disease. Understanding BAT and WAT physiology and dysfunction necessitates clinical trials complemented by mechanistic experiments at the cellular level. These require standardized in vitro models, currently lacking, that establish references for gene expression and function. In response, we generated and characterized a pair of immortalized, clonal human brown (hBA) and white (hWA) preadipocytes derived from the perirenal and subcutaneous depots, respectively, of a 40-year-old male...
November 7, 2023: Endocrinology
Paul G Morris, Allan E Herbison
The mechanism by which arcuate kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to drive pulsatile hormone secretion remains unclear in females. In order to study spontaneous synchronization within the ARNKISS neuron network, acute brain slices were prepared from adult female Kiss1-GCaMP6 mice. Analysis of both spontaneous synchronizations and those driven by high frequency stimulation of individual ARNKISS neurons revealed that the network exhibits semi-random emergent excitation dependent upon glutamate signaling through AMPA receptors...
November 4, 2023: Endocrinology
Mariska A M Schröder, David Greenald, Renate Lodewijk, Antonius E van Herwaarden, Paul N Span, Fred C G J Sweep, Rod T Mitchell, Hedi L Claahsen-van der Grinten
Testicular adrenal rest tumors (TART), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. It is not yet established whether the human fetal testis (HFT) is responsive to ACTH. To investigate this, we cultured HFT tissue with and without ACTH for up to 5 days, and quantified adrenal steroid hormones and expression of adrenal steroidogenic enzymes. Fetal testis and adrenal tissue produced high levels of testosterone and cortisol, respectively, indicating viability...
November 3, 2023: Endocrinology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.