Journals American Journal of Veterinary...

American Journal of Veterinary Research
William A Fried, Maria Soltero-Rivera, Akshaya Ramesh, Milinda J Lommer, Boaz Arzi, Joseph L DeRisi, Jeremy A Horst
OBJECTIVE: To identify associations between microbes and host genes in cats with feline chronic gingivostomatitis (FCGS), a debilitating inflammatory oral mucosal disease with no known cause, compared with healthy cats and cats with periodontitis (control cats). ANIMALS: 19 control cats and 23 cats with FCGS. PROCEDURES: At least 1 caudal oral mucosal swab specimen was obtained from each cat. Each specimen underwent unbiased metatranscriptomic next-generation RNA sequencing (mNGS)...
May 2021: American Journal of Veterinary Research
Jessica L Sullivan, Nobuko Wakamatsu, Ji-Hang Yin, Tanner Roberts, R Avery Bennett
OBJECTIVE: To assess the feasibility of a novel technique involving a vessel and tissue-sealing device (VTSD) for ovariectomy in chickens to evaluate the potential application of the procedure to other avian species. ANIMALS: 20 domestic laying hens ( Gallus domesticus ), of which 10 were immature (< 4 months old) and 10 were adults (> 18 months old). PROCEDURES: Ovariectomy was performed with a VTSD through a left lateral celiotomy...
April 2021: American Journal of Veterinary Research
Tamas D Ambrisko, Stephanie C Dantino, Stephanie C J Keating, Danielle E Strahl-Heldreth, Adrianna M Sage, Felipe Da Costa Martins, Tisha A M Harper, Pamela A Wilkins
OBJECTIVE: To evaluate the repeatability and accuracy of fingertip pulse oximeters (FPO) for measurement of hemoglobin oxygen saturation in arterial blood and pulse rate (PR) in anesthetized dogs breathing 100% O2 . ANIMALS: 29 healthy client-owned anesthetized dogs undergoing various surgical procedures. PROCEDURES: In randomized order, each of 7 FPOs or a reference pulse oximeter (PO) was applied to the tongue of each intubated anesthetized dog breathing 100% O2 ...
April 2021: American Journal of Veterinary Research
Daniel J Duffy, Yi-Jen Chang, Lewis Gaffney, Matthew B Fisher, George E Moore
OBJECTIVE: To evaluate the effect of a continuous locking novel epitendinous suture (nES) pattern with and without a core locking-loop (LL) suture on the biomechanical properties of ex vivo canine superficial digital flexor tendon (SDFT) tenorrhaphy constructs. SAMPLE: 54 cadaveric forelimb SDFTs from 27 musculoskeletally normal adult dogs. PROCEDURES: Tendons were assigned to 3 groups (18 SDFTs/group): sharply transected and repaired with a core LL suture alone (group 1), an nES pattern alone (group 2), or a combination of a core LL suture and nES pattern (group 3)...
April 2021: American Journal of Veterinary Research
(no author information available yet)
No abstract text is available yet for this article.
April 2021: American Journal of Veterinary Research
Natalia Druzhaeva, Aleksandra Domanjko Petrič, Gabrijela Tavčar-Kalcher, Janja Babič, Alenka Nemec Svete
OBJECTIVE: To determine the dose of coenzyme Q10 (CoQ10 ) needed to achieve at least a 3-fold increase in plasma CoQ10 concentration in dogs with myxomatous mitral valve disease (MMVD) and congestive heart failure (CHF). ANIMALS: 18 dogs with CHF due to MMVD and 12 healthy dogs. PROCEDURES: In a randomized, double-blinded, controlled trial, dogs with MMVD were given 50 or 100 mg of water-soluble CoQ10 (ubiquinone; total daily dose, 100 mg [n = 5] or 200 mg [6]) or a placebo (7), PO, twice a day for 2 weeks in addition to regular cardiac treatment...
April 2021: American Journal of Veterinary Research
Claudia L Reyner, Randolph L Winter, Kara L Maneval, Lindsey H Boone, Anne A Wooldridge
OBJECTIVE: To investigate the effects of recombinant equine IL-1β on function of equine endothelial colony-forming cells (ECFCs) in vitro. SAMPLE: ECFCs derived from peripheral blood samples of 3 healthy adult geldings. PROCEDURES: Function testing was performed to assess in vitro wound healing, tubule formation, cell adhesion, and uptake of 1,1'-dioctadecyl-3,3,3',3' tetramethylindocarbocyanine perchlorate-labeled acetylated low-density lipoprotein (DiI-Ac-LDL) by cultured ECFCs...
April 2021: American Journal of Veterinary Research
Pengju Wang, Catherine Takawira, Takashi Taguchi, Xiao Niu, Munir D Nazzal, Mandi J Lopez
OBJECTIVE: To assess the effect of horseshoes with and without traction adaptations on the gait kinetics of nonlame horses during a trot on a concrete runway. ANIMALS: 5 nonlame adult light-breed horses. PROCEDURES: Kinetic data were obtained for each horse when it was trotted across a force platform within a concrete runway unshod (control) and shod with standard horseshoes; standard horseshoes with high profile-low surface area calks, with low profile-high surface area calks, and coated with a thin layer of tungsten carbide (TLTC); and plastic-steel composite (PSC) horseshoes...
April 2021: American Journal of Veterinary Research
Stephanie C J Keating, Carolyn L Kerr
OBJECTIVE: To determine the cardiopulmonary effects of IV administration of fentanyl to cats anesthetized with isoflurane and during anesthetic recovery with concurrent administration of acepromazine or dexmedetomidine. ANIMALS: 6 healthy adult cats. PROCEDURES: Cats received an IV bolus (5 μg/kg) followed by an IV infusion (5 μg/kg/h) of fentanyl for 120 minutes during isoflurane anesthesia and for 30 minutes after discontinuing isoflurane...
April 2021: American Journal of Veterinary Research
Saechol Park, Jeongwoo Choi, Kyeonga Kim, Donghyun Oh, Junghee Yoon, Mincheol Choi
OBJECTIVE: To evaluate stiffness of the liver parenchyma in healthy adult cats by means of point shear wave elastography (PSWE). ANIMALS: 18 client-owned adult (1- to 6-year-old) healthy cats. PROCEDURES: Echogenicity and echotexture of the liver parenchyma were assessed by means of conventional B-mode ultrasonography. The shear wave velocity (Vs) of the right and left portions of the liver were measured by means of PSWE. RESULTS: B-mode ultrasonography revealed no abnormalities in echotexture or echogenicity of the liver parenchyma in any cat...
April 2021: American Journal of Veterinary Research
(no author information available yet)
No abstract text is available yet for this article.
April 2021: American Journal of Veterinary Research
Tomoya Morita, Kensuke Nakamura, Tatsuyuki Osuga, Mitsuyoshi Takiguchi
OBJECTIVE: To determine repeatability, reproducibility, and reference intervals of indices of right atrial longitudinal strain (RALS) derived from speckle-tracking echocardiography (STE) in dogs without heart disease. ANIMALS: 110 client-owned dogs and 10 laboratory Beagles. PROCEDURES: To determine intraobserver within-day (repeatability) and interobserver (reproducibility) coefficients of variation, RALS during ventricular systole (ϵS), ventricular early diastole (ϵE), and atrial systole (ϵA), as derived with STE, were obtained by 2 investigators for 5 randomly selected client-owned dogs and analyzed by linear regression...
April 2021: American Journal of Veterinary Research
Sarah K Shaffer, Natalia Sachs, Tanya C Garcia, David P Fyhrie, Susan M Stover
OBJECTIVE: To assess the motion of the proximal sesamoid bones (PSBs) relative to the third metacarpal bone (MC3) of equine forelimbs during physiologic midstance loads. SAMPLE: 8 musculoskeletally normal forelimbs (7 right and 1 left) from 8 adult equine cadavers. PROCEDURES: Each forelimb was harvested at the mid-radius level and mounted in a material testing system so the hoof could be moved in a dorsal direction while the radius and MC3 remained vertical...
March 2021: American Journal of Veterinary Research
Kentaro Yamazaki, Aritada Yoshimura, Shunsuke Miyahara, Shoma Sugi, Maho Itono, Mina Kondo, Nanako Tsuji, Miki Shimizu, Ryuji Fukushima, Miori Kishimoto
OBJECTIVE: To examine whether glucocorticoid (GC) administration alters hippocampal cerebral blood flow (CBF) or volume in dogs. ANIMALS: 6 clinically normal adult Beagles. PROCEDURES: Each dog underwent CT and MRI to measure the CBF in the hippocampus, basal ganglia, thalamus, and cerebral cortex and the volume of the hippocampus in each hemisphere of the brain before (day 0) and during (days 7 and 21) a 21-day treatment with prednisolone (1...
March 2021: American Journal of Veterinary Research
(no author information available yet)
No abstract text is available yet for this article.
March 2021: American Journal of Veterinary Research
Butch KuKanich, Kate KuKanich, Charles W Locuson, David C Rankin, Alyson H Fitzgerald, Peter Cho, Marissa S Komp
OBJECTIVE: To assess the pharmacokinetics and opioid effects of methadone after administration of multiple doses by means of 2 dosing regimens of methadone-fluconazole-naltrexone. ANIMALS: 12 healthy Beagles. PROCEDURES: Dogs were randomly allocated (6 dogs/group) to receive 1 of 2 oral dosing regimens of methadone-fluconazole-naltrexone. Treatment 1 doses were administered at 0 (methadone-to-fluconazole-to-naltrexone ratio of 1:5:0.25 mg/kg), 14 (1:5:0...
March 2021: American Journal of Veterinary Research
André Escobar, Michele Barletta, Bruno H Pypendop, Daniel M Sakai, Julie Gordon, Jane E Quandt
OBJECTIVE: To determine the pharmacokinetics and pharmacodynamics of methadone after IV or IM administration to isoflurane-anesthetized chickens. ANIMALS: 6 healthy adult Hy-Line hens. PROCEDURES: In a randomized crossover-design study, methadone (6 mg/kg) was administered IV and IM to isoflurane-anesthetized chickens with a 1-week washout period between experiments. Blood samples were collected immediately before and at predetermined time points up to 480 minutes after methadone administration...
March 2021: American Journal of Veterinary Research
Elena Benvenuti, Alessio Pierini, Silvia L Benali, Eleonora Gori, Francesca Abramo, Enrico Bottero, Marco Pietra, Pietro Ruggiero, Veronica Marchetti
OBJECTIVE: To prospectively evaluate the clinical and prognostic importance of duodenal endoscopic and histologic findings, including duodenal mucosal counts of forkhead box P3-positive regulatory T cells (Foxp3+ Tregs), in dogs with immunosuppressant-responsive enteropathy (IRE). ANIMALS: 57 client-owned dogs with IRE. PROCEDURES: The canine chronic enteropathy clinical activity index (CCECAI) was used to assess each dog when IRE was diagnosed (T0) and 1, 3, 6, and 12 months later...
March 2021: American Journal of Veterinary Research
Dagmar S Trachsel, Kirstine Calloe, Elin J Rgensen, Christine S Lunddahl, Philip J Pedersen, J Rgen K Kanters, Dan A Klaerke, Rikke Buhl
OBJECTIVE: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses. ANIMALS: 9 healthy adult horses. PROCEDURES: Each horse received 4 treatments in a blinded, randomized, crossover study design as follows: TMS, 16 to 24 mg/kg, IV; DET, 0.015 to 0.02 mg/kg, IV; TMS plus DET; and saline (0.9% NaCl) solution. Surface ECG traces were obtained over 24 hours, and repolarization parameters were measured at predefined time points after each treatment and compared with a 2-way ANOVA for repeated measures...
March 2021: American Journal of Veterinary Research
Claudia Kabakchiev, Ameet Singh, Samantha Dobson, Hugues Beaufrère
OBJECTIVE: To compare intraoperative and short-term postoperative variables pertaining to laparoscopic ovariectomy (LapOVE) and open ovariectomy (OVE) in rabbits ( Oryctolagus cuniculus ). ANIMALS: Twelve 4- to 5-month-old female New Zealand White rabbits. PROCEDURES: Rabbits were randomly assigned to undergo LapOVE (n = 6) or OVE (6), with a vessel-sealing device used to seal and transect the ovarian pedicles. Laparoscopic ovariectomy was performed with a 3-port approach...
March 2021: American Journal of Veterinary Research
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