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American Journal of Veterinary Research

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https://read.qxmd.com/read/31034278/effect-of-topical-ophthalmic-administration-of-0-005-latanoprost-solution-on-aqueous-humor-flow-rate-and-intraocular-pressure-in-ophthalmologically-normal-adult-beagles
#1
Katelyn E Fentiman, Amy J Rankin, Jessica M Meekins, James K Roush
OBJECTIVE: To determine the effect of topical ophthalmic administration of 0.005% latanoprost solution on aqueous humor flow rate (AHFR) and intraocular pressure (IOP) in ophthalmologically normal dogs. ANIMALS: 12 adult Beagles. PROCEDURES: In a masked crossover design involving two 10-day experimental periods separated by a 7-day washout period, dogs were randomly assigned to first receive latanoprost or artificial tears (control) solution and then the opposite treatment in the later experimental period...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034277/evaluation-of-atipamezole-as-a-treatment-for-dexmedetomidine-induced-cardiovascular-depression-in-anesthetized-cats
#2
Kathryn K Zatroch, Daniel M Sakai, Stephen Parry, Luis Campoy, Manuel Martin-Flores
OBJECTIVE: To evaluate the cardiovascular effects of atipamezole administered at half the volume or the same volume as dexmedetomidine to isoflurane-anesthetized cats. ANIMALS: 6 adult (1 to 2 years old) domestic shorthair cats (body weight, 3 to 6 kg). PROCEDURES: Each cat was anesthetized with isoflurane and rocuronium 3 times; there was a 1-week washout period between successive anesthetic procedures. For each anesthetic procedure, dexmedetomidine (5 μg/kg) was administered IV...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034276/development-validation-and-application-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-quantitative-determination-of-trans-4-hydroxy-l-proline-concentration-in-the-serum-of-dogs-with-chronic-hepatitis
#3
Yuri A Lawrence, Aline Rodrigues-Hoffmann, Jörg M Steiner, Jan S Suchodolski, Smriti Shankar, Cory L Klemashevich, Jonathan A Lidbury
OBJECTIVE: To develop and analytically validate a liquid chromatography-tandem mass spectrometry method for measurement of endogenous trans-4-hydroxy-l-proline concentrations in canine serum and to assess serum trans-4-hydroxy-l-proline concentrations in dogs with chronic hepatitis. SAMPLE: Serum samples obtained from 20 dogs with histopathologically confirmed chronic hepatitis and 20 healthy control dogs. PROCEDURES: A liquid chromatography-tandem mass spectrometry method for quantification of trans-4-hydroxy-l-proline concentration was developed and assessed for analytic sensitivity, linearity, accuracy, precision, and reproducibility...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034275/biomechanical-comparison-of-four-prosthetic-ligament-repair-techniques-for-tarsal-medial-collateral-ligament-injury-in-dogs
#4
Yoanna Martin, Matthew D Johnson, Collin J Travers, James Colee, Marina J McConkey, Scott A Banks
OBJECTIVE: To compare joint stability and ultimate strength among 4 prosthetic ligament constructs for repair of tarsal medial collateral ligament (MCL) injury in dogs. SAMPLE: 13 canine cadavers (26 hind limbs). PROCEDURES: Each limb was stripped of all soft tissues except those associated with the tarsal joint and assigned to 1 of 4 prosthetic ligament constructs. The AN construct consisted of 3 bone anchors connected with monofilament nylon suture...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034274/identification-of-reference-genes-for-micrornas-of-extracellular-vesicles-isolated-from-plasma-samples-of-healthy-dogs-by-ultracentrifugation-precipitation-and-membrane-affinity-chromatography-methods
#5
Momoko Narita, Hidetaka Nishida, Ryota Asahina, Kohei Nakata, Hirohito Yano, Tomoyuki Ueda, Masatoshi Inden, Hideo Akiyoshi, Sadatoshi Maeda, Hiroaki Kamishina
OBJECTIVE: To compare ultracentrifugation, precipitation, and membrane affinity chromatography methods for isolation of extracellular vesicles (EVs) from canine plasma samples and to identify suitable reference genes for incorporation into a quantitative reverse transcription PCR assay of microRNA expression in plasma EVs of healthy dogs. ANIMALS: 6 healthy Beagles. PROCEDURES: Plasma samples were obtained from each dog, and EVs were isolated from 0...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034273/pharmacokinetics-and-pharmacodynamics-of-oral-pradofloxacin-administration-in-dogs
#6
(no author information available yet)
No abstract text is available yet for this article.
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034272/-javma-news-digest
#7
(no author information available yet)
No abstract text is available yet for this article.
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034271/pharmacokinetics-and-competitive-pharmacodynamics-of-adp-induced-platelet-activation-after-oral-administration-of-clopidogrel-to-horses
#8
Jeffrey W Norris, Johanna L Watson, Fern Tablin, Tania A Kozikowski, Heather K Knych
OBJECTIVE: To determine pharmacokinetics and pharmacodynamics after oral administration of a single dose of clopidogrel to horses. ANIMALS: 6 healthy adult horses. PROCEDURES: Blood samples were collected before and at various times up to 24 hours after oral administration of clopidogrel (2 mg/kg). Reactivity of platelets from each blood sample was determined by optical aggregometry and phosphorylation of vasodilator-stimulated phosphoprotein (VASP)...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034270/effects-of-orally-administered-raltegravir-in-cats-with-experimentally-induced-ocular-and-respiratory-feline-herpesvirus-1-infection
#9
Chloe B Spertus, Matthew R Pennington, Gerlinde R Van de Walle, Zachary I Badanes, Bonnie E Judd, Hussni O Mohammed, Eric C Ledbetter
OBJECTIVE: To determine the effects of orally administered raltegravir in cats with experimentally induced ocular and respiratory feline herpesvirus-1 (FHV-1) infection. ANIMALS: 14 healthy 6-month-old unvaccinated specific pathogen-free cats. PROCEDURES: On day 0, all cats were experimentally inoculated by topical application of 0.1 mL of a solution containing 106 plaque-forming units of FHV-1 strain FH2CS to the inferior conjunctival fornix of each eye...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034269/use-of-three-dimensional-time-of-flight-magnetic-resonance-angiography-at-1-5-tesla-to-evaluate-the-intracranial-arteries-of-39-dogs-with-idiopathic-epilepsy
#10
Chieko Ishikawa, Daisuke Ito, Natsumi Tanaka, Masato Kitagawa
OBJECTIVE: To assess visualization of the intracranial arteries and internal carotid artery (ICA) on 3-D time-of-flight (TOF) magnetic resonance angiography (MRA) images obtained at 1.5 T and to investigate factors that affect the image quality of those arteries in dogs. ANIMALS: 39 dogs with idiopathic epilepsy. PROCEDURES: Each dog underwent 3-D TOF MRA, and 5 pairs of intracranial arteries, the basilar artery, and both ICAs were evaluated...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034268/evaluation-of-recovery-of-limb-function-by-use-of-force-plate-gait-analysis-after-tibial-plateau-leveling-osteotomy-for-management-of-dogs-with-unilateral-cranial-cruciate-ligament-rupture
#11
Hirokazu Amimoto, Tetsuaki Koreeda, Naomi Wada
OBJECTIVE: To evaluate recovery of limb function by use of gait force analysis after tibial plateau leveling osteotomy (TPLO) in dogs with unilateral cranial cruciate ligament (CrCL) rupture. ANIMALS: 19 dogs with unilateral CrCL rupture treated with TPLO. PROCEDURES: Force plate gait analysis was performed before and 1, 2, 4, and 7 months after TPLO. Ground reaction forces (GRFs; which comprised peak vertical force [PVF], vertical impulse [VI], peak braking force, braking impulse, peak propulsion force [PPF], and propulsion impulse), time to switching from braking to propulsion, and vector magnitude at PVF in the forelimbs and hind limbs were evaluated...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/31034267/dynamic-viscoelastic-coagulometry-of-blood-obtained-from-healthy-chickens
#12
Cassandra I Rodenbaugh, Shane D Lyon, Andrew S Hanzlicek, Ian Kanda, Mark E Payton, Theresa E Rizzi, LaRinda A Holland, João Brandão
OBJECTIVE: To assess feasibility of the use of a dynamic viscoelastic coagulometer on chicken blood and compare coagulation variables for fresh whole blood and sodium citrate-preserved whole blood as well as effects of 3 coagulation activators on blood from chickens. SAMPLE: Blood samples from 30 hens. PROCEDURES: Chickens were allowed to rest undisturbed for 1 hour. A blood sample was collected from an ulnar vein; 1.4 mL was analyzed immediately, and 1...
May 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919681/quantitative-characterization-of-viscoelastic-properties-of-synovial-fluid-from-forelimb-joints-of-orthopedically-normal-thoroughbreds-and-warmblood-horses
#13
Panagiota C Tyrnenopoulou, Eleftherios D Rizos, Maria Kritsepi-Konstantinou, Paraskevi L Papadopoulou, Michail N Patsikas, Lysimachos G Papazoglou, Amalia Aggeli, Nikolaos E Diakakis
OBJECTIVE: To determine whether differences existed in the viscoelastic properties of synovial fluid samples from the metacarpophalangeal, intercarpal, and distal interphalangeal joints of orthopedically normal athletic horses. ANIMALS: 45 warmblood horses and 30 Thoroughbreds (age range, 4 to 16 years). PROCEDURES: Synovial fluid samples were aseptically obtained via arthrocentesis from 1 metacarpophalangeal, intercarpal, and distal interphalangeal joint of each horse, and nucleated cell counts were performed...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919680/in-vitro-evaluation-of-a-medial-approach-for-intra-articular-injection-of-the-tarsometatarsal-joints-of-horses
#14
Paolo Canonici, Francesca Beccati, Fernando Canonici, Marco Pepe
OBJECTIVE: To develop a reliable method for injection of the tarsometatarsal (TMT) joint of horses through a medial approach and to characterize anatomy of the synovial recesses of the TMT joint with CT. SAMPLE: 13 pairs of fresh cadaveric equine tarsi. PROCEDURES: TMT joints were assessed with radiography and CT. Twelve pairs of TMT joints were assigned to an experienced veterinarian (8 joints) or veterinary student (16 joints) for injection with contrast medium through a medial or a lateral approach...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919679/hepatic-computed-tomography-and-cholangiography-by-use-of-gadoxetic-acid-in-healthy-cats
#15
Joanna L Pilton, Jennifer Chau, Timothy S Foo, Evelyn J Hall, Fernando Martinez-Taboada, Juan M Podadera, Mariano A Makara
OBJECTIVE: To evaluate 3 doses of gadoxetic acid (Gd-EOB-DPTA) for hepatic CT and cholangiography in cats and to determine optimal timing for hepatobiliary image acquisition and evaluation of the contrast-enhanced hepatobiliary anatomy. ANIMALS: 6 healthy cats. PROCEDURES: Cats were anesthetized; sequential CT scans were performed 0, 5, 25, 45, 65, and 85 minutes after IV administration of Gd-EOB-DTPA at low (0.0125 mmol/kg), medium (0.1 mmol/kg), and high (0...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919678/tikhonov-gamma-variate-adaptive-regularization-applied-to-technetium-tc-99m-diethylenetriamine-pentaacetic-acid-plasma-clearance-compared-with-three-other-methods-for-measuring-glomerular-filtration-rate-in-cats
#16
Elisabeth C Snead, Jewel E Milo, Carling A McCrea, James E Montgomery, Cindy Xin Feng, Michal J Wesolowski, Surajith N Wanasundara, Carl A Wesolowski
OBJECTIVE: To evaluate agreement of 4 methods (Tikhonov gamma variate adaptive regularization of plasma concentration-time curve fitting applied to technetium Tc 99m diethylenetriamine pentaacetic acid [99m Tc-DTPA] plasma clearance [Tk-GV], plasma clearance of exogenous creatinine [CrCL], Gates gamma camera-based measurement method with 99m Tc-DTPA renal clearance and dynamic scintigraphy [GTS], and iohexol renal clearance assessed with dynamic CT with Patlak plotting [CT-Pp]) for measuring glomerular filtration rates (GFR) in healthy cats...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919677/single-day-and-multiday-repeatability-of-stance-analysis-results-for-dogs-with-hind-limb-lameness
#17
Megan L Wilson, James K Roush, Walter C Renberg
OBJECTIVE: To assess single-day and multiday repeatability of weight distribution (stance) data obtained with a commercial analyzer for dogs with naturally occurring hind limb lameness. ANIMALS: 46 dogs (15 and 31 for single-day and multiday trials, respectively). PROCEDURES: For single-day trials, 5 to 10 measurements/trial were collected to determine body weight (BW), weight distribution on each limb, and forelimb and hind limb symmetry indices (SIs)...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919675/biomechanical-comparison-of-a-modified-three-loop-pulley-technique-and-a-three-level-self-locking-technique-for-repair-of-patellar-tendon-rupture-in-dogs
#18
Mariajesus Soula, Justin W Shmalberg, Matthew D Johnson
OBJECTIVE: To compare use of a 3-level self-locking suture (3LSLS) technique with use of a previously described modified 3-loop pulley (M3LP) technique to repair rupture of the proximal aspect of patellar tendons in limbs from canine cadavers. SAMPLE: Paired hind limbs of 6 adult mixed-breed dogs. PROCEDURES: A limb from each pair was randomly assigned to be repaired by the 3LSLS technique or M3LP technique with size-2 ultrahigh-molecular-weight polyethylene and size-0 monofilament polypropylene suture, respectively...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919674/development-and-assessment-of-a-novel-precordial-lead-system-for-accurate-detection-of-right-atrial-and-ventricular-depolarization-in-dogs-with-various-thoracic-conformations
#19
Roberto A Santilli, Dolores Maria Porteiro Vázquez, Magda Gerou-Ferriani, Sergio F Lombardo, Manuela Perego
OBJECTIVE: To assess recording accuracy of right atrial and ventricular depolarization during 12-lead ECG when precordial lead V1 was positioned at each of 5 locations on the thorax of dogs with various thoracic conformations. ANIMALS: 60 healthy client-owned dogs. PROCEDURES: 20 dogs were allocated to each of 3 groups (brachymorphic, mesomorphic, or dolichomorphic) on the basis of thoracic conformation. Each dog remained unsedated and was positioned in right lateral recumbency for a series of five 12-lead surface ECGs, with V1 located adjacent to the sternum in the fifth intercostal space (ICS; control), at the costochondral junction (CCJ) of the right first ICS (1st-R), at the CCJ of the right third ICS, at the right third ICS where the thorax was the widest, and at the CCJ of the left first ICS...
April 2019: American Journal of Veterinary Research
https://read.qxmd.com/read/30919673/variability-among-strain-variables-derived-from-two-dimensional-speckle-tracking-echocardiography-in-dogs-by-use-of-various-software
#20
Giorgia Santarelli, Marco Baron Toaldo, Jonathan Bouvard, Tony M Glaus, Josefa Fernández Del Palacio
OBJECTIVE: To determine variability of global longitudinal strain (GLS) and strain rate (SR) measurements in dogs with and without cardiac disease derived from 2-D speckle tracking echocardiography (STE) by use of various software. ANIMALS: 2 cohorts comprising 44 dogs (23 cardiovascularly healthy and 21 with cardiac disease) and 40 dogs (18 cardiovascularly healthy and 22 with cardiac disease). PROCEDURES: Transthoracic echocardiographic images in each cohort were analyzed with vendor-independent software and vendor-specific 2-D STE software for each of 2 vendors...
April 2019: American Journal of Veterinary Research
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