journal
https://read.qxmd.com/read/37815066/inflammatory-cytokines-in-tears-of-patients-with-lacrimal-duct-obstruction
#61
LETTER
Bharat Gurnani, Kirandeep Kaur
No abstract text is available yet for this article.
October 10, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37815065/vitamin-d-status-bone-health-in-patients-with-liver-cirrhosis
#62
JOURNAL ARTICLE
Indu Grover, Namrata Singh, Deepak Gunjan, Jaya Benjamin, Lakshmy Ramakrishnan, R M Pandey, Hem Chandra Sati, Anoop Saraya
BACKGROUND & OBJECTIVES: Vitamin D plays an important role in bone metabolism, and liver is the intermediary site of vitamin D metabolism. The purpose of this study was to study the prevalence of vitamin D deficiency and bone health in patients with cirrhosis. METHODS: Prospectively, serum 25-hydroxy vitamin D [25(OH)D] level were assessed in cirrhotics by chemiluminescence method. Endocrine Society Clinical practice guideline was used to define deficiency and insufficiency of vitamin D...
October 10, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006347/acinetobacter-baumannii-in-suspected-bacterial-infections-association-between-multidrug-resistance-virulence-genes-biofilm-production
#63
JOURNAL ARTICLE
Deepan Gautam, Karma Gurmey Dolma, Bidita Khandelwal, Ramesh Kumar Goyal, Watcharapong Mitsuwan, Maria de Lourdes Gomes Pereira, Wiyada Kwanhian Klangbud, Madhu Gupta, Polrat Wilairatana, Abolghasem Siyadatpanah, Christophe Wiart, Veeranoot Nissapatorn
BACKGROUND OBJECTIVES: Acinetobacter baumannii has emerged as a nosocomial pathogen with a tendency of high antibiotic resistance and biofilm production. This study aimed to determine the occurrence of A. baumannii from different clinical specimens of suspected bacterial infections and furthermore to see the association of biofilm production with multidrug resistance and expression of virulence factor genes in A. baumannii. METHODS: A. baumannii was confirmed in clinical specimens by the detection of the blaOXA-51-like gene...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006346/modulation-of-semaphorin-3c-4d-expression-in-cancerous-tissues-from-individuals-with-laryngeal-squamous-cell-carcinoma
#64
JOURNAL ARTICLE
Marzieh Sajadian, Bijan Khademi, Leila Moinzadeh, Abbas Ghaderi, Abdollah Jafarzadeh, Mahboobeh Razmkhah
BACKGROUND OBJECTIVES: Semaphorins were initially characterized as axon guidance factors but were subsequently implicated in the regulation of immune responses, angiogenesis, organ formation and a variety of other physiological and developmental functions. Various semaphorins enhance or inhibit tumour progression through different mechanisms. The objective of this study was to assess the expression of various semaphorins and vascular endothelial growth factor (VEGF) gene transcripts as well as the serum level of Sema3A in individuals with laryngeal squamous cell carcinoma (LSCC)...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006345/comparison-of-acceptability-efficacy-of-thermal-ablation-thermocoagulation-cryotherapy-in-via-positive-cervical-lesions-a-pilot-study
#65
JOURNAL ARTICLE
Manju Lata Verma, Parul Sharma, Uma Singh, Rekha Sachan, Pushp Lata Sankhwar
BACKGROUND OBJECTIVES: The World Health Organization (WHO) has endorsed thermal ablation (thermocoagulation) as an efficient and safe modality for treatment of cervical pre-cancer lesions. More evidence is being looked up by WHO through rigorous studies for health delivery models using screen-and-treat strategies incorporating thermal ablation and studies comparing it against the conventional standard modality cryotherapy. The objective of this study was to assess the acceptability of thermal ablation both among the providers and clients and compare the same with cryotherapy...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006344/correlation-of-microvessel-density-with-histopathological-parameters-of-carcinoma-breast
#66
JOURNAL ARTICLE
Aditi V Goyal, Samarth Shukla, Sourya Acharya, Sunita Vagha, Suhas Jajoo
BACKGROUND OBJECTIVES: Microvessel density (MVD) is a surrogate measure of tumour angiogenesis, and is well known for over two decades to identify individuals with a high risk of recurrence with greater prevision than traditional markers. This study aims to assess the utility of MVD and its correlation with the Nottingham Prognostic Index (NPI) and other routine histopathological parameters in carcinoma breast. METHODS: This two year retrospective, cross-sectional and analytical study evaluated 143 women with breast cancer presenting to rural tertiary hospital in central India...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006343/challenges-in-screening-for-sickle-cell-disease-among-newborns-from-the-tribal-region-of-palghar-maharashtra-during-the-covid-19-pandemic
#67
JOURNAL ARTICLE
Suchitra Surve, Sanjay Chauhan, Ragini Kulkarni, Neha Salvi, Anita Nadkarni, Manisha Madkaikar, Khushbu Chaudhary, Abhijit Chavan, Dayanand Suryavanshi, Anil Thorat, Harpreet Kaur
BACKGROUND OBJECTIVES: Despite several adversities imposed by the COVID-19 pandemic, it was crucial to sustain research having public health relevance such as investigations around sickle cell disease (SCD). Against this background, an ongoing ICMR-multicentric study for newborn screening of SCD in the tribal population at Model Rural Health Research Unit (MRHRU-Dahanu) in Palghar District, Maharashtra constituted the current study setting. This was a descriptive study wherein, certain measures were undertaken and strategies were developed in view of the challenges in newborn screening for SCD due to the COVID-19 pandemic during December 2019-September 2021 at Sub District Hospital, MRHRU-Dahanu...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/38006342/ocular-morbidity-among-children-aged-6-18-yr-of-the-tribal-area-of-melghat-india-a-community-based-study
#68
JOURNAL ARTICLE
Kavita A Satav, Ashish R Satav, Vibhawari S Dani, Parikshit M Gogate, Shraddha D Kumbhare, Pradeep Reddy
BACKGROUND OBJECTIVES: Most of the ocular morbidities among school children are preventable or treatable. Melghat, a difficult to access, hilly, forest, tribal area with poorly developed infrastructure in the Amravati district of Maharashtra. Scarcity of ophthalmologists and low health-seeking behaviour of tribal people contributes to the high burden of ocular morbidity. Given the lack of published studies on the ocular morbidity among children in Melghat, outreach programmes are essential to diagnose and treat visual impairments promptly...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37991331/serum-anti-m%C3%A3-llerian-hormone-a-potential-biomarker-for-polycystic-ovary-syndrome
#69
JOURNAL ARTICLE
Ashutosh Halder, Hemant Kumar, Mona Sharma, Manish Jain, Amanpreet Kaur Kalsi, Shivam Pandey
BACKGROUND OBJECTIVES: Polycystic ovary syndrome (PCOS) is characterized by chronic ovulatory dysfunction, hyperandrogenism and polycystic ovary morphology (PCOM). Although hyperandrogenism is one of the major features of PCOS, it is rarely observed in southeast Asia. Recently, however, there has been growing evidence on association of anti-Müllerian hormone (AMH) with PCOS. The objective of this study was to investigate the diagnostic potentials of AMH in PCOS individuals. METHODS: This case-control study included a total of 131 women with PCOS and 49 healthy controls who were enrolled after the exclusion of secondary causes of PCOS...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37987999/early-prediction-of-pre-eclampsia-using-circulating-placental-exosomes-newer-insights
#70
REVIEW
Aishwarya Rao, Uma Shinde, Dhanjit Kumar Das, Nafisa Balasinor, Taruna Madan
Pre-eclampsia (PE), a multifactorial de novo hypertensive pregnancy disorder, is one of the leading causes of foeto-maternal morbidity and mortality. Currently, antihypertensive drugs are the first-line therapy for PE and evidence suggests that low-dose aspirin initiated early in high risk pregnancies may reduce the risk of development or severity of PE. However, an early prediction of this disorder remains an unmet clinical challenge. Several potential serum biomarkers associated with maternal immunoregulation and placental angiogenesis have been evaluated but are ineffective and inconsistent for early prediction...
October 1, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37706372/prognostic-significance-of-prolonged-corrected-qt-interval-in-cerebral-contusion
#71
JOURNAL ARTICLE
Ahmed Yasin Yavuz, Ozan Baskurt, Yunus Kurtulus, Idris Avci
BACKGROUND & OBJECTIVES: Cerebral contusion (CC) results in a release of catecholamines, autonomic dysfunction and neural stimulation that can lead to a number of cardiac adverse events, so it is critical to determine these. So the objective of this study was to investigate the prognostic significance of electrocardiographic changes, particularly the effects of a prolonged corrected QT (QTc) interval in CC. METHODS: In this retrospective cohort study, 110 patients with CC were evaluated...
September 14, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37706371/book-review
#72
JOURNAL ARTICLE
Atul Prabhakar Kulkarni
No abstract text is available yet for this article.
September 14, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37706370/association-of-cyp3a5-3-cyp3a4-18-cyp2b6-6-polymorphisms-with-imatinib-treatment-outcome-in-azerbaijani-chronic-myeloid-leukaemia-patients
#73
JOURNAL ARTICLE
Chingiz Asadov, Nigar Karimova, Aypara Hasanova, Bayram Bayramov, Aytan Shirinova, Zohra Alimirzoyeva
BACKGROUND & OBJECTIVES: Imatinib mesylate (IM) is a reliable first line treatment for chronic myeloid leukaemia (CML). Nevertheless, despite promising results, a considerable proportion of patients develop resistance to the drug. Cytochrome P450 (CYP) enzymes play a crucial role in IM metabolism. Thus, point mutations in CYP genes may modify IM enzyme activity resulting in insufficient treatment response. This investigation was aimed to identify the functional impact of CYP3A5*3, CYP3A4*18 and CYP2B6*6 polymorphisms on the IM response in patients with CML in Azerbaijan...
September 14, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675692/correlation-of-cyp2r1-gene-promoter-methylation-with-circulating-vitamin-d-levels-among-healthy-adults
#74
JOURNAL ARTICLE
Ashvin Varadharajan, M K Sibin, S V Athira, Arijit Kumar Ghosh, Pratibha Misra
BACKGROUND & OBJECTIVES: Despite being a tropical country, vitamin D deficiency is highly prevalent in India with studies indicating 40-99 per cent prevalence. Apart from calcium and phosphate metabolism, vitamin D is involved in cell cycle regulation, cardiovascular, hepatoprotection. The metabolism of vitamin D is regulated by vitamin D tool genes (CYP2R1/CYP27B1/CYP24A1/VDR). The promoter regions of some of these genes have CpG islands, making them prone to methylation induced gene silencing, which may cause a reduction in circulating vitamin D levels...
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675691/spatio-temporal-distribution-seasonality-of-highly-pathogenic-avian-influenza-h5n1-h5n8-outbreaks-in-india-2006-2021
#75
JOURNAL ARTICLE
Shailesh D Pawar, Sadhana S Kode, Sachin S Keng, Deeksha S Tare, Satish A Pande
BACKGROUND & OBJECTIVES: The highly pathogenic avian influenza (HPAI) H5N1 and H5N8 viruses have been one of the leading causes of avian diseases worldwide, resulting in severe economic losses and posing potential zoonotic risk. There are no reports on the correlation of the seasonality of H5N1 and H5N8 viruses with the migratory bird season in India, along with the species affected. The present report describes the distribution and seasonality of HPAI outbreaks in India from 2006 to 2021...
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675690/authors-response
#76
LETTER
Jatin Sharma, C S Gautam, Harmanjit Singh, Jagjit Singh
No abstract text is available yet for this article.
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675689/determinants-of-post-discharge-mortality-among-hospitalized-covid-19-patients-nested-matched-case-control-analyses-from-the-national-clinical-registry-for-covid-19
#77
JOURNAL ARTICLE
Gunjan Kumar, Arunansu Talukdar, Alka Turuk, Ashish Bhalla, Subhasis Mukherjee, Pankaj Bhardwaj, Tarun Bhatnagar, Aparna Mukherjee
BACKGROUND & OBJECTIVES: : The post-acute effects of COVID-19 are continually being updated. This investigation was conducted to evaluate the determinants of post discharge mortality in hospitalized COVID-19 patients, especially 18-45 yr of age. METHODS: : A series of three nested case-control analyses was conducted on follow up data collected in the National Clinical Registry for COVID-19 between September 2020 and February 2023 from 31 hospitals. Matching (1:4) was done by the date of hospital admission ±14 days for the following comparisons: (i) case-patients reported as dead vs...
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675688/tafenoquine-for-the-radical-cure-versus-prophylaxis-of-plasmodium-vivax-malaria-the-importance-of-using-the-appropriate-data-set
#78
LETTER
Raman Sharma, Chao Chen, Ioana-Gabriela Fiţa, Rachel A Gibson, Siôn Jones, Anup Pingle, Katie Rolfe, Hema Sharma, Panayota Bird
No abstract text is available yet for this article.
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675687/eco-epidemiology-triad-to-explain-infectious-diseases
#79
JOURNAL ARTICLE
T Jacob John, Rajeev Zachariah Kompithra
No abstract text is available yet for this article.
September 6, 2023: Indian Journal of Medical Research
https://read.qxmd.com/read/37675686/biofilm-profile-of-candidaemia-isolates
#80
JOURNAL ARTICLE
M S Sheena, Rakesh Singh
No abstract text is available yet for this article.
September 6, 2023: Indian Journal of Medical Research
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