Allison Welham, Elizabeth Chorvinsky, Surajit Bhattacharya, Betelehem Solomon Bera, Kyle Salka, Jered Weinstock, Xilei Xu Chen, Geovanny F Perez, Dinesh K Pillai, Maria J Gutierrez, Hiroki Morizono, Jyoti Jaiswal, Gustavo Nino
Thymic stromal lymphopoietin (TSLP) is a primarily epithelial-derived cytokine that drives type 2 allergic immune responses. Early life viral respiratory infections elicit high TSLP production, which leads to the development of type 2 inflammation and airway hyperreactivity. The goal of this study was to examine in vivo and in vitro the human airway epithelial responses leading to high TSLP production during viral respiratory infections in early infancy. A total of 129 infants (<1-24 m, median age 10 m) with severe viral respiratory infections were enrolled for in vivo (n = 113), and in vitro studies (n = 16)...
December 26, 2023: Immunology