Carlos A Fuzo, Thais F C Fraga-Silva, Sandra R Maruyama, Víctor A F Bastos, Luana A Rogerio, Nayore T Takamiya, Pedro V da Silva-Neto, Vinícius E Pimentel, Diana M Toro, Malena M Pérez, Jonatan C S de Carvalho, Ingryd Carmona-Garcia, Camilla N S Oliveira, Augusto M Degiovani, Fátima M Ostini, Leticia F Constant, Alessandro P de Amorim, Fernando C Vilar, Marley R Feitosa, Rogerio S Parra, José J R da Rocha, Omar Feres, Gilberto G Gaspar, Angelina L Viana, Ana P M Fernandes, Isabel K F M Santos, Elisa M S Russo, Cristina R B Cardoso, Carlos A Sorgi, Lúcia H Faccioli, Vânia L D Bonato, Marcelo Dias-Baruffi
COVID-19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite the advances in COVID-19 research, it is still crucial to seek a panel of molecular markers that enable accurate stratification of COVID-19 patients. Here, we performed a study that combined analysis of blood transcriptome, demographic data, clinical aspects, and laboratory findings from sixty-six participants classified into different degrees of COVID-19 severity and healthy subjects. We identified a perturbation in blood-leukocyte transcriptional profile associated with COVID-19 aggravation, which was mainly related to processes that disfavored lymphocyte activation and favored neutrophil activation...
February 5, 2023: Immunology