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Hereditas

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https://read.qxmd.com/read/30774581/global-transcriptome-analysis-of-h5n1-influenza-virus-infected-human-cells
#1
Ying Cao, Kun Zhang, Lirong Liu, Wei Li, Bin Zhu, Shuang Zhang, Ping Xu, Wenjun Liu, Jing Li
Background: Influenza A virus (IAV) belongs to the Orthomyxoviridae family. IAV causes a highly contagious respiratory disease in humans that exacts severe economic losses globally. The virus uses strategies developed to exploit and subvert cellular proteins and pathways to increase its own replication and to inhibit antiviral immune response. Results: A/bar-headed goose/Qinghai/1/2005 (A/QH) was able to infect A549 and 293 T cells, with a high infection rate for A549 cells...
2019: Hereditas
https://read.qxmd.com/read/30774580/characterization-of-the-tibet-plateau-jerusalem-artichoke-helianthus-tuberosus-l-transcriptome-by-de-novo-assembly-to-discover-genes-associated-with-fructan-synthesis-and-ssr-analysis
#2
Shipeng Yang, Xuemei Sun, Xiaoting Jiang, Lihui Wang, Jie Tian, Li Li, Mengliang Zhao, Qiwen Zhong
Background: Jerusalem artichoke ( Helianthus tuberosus L.) is a characteristic crop in the Qinghai-Tibet Plateau which has rapidly developed and gained socioeconomic importance in recent years. Fructans are abundant in tubers and represent the foundation for their formation, processing and utilization of yield; and are also widely used in new sugar-based materials, bioenergy processing, ecological management, and functional feed. To identify key genes in the metabolic pathway of fructans in Jerusalem artichoke, high-throughput sequencing was performed using Illumina Hi Seq™ 2500 equipment to construct a transcriptome library...
2019: Hereditas
https://read.qxmd.com/read/30733654/genetic-diversity-and-structure-of-elymus-tangutorum-accessions-from-western-china-as-unraveled-by-aflp-markers
#3
Wen-Dan Wu, Wen-Hui Liu, Ming Sun, Ji-Qiong Zhou, Wei Liu, Cheng-Lin Zhang, Xing-Quan Zhang, Yan Peng, Lin-Kai Huang, Xiao Ma
Background: Understanding genetic diversity of wild plant germplasm and the relationships between ecogeographic and genetic characteristics may provide insights for better utilizing and conserving genetic resources. Elymus tangutorum (Nevski) Hand.-Mazz, a cool-season hexaploid perennial, is an important pasture bunchgrass species used for forages and grassland restoration in Qinghai-Tibet Plateau and northwest China. In this study, 27 E. tangutorum accessions from diverse origins of western China were evaluated using AFLP markers in an effort to delve into the genetic relationships among them...
2019: Hereditas
https://read.qxmd.com/read/30723390/bladder-cancer-stage-associated-hub-genes-revealed-by-wgcna-co-expression-network-analysis
#4
Yu Di, Dongshan Chen, Wei Yu, Lei Yan
Background: Bladder cancer was a malignant disease in patients, our research aimed at discovering the possible biomarkers for the diseases. Results: The gene chip GSE31684, including 93samples, was downloaded from the GEO datasets and co-expression network was constructed by the data. Molecular complex detection(MCODE) was used to identify hub genes. The most significant cluster including 16 genes: CDH11 , COL3A1 , COL6A3 , COL5A1 , AEBP1 , COL1A2 , NTM , COL11A1 , THBS2 , COL8A1 , COL1A1 , BGN , MMP2 , PXDN , THY1 , and TGFB1I1 was identified...
2019: Hereditas
https://read.qxmd.com/read/30700972/a-new-model-of-the-mechanism-underlying-lead-poisoning-snp-in-mirna-target-region-influence-the-agt-expression-level
#5
Yu Wu, Miaomiao Wang, Jinlong Zhang, Na Sun, Chunping Li
Background: To determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene ( AGT ) altered AGT gene expression and the risk of lead poisoning. A case-control study and luciferase reporter gene assay identified a significant association between rs7079 variants and the risk of lead poisoning. Results: Serum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype...
2019: Hereditas
https://read.qxmd.com/read/30679936/the-evolution-of-transcriptional-repressors-in-the-notch-signaling-pathway-a-computational-analysis
#6
Dieter Maier
Background: The Notch signaling pathway governs the specification of different cell types in flies, nematodes and vertebrates alike. Principal components of the pathway that activate Notch target genes are highly conserved throughout the animal kingdom. Despite the impact on development and disease, repression mechanisms are less well studied. Repressors are known from arthropods and vertebrates that differ strikingly by mode of action: whereas Drosophila Hairless assembles repressor complexes with CSL transcription factors, competition between activator and repressors occurs in vertebrates (for example SHARP/MINT and KyoT2)...
2019: Hereditas
https://read.qxmd.com/read/30679935/common-variants-in-the-slc28a2-gene-are-associated-with-serum-uric-acid-level-and-hyperuricemia-and-gout-in-han-chinese
#7
Zhaowei Zhou, Zhiqiang Li, Can Wang, Xinde Li, Xiaoyu Cheng, Changgui Li, Yongyong Shi
Background: Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2 , exerts susceptibility for SUA fluctuation and incidence of HUA and gout in the Han Chinese population. Results: Three sample sets of 1376 gout patients, 1290 long-term HUA subjects (no gout attack) and 1349 normouricemic controls were recruited for this study. Eight polymorphisms in the SLC28A2 gene were genotyped using the ligase detection reaction-polymerase chain reaction (LDR-PCR) technology...
2019: Hereditas
https://read.qxmd.com/read/30675136/global-mapping-of-binding-sites-for-phic31-integrase-in-transgenic-maden-darby-bovine-kidney-cells-using-chip-seq
#8
Lijuan Qu, Lei Wang, Xueyuan Zhu, Yan Zhang, Qiang Ou, Aying Ma, Fengying Sheng, Xiaoqing Wei, Yue Dai, Guoting Li, Shuwu Xie
Background: ΦC31 integrase, a site-specific recombinase, can efficiently target attB-bearing transgenes to endogenous pseudo attP sites within mammalian genomes. The sequence features of endogenous binding sites will help us to fully understand the site-specific recognition function by ΦC31 integrase. The present study was aimed to uncover the global map of ΦC31 integrase binding sites in bovine cells and analysis the features of these binding sites by comprehensive bioinformatics methods...
2019: Hereditas
https://read.qxmd.com/read/30655731/genetic-characterization-of-maize-germplasm-derived-from-suwan-population-and-temperate-resources
#9
Xun Wu, Angui Wang, Xiangyang Guo, Pengfei Liu, Yunfang Zhu, Xiushi Li, Zehui Chen
Background: The Suwan population is a well-known maize germplasm that has greatly contributed to the development of maize breeding in tropical and subtropical regions, especially in southern China. Inbred lines derived from the Suwan population always contain stronger resistance and extensive adaptability in different environments. To evaluate the genetic character of inbred lines derived from the Suwan population, a panel including 226 inbred line derived from the Suwan population and temperate resources was assembled and genotyped by using MaizeSNP50 BeadChip, which contained 56,110 genome-wide single nucleotide polymorphism (SNP) markers...
2019: Hereditas
https://read.qxmd.com/read/30636949/natural-selection-and-local-adaptation-of-blood-pressure-regulation-and-their-perspectives-on-precision-medicine-in-hypertension
#10
REVIEW
Boon-Peng Hoh, Thuhairah Abdul Rahman, Khalid Yusoff
Prevalence of hypertension (HTN) varies substantially across different populations. HTN is not only common - affecting at least one third of the world's adult population - but is also the most important driver for cardiovascular diseases. Yet up to a third of hypertensive patients are resistant to therapy, contributed by secondary hypertension but more commonly the hitherto inability to precisely predict response to specific antihypertensive agents. Population and individual genomics information could be useful in guiding the selection and predicting the response to treatment - an approach known as precision medicine...
2019: Hereditas
https://read.qxmd.com/read/30564067/differences-in-the-neanderthal-brca2-gene-might-be-related-to-their-distinctive-cognitive-profile
#11
Antonio Benítez-Burraco
The unique divergence of the BRCA2 gene in Neanderthals compared to modern humans has been hypothesized to account for a differential susceptibility to cancer. However, the role of the gene in brain development and its connection with autism suggest that these differences might be (also) related to the more encapsulated nature of the Neanderthal cognition and their (inferred) autistic-like features.
2018: Hereditas
https://read.qxmd.com/read/30473656/construction-of-a-high-density-genetic-map-genotyping-by-sequencing-gbs-to-map-purple-seed-coat-color-psc-in-hulless-barley
#12
Xiaohua Yao, Kunlun Wu, Youhua Yao, Yixiong Bai, Jingxiu Ye, Dezhao Chi
Background: Colored hulless barley are more suitable in food processing compared to normal (yellow) varieties because it is rich in bioactive compounds and produces higher extraction pearling fractions. Therefore, seed coat color is an important agronomic trait for the breeding and study of hulless barley. Results: Genotyping-by-sequencing single-nucleotide polymorphism (GBS-SNP) analysis of a doubled haploid (DH) mapping population (Nierumuzha × Kunlun10) was conducted to map the purple seed coat color genes ( Psc )...
2018: Hereditas
https://read.qxmd.com/read/30473655/de-novo-transcriptome-assembly-of-brackish-water-flea-diaphanosoma-celebensis-based-on-short-term-cadmium-and-benzo-a-pyrene-exposure-experiments
#13
Bo-Mi Kim, Seunghyun Kang, Ryeo-Ok Kim, Jee-Hyun Jung, Kyun-Woo Lee, Jae-Sung Rhee, Young-Mi Lee
To develop a brackish water flea as a promising model for marine monitoring, Diaphanosoma celebensis were exposed to two pollutants, cadmium (Cd) and benzo[ a ]pyrene (BaP), which have different chemical characteristics and distinct modes of metabolic action on aquatic animals. Twenty-four hours after exposure to Cd (2 mg/L) or BaP (25 μg/L), whole body transcriptomes were analyzed. In total, 99.6 Mbp were assembled from nine libraries, resulting in 98,458 transcripts with an N50 of 1883 bp and an average contig length of 968 bp...
2018: Hereditas
https://read.qxmd.com/read/30459533/genetic-diversity-of-bletilla-striata-assessed-by-scot-and-irap-markers
#14
Yan Guo, Lina Zhai, Hao Long, Nipi Chen, Chengxian Gao, Zhishan Ding, Bo Jin
Background: Bletilla striata is a well-known traditional Chinese herb with varieties of functions. In China, the natural resources of Bletilla striata have been severely damaged because of the excessive exploitation and destruction of natural habitats. The aim of present study was to provide a reference for fully exploiting and utilizing the germplasm resources of Bletilla striata . Results: The genetic diversity of 50 varieties of Bletilla striata from different area in China was analyzed by SCoT and IRAP molecular marker technique...
2018: Hereditas
https://read.qxmd.com/read/30410429/unique-divergence-of-the-breast-cancer-2-brca2-gene-in-neanderthals
#15
Pawel Michalak, Lin Kang
Unique divergence of the BRCA2, a tumor suppressor gene, in Neanderthals relative to other primates, including modern humans, is highlighted. This divergence with potentially pathogenic consequences raises a question about cancer susceptibility in the archaic species that was replaced by modern humans about 40,000 years ago.
2018: Hereditas
https://read.qxmd.com/read/30305809/enhancement-of-grain-number-per-spike-by-rna-interference-of-cytokinin-oxidase-2-gene-in-bread-wheat
#16
Yulian Li, Guoqi Song, Jie Gao, Shujuan Zhang, Rongzhi Zhang, Wei Li, Mingli Chen, Min Liu, Xianchun Xia, Thierry Risacher, Genying Li
Background: This study aimed to validate the function of CKX gene on grain numbers in wheat. Methods: we constructed and transformed a RNA interference expression vector of TaCKX2.4 in bread wheat line NB1. Southern blotting analysis was used to select transgenic plants with single copy. The expression of TaCKX2.4 gene was estimated by Quantitative real-time PCR (qRT-PCR) analysis. Finally, the relation between expression of TaCKX2.4 gene and grain numbers was validated...
2018: Hereditas
https://read.qxmd.com/read/30279644/long-read-sequencing-identified-a-causal-structural-variant-in-an-exome-negative-case-and-enabled-preimplantation-genetic-diagnosis
#17
Hefan Miao, Jiapeng Zhou, Qi Yang, Fan Liang, Depeng Wang, Na Ma, Bodi Gao, Juan Du, Ge Lin, Kai Wang, Qianjun Zhang
Background: For a proportion of individuals judged clinically to have a recessive Mendelian disease, only one heterozygous pathogenic variant can be found from clinical whole exome sequencing (WES), posing a challenge to genetic diagnosis and genetic counseling. One possible reason is the limited ability to detect disease causal structural variants (SVs) from short reads sequencing technologies. Long reads sequencing can produce longer reads (typically 1000 bp or longer), therefore offering greatly improved ability to detect SVs that may be missed by short-read sequencing...
2018: Hereditas
https://read.qxmd.com/read/30279643/variations-in-morphological-traits-of-bermudagrass-and-relationship-with-soil-and-climate-along-latitudinal-gradients
#18
Jingxue Zhang, Miaoli Wang, Zhipeng Guo, Yongzhuo Guan, Yuxia Guo, Xuebing Yan
Background: This complex environmental heterogeneity coupled with the long-standing history offers scenario suitable for and favoring the evolution and existence of variation of morphological traits. Methods: In this study, we measured 10 morphological traits of 310 Cynodon dactylon individuals sampled at 16 different locations along latitudinal gradients between 22°35'N and 36°18'N to reveal phenotypic plasticity influenced by latitude. In addition, the relationships between morphological variation and soil nutrient and climate factors were analyzed...
2018: Hereditas
https://read.qxmd.com/read/30275809/development-of-17-polymorphic-microsatellite-loci-from-jeju-striped-field-mouse-apodemus-agrarius-chejuensis-rodentia-muridae-by-454-pyrosequencing
#19
Han-Na Kim, Han-Ul Kim, Yeong-Seok Jo, Jongwoo Jung
Background: The striped field mouse, Apodemus agrarius , is the most common mammal in Korea. Although microsatellite loci for the species have been identified from populations in southwestern China, amplification of those markers for Korean populations have been unsuccessful. The complicated taxonomy of Korean striped field mouse including populations on Jeju Island ( A. a chejuensis ) necessitates identification of additional molecular markers. Findings: We applied 454 pyrosequencing systems to develop a suite of microsatellite markers...
2018: Hereditas
https://read.qxmd.com/read/30258345/comparative-analysis-of-the-genetic-variability-within-the-q-type-c2h2-zinc-finger-transcription-factors-in-the-economically-important-cabbage-canola-and-chinese-cabbage-genomes
#20
Susan D Lawrence, Nicole G Novak
Background: Brassica oleracea, B. rapa and B. napus encompass many economically important vegetable and oil crops; such as cabbage, broccoli, canola and Chinese cabbage. The genome sequencing of these species allows for gene discovery with an eye towards discerning the natural variability available for future breeding. The Q-type C2H2 zinc-finger protein (ZFP) transcription factors contain zinc finger motifs with a conserved QALGGH as part of the motif and they may play a critical role in the plants response to stress...
2018: Hereditas
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