Sarit Appel, Akram Saad, Damien Urban, Amir Onn, Ran Yosef Kremer, Alon Ben-Nun, Marina Perelman, Efrat Ofek, Rinat Yacobi, Edith Michelle Marom, Sameh Daher, Hadas Gantz-Sorotsky, Adi Rasco, Zvi Symon, Yaacov Richard Lawrence, Jair Bar, Jeffrey Goldstein
OBJECTIVES: We hypothesized that driver mutations in epidermal growth factor receptor (EGFR) are associated with decreased pathologic response to neoadjuvant chemoradiation (NA-ChRT) in locally advanced non-small cell lung cancer (LA-NSCLC). METHODS: Patients with stage IIB-IIIA NSCLC treated with NA-ChRT, completion surgery, and underwent molecular profile testing were identified in a lung cancer database. Pathologic response was quantified using: (i) major pathologic response (MPR), (ii) complete pathologic response (pCR), and (iii) mean residual viable tumor cells (MRTC)...
September 26, 2023: British Journal of Radiology