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Indian Journal of Tuberculosis

Sangeeta Sharma
The WHO's End TB Strategy and the United Nations' (UN) Sustainable Development Goals (SDGs) share the common aim to end the global TB epidemic. Specific targets have been set in the End TB Strategy, for the period 2016-2035, which include a 90% reduction in TB deaths and an 80% reduction in TB incidence (new cases per year) by 2030, in comparison with 2015. Globally, though the TB incidence and mortality is falling at the rate of about 2% and 3% per year, by 2020, these figures need to improve to 4-5% per year and 10%, respectively, so that incidence can fall faster to reach the first (2020) milestones of the End TB Strategy3 ...
January 2019: Indian Journal of Tuberculosis
Rohit Sarin, Neeta Singla, Vikram Vohra, Rupak Singla, M M Puri, Sushil Munjal, U K Khalid, V P Myneedu, Ajoy Kumar Verma, K K Mathuria
BACKGROUND: Bedaquiline (BDQ) was approved for treatment of drug resistant TB (DR-TB) under Conditional Access Programme (CAP) of Revised National Tuberculosis Control Programme (RNTCP) and was also implemented in the National Institute of TB and Respiratory Diseases (NITRD). We present early efficacy and safety of BDQ containing regimens for DR-TB. OBJECTIVE: To ascertain the early efficacy and safety of Bedaquline containing regimens in treatment of DR-TB. METHODS: BDQ containing regimens along with other drugs were designed as per WHO recommendations for DR-TB patients...
January 2019: Indian Journal of Tuberculosis
Chitra C Iravatham, Venkata Sanjeev Kumar Neela, Vijaya Lakshmi Valluri
SETTING: Mahavir DOT Centre, Hyderabad, Telangana, India INTRODUCTION: Urban slums are characterized by crowding, poverty. In such setting due to lack of infection control the transmission of tuberculosis is known to rise, thereby creating a "Hot" spot. Distribution of residences in such areas does not necessarily follow postal codes, making it difficult for health workers to locate TB patients unless accompanied by the STLS. OBJECTIVE: To investigate the utility of integrating the help of local postman and geographic positioning system (GPS) to identify and create map of hot spots in an area under a regional DOT centre...
January 2019: Indian Journal of Tuberculosis
Mina Chandra, Proteesh Rana, Kalpana Chandra, Vijay Kumar Arora
INTRODUCTION: Depression is common in Tuberculosis (TB) and associated with adverse outcomes through pathogenic mechanisms and impaired self-care behaviours including reduced treatment adherence. Undiagnosed depression can threaten the robustness of DOTS model despite large public health investment. The Depression-Tuberculosis Syndemic requires collaborative partnership with mental health professionals. AIM: To study the evidence base for Depression-Tuberculosis Syndemic...
January 2019: Indian Journal of Tuberculosis
Anurag Bhargava, Madhavi Bhargava, Tripti Pande, Raghuram Rao, Malik Parmar
Undernutrition is the most prevalent comorbidity in patients with tuberculosis (TB) in India. Undernutrition is often severe and results in higher risk of death, drug toxicity during treatment, poor functional status at end of treatment and a higher risk of relapse after successful treatment. A World Health Organization guideline has recommended nutritional assessment, counseling, and care as integral parts of TB care. The Revised National Tuberculosis Control Programme has recognized undernutrition as a significant comorbidity, released a guidance document for improving nutritional care and support, and launched a scheme for direct bank transfer of monthly cash benefit to TB patients...
January 2019: Indian Journal of Tuberculosis
Chandra Kumar Dolla, Baskaran Dhanraj, Muniyandi Malaisamy, C Padma Priyadarshini, S Syeed Hissar, Mohan Natrajan, Rajendran Krishnan, Srikanth Prasad Tripathy
BACKGROUND: The risk of spread of Pulmonary Tuberculosis (PTB) disease depends on several factors. One important factor is the situational and environmental vulnerabilities of the prison setting. Study was conducted in central prison in Chennai, south state, India to estimate the prevalence of PTB disease in 2013. METHODS: All inmates aged 15 years and above were available during survey period screened for symptoms suggestive of PTB and X-ray taken chest PA view...
January 2019: Indian Journal of Tuberculosis
Rohit Sarin, Vikram Vohra, Neeta Singla, Rupak Singla, M M Puri, S K Munjal, U K Khalid, V P Myneedu, Ajoy Verma, K K Mathuria
BACKGROUND: Drug-Resistant Tuberculosis (DR-TB) patients for whom a WHO recommended regimen along with Bedaquiline (BDQ) cannot be prescribed, Delamanid (DLM) was added along with other drugs to provide a "Salvage Regimen". The experience of the Institute in respect of early efficacy and safety of both drugs given together is presented. OBJECTIVE: To ascertain the early efficacy, safety and tolerability of Bedaquline and Delamanid given together as a part of salvage regimen...
January 2019: Indian Journal of Tuberculosis
V K Arora, K K Chopra
NTP was pilot tested in Anantapur district of Andhra Pradesh during 1961 and thereafter the programme was launched throughout the country. In 1992, the Government of India together with the World Health Organization (WHO) and Swedish International Development Agency (SIDA) reviewed the National TB Programme and concluded that it suffered from managerial weakness, inadequate funding, over-reliance on x-ray, non-standard treatment regimens, low rates of treatment completion and lack of systematic information on treatment outcomes...
January 2019: Indian Journal of Tuberculosis
V K Chadha, P Praseeja
Community based active case finding (ACF) for tuberculosis (TB) has seen resurrection in the current armamentarium of many TB managers in their fight toward eliminating TB. This article explores the accuracy and approximate cost of various ACF algorithms currently in vogue in India or those which could be useful, while inputting the sensitivity and specificity of screening and diagnostic tools as estimated from recently conducted community based surveys. This analysis informs that ACF may be prioritized to higher prevalence settings and the diagnostic algorithm for specific setting may be chosen taking into account the expected prevalence, estimated accuracy of the algorithm and resource availability...
January 2019: Indian Journal of Tuberculosis
Hans L Rieder
No abstract text is available yet for this article.
January 2019: Indian Journal of Tuberculosis
Kuldeep S Sachdeva, Sundari R Mase
India has made great progress towards TB prevention and control with the adoption of the National Strategic Plan 2017-2025 with significantly greater allocated resources and high level political commitment. Aligning with the global End TB Strategy, India has announced the target of ending TB by 2025, five years ahead of the rest of the world. The End TB strategy is comprised of a multi-pronged approach incorporating patient-centered care and prevention, bold policies and supportive systems, and intensified research and innovation...
January 2019: Indian Journal of Tuberculosis
K K Chopra, V K Arora
No abstract text is available yet for this article.
January 2019: Indian Journal of Tuberculosis
V K Chadha, S M Anjinappa, Kiran Rade, D Baskaran, P Narang, C Kolappan, J Ahmed, P Praseeja
SETTING: Community based five pulmonary tuberculosis (PTB) surveys among adults. OBJECTIVES: Estimate sensitivity and specificity of screening tools for PTB and sputum microscopy. METHODS: For each survey site, we estimated sensitivity and specificity of different screening criteria and microscopy against culture; pooled estimates were obtained using Random Effects Model. RESULTS: Sensitivity of cough alone, screening for any symptom (persistent cough ≥2 weeks, fever or chest pain ≥1 month, hemoptysis), any symptom or history of anti-TB treatment (h/o ATT) were 56...
January 2019: Indian Journal of Tuberculosis
Asvene K Sharma, Pratibha Vats
BACKGROUND: Tuberculosis (TB) caused 1.8 million deaths worldwide with increased multiple drug resistance (MDR) cases estimated 4.8 lakhs in the year 2015. β-Lactam antibiotics could be a hope for TB treatment. Therefore, in this study, uniformity in the biochemical and molecular nature of β-lactamases was analyzed to evaluate the potential of β-lactam antibiotics as a treatment regimen against Mycobacterium tuberculosis (MTB). MATERIALS AND METHODS: β-Lactamase enzymes in 233 MTB clinical isolates along with control H37Rv strain were characterized by enzyme kinetic using nitrocefin and cefotaxime as a substrate, isoelectric points by isoelectric focusing electrophoresis (IEF) and by PCR and Southern blotting...
January 2019: Indian Journal of Tuberculosis
Jai B Mullerpattan, Zal Z Udwadia, Radhika A Banka, Shashank R Ganatra, Zarir F Udwadia
BACKGROUND: Private healthcare is choice of point of care for 70% of Indians. Multidrug resistant tuberculosis (MDR-TB) treatment is costly and involves duration as long as 2 years. AIM: To estimate costs to patients undergoing treatment for MDR-TB. METHODS: A health-economics questionnaire was administered to 50 consecutive patients who successfully completed ambulatory private treatment for MDR-TB. Direct costs included drug costs, investigations, consultation fees, travel costs, hospitalisation and invasive procedures and cost prior to presentation to us...
January 2019: Indian Journal of Tuberculosis
Bhumika Vaishnav, Nilay Suthar, Sameer Shaikh, Rahul Tambile
BACKGROUND/OBJECTIVES: Spinal tuberculosis (TB) is a destructive extra-pulmonary disease manifestation of Mycobacterium tuberculosis infection. It is responsible for many cases of paraparesis and quadriparesis in developing countries where patients seek treatment late. The aim of this study was to understand and analyze the clinical and radiological profile of patients with spinal TB and correlate it with the anatomical site affected by it. METHODS: A retrospective, observational study of 100 cases of spinal TB admitted over a period of three years...
January 2019: Indian Journal of Tuberculosis
Sumal Nandasena, Chaminda Senavirathna, Champa Munasinghe, Chapa Wijesena, Ridmi Sucharitharathna
BACKGROUND: Tuberculosis (TB) is an infectious bacterial disease; remains as one of the important public health problem affecting every part of the world. Substantial number of TB cases are reported from Sri Lanka every year irrespective of its strong preventive health system. The aim of this analysis is to describe the characteristics of TB patients and to assess the factors associated with sputum conversion. This analysis was based on the data from the District Chest Clinic of Kalutara district, Sri Lanka...
January 2019: Indian Journal of Tuberculosis
Beatriz Silva-Ramírez, Cyntia A Saenz-Saenz, Leonardo A Bracho-Vela, Katia Peñuelas-Urquides, Viviana Mata-Tijerina, Brenda L Escobedo-Guajardo, Nelly R González-Ríos, Ofelia Vázquez-Monsiváis, Mario Bermúdez de León
BACKGROUND AND AIMS: The impact of host genetic variation in susceptibility of tuberculosis is well documented. The vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results...
January 2019: Indian Journal of Tuberculosis
Bernadette Dian Novita, Mulyohadi Ali, Agung Pranoto, Endang Isbandiati Soediono, Ni Made Mertaniasih
Metformin (MET) is a potential combination drug to elevate anti-TB efficacy. However, the clinical effect, especially smear reversion, during metformin applied with anti-tuberculosis and insulin in patients with type 2 DM newly TB co-infection were remain unknown. An observational clinical study was done in DM newly TB co-infection outpatients at Surabaya Paru Hospital. This study evaluated MET therapy, at least 2 months, accompanying with insulin and anti-TB regimens and compared to comparison group. The smear, microtubule-associated Protein1 Light Chain 3B (MAP1LC3B) level, as the presentation of autophagy, Superoxide Dismutase (SOD) level, Interferon (IFN)-γ and Interleukin (IL)-10 levels were evaluated twice...
January 2019: Indian Journal of Tuberculosis
Richa Sinha, Rahul
Tuberculosis (TB) of breast is an uncommon entity even in endemic regions. Moreover, it is seldom reported. It often presents in young lactating females as a painless breast lump and confused with breast malignancy or pyogenic abscess. A high index of suspicion is required. Fine needle aspiration cytology is important to direct the patient to further tests pertaining to TB. New diagnostic modalities based on detection of nucleic acids have improved the accuracy and cut down the time to diagnosis. Anti-tubercular chemotherapy remains the standard of care...
January 2019: Indian Journal of Tuberculosis
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