journal
https://read.qxmd.com/read/38787653/super-assembled-periodic-mesoporous-organosilica-membranes-with-hierarchical-channels-for-efficient-glutathione-sensing
#1
JOURNAL ARTICLE
Hui Zeng, Shan Zhou, Xin Zhang, Qirui Liang, Miao Yan, Yeqing Xu, Yaxin Guo, Xiaomeng Hu, Lei Jiang, Biao Kong
Bioinspired nanochannel-based sensors have elicited significant interest because of their excellent sensing performance, and robust mechanical and tunable chemical properties. However, the existing designs face limitations due to material constraints, which hamper broader application possibilities. Herein, a heteromembrane system composed of a periodic mesoporous organosilica (PMO) layer with three-dimensional (3D) network nanochannels is constructed for glutathione (GSH) detection. The unique hierarchical pore architecture provides a large surface area, abundant reaction sites and plentiful interconnected pathways for rapid ionic transport, contributing to efficient and sensitive detection...
May 24, 2024: Analyst
https://read.qxmd.com/read/38780058/fabrication-of-an-all-in-one-self-enhanced-solid-state-electrochemiluminescence-sensing-platform-for-the-selective-detection-of-spermine
#2
JOURNAL ARTICLE
Mathavan Sornambigai, Antony Samy Roselin Pavithra, Shekhar Hansda, Shanmugam Senthil Kumar
The fabrication of an all-in-one solid-state ECL sensing platform is beneficial not only for expediting the miniaturization of sensing devices, but also, more importantly, for enabling point-of-care applications. In the present work, a self-enhanced solid-state ECL sensing platform is fabricated using newly synthesised silica polyethylene nanoparticles (SiO2 -PEI NPs) which generate a co-reactant in situ and easily self-assemble with Ru(bpy)3 2+ and shows selective and sensitive detection of spermine at physiological pH (7...
May 23, 2024: Analyst
https://read.qxmd.com/read/38775334/an-effective-urobilin-clearance-strategy-based-on-paramagnetic-beads-facilitates-microscale-proteomic-analysis-of-urine
#3
JOURNAL ARTICLE
Kemiao Zhen, Wenhao Hou, Lu Bai, Mingchao Wang, Zhan Yue, Zanxin Xu, Deyun Xiong, Li Gao, Wantao Ying
Urine provides an ideal source for disease biomarker discovery. High-adhesion contaminants such as urobilin, which are difficult to remove from urine, can severely interfere with urinary proteomic analysis. Here, we aimed to establish a strategy based on single-pot, solid-phase-enhanced sample preparation (SP3) technology to prepare samples for urinary proteomics analysis that almost completely eliminates the impact of urobilin. A systematic evaluation of the effects of two urinary protein precipitation methods, two types of protein lysis buffers, and different ratios of magnetic digestion beads on the identification and quantification of the microscale urinary proteome was conducted...
May 22, 2024: Analyst
https://read.qxmd.com/read/38775016/sea-urchin-nanostructured-nickel-cobaltite-modified-carbon-cloth-integrated-wearable-patches-for-the-on-site-detection-of-the-immunosuppressant-drug-mycophenolate-mofetil
#4
JOURNAL ARTICLE
K Niyas, Bartholomew Richard, Menon Ankitha, P Abdul Rasheed
Mycophenolate mofetil (MpM) is a medication used to prevent the rejection of transplanted organs, particularly in kidney, heart, and liver transplant surgeries. It is extremely important to be conscious that MpM can raise the risk of severe infections and some cancers if it exceeds the recommended dose while lower doses will result in organ rejections. So, it is essential to monitor the dosage of MpM in real time in the micromolar range. In this work, we have synthesized 3-aminopropyltriethoxysilane (APTES) functionalized nickel cobaltite (NiCo2 O4 ) and this amino functionalization was chosen to enhance the stability and electrochemical activity of NiCo2 O4 ...
May 22, 2024: Analyst
https://read.qxmd.com/read/38770583/analytical-applications-of-droplet-deposition-raman-spectroscopy
#5
REVIEW
Eva Kočišová, Alžbeta Kuižová, Marek Procházka
The droplet deposition methods in Raman spectroscopy have received considerable attention in the field of analytical sensing focusing on effective pre-concentration of the studied analyte (coffee-ring effect or small spots). This review covers different analytical applications of drop-coating deposition Raman scattering (DCDRS) and droplet deposition surface-enhanced Raman scattering (SERS) spectroscopy. Two main advantages of droplet deposition Raman techniques are considered: the drying-induced segregation of the components from the mixtures (such as body fluids) and the sensitivity of detection of various analytically important molecules...
May 21, 2024: Analyst
https://read.qxmd.com/read/38767669/a-bimodal-time-gated-luminescence-magnetic-resonance-imaging-nanoprobe-based-on-a-europium-iii-complex-anchored-on-bsa-coated-mno-2-nanosheets-for-highly-selective-detection-of-h-2-o-2
#6
JOURNAL ARTICLE
Bo Song, Ziyao Wang, Huinan Yan, Xinyue Zhang, Qi Liu, Jiawen Luo, Jingli Yuan
A novel nanocomposite, [Eu(BTD)3 (DPBT)]-BSA@MnO2 , is reported to serve as an effective nanoprobe for bimodal time-gated luminescence (TGL) and magnetic resonance (MR) imaging of H2 O2 in vitro and in vivo . The nanoprobe was fabricated by immobilizing visible-light-excitable Eu3+ complexes in bovine serum albumin (BSA)-coated lamellar MnO2 nanosheets. The TGL of the Eu3+ complex was effectively quenched by the MnO2 nanosheets. Upon exposure to H2 O2 , the MnO2 nanosheets underwent reduction to Mn2+ , which simultaneously triggered rapid, selective and sensitive "turn-on" responses toward H2 O2 in both TGL and MR detection modes...
May 20, 2024: Analyst
https://read.qxmd.com/read/38767613/farpa-based-tube-array-coupled-with-quick-dna-extraction-enables-ultra-fast-bedside-detection-of-antibiotic-resistant-pathogens
#7
JOURNAL ARTICLE
Jinling Huang, Huijie Yue, Wei Wei, Jingwen Shan, Yue Zhu, Liying Feng, Yi Ma, Bingjie Zou, Haiping Wu, Guohua Zhou
Rapid and accurate detection of pathogens and antimicrobial-resistant (AMR) genes of the pathogens are crucial for the clinical diagnosis and effective treatment of infectious diseases. However, the time-consuming steps of conventional culture-based methods inhibit the precise and early application of anti-infection therapy. For the prompt treatment of pathogen-infected patients, we have proposed a novel tube array strategy based on our previously reported FARPA (FEN1-aided recombinase polymerase amplification) principle for the ultra-fast detection of antibiotic-resistant pathogens on site...
May 20, 2024: Analyst
https://read.qxmd.com/read/38767610/online-monitoring-of-epithelial-barrier-kinetics-and-cell-detachment-during-cisplatin-induced-toxicity-of-renal-proximal-tubule-cells
#8
JOURNAL ARTICLE
Yuji Takata, Ramin Banan Sadeghian, Kazuya Fujimoto, Ryuji Yokokawa
Real-time and non-invasive assessment of tissue health is crucial for maximizing the potential of microphysiological systems (MPS) for drug-induced nephrotoxicity screening. Although impedance has been widely considered as a measure of the barrier function, it has not been incorporated to detect cell detachment in MPS with top and bottom microfluidic channels separated by a porous membrane. During cell delamination from the porous membrane, the resistance between both channels decreases, while capacitance increases, allowing the detection of such detachment...
May 20, 2024: Analyst
https://read.qxmd.com/read/38767148/a-sars-cov-2-m-pro-fluorescent-sensor-for-exploring-pharmacodynamic-substances-from-traditional-chinese-medicine
#9
JOURNAL ARTICLE
Lei Han, Bing Wang, Kunhui Sun, Muqadas Sitara, Meifang Li, Ping Wang, Ning Chen, Xie-An Yu, Jiangwei Tian
The main protease of SARS-CoV-2 (SARS-CoV-2 Mpro ) plays a critical role in the replication and life cycle of the virus. Currently, how to screen SARS-CoV-2 Mpro inhibitors from complex traditional Chinese medicine (TCM) is the bottleneck for exploring the pharmacodynamic substances of TCM against SARS-CoV-2. In this study, a simple, cost-effective, rapid, and selective fluorescent sensor (TPE-S-TLG sensor) was designed with an AIE (aggregation-induced emission) probe (TPE-Ph-In) and the SARS-CoV-2 Mpro substrate (S-TLG)...
May 20, 2024: Analyst
https://read.qxmd.com/read/38758167/acoustic-detection-of-a-mutation-specific-ligase-chain-reaction-based-on-liposome-amplification
#10
JOURNAL ARTICLE
Nikoletta Naoumi, Monica Araya-Farias, Maria Megariti, Lucile Alexandre, George Papadakis, Stephanie Descroix, Electra Gizeli
Single nucleotide variants (SNVs) play a crucial role in understanding genetic diseases, cancer development, and personalized medicine. However, existing ligase-based amplification and detection techniques, such as Rolling Circle Amplification and Ligase Detection Reaction, suffer from low efficiency and difficulties in product detection. To address these limitations, we propose a novel approach that combines Ligase Chain Reaction (LCR) with acoustic detection using highly dissipative liposomes. In our study, we are using LCR combined with biotin- and cholesterol-tagged primers to produce amplicons also modified at each end with a biotin and cholesterol molecule...
May 17, 2024: Analyst
https://read.qxmd.com/read/38758107/high-throughput-direct-screening-of-restriction-endonuclease-using-a-microfluidic-fluorescence-activated-drop-sorter-based-on-the-sos-response-in-escherichia-coli
#11
JOURNAL ARTICLE
Yizhe Zhang, Jeremy J Agresti, Yu Zheng, David A Weitz
A restriction endonuclease (RE) is an enzyme that can recognize a specific DNA sequence and cleave that DNA into fragments with double-stranded breaks. This sequence-specific cleaving ability and its ease of use have made REs commonly used tools in molecular biology since their first isolation and characterization in 1970s. While artificial REs still face many challenges in large-scale synthesis and precise activity control for practical use, searching for new REs in natural samples remains a viable route to expanding the RE pool for fundamental research and industrial applications...
May 17, 2024: Analyst
https://read.qxmd.com/read/38757739/a-binding-triggered-hybridization-chain-reaction-cascade-multi-site-activated-crispr-cas12a-signal-amplification-strategy-for-sensitive-detection-of-%C3%AE-synuclein
#12
JOURNAL ARTICLE
Zhenzhuo Wan, Jiahao Lu, Lu Lu, Weichong Zhao, Wei Jiang
Alpha-synuclein (α-syn) is closely related to the pathological process of Parkinson's disease (PD). Sensitive detection of α-syn is important for the early diagnosis and disease progression monitoring of PD. Herein, we report a binding-triggered hybridization chain reaction (HCR) cascade multi-site activated CRISPR/Cas12a signal amplification strategy for sensitive detection of α-syn. In this method, antibody-DNA capture probes recognized α-syn and bound with it to increase the local effective concentrations of two DNA strands, promoting their hybridization to form a split HCR trigger...
May 17, 2024: Analyst
https://read.qxmd.com/read/38757525/electroactive-polymer-tag-modified-nanosensors-for-enhanced-intracellular-atp-detection
#13
JOURNAL ARTICLE
Yi-Ran Kang, Yu-Ting Jiao, Chen-Fei Zhao, Xin-Wei Zhang, Wei-Hua Huang
ATP plays a crucial role in cell energy supply, so the quantification of intracellular ATP levels is particularly important for understanding many physio-pathological processes. The intracellular quantification of this non-electroactive molecule can be realized using aptamer-modified nanoelectrodes, but is hindered by the limited quantity of modification and electroactive tags on the nanosized electrodes. Herein, we developed a simple but effective electrochemical signal amplification strategy for intracellular ATP detection, which replaces the regular ATP aptamer-linked ferrocene monomer with a polymer, thus greatly magnifying the amounts of electrochemical reporters linked to one chain of the aptamer and enhancing the signals...
May 17, 2024: Analyst
https://read.qxmd.com/read/38752735/preparation-and-utilization-of-carbon-dots-as-a-nanoprobe-for-sensitive-detection-of-tartrazine-and-palladium-ii
#14
JOURNAL ARTICLE
Kai-Qi Liu, Zhong-Xia Wang, Feng Li, Heng-Ye Li, Wei Wang
We prepared novel green, eco-friendly carbon dots as a dual-channel probe for highly sensitive and selective detection of tartrazine (Trz) and palladium(II) (Pd(II)) involving, respectively, FRET and electron transfer mechanisms. Furthermore, the successful utilization of the carbon dots for detecting Trz and Pd(II) in actual samples implies its potential application prospects in analysis.
May 16, 2024: Analyst
https://read.qxmd.com/read/38751212/development-of-a-novel-x-ray-fluorescence-instrument-equipped-with-a-noble-gas-filter
#15
JOURNAL ARTICLE
Tsugufumi Matsuyama, Tomoya Miyahara, Hiroshi Yoshii, Lim Lee Wah, Kouichi Tsuji
In X-ray fluorescence (XRF) analysis, which has been used to analyze elements in various samples, it is important to decrease the background (BG) intensity. Generally, BG signals are reduced by inserting metal foils of various types and thicknesses between the X-ray tube and sample as primary X-ray filters. In this study, we developed a unique gas filter-XRF (GF-XRF) instrument to easily reduce the BG effect by changing the pressure of the gas to ensure that the absorption edge of the gas element is slightly lower than the energy of the XRF peak of the target element...
May 16, 2024: Analyst
https://read.qxmd.com/read/38747517/remediate-and-sense-alginate-beads-empowered-by-portable-electrochemical-strips-for-copper-ion-removal-and-detection-at-environmental-sites
#16
JOURNAL ARTICLE
Ada Raucci, Mayla Metitiero, Chiara Cuzzi, Panagiota M Kalligosfyri, Marianna Messina, Michele Spinelli, Angela Amoresano, Sheridan L Woo, Ilaria Cacciotti, Stefano Cinti
The contamination of environmental sites due to the presence of persistent species represents an important issue to be tackled. In particular, the presence of high levels of metals in soil and surface water is more frequent. One of the metals that sometimes exceeds the permissible limit set by regulatory authorities is copper. For instance, copper-based fungicides are widely used in viticulture. However, copper ions remain in soil and can enter the food chain, posing threats to human health and environmental safety...
May 15, 2024: Analyst
https://read.qxmd.com/read/38742449/post-column-infusion-of-an-internal-standard-into-lc-ft-icr-ms-enables-semi-quantitative-comparison-of-dissolved-organic-matter-in-original-samples
#17
JOURNAL ARTICLE
Rebecca Rodrigues Matos, Elaine K Jennings, Jan Kaesler, Thorsten Reemtsma, Boris P Koch, Oliver J Lechtenfeld
Ultrahigh resolution mass spectrometry hyphenated with liquid chromatography (LC) is an emerging tool to explore the isomeric composition of dissolved organic matter (DOM). However, matrix effects limit the potential for semi-quantitative comparison of DOM molecule abundances across samples. We introduce a post-column infused internal standard (PCI-IS) for reversed-phase LC-FT-ICR MS measurements of DOM and systematically evaluate matrix effects, detector linearity and the precision of mass peak intensities...
May 14, 2024: Analyst
https://read.qxmd.com/read/38742381/shadow-electrochemiluminescence-imaging-of-giant-liposomes-opening-at-polarized-electrodes
#18
JOURNAL ARTICLE
Fatma Ben Trad, Jérôme Delacotte, Frédéric Lemaître, Manon Guille-Collignon, Stéphane Arbault, Neso Sojic, Eric Labbé, Olivier Buriez
In this work, the release of giant liposome (∼100 μm in diameter) content was imaged by shadow electrochemiluminescence (ECL) microscopy. Giant unilamellar liposomes were pre-loaded with a sucrose solution and allowed to sediment at an ITO electrode surface immersed in a solution containing a luminophore ([Ru(bpy)3 ]2+ ) and a sacrificial co-reactant (tri- n -propylamine). Upon polarization, the electrode exhibited illumination over its entire surface thanks to the oxidation of ECL reagents. However, as soon as liposomes reached the electrode surface, dark spots appeared and then spread over time on the surface...
May 14, 2024: Analyst
https://read.qxmd.com/read/38738996/unveiling-the-potential-of-polymer-cholesteric-liquid-crystal-interpenetrating-networks-as-a-label-free-alcohol-biochemical-sensor
#19
JOURNAL ARTICLE
Bhupendra Pratap Singh, Shug-June Hwang
In this study, an optical sensor is developed, incorporating hydrogen-bonded photonic array dots containing poly(acrylic acid) (PAA) within a polymer cholesteric liquid crystal interpenetrating polymer network (PCLCIPN ) framework, thereby effectively controlling porosity. This methodology involves the fabrication of a porous photonic film, subsequent infusion with a hydrogel (PAA), and precise UV-curing to generate patterned array dots. The sensor exhibits exceptional discriminatory capability between methanol and ethanol, accurately discerning their varying concentrations within alcohol solutions...
May 13, 2024: Analyst
https://read.qxmd.com/read/38738731/correction-a-compact-and-high-performance-setup-of-capillary-electrophoresis-with-capacitively-coupled-contactless-conductivity-detection-ce-c-4-d
#20
Lin Li, Yun-Peng Song, Dou-Dou Ren, Tang-Xiu Li, Ming-Hui Gao, Lei Zhou, Zhi-Cong Zeng, Qiaosheng Pu
Correction for 'A compact and high-performance setup of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4 D)' by Lin Li et al. , Analyst , 2024, https://doi.org/10.1039/d4an00354c.
May 13, 2024: Analyst
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