O S Timofeeva, S V Logvinov, I A Petrov, O A Tikhonovskaya, Yu G Samoilova, Zh F Gaifulina, L R Mustafina, M S Petrova, A A Zhdankina, I G Kutsenko, D A Kudlay, K A Sidorenkova
We studied the expression of insulin-like growth factor 1 (IGF-1), androgen receptor (AR) and luteinizing hormone receptor (LHR) in the ovaries under the conditions of the modeling and subsequent treatment of functional ovarian cysts with gonadotropin-releasing hormone antagonist (ant-GnRH). The intensity of IGF-1, LHR, and AR expression in the generative elements of rat ovaries changed under conditions of functional ovarian cysts simulation, as well as during treatment with ant-GnRH. In both experimental groups, the expression levels of the studied markers in preantral follicles and epithelial lining of cysts were found to be related to the number of growing follicles and cysts...
February 12, 2024: Bulletin of Experimental Biology and Medicine