journal
https://read.qxmd.com/read/38759776/activity-of-pyridyl-pyrazolone-derivatives-against-trypanosoma-cruzi
#1
JOURNAL ARTICLE
Denise da Gama Jaen Batista, Ludmila Ferreira de Almeida Fiuza, Frédérique Klupsch, Krislayne Nunes da Costa, Marcos Meuser Batista, Ketlym da Conceição, Hassiba Bouafia, Gérard Vergoten, Régis Millet, Xavier Thuru, Christian Bailly, Maria de Nazaré Correia Soeiro
New affordable drugs are needed for the treatment of infection with the protozoan parasite Trypanosoma cruzi responsible for the Chagas disease (CD). Only two old drugs are currently available, nifurtimox and benznidazole (Bz) but they exhibit unwanted side effects and display a weak activity in the late chronic phase of the disease. In this context, we evaluated the activity of a series of aryl-pyrazolone derivatives against T cruzi, using both bloodstream trypomastigote and intracellular amastigote forms of the parasite...
May 15, 2024: Experimental Parasitology
https://read.qxmd.com/read/38759775/giardia-intestinalis-extracellular-vesicles-induce-changes-in-gene-expression-in-human-intestinal-epithelial-cells-in-vitro
#2
JOURNAL ARTICLE
Dongming Yang, Yingnan Liu, Yupeng Ren, Lili Hao, Xichen Zhang, Hongjun Chen, Jingyi Liu
Giardiasis is a common waterborne zoonotic disease caused by Giardia intestinalis. Upon infection, Giardia releases excretory and secretory products (ESPs) including secreted proteins (SPs) and extracellular vesicles (EVs). Although the interplay between ESPs and intestinal epithelial cells (IECs) has been previously described, the functions of EVs in these interactions and their differences from those of SPs require further exploration. In the present study, EVs and EV-depleted SPs were isolated from Giardia ESPs...
May 15, 2024: Experimental Parasitology
https://read.qxmd.com/read/38754618/isolation-characterization-and-pathogenicity-assay-of-acanthamoeba-and-its-endosymbionts-in-respiratory-disorders-and-covid-19-hospitalized-patients-northern-iran
#3
JOURNAL ARTICLE
Eissa Soleymani, Mahdi Fakhar, Lotfollah Davoodi, Seyedmousa Motavallihaghi, Ali Sharifpour, Amir Hossein Maghsood
Acanthamoeba spp., are common free-living amoebae found in nature that can serve as reservoirs for certain microorganisms. The SARS-CoV-2 virus is a newly emerged respiratory infection, and the investigation of parasitic infections remains an area of limited research. Given that Acanthamoeba can act as a host for various endosymbiotic microbial pathogens and its pathogenicity assay is not fully understood, this study aimed to identify Acanthamoeba and its bacterial and fungal endosymbionts in patients with chronic respiratory disorders and hospitalized COVID-19 patients in northern Iran...
May 14, 2024: Experimental Parasitology
https://read.qxmd.com/read/38750807/development-of-a-gaussia-luciferase-immunoprecipitation-assay-for-detecting-schistosoma-japonicum-infection
#4
JOURNAL ARTICLE
Xiaoxu Wang, Bikash R Giri, Zhoukai Cui, Tserendorj Munkhjargal, Chunren Wang, Ian Kendrich C Fontanilla, Guofeng Cheng
Timely and accurate diagnosis of Schistosoma infection is important to adopt effective strategies for schistosomiasis control. Previously, we demonstrated that Schistosoma japonicum can secret extracellular vesicles and their cargos may serve as a novel type of biomarkers for diagnosing schistosomiasis. Here, we developed a Gaussia luciferase immunoprecipitation assay combined with S. japonicum extracellular vesicle (SjEV) protein to evaluate its potential for diagnosing schistosomiasis. A saposin-like protein (SjSLP) identified from SjEVs was fused to the Gaussia luciferase as the diagnostic antigen...
May 13, 2024: Experimental Parasitology
https://read.qxmd.com/read/38735520/in-vitro-ovicidal-and-larvicidal-activity-of-a-hydroalcoholic-extract-and-its-fractions-from-cyrtocarpa-procera-fruits-on-haemonchus-contortus
#5
JOURNAL ARTICLE
Xochitl De Jesús-Martínez, Nallely Rivero-Pérez, Alejandro Zamilpa, Manases González-Cortázar, Jaime Olivares-Pérez, Adrian Zaragoza-Bastida, Pedro Mendoza-de Gives, Abel Villa-Mancera, Agustín Olmedo-Juárez
This study describes the in vitro anthelmintic effect of a hydroalcoholic extract (HA-E) and its fractions from Cyrtocarpa procera fruits against Haemonchus contortus eggs and infective larvae. The HA-E was subjected to bipartition using ethyl acetate, which resulted in an aqueous fraction (Aq-F) and an organic fraction (EtOAc-F). The HA-E and both fractions were tested using the egg hatching inhibition assay (EHIA) and the larval mortality test (LMT). Fractionation of the EtOAc-F was achieved using different chromatographic processes, i...
May 10, 2024: Experimental Parasitology
https://read.qxmd.com/read/38735519/effect-of-cattle-and-horse-feces-storage-methods-on-nematode-egg-viability-and-sensitivity-for-egg-hatch-test
#6
JOURNAL ARTICLE
Mariana Green de Freitas, Dyego Gonçalves Lino Borges, Mário Henrique Conde, Matheus Takemi Muchon Nakatani, Juliane Francieli Tutija, Giulia Ornellas Fuzaro Scaléa, Guilherme Henrique Reckziegel, Fernando de Almeida Borges
The aim of the present study was to validate methods of stool sample conservation for the egg hatch test (EHT). This study involved the use of a bovine naturally infected predominantly by Cooperia spp. and one equine naturally infected predominantly by cyathostomins characterized as susceptible to benzimidazoles in the EHT. Fecal samples were submitted to three treatments: aerobic methods (anaerobic storage in plastic bottles, anaerobic storage in vacuum-sealed bags or aerobic storage in plastic bags), under two temperature conditions (room temperature and refrigeration) analyzed at four different assessment times (48, 72, 96 and 120 hours)...
May 10, 2024: Experimental Parasitology
https://read.qxmd.com/read/38735518/moxidectin-versus-ivermectin-in-the-prevention-and-treatment-of-acute-and-chronic-experimental-trichinellosis-spiralis
#7
JOURNAL ARTICLE
Dalia A Elmehy, Ghada A Gamea, Dina M El-Guindy, Dina M Tahoon, Reem A Elkholy, Hager S Zoghroban
The limited activity of the traditional medications against T. spiralis encysted larvae handicaps complete cure of trichinellosis till now due to decreased permeability and absorption through tissues. MOX is listed worldwide for prevention and treatment of several internal and external nematodes. Consequently, the aim of this work was to investigate the effect of moxidectin versus ivermectin on experimental acute and chronic trichinellosis and to illuminate the potential mechanisms of their effects. 105 Mice were divided into four groups; Group I: Uninfected healthy control; Group II: Infected untreated control; Group III: infected and treated with IVM and Group IV: infected and treated with MOX...
May 10, 2024: Experimental Parasitology
https://read.qxmd.com/read/38735517/in-vitro-and-in-vivo-anthelmintic-effect-of-essential-oil-obtained-from-thymus-capitatus-flowers-against-haemonchus-contortus-and-heligmosomoides-polygyrus
#8
JOURNAL ARTICLE
Abidi Amel, Essia Sebai, Moez Mhadhbi, Hafidh Akkari
Sheep haemonchosis is a disease that causes serious losses in livestock production, particularly with the increase of cases of anthelmintic resistance around the world. This justifies the urgent need of alternative solutions. The aim of this study was to determine the chemical profile, in vitro, and, in vivo, anthelmintic properties of Thymus capitatus essential oil. To evaluate the, in vitro, anthelmintic activity of the T. capitatus EO on Haemonchus contortus, two tests were used: egg hatch assay (EHA) and adult worm motility (AWM) assay...
May 10, 2024: Experimental Parasitology
https://read.qxmd.com/read/38723847/copaifera-spp-oleoresins-and-two-isolated-compounds-ent-kaurenoic-and-ent-polyalthic-acid-inhibit-toxoplasma-gondii-growth-in-vitro
#9
JOURNAL ARTICLE
Samuel Cota Teixeira, Guilherme de Souza, Joed Pires de Lima Junior, Alessandra Monteiro Rosini, Aryani Felixa Fajardo Martínez, Thales Alves de Melo Fernandes, Sergio Ricardo Ambrósio, Rodrigo Cassio Sola Veneziani, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins, Bellisa Freitas Barbosa, Eloisa Amália Vieira Ferro
Toxoplasmosis affects about one-third of the world's population. The disease treatment methods pose several side effects and do not efficiently eliminate the parasite, making the search for new therapeutic approaches necessary. We aimed to assess the anti-Toxoplasma gondii activity of four Copaifera oleoresins (ORs) and two isolated diterpene acids, named ent-kaurenoic and ent-polyalthic acid. We used HeLa cells as an experimental model of toxoplasmosis. Uninfected and infected HeLa cells were submitted to the treatments, and the parasite intracellular proliferation, cytokine levels and ROS production were measured...
May 7, 2024: Experimental Parasitology
https://read.qxmd.com/read/38723846/study-of-specific-immunodominant-antigens-in-different-stages-of-neospora-caninum-toxoplasma-gondii-sarcocystis-spp-and-hammondia-spp
#10
JOURNAL ARTICLE
A Dellarupe, G Moré, J M Unzaga, L Pardini, M C Venturini
No abstract text is available yet for this article.
May 7, 2024: Experimental Parasitology
https://read.qxmd.com/read/38723845/andrographolide-induced-cytotoxicity-and-cell-cycle-arrest-in-giardia-trophozoites
#11
JOURNAL ARTICLE
Tapas Haldar, Sanjib K Sardar, Ajanta Ghosal, Akash Prasad, Yumiko Saito Nakano, Shanta Dutta, Tomoyoshi Nozaki, Sandipan Ganguly
Giardiasis is a prevalent parasitic diarrheal disease caused by Giardia lamblia, affecting people worldwide. Recently, the availability of several drugs for its treatment has highlighted issues such as multidrug resistance, limited effectiveness and undesirable side effects. Therefore, it is necessary to develop alternative new drugs and treatment strategies that can enhance therapeutic outcomes and effectively treat giardiasis. Natural compounds show promise in the search for more potent anti-giardial agents...
May 7, 2024: Experimental Parasitology
https://read.qxmd.com/read/38718530/corrigendum-to-correlations-between-the-degree-of-infection-by-wild-strain-of-toxoplasma-gondii-in-vitro-and-porcine-hematological-parameters-experiment-parasitol-261-june-2024-108754
#12
Carlos Vinicius Barros Oliveira, Maria Elenilda Paulino da Silva, Jailson Renato de Lima Silva, Amanda Maria Tavares Moreira, Maria Jéssica Mendes Brito, Cicera Alane Coelho Gonçalves, João Eudes Lemos de Barros, Romario Matheus Conceição de Oliveira, Jean Paul Kamdem, Luiz Marivando Barros, Antonia Eliene Duarte
No abstract text is available yet for this article.
May 7, 2024: Experimental Parasitology
https://read.qxmd.com/read/38704016/novel-polymorphisms-in-the-octopamine-receptor-gene-of-amitraz-resistant-population-of-rhipicephalus-sanguineus-sensu-lato-in-south-india
#13
JOURNAL ARTICLE
Nikhat Reena Shaik, Bindu Lakshmanan, N Suresh Nair, Amrutha Anand, R Radhika, K Syamala
The brown dog tick or Rhipicephalus sanguineus sensu lato is an ixodid tick, responsible for the dissemination of pathogens that cause canine infectious diseases besides inflicting the direct effects of tick bite. The hot humid climate of Kerala, a south Indian state, is favorable for propagation of tick vectors and acaricides are the main stay of tick control. Though the resistance against synthetic pyrethroids is reported among these species, the status of amitraz resistance in R. sanguineus s. l. in the country is uncertain due to the lack of molecular characterization data and scarce literature reports...
May 2, 2024: Experimental Parasitology
https://read.qxmd.com/read/38679126/comparison-of-extracellular-vesicle-isolation-methods-for-the-study-of-exosome-cargo-within-toxocara-canis-and-toxocara-cati-excretory-secretory-tes-products
#14
JOURNAL ARTICLE
Timothy K Wu, Janice L Liotta, Dwight D Bowman
Toxocara is a genus of nematodes, which infects a variety of hosts, principally dogs and cats, with potential zoonotic risks to humans. Toxocara spp. larvae are capable of migrating throughout the host tissues, eliciting eosinophilic and granulomatous reactions, while surviving for extended periods of time, unchanged, in the host. It is postulated that larvae are capable of altering the host's immune response through the release of excretory-secretory products, containing both proteins and extracellular vesicles (EVs)...
April 26, 2024: Experimental Parasitology
https://read.qxmd.com/read/38679125/design-in-silico-study-synthesis-and-evaluation-of-hybrid-pyrazole-substituted-1-3-5-triazine-derivatives-for-antimalarial-activity
#15
JOURNAL ARTICLE
Pritom Borgohain, Anshul Shakya, Surajit Kumar Ghosh, Neelutpal Gogoi, Saurav Jyoti Patgiri, Ipsita Pal Bhowmick, Dibya Ranjan Bhattacharyya, Udaya Pratap Singh, Hans Raj Bhat
OBJECTIVES: Malaria is a significant global health challenge, particularly in Africa, Asia, and Latin America, necessitating immediate investigation into innovative and efficacious treatments. This work involves the development of pyrazole substituted 1,3,5-triazine derivatives as antimalarial agent. METHODS: In this study, ten compounds 7(a-j) were synthesized by using nucleophilic substitution reaction, screened for in silico study and their antimalarial activity were evaluated against 3D7 (chloroquine-sensitive) strain of P...
April 26, 2024: Experimental Parasitology
https://read.qxmd.com/read/38679124/anthelmintic-efficacy-of-an-organic-fraction-from-guazuma-ulmifolia-leaves-and-evaluation-of-reactive-oxidative-stress-on-haemonchus-contortus
#16
JOURNAL ARTICLE
Guillermo Reséndiz-González, Agustín Olmedo-Juárez, Roberto González-Garduño, Jorge Alberto Cortes Morales, Manasés González Cortazar, Ana Elvia Sánchez-Mendoza, María Eugenia López-Arellano, Crisóforo Mercado-Márquez, Alejandro Lara-Bueno, Rosa Isabel Higuera-Piedrahita
This study describes the anthelmintic efficacy of an organic fraction (EtOAc- F) from Guazuma ulmifolia leaves and evaluation of its reactive oxidative stress on Haemonchus contortus. The first step was to assess the anthelmintic effect of EtOAc-F at 0.0, 3.5, 7.0 and 14 mg kg of body weight (BW) in gerbil's (Meriones unguiculatus) artificially infected with H. contortus infective larvae (L3). The second step was to evaluate the preliminary toxicity after oral administration of the EtOAc-F in gerbils. Finally, the third step was to determine the relative expression of biomarkers as glutathione (GPx), catalase (CAT), and superoxide dismutase (SOD) against H...
April 26, 2024: Experimental Parasitology
https://read.qxmd.com/read/38677581/bioactive-components-in-psidium-guajava-extracts-elicit-biotoxic-attributes-and-distinct-antioxidant-enzyme-modulation-in-the-larvae-of-vectors-of-lymphatic-filariasis-and-dengue
#17
JOURNAL ARTICLE
Harun K Aremu, Olu I Oyewole, Adeola Adenmosun, Lateefah Oyafajo, Zarat O Iwalewa, Adenike Ademola, Luqmon A Azeez, Monsuru A Adeleke
Control of mosquito vectors, which have caused a global disease burden, has employed various methods. However, the challenges posed by current physical and chemical methods have raised concerns about vector control programs, leading to the search for alternative methods that are less toxic, eco-friendly, and cost-effective. This study investigated the larvicidal potential of aqueous, methanol, and ethylacetate extracts of Guava (Psidium guajava) against Aedes aegypti and Culex quinquefasciatus larvae. Functional group and phytochemical characterization were performed using Fourier-Transform Infrared Spectroscopy (FTIR) and GC-MS analysis to identify the bioactive compounds in the extracts...
April 25, 2024: Experimental Parasitology
https://read.qxmd.com/read/38677580/oxfendazole-nitazoxanide-combination-in-experimental-neurocysticercosis-anti-inflammatory-and-cysticidal-effects
#18
JOURNAL ARTICLE
Jefferson Aber Alves Araújo, Taynara Cristina Gomes, Vanessa Cindy Neres Lima, Yngrid Batista da Silva, Ruy de Souza Lino Junior, Marina Clare Vinaud
Neurocysticercosis (NCC) is a parasitic infection caused by the larval stage of the pork tapeworm, Taenia solium. The complications of NCC include seizures, headaches, cognitive impairment, and focal neurological deficits. In addition to antiparasitic drugs and surgery, the management of NCC includes the use of corticosteroids to reduce inflammation and control symptoms. The traditional treatment with albendazole and praziquantel has not been altered over 30 years and present several side effects. There are other anti-helminthic drugs such as oxfendazole and nitazoxanide that may show efficacy in NCC treatment...
April 25, 2024: Experimental Parasitology
https://read.qxmd.com/read/38636935/correlations-between-the-degree-of-infection-by-wild-strain-of-toxoplasma-gondii-in-vitro-and-porcine-hematological-parameters
#19
JOURNAL ARTICLE
Carlos Vinicius Barros Oliveira, Maria Elenilda Paulino da Silva, Jailson Renato de Lima, Amanda Maria Tavares Moreira, Maria Jéssica Mendes Brito, Cicera Alane Coelho Gonçalves, João Eudes Lemos de Barros, Romário Matheus de Oliveira, Jean Paul Kamdem, Luiz Marivando Barros, Antonia Eliene Duarte
The apicomplexa Toxoplasma gondii is capable of actively proliferating in numerous types of nucleated cells, and therefore has a high potential for dissemination and resistance. Thus, the present work aimed to correlate the inoculum concentrations and amount of post-infection parasites with porcine hematological parameters (including biochemistry) through in vitro culture. Porcine blood was incubated with different concentrations of parasites (1.2 x 107 , 6 / 3 / 1.5 x 106 cells/mL), then the concentrations of red blood cells (RBC) and their morphology, total and differential leukocytes, and free peptides were evaluated...
April 16, 2024: Experimental Parasitology
https://read.qxmd.com/read/38621506/synergistic-effects-of-using-sodium-hypochlorite-bleach-and-desiccation-in-surface-inactivation-for-toxocara-spp
#20
JOURNAL ARTICLE
Janice L Liotta, Alexandra Helfer, Lucy Huang, Timothy Wu, Dwight D Bowman, Carlo Castillo, Hussni O Mohammed, Bryant S Blank
Toxocara cati and T. canis are parasitic nematodes found in the intestines of cats and dogs respectively, with a cosmopolitan distribution, and the potential for anthropozoonotic transmission, resulting in human toxocariasis. Spread of Toxocara spp. is primarily through the ingestion of embryonated eggs contaminating surfaces or uncooked food, or through the ingestion of a paratenic host containing a third-stage larva. The Toxocara spp. eggshell is composed of a lipid layer providing a permeability barrier, a chitinous layer providing structural strength, and thin vitelline and uterine layers, which combined create a biologically resistant structure, making the Toxocara spp...
April 13, 2024: Experimental Parasitology
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