journal
https://read.qxmd.com/read/38395215/state-dependent-alteration-of-respiration-in-a-rat-model-of-parkinson-s-disease
#21
JOURNAL ARTICLE
Walker Jean Jacques, Meunier Estelle, Garcia Samuel, Messaoudi Belkacem, Mouly Anne-Marie, Veyrac Alexandra, Buonviso Nathalie, Courtiol Emmanuelle
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordination, patients may also display sensory and cognitive impairments, which are often overlooked despite being inherently part of the PD symptomatology. Amongst those symptoms, respiration, a key mechanism involved in the regulation of multiple physiological and neuronal processes, appears to be altered. Importantly, breathing patterns are highly correlated with the animal's behavioral states...
February 21, 2024: Experimental Neurology
https://read.qxmd.com/read/38373483/investigating-neuropathological-changes-and-underlying-neurobiological-mechanisms-in-the-early-stages-of-primary-blast-induced-traumatic-brain-injury-insights-from-a-rat-model
#22
JOURNAL ARTICLE
Xiyan Zhu, Xiang Chu, Hao Wang, Zhikang Liao, Hongyi Xiang, Wenbing Zhao, Li Yang, Pengfei Wu, Xing Liu, Diyou Chen, Jingru Xie, Wei Dai, Lei Li, Jianmin Wang, Hui Zhao
The utilization of explosives and chemicals has resulted in a rise in blast-induced traumatic brain injury (bTBI) in recent times. However, there is a dearth of diagnostic biomarkers and therapeutic targets for bTBI due to a limited understanding of biological mechanisms, particularly in the early stages. The objective of this study was to examine the early neuropathological characteristics and underlying biological mechanisms of primary bTBI. A total of 83 Sprague Dawley rats were employed, with their heads subjected to a blast shockwave of peak overpressure ranging from 172 to 421 kPa in the GI, GII, and GIII groups within a closed shock tube, while the body was shielded...
February 17, 2024: Experimental Neurology
https://read.qxmd.com/read/38365135/social-isolation-initiated-post-weaning-augments-ischemic-brain-injury-by-promoting-pro-inflammatory-responses
#23
JOURNAL ARTICLE
Muhammed Furkan Dasdelen, Ahmet Burak Caglayan, Sezgin Er, Mustafa Caglar Beker, Nilay Ates, Janine Gronewold, Thorsten Roland Doeppner, Dirk M Hermann, Ertugrul Kilic
Social isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects of social isolation initiated post-weaning on ischemic injury, cytokine/chemokine responses and cell signaling using a broad panel of techniques that involved immunocytochemistry, cytokine/chemokine array and Western blots. Social isolation initiated post-weaning elevated infarct size, brain edema and neuronal injury in the ischemic brain tissue 3 days after MCAo, and increased microglia/ macrophage and leukocyte accumulation...
February 15, 2024: Experimental Neurology
https://read.qxmd.com/read/38365134/pi3k%C3%AE-inhibition-alleviates-the-brain-injury-during-cerebral-ischemia-reperfusion-via-suppressing-pericyte-contraction-in-a-tnf-%C3%AE-dependent-manner
#24
JOURNAL ARTICLE
Jing Qiu, Yi-Han Wang, Xiu-Ming Wang, Hui-Sheng Chen
The pericytes (PCs) surrounding capillaries are vital regulators of capillary constriction. Persistent PC contraction results in the increased capillary constriction, therefore leading to the impaired cerebral blood flow (CBF) recovery after reperfusion and worsening the clinical outcomes in stroke patients. However, the potential determinants of PC functions during ischemia/reperfusion are poorly understood. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta (PIK3CD/PI3Kδ) is a crucial factor involved with neuronflammation during ischemic stroke...
February 15, 2024: Experimental Neurology
https://read.qxmd.com/read/38365133/ndfip1-protected-dopaminergic-neurons-via-regulating-mitochondrial-function-and-ferroptosis-in-parkinson-s-disease
#25
JOURNAL ARTICLE
Xiaomin Fu, Le Qu, Huamin Xu, Junxia Xie
Increasing evidence has shown that mitochondrial dysfunction and iron accumulation contribute to the pathogenesis of Parkinson's disease (PD). Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein of the Nedd4 E3 ubiquitin ligases. We have previously reported that Ndfip1 showed a neuroprotective effect in cell models of PD. However, whether Ndfip1 could protect dopaminergic neurons in PD animal models in vivo and the possible mechanisms are not known. Here, our results showed that the expression of Ndfip1 decreased in the substantia nigra (SN) of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mouse model...
February 15, 2024: Experimental Neurology
https://read.qxmd.com/read/38365132/effects-of-dim-light-at-night-in-c57bl-6%C3%A2-j-mice-on-recovery-after-spinal-cord-injury
#26
JOURNAL ARTICLE
John C Aldrich, Ashley R Scheinfeld, Sydney E Lee, Kalina J Dusenbery, Kathryn M Mahach, Brigid C Van de Veire, Laura K Fonken, Andrew D Gaudet
Spinal cord injury (SCI) can cause long-lasting locomotor deficits, pain, and mood disorders. Anatomical and functional outcomes are exacerbated by inflammation after SCI, which causes secondary damage. One promising target after SCI is manipulating the circadian system, which optimizes biology and behavior for time of day - including neuroimmune responses and mood-related behaviors. Circadian disruption after SCI is likely worsened by a disruptive hospital environment, which typically includes dim light-at-night (dLAN)...
February 14, 2024: Experimental Neurology
https://read.qxmd.com/read/38360257/the-paradox-of-tpa-in-ischemic-stroke-tpa-knockdown-following-recanalization-improves-functional-and-histological-outcomes
#27
JOURNAL ARTICLE
Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A Fornal, Isidra M Baker, Adithya Mohandass, Sahil Reddy Mada, Billy C Wang, David M Pinson, Sourabh Lahoti, Jeffrey D Klopfenstein, Krishna Kumar Veeravalli
Previous studies have demonstrated that endogenous tissue-type plasminogen activator (tPA) is upregulated in the brain after an acute ischemic stroke (AIS). While mixed results were observed in genetic models, the pharmacological inhibition of endogenous tPA showed beneficial effects. Treatment with exogenous recombinant tPA exacerbated brain damage in rodent models of stroke. Despite the detrimental effects of tPA in ischemic stroke, recombinant tPA is administered to AIS patients to recanalize the occluded blood vessels because the benefits of its administration outweigh the risks associated with tPA upregulation and increased activity...
February 14, 2024: Experimental Neurology
https://read.qxmd.com/read/38342181/to-evaluate-the-effect-of-endothelin-receptor-agonist-irl-1620-alone-and-in-combination-with-donepezil-in-modulating-neurodegeneration-elicited-by-amyloid-%C3%AE-in-rats
#28
JOURNAL ARTICLE
Eshani Mahajan, Anupam Raja, Amit Raj Sharma, Ashish Jain, Praisy K Prabha, Ajay Prakash, Bikash Medhi
The development of efficient therapies for Alzheimer''s disease is essential since it is a serious public health problem. This investigation sought to ascertain any potential synergistic benefits of treating Alzheimer's disease with IRL-1620 monotherapy in addition to Donepezil. Additionally, the effect of IRL-1620 was evaluated using different doses (5 μg/kg,7 μg/kg, and 9 μg/kg). The study further assessed neurobehavioral, biochemical, molecular, and histopathological parameters to evaluate the efficacy of both IRL1620 by its own and in association with Donepezil...
February 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38342180/microrna-9a-5p-disrupts-the-elavl1-vegf-axis-to-alleviate-traumatic-brain-injury
#29
JOURNAL ARTICLE
Chenxi Feng, Qiuyan Tian, Xiaojuan Tang, Jian Yu, Hong Li, Changxing Geng, Lixiao Xu
Plasma microRNA (miR)-9 has been identified as a promising diagnostic biomarker for traumatic brain injury (TBI). This study aims to investigate the possible role and mechanisms of miR-9a-5p affecting TBI. Microarray-based gene expression profiling of TBI was used for screening differentially expressed miRNAs and genes. TBI rat models were established. miR-9a-5p, ELAVL1 and VEGF expression in the brain tissue of TBI rats was detected. The relationship among miR-9a-5p, ELAVL1 and VEGF was tested. TBI modeled rats were injected with miR-9a-5p-, ELAVL1 or VEGF-related sequences to identify their effects on TBI...
February 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38336286/cisplatin-induces-bdnf-downregulation-in-middle-aged-female-rat-model-while-bdnf-enhancement-attenuates-cisplatin-neurotoxicity
#30
JOURNAL ARTICLE
Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Joni L Ricks-Oddie, Daniela A Bota
Cancer-related cognitive impairments (CRCI) are neurological complications associated with cancer treatment, and greatly affect cancer survivors' quality of life. Brain-derived neurotrophic factor (BDNF) plays an essential role in neurogenesis, learning and memory. The reduction of BDNF is associated with the decrease in cognitive function in various neurological disorders. Few pre-clinical studies have reported on the effects of chemotherapy and medical stress on BDNF levels and cognition. The present study aimed to compare the effects of medical stress and cisplatin on serum BDNF levels and cognitive function in 9-month-old female Sprague Dawley rats to age-matched controls...
February 7, 2024: Experimental Neurology
https://read.qxmd.com/read/38331161/changes-in-glial-cell-activation-and-extracellular-vesicles-production-precede-the-onset-of-disease-symptoms-in-transgenic-hsod1-g93a-pigs
#31
JOURNAL ARTICLE
Maria Teresa Golia, Roberto Frigerio, Susanna Pucci, Francesca Sironi, Cassandra Margotta, Laura Pasetto, Camilla Testori, Elena Berrone, Francesco Ingravalle, Marcella Chiari, Alessandro Gori, Roberto Duchi, Andrea Perota, Luca Bergamaschi, Antonio D'Angelo, Giulia Cagnotti, Cesare Galli, Cristiano Corona, Valentina Bonetto, Caterina Bendotti, Marina Cretich, Sara Francesca Colombo, Claudia Verderio
SOD1 gene is associated with progressive motor neuron degeneration in the familiar forms of amyotrophic lateral sclerosis. Although studies on mutant human SOD1 transgenic rodent models have provided important insights into disease pathogenesis, they have not led to the discovery of early biomarkers or effective therapies in human disease. The recent generation of a transgenic swine model expressing the human pathological hSOD1G93A gene, which recapitulates the course of human disease, represents an interesting tool for the identification of early disease mechanisms and diagnostic biomarkers...
February 6, 2024: Experimental Neurology
https://read.qxmd.com/read/38325655/rab11-promotes-single-mauthner-cell-axon-regeneration-in-vivo-through-axon-guidance-molecule-ntng2b
#32
JOURNAL ARTICLE
Huaitong Yao, Yueru Shen, Zheng Song, Along Han, Xinghan Chen, Yawen Zhang, Bing Hu
Effective axon regeneration within the central nervous system (CNS) is pivotal for achieving functional recovery following spinal cord injury (SCI). Numerous extrinsic and intrinsic factors exert influences on the axon regeneration. While prior studies have demonstrated crucial involvement of specific members the Rab protein family in axon regeneration in the peripheral nervous system (PNS), the precise function of Rab11 in CNS axon regeneration in vivo remains elusive. Thus, our study aimed to elucidate the impact of Rab11 on the axon regeneration of Mauthner cells (M-cells) in zebrafish larvae...
February 5, 2024: Experimental Neurology
https://read.qxmd.com/read/38325654/maternal-environmental-enrichment-protects-neonatal-brains-from-hypoxic-ischemic-challenge-by-mitigating-brain-energetic-dysfunction-and-modulating-glial-cell-responses
#33
JOURNAL ARTICLE
L E Durán-Carabali, F K Odorcky, L K Grun, F Schmitz, O V Ramires Junior, M R de Oliveria, K F Campos, E Hoeper, A V S Carvalho, S Greggio, G T Venturine, E R Zimmer, F Barbé-Tuana, A T S Wyse, C A Netto
There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the newborn, even in case of neonatal brain hypoxia-ischemia (HI). The present study aimed to investigate the effects of maternal environmental enrichment (EE) on HI-induced energetic and metabolic failure, along with subsequent neural cell responses in the early postnatal period. Male Wistar pups born to dams exposed to maternal EE or standard conditions (SC) were randomly divided into Sham-SC, HI-SC, Sham-EE, and HI-EE groups...
February 5, 2024: Experimental Neurology
https://read.qxmd.com/read/38325653/the-cellular-senescence-response-and-neuroinflammation-in-juvenile-mice-following-controlled-cortical-impact-and-repetitive-mild-traumatic-brain-injury
#34
JOURNAL ARTICLE
Zahra F Al-Khateeb, Hasna Boumenar, Joycee Adebimpe, Shenel Shekerzade, Siân M Henson, Jordi L Tremoleda, Adina T Michael-Titus
Traumatic brain injury (TBI) is a leading cause of disability and increases the risk of developing neurodegenerative diseases. The mechanisms linking TBI to neurodegeneration remain to be defined. It has been proposed that the induction of cellular senescence after injury could amplify neuroinflammation and induce long-term tissue changes. The induction of a senescence response post-injury in the immature brain has yet to be characterised. We carried out two types of brain injury in juvenile CD1 mice: invasive TBI using controlled cortical impact (CCI) and repetitive mild TBI (rmTBI) using weight drop injury...
February 5, 2024: Experimental Neurology
https://read.qxmd.com/read/38311020/csf1r-mediated-myeloid-cell-depletion-shifts-the-ratio-of-motor-cortical-excitatory-to-inhibitory-neurons-in-a-multiple-system-atrophy-model
#35
JOURNAL ARTICLE
C Gauer, K Battis, Y Schneider, J B Florio, M Mante, H Y Kim, R A Rissman, A Hoffmann, J Winkler
Motor cortical circuit functions critically rely on precisely tuned synaptic excitation and inhibition executed by excitatory glutamatergic pyramidal neurons and GABA-releasing inhibitory interneurons. In particular, GABAergic interneurons play fundamental roles in temporally refining the glutamatergic response of layer V pyramidal neurons. Microglia, the brain resident macrophages, participate in shaping neuronal circuit functions by surveilling neuronal microenvironment and pruning synapses. Previously, we showed that colony-stimulating factor 1 receptor (CSF1R)-mediated myeloid cell depletion extended the lifespan, but impaired motor functions of MBP29 mice, a mouse model for multiple system atrophy...
February 2, 2024: Experimental Neurology
https://read.qxmd.com/read/38301864/neuroinflammation-blood-brain-barrier-dysfunction-hippocampal-atrophy-and-delayed-neurodevelopment-contributions-for-a-rat-model-of-congenital-zika-syndrome
#36
JOURNAL ARTICLE
Adriana Souza Dos Santos, Meirylanne Gomes da Costa, Aline Martins Faustino, Wellington de Almeida, Chris Krebs Danilevicz, Ariadni Mesquita Peres, Bruna Carolina de Castro Saturnino, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Paulo Michel Roehe, Rachel Krolow, Carla Dalmaz, Lenir Orlandi Pereira
The congenital Zika syndrome (CZS) has been characterized as a set of several brain changes, such as reduced brain volume and subcortical calcifications, in addition to cognitive deficits. Microcephaly is one of the possible complications found in newborns exposed to Zika virus (ZIKV) during pregnancy, although it is an impacting clinical sign. This study aimed to investigate the consequences of a model of congenital ZIKV infection by evaluating the histopathology, blood-brain barrier, and neuroinflammation in pup rats 24 h after birth, and neurodevelopment of the offspring...
January 30, 2024: Experimental Neurology
https://read.qxmd.com/read/38290652/inhibiting-ripk1-driven-neuroinflammation-and-neuronal-apoptosis-mitigates-brain-injury-following-experimental-subarachnoid-hemorrhage
#37
JOURNAL ARTICLE
Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhang
RIPK1, a receptor-interacting serine/threonine protein kinase, plays a crucial role in maintaining cellular and tissue homeostasis by integrating inflammatory responses and cell death signaling pathways including apoptosis and necroptosis, which have been implicated in diverse physiological and pathological processes. Suppression of RIPK1 activation is a promising strategy for restraining the pathological progression of many human diseases. Neuroinflammation and neuronal apoptosis are two pivotal factors in the pathogenesis of brain injury following subarachnoid hemorrhage (SAH)...
January 28, 2024: Experimental Neurology
https://read.qxmd.com/read/38281587/positive-relation-between-dopamine-neuron-degeneration-and-metabolic-connectivity-disruption-in-the-mptp-plus-probenecid-mouse-model-of-parkinson-s-disease
#38
JOURNAL ARTICLE
Margherita Tassan Mazzocco, Marcello Serra, Marco Maspero, Angela Coliva, Luca Presotto, Maria Antonietta Casu, Micaela Morelli, Rosa Maria Moresco, Sara Belloli, Annalisa Pinna
The clinical manifestation of Parkinson's disease (PD) appears when neurodegeneration is already advanced, compromising the efficacy of disease-modifying treatment approaches. Biomarkers to identify the early stages of PD are therefore of paramount importance for the advancement of the therapy of PD. In the present study, by using a mouse model of PD obtained by subchronic treatment with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the clearance inhibitor probenecid (MPTPp), we identified prodromal markers of PD by combining in vivo positron emission tomography (PET) imaging and ex vivo immunohistochemistry...
January 26, 2024: Experimental Neurology
https://read.qxmd.com/read/38278205/exploring-new-horizons-emerging-therapeutic-strategies-for-pediatric-stroke
#39
REVIEW
Barbara Buccilli
Pediatric stroke presents unique challenges, and optimizing treatment strategies is essential for improving outcomes in this vulnerable population. This review aims to provide an overview of new, innovative, and potential treatments for pediatric stroke, with a primary objective to stimulate further research in this field. Our review highlights several promising approaches in the realm of pediatric stroke management, including but not limited to stem cell therapy and robotic rehabilitation. These innovative interventions offer new avenues for enhancing functional recovery, reducing long-term disability, and tailoring treatments to individual patient needs...
January 24, 2024: Experimental Neurology
https://read.qxmd.com/read/38272160/incomplete-accumulation-of-perilesional-reactive-astrocytes-exacerbates-wound-healing-after-closed-head-injury-by-increasing-inflammation-and-bbb-disruption
#40
JOURNAL ARTICLE
Nitin Sawant, Airi Watanabe, Haruna Ueda, Hideyuki Okano, Mitsuhiro Morita
Wound healing after closed-head injury is a significant medical issue. However, conventional models of focal traumatic brain injury, such as fluid percussion injury and controlled cortical impact, employ mechanical impacts on the exposed cerebral cortex after craniotomy. These animal models are inappropriate for studying gliosis, as craniotomy itself induces gliosis. To address this, we developed a closed-head injury model and named "photo injury", which employs intense light illumination through a thinned-skull cranial window...
January 23, 2024: Experimental Neurology
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