journal
https://read.qxmd.com/read/38789025/establishment-of-a-novel-cellular-model-for-alzheimer-s-disease-in-vitro-studies
#1
JOURNAL ARTICLE
Rady E El-Araby, Komal Wasif, Rebecca Johnson, Qisheng Tu, Tarek Aboushousha, Zoe Xiaofang Zhu, Jake Chen
UNLABELLED: Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral and psychological symptoms of dementia. The limited efficacy of drugs for the treatment of neurodegenerative diseases reflects their complex etiology and pathogenesis. A novel in vitro model may help to bridge the gap between existing preclinical animal models and human clinical trials, thus identifying promising therapeutic targets that can be explored in upcoming clinical trials...
May 22, 2024: Experimental Neurology
https://read.qxmd.com/read/38789024/neonatal-resveratrol-treatment-in-cerebral-palsy-model-recovers-neurodevelopment-impairments-by-restoring-the-skeletal-muscle-morphology-and-decreases-microglial-activation-in-the-cerebellum
#2
JOURNAL ARTICLE
Sabrina da Conceição Pereira, Vanessa da Silva Souza, Caio Matheus Santos da Silva Calado, Beatriz Souza de Silveira, Letícia Nicoly Ferreira Barbosa, Luz Torner, Omar Guzmán-Quevedo, Raul Manhães-de-Castro, Ana Elisa Toscano
Cerebral Palsy (CP) is the main motor disorder in childhood resulting from damage to the developing brain. Treatment perspectives are required to reverse the primary damage caused by the early insult and consequently to recover motor skills. Resveratrol has been shown to act as neuroprotection with benefits to skeletal muscle. This study aimed to investigate the effects of neonatal resveratrol treatment on neurodevelopment, skeletal muscle morphology, and cerebellar damage in CP model. Wistar rat pups were allocated to four experimental groups (n = 15/group) according CP model and treatment: Control+Saline (CS), Control+Resveratrol (CR), CP + Saline (CPS), and CP + Resveratrol (CPR)...
May 22, 2024: Experimental Neurology
https://read.qxmd.com/read/38789023/pten-inhibition-promotes-robust-growth-of-bulbospinal-respiratory-axons-and-partial-recovery-of-diaphragm-function-in-a-chronic-model-of-cervical-contusion-spinal-cord-injury
#3
JOURNAL ARTICLE
Pauline Michel-Flutot, Lan Cheng, Samantha J Thomas, Brianna Lisi, Harrison Schwartz, Sandy Lam, Megan Lyttle, David A Jaffe, George Smith, Shuxin Li, Megan C Wright, Angelo C Lepore
High spinal cord injury (SCI) leads to persistent and debilitating compromise in respiratory function. Cervical SCI not only causes the death of phrenic motor neurons (PhMNs) that innervate the diaphragm, but also damages descending respiratory pathways originating in the rostral ventral respiratory group (rVRG) located in the brainstem, resulting in denervation and consequent silencing of spared PhMNs located caudal to injury. It is imperative to determine whether interventions targeting rVRG axon growth and respiratory neural circuit reconnection are efficacious in chronic cervical contusion SCI, given that the vast majority of individuals are chronically-injured and most cases of SCI involve contusion-type damage to the cervical region...
May 22, 2024: Experimental Neurology
https://read.qxmd.com/read/38789022/gut-microbiota-is-necessary-for-pair-housing-to-protect-against-post-stroke-depression-in-mice
#4
JOURNAL ARTICLE
Su-Ting Jiang, Yao-Huan Sun, Ya Li, Meng-Qing Wang, Xu-Yang Wang, Yin-Feng Dong
The goal of this study is to investigate the role of microbiota-gut-brain axis involved in the protective effect of pair-housing on post-stroke depression (PSD). PSD model was induced by occluding the middle cerebral artery (MCAO) plus restraint stress for four weeks. At three days after MCAO, the mice were restrained 2 h per day. For pair-housing (PH), each mouse was pair housed with a healthy isosexual cohabitor for four weeks. While in the other PH group, their drinking water was replaced with antibiotic water...
May 22, 2024: Experimental Neurology
https://read.qxmd.com/read/38782352/effects-of-exercise-and-doxorubicin-on-acute-diaphragm-neuromuscular-transmission-failure
#5
JOURNAL ARTICLE
Branden L Nguyen, Dryden R Baumfalk, Stephanie S Lapierre-Nguyen, Renjia Zhong, Vivian Doerr, Ryan N Montalvo, Lan Wei-LaPierre, Ashley J Smuder
Doxorubicin (DOX) is a highly effective anthracycline antibiotic used to treat a wide variety of cancers including breast cancer, leukemia and lymphoma. Unfortunately, clinical use of DOX is limited due to adverse off-target effects resulting in fatigue, respiratory muscle weakness and dyspnea. The diaphragm is the primary muscle of inspiration and respiratory insufficiency is likely the result of both muscle weakness and neural impairment. However, the contribution of neuropathology to DOX-induced respiratory muscle dysfunction is unclear...
May 21, 2024: Experimental Neurology
https://read.qxmd.com/read/38782351/live-and-pasteurized-akkermansia-muciniphila-ameliorates-diabetic-cognitive-impairment-by-modulating-gut-microbiota-and-metabolites-in-db-db-mice
#6
JOURNAL ARTICLE
Yage Du, Yu An, Ying Song, Nan Li, Jie Zheng, Yanhui Lu
The established role of disturbances in the microbiota-gut-brain axis in the development of diabetic cognitive impairment (DCI) has long been recognized. It has shown the potential of Akkermansia muciniphila (A. muciniphila) in improving metabolic disorders and exerting anti-inflammatory effects. However, there remains a lack of comprehensive understanding regarding the specific effects and mechanisms underlying the treatment of DCI with A. muciniphila. This study aimed to evaluate the potential of A. muciniphila in alleviating DCI in db/db mice...
May 21, 2024: Experimental Neurology
https://read.qxmd.com/read/38782350/fenobam-modulates-distinct-electrophysiological-mechanisms-for-regulating-excessive-gamma-oscillations-in-the-striatum-of-dyskinetic-rats
#7
JOURNAL ARTICLE
Pengfei Wang, Weina Dai, Hongbin Liu, Han Liu, Yuming Xu
Gamma oscillations have been frequently observed in levodopa-induced dyskinesia (LID), manifest as broadband (60-120 Hz) and narrowband (80-110 Hz) gamma activity in cortico-striatal projection. We investigated the electrophysiological mechanisms and correlation of gamma oscillations with dyskinesia severity, while assessing the administration of fenobam, a selective metabotropic glutamate receptor 5 (mGluR5) antagonist, in regulating dyskinesia-associated gamma activity. We conducted simultaneous electrophysiological recordings in Striatum (Str) and primary motor cortex (M1), together with Abnormal Involuntary Movement Scale scoring (AIMs)...
May 21, 2024: Experimental Neurology
https://read.qxmd.com/read/38782349/intermittent-theta-burst-stimulation-alleviates-hypoxia-ischemia-caused-myelin-damage-and-neurologic-disability
#8
JOURNAL ARTICLE
Yu Feng, Zhihai Huang, Xiaohui Ma, Xuemei Zong, Peisheng Xu, Hung Wen Lin, Quanguang Zhang
Neonatal hypoxia-ischemia (HI) results in behavioral deficits, characterized by neuronal injury and retarded myelin formation. To date, limited treatment methods are available to prevent or alleviate neurologic sequelae of HI. Intermittent theta-burst stimulation (iTBS), a non-invasive therapeutic procedure, is considered a promising therapeutic tool for treating some neurocognitive disorders and neuropsychiatric diseases. Hence, this study aims to investigate whether iTBS can prevent the negative behavioral manifestations of HI and explore the mechanisms for associations...
May 21, 2024: Experimental Neurology
https://read.qxmd.com/read/38777251/pericytes-in-alzheimer-s-disease-key-players-and-therapeutic-targets
#9
REVIEW
Yu Zhang, Be-Rong Mu, Zhao Ran, Tao Zhu, Xin-Huang, Yang Xiong, Dong-Mei Wang, Quan-Hong Ma, Mei-Hong Lu
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to progressive cognitive decline and neuropathological changes. Pericytes, which are vessel mural cells on the basement membrane of capillaries, play a crucial role in regulating cerebrovascular functions and maintaining neurovascular unit integrity. Emerging research substantiates the involvement of pericytes in AD. This review provides a comprehensive overview of pericytes, including their structure, origin, and markers and various functions within the central nervous system...
May 20, 2024: Experimental Neurology
https://read.qxmd.com/read/38777250/modulating-monocyte-derived-macrophage-polarization-in-cerebral-ischemic-injury-with-hyperglycemia
#10
JOURNAL ARTICLE
A Ra Goh, Joohyun Park, A Young Sim, Bon-Nyeo Koo, Yong-Ho Lee, Jong Youl Kim, Jong Eun Lee
Ischemic stroke (IS), characterized by high mortality rate, occurs owing to diminished or blocked blood flow to the brain. Hyperglycemia (HG) is a major contributor to the risk of IS. HG induces augmented oxidative stress and Blood-Brain Barrier breakdown, which increases the influx of blood-derived myeloid cells into the brain parenchyma. In cerebral ischemia, infiltrating monocytes undergo differentiation into pro-inflammatory or anti-inflammatory macrophages, having a large effect on outcomes of ischemic stroke...
May 20, 2024: Experimental Neurology
https://read.qxmd.com/read/38763355/%C3%AE-hydroxybutyrate-alleviates-neurological-deficits-by-restoring-glymphatic-and-inflammation-after-subarachnoid-hemorrhage-in-mice
#11
JOURNAL ARTICLE
Xiaoli Tan, Xiaohong Li, Ruhua Li, Weiting Meng, Zhuoxi Xie, Jing Li, Yeyu Pang, Guilan Huang, Li Li, Hao Li
BACKGROUND: Both glymphatic system dysfunction and inflammatory response aggravate neurological dysfunction after subarachnoid hemorrhage (SAH). Studies have shown that β-hydroxybutyrate (BHB) may mitigate painful diabetic neuropathy (PDN) by upregulating SNTA1 expression and reinstating AQP4 polarity. However, the potential of BHB to ameliorate glymphatic system function and inflammatory response in SAH mice remains uncertain. METHODS: The SAH models were constructed by injection of arterial blood into cisterna Magana...
May 17, 2024: Experimental Neurology
https://read.qxmd.com/read/38763354/advances-in-neuronal-reprogramming-for-neurodegenerative-diseases-strategies-controversies-and-opportunities
#12
REVIEW
Si-Tong Li, Yue Wan, Li Chen, Yan Ding
Neuronal death is often observed in central nervous system injuries and neurodegenerative diseases. The mammalian central nervous system manifests limited neuronal regeneration capabilities, and traditional cell therapies are limited in their potential applications due to finite cell sources and immune rejection. Neuronal reprogramming has emerged as a novel technology, in which non-neuronal cells (e.g. glial cells) are transdifferentiated into mature neurons. This process results in relatively minimal immune rejection...
May 17, 2024: Experimental Neurology
https://read.qxmd.com/read/38762094/astrocyte-modulation-in-cerebral-ischemia-reperfusion-injury-a-promising-therapeutic-strategy
#13
REVIEW
Ziyu Wang, Xiaolu Zhang, Guangming Zhang, Yu Jia Zheng, Anliu Zhao, Xijuan Jiang, Jiali Gan
Cerebral ischemia-reperfusion injury (CIRI) poses significant challenges for drug development due to its complex pathogenesis. Astrocyte involvement in CIRI pathogenesis has led to the development of novel astrocyte-targeting drug strategies. To comprehensively review the current literature, we conducted a thorough analysis from January 2012 to December 2023, identifying 82 drugs aimed at preventing and treating CIRI. These drugs target astrocytes to exert potential benefits in CIRI, and their primary actions include modulation of relevant signaling pathways to inhibit neuroinflammation and oxidative stress, reduce cerebral edema, restore blood-brain barrier integrity, suppress excitotoxicity, and regulate autophagy...
May 16, 2024: Experimental Neurology
https://read.qxmd.com/read/38762093/a-practical-guide-to-data-management-and-sharing-for-biomedical-laboratory-researchers
#14
JOURNAL ARTICLE
K Fouad, R Vavrek, M C Surles-Zeigler, J R Huie, H Radabaugh, G G Gurkoff, U Visser, J S Grethe, M E Martone, A R Ferguson, J C Gensel, A Torres-Espin
Effective data management and sharing have become increasingly crucial in biomedical research; however, many laboratory researchers lack the necessary tools and knowledge to address this challenge. This article provides an introductory guide into research data management (RDM), and the importance of FAIR (Findable, Accessible, Interoperable, and Reusable) data-sharing principles for laboratory researchers produced by practicing scientists. We explore the advantages of implementing organized data management strategies and introduce key concepts such as data standards, data documentation, and the distinction between machine and human-readable data formats...
May 16, 2024: Experimental Neurology
https://read.qxmd.com/read/38750949/prolonged-intermittent-hypoxia-differentially-regulates-phrenic-motor-neuron-serotonin-receptor-expression-in-rats-following-chronic-cervical-spinal-cord-injury
#15
JOURNAL ARTICLE
Elisa J Gonzalez-Rothi, Latoya L Allen, Yasin B Seven, Marissa C Ciesla, Ashley E Holland, Juliet V Santiago, Gordon S Mitchell
Low-dose (< 2 h/day), acute intermittent hypoxia (AIH) elicits multiple forms of serotonin-dependent phrenic motor plasticity and is emerging as a promising therapeutic strategy to restore respiratory and non-respiratory motor function after spinal cord injury (SCI). In contrast, high-dose (> 8 h/day), chronic intermittent hypoxia (CIH) undermines some forms of serotonin-dependent phrenic motor plasticity and elicits pathology. CIH is a hallmark of sleep disordered breathing, which is highly prevalent in individuals with cervical SCI...
May 13, 2024: Experimental Neurology
https://read.qxmd.com/read/38735456/investigating-the-effect-of-parasites-toxoplasma-gondii-rh-strain-leishmania-major-mrho-ir-75-er-and-hydatid-cyst-antigens-on-alzheimer-s-disease-an-in-vivo-evaluation
#16
JOURNAL ARTICLE
Nastaran Barati, Ali Shojaeian, Mahdi Ramezani, Fereshte Kalhori, Mohammad Sajjad Yavari Bazl, Salman Zafari, Sara Soleimani Asl, Seyedmousa Motavallihaghi
This study aimed to investigate the effects of parasite antigens on Alzheimer's symptoms in animal model. Alzheimer's model was induced in Wistar rats using Amyloid-beta peptide, and treated with parasite crude antigens from T. gondii RH strain, L. major (MRHO/IR/75/ER), and HC. Spectrophotometry and real-time PCR were used to evaluate the oxidative stress levels, antioxidant enzyme activity, and gene expression of NLRP3, IL-8, IL-1β, and Caspase-1. Histological assays were performed to investigate structural changes in the hippocampus...
May 10, 2024: Experimental Neurology
https://read.qxmd.com/read/38729551/pharmacological-inhibition-of-receptor-interacting-protein-kinase-2-ripk2-elicits-neuroprotective-effects-following-experimental-ischemic-stroke
#17
JOURNAL ARTICLE
Jonathan Larochelle, John Aaron Howell, Changjun Yang, Lei Liu, Rachel E Gunraj, Sofia M Stansbury, Antonio Carlos Pinheiro de Oliveira, Shairaz Baksh, Eduardo Candelario-Jalil
Ischemic stroke induces a debilitating neurological insult, where inflammatory processes contribute greatly to the expansion and growth of the injury. Receptor-interacting protein kinase 2 (RIPK2) is most well-known for its role as the obligate kinase for NOD1/2 pattern recognition receptor signaling and is implicated in the pathology of various inflammatory conditions. Compared to a sham-operated control, ischemic stroke resulted in a dramatic increase in the active, phosphorylated form of RIPK2, indicating that RIPK2 may be implicated in the response to stroke injury...
May 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38729552/stau1-exhibits-a-dual-function-by-promoting-amyloidogenesis-and-tau-phosphorylation-in-cultured-cells
#18
JOURNAL ARTICLE
Chen-Lu Li, Gui-Feng Zhou, Xiao-Yong Xie, Lu Wang, Xue Chen, Qiu-Ling Pan, Ya-Lan Pu, Jie Yang, Li Song, Guo-Jun Chen
Staufen-1 (STAU1) is a double-stranded RNA-binding protein (RBP) involved in a variety of pathological conditions. In this study, we investigated the potential role of STAU1 in Alzheimer's disease (AD), in which two hallmarks are well-established as cerebral β-amyloid protein (Aβ) deposition and Tau-centered neurofibrillary tangles. We found that STAU1 protein level was significantly increased in cells that stably express full-length APP and the brain of APP/PS1 mice, an animal model of AD. STAU1 knockdown, as opposed to overexpression, significantly decreased the protein levels of β-amyloid converting enzyme 1 (BACE1) and Aβ...
May 8, 2024: Experimental Neurology
https://read.qxmd.com/read/38723859/age-dependent-small-fiber-neuropathy-mechanistic-insights-from-animal-models
#19
REVIEW
Daniel G Taub, Clifford J Woolf
Small fiber neuropathy (SFN) is a common and debilitating disease in which the terminals of small diameter sensory axons degenerate, producing sensory loss, and in many patients neuropathic pain. While a substantial number of cases are attributable to diabetes, almost 50% are idiopathic. An underappreciated aspect of the disease is its late onset in most patients. Animal models of human genetic mutations that produce SFN also display age-dependent phenotypes suggesting that aging is an important contributor to the risk of development of the disease...
May 7, 2024: Experimental Neurology
https://read.qxmd.com/read/38714285/leptin-combined-with-withaferin-a-boost-posthemorrhagic-neurogenesis-via-activation-of-stat3-socs3-pathway
#20
JOURNAL ARTICLE
Dongshan Ya, Wenjing Xiang, Yanlin Jiang, Yingmei Zhang, Zixian Zhou, Xiaoxia Li, Jungang Deng, Meiling Chen, Bin Yang, Xiaohui Lin, Rujia Liao
Neurogenesis as a potential strategy to improve the consequences of intracerebral hemorrhage (ICH). The current study investigates the effects of withaferin A (WFA) in combination with leptin (LEP) on ICH and neurogenesis mechanisms. LEP levels were dramatically reduced on days 7 and 14 following ICH insults in mice, but continuous WFA therapy significantly improved the potency of intrinsic LEP on day 14 after ICH. Furthermore, WFA combined with LEP enhances intrinsic neurogenesis and lessen motor deficits and long-term cognitive outcomes after ICH...
May 5, 2024: Experimental Neurology
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