Rui Fang, Jin-He Li, Hai-Long Li, Pei-Lin Yue, Xue-Fei Ding, Yu-Xuan Jia, Zhao-Chuan Liu, Hong-Gang Zhou, Cheng Yang, Xu-Dong Song
Cataract is the leading cause of blindness in the world, and there is a lack of effective treatment drugs. CircRNA plays an important part in a variety of diseases, however, the role of circRNA in cataracts remains largely unknown. In this study, we constructed a cataract model of rats and obtained the circRNAs related to cataracts by whole transcriptome sequencing and circRNA-mRNA co-expression network. To investigate the effect and mechanism of circRNA 06209 on cataracts, we performed several in vivo and in vitro experiments, including CCK8 assay, flow cytometry, dual luciferase reporter assay, RIP assay, actinomycin D assay, and Western blot analysis...
September 4, 2023: Experimental Eye Research