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Endokrynologia Polska

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https://read.qxmd.com/read/30742299/acromegaly-associated-with-gist-non-small-cell-lung-cancer-clear-cell-renal-cancer-myeloma-multiplex-medulla-oblongata-tumor-adrenal-adenoma-and-follicular-thyroid-nodules
#1
Aleksandra Jawiarczyk-Przybyłowska, Beata Wojtczak, James Whitworth, Krzysztof Sutkowski, Martin Bidlingmaier, Márta Korbonits, Marek Bolanowski
BACKGROUND: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth. CASE PRESENTATION: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Abdominal and chest CT showed tumors of the stomach, right adrenal gland and right lung...
February 11, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30699232/the-efficacy-of-microperimetry-and-contrast-sensitivity-test-in-the-diagnosis-of-optic-chiasm-compression-due-to-pituitary-adenomas
#2
Monika Sarnat-Kucharczyk, Beata Kos-Kudła, Dariusz Kajdaniuk, Ewa Mrukwa-Kominek
INTRODUCTION: The aim of the study was to determine which microperimetry and contrast sensitivity test parameters would prove the most valuable during diagnosing optic chiasm compression due to pituitary adenomas. METHODS: Control group comprised healthy individuals (Group 1). Patients with pituitary macroadenoma were divided into two groups: Group 2 - absent optic chiasm compression, Group 3 - present optic chiasm compression detected on contrast-enhanced Magnetic Resonance Imaging (MRI)...
January 30, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30699231/expression-of-%C3%AE-klotho-protein-in-human-thyroid-cancers-an-immunohistochemical-study
#3
Marek Pawlikowski, Hanna Pisarek, Magdalena Borkowska, Katarzyna Winczyk
BACKGROUND: The α-Klotho protein was discovered as a gene controlling the process of aging but the further studies indicated that it also plays a role of a tumour suppressor. Although the numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce. Our study presents the immunohistochemical investigation of α-Klotho expression in benign and malignant thyroid tumours. MATERIAL AND METHODS: The material included samples of benign (nodular hyperplasia, follicular adenoma), differentiated (follicular and papillary) cancers and aggressive thyroid cancers of low differentiation grade...
January 30, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30648728/pernicious-anemia-and-endocrine-glands-antibodies
#4
Elżbieta Morawiec-Szymonik, Wanda Foltyn, Bogdan Marek, Beata Kos-Kudła, Dariusz Kajdaniuk
INTRODUCTION: The aim of the study was to determine the frequency of occurrence of antibodies participating in the development of endocrine diseases in patients with autoimmune hematopoietic disease, thus documenting the potential suitability of specific diagnostic and screening tests. MATERIAL AND METHODS: The study group consisted of 124 persons (men and women) with newly diagnosed Pernicious Anemia (PA) and the control group (C) of 41 healthy people. Antibodies against: internal factor (IFAb), gastric parietal cells (APCA), thyroid peroxidase (TPOAb), thyroglobulin (TgAb), adrenal cortex (AdrenalAb) and pituitary anterior lobe (PituitaryAb) were determined in the blood...
January 16, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30633319/spatio-temporal-image-correlation-stic-in-evaluation-of-advanced-neuroendocrine-tumors
#5
Ksenia Janas, Marek Kudła, Adam Janas, Jolanta Blicharz-Dorniak, Beata Kos-Kudła
BACKGROUND: 4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization. AIM: To assess whether HDF STIC technique could be a useful tool for evaluation of gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) advancement. METHOD: Forty-eight patients (mean age 57...
January 11, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30633318/novel-inflammatory-biomarkers-may-reflect-subclinical-inflammation-in-young-healthy-adults-with-obesity
#6
Tadeusz Osadnik, Kamil Bujak, Kamila Osadnik, Hanna Czarnecka, Natalia Pawlas, Rafał Reguła, Martyna Fronczek, Mateusz Lejawa, Marcin Gawlita, Małgorzata Gonera, Marta Góral, Joanna Katarzyna Strzelczyk, Marek Gierlotka, Andrzej Lekston, Janusz Kasperczyk, Lech Poloński, Mariusz Gąsior
INTRODUCTION: Obesity is often accompanied by low-grade inflammation. In the last years a few blood-based inflammatory markers - neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein ratio (MHR) have been identified. They have been proven to correlate well with established inflammatory markers such as hsCRP, and have a prognostic value among others in patients with coronary artery disease, heart failure and malignancies...
January 11, 2019: Endokrynologia Polska
https://read.qxmd.com/read/30480749/adropin-in-women-with-polycystic-ovary-syndrome
#7
Justyna Kuliczkowska-Płaksej, Agata Mierzwicka, Maja Jonczyk, Barbara Stachowska, Alina Urbanovych, Marek Bolanowski
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) frequently develop metabolic complications. Among the new markers responsible for metabolic disorders, adropin seems to be of the great significance. MATERIAL AND METHODS: 134 women aged 17-45 years were enrolled. PCOS group consisted of 73 women, diagnosed on the basis of ESHRE-ASRM criteria. All PCOS women presented phenotype A of PCOS. Control group consisted of 61 women with regular menstrual cycles, matched for nutritional status...
December 10, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30480752/the-influence-of-hypothyroidism-and-substitution-treatment-on-thyroid-hormone-conversion-ratios-and-rt3-concentration-in-patients-with-end-stage-renal-failure
#8
Iwanna Dubczak, Longin Niemczyk, Katarzyna Szamotulska, Mariusz Jasik, Aleksandra Rymarz, Stanisław Niemczyk
The increasing number of patients with end-stage renal disease (ESRD) requires seeking new opportunities to improve their quality of life not only because of kidney disease, but also due to other disturbances, such as thyroid hormone disorders. The aim of the study The objective of the study was to evaluate the influence of coexisting hypothyroidism and thyroid hormone therapy in patients with ESRD on thyroid hormone conversion ratios and rT3 concentration. Material and methods The study involved 85 patients aged 26 to 87 years, with a mean age of 59,62±15,45 years...
November 27, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30480751/subclinical-hyperthyroidism-in-the-course-of-autonomous-nodules-clinical-evaluation
#9
Grzegorz Mieczysław Rudzki, Monika Lenart-Lipińska, Agata Smoleń, Beata E Chrapko, Beata Matyjaszek-Matuszek
Introduction Subclinical hyperthyroidism (SCH) also known as mildly symptomatic has recently been diagnosed more frequently. One of the main endogenous causes of this disorder is autonomously functioning thyroid nodule (AFTN). Despite the fact that it is usually asymptomatic SCH entails repercussions on the cardiovascular system and bone as well as carries a risk of progression to overt hyperthyroidism with a typical clinical picture. Treatment is still controversial and its benefits are widely debated in literature...
November 27, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30480750/comparison-of-adipose-tissue-derived-genes-in-endogenous-cushing-s-syndrome-versus-diet-induced-obesity
#10
Judit Denes, Adrienn Zsippai, Laszlo Kovacs, Zoltan Gorombey, Gabor L Kovacs, Miklos Goth, Peter Igaz, Erika Hubina
INTRODUCTION: Dysregulation of adipokine secretion and action are characteristic features of obesity that is a main clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue derived gene expression. MATERIAL AND METHODS: mRNA expression of adipokines; adiponectin, resistin, tumor necrosis factor-, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients...
November 27, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30480748/the-association-of-thyroid-stimulating-hormone-tsh-and-free-thyroxine-ft4-concentration-levels-with-carbohydrate-and-lipid-metabolism-in-obese-and-overweight-teenagers
#11
Katarzyna Anna Korzeniowska, Michal Brzezinski, Kamila Szarejko, Marcin Radziwiłł, Tomasz Anyszek, Leszek Czupryniak, Piotr Soszyński, Per-Olof Berggren, Malgorzata Mysliwiec
INTRODUCTION: Obesity has increased rapidly among children and adolescents during the last 30 years. Pediatric patients with a BMI >85th centile are more often diagnosed with increased TSH levels than children with proper body weight. MATERIALS AND METHODS: The data of 961 overweight and obese children, aged 13, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters...
November 27, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30450534/-tc-99m-thyroid-scintigraphy-in-more-than-210-cases-of-permanent-congenital-hypothyroidism-and-its-correlation-with-the-1st-diagnostic-serum-thyrotropin
#12
Majid Aminzadeh
OBJECTIVE: A big part of cases of congenital hypothyroidism(CH) in Iran are transient. This study designed to investigate etiology of permanent CH(PCH) by thyroid scintigraphy(TS) and its relationship with the first diagnostic thyrotropin(TSH). METHODS: During twelve years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until the 3rd birthday that they were reevaluated for serum T4,TSH after 3-4 weeks treatment discontinuation...
November 19, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30450533/resistance-to-thyroid-hormone-with-a-mutation-of-the-thyroid-%C3%AE-receptor-gene-in-an-eight-month-old-infant-case-report
#13
Elżbieta Anna Foryś-Dworniczak, Carla Moran, Barbara Kalina-Faska, Ewa Małecka-Tendera, Agnieszka Zachurzok
INTRODUCTION: Resistance to thyroid hormone (RTHβ) is a rare syndrome of impaired tissue responsiveness to thyroid hormones (THs). The disorder has autosomal dominant or recessive pattern of inheritance. Most of reported mutations have been detected in the thyroid hormone receptor β gene (THRB). CASE REPORT: We present an 8-month-old infant with poor linear growth, decreased body weight, tachycardia, positive family history and suggestive neonatal features of RTHβ...
November 19, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30450532/the-role-of-adiponectin-and-leptin-in-the-treatment-of-ovarian-cancer-patients
#14
Grzegorz Jarosław Slomian, Damian Nowak, Marta Buczkowska, Anna Głogowska-Gruszka, Szymon Piotr Słomian, Wojciech Roczniak, Szymon Janyga, Przemysław Nowak
INTRODUCTION: Ovarian cancer is most frequently detected in the advanced stage. Although its pathogenesis is not fully elucidated, it is assumed that body susceptibility and hormonal disorders are responsible. The role of some cytokines as predictors in the treatment process is still investigated. The aim of the study was to determine the relationship of adiponectin and leptin with the disease severity and response to chemotherapy. MATERIALS AND METHODS: 43 ovarian cancer patients were treated in the Department of Oncology of Specialist Hospital in Rybnik...
November 19, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30359462/capecitabine-plus-temozolomide-in-well-or-moderately-differentiated-primary-atypical-neuroendocrine-tumors-a-single-centre-experience-of-two-cases
#15
Anna La Salvia, Maria Pia Brizzi, Leonardo Muratori, Elena Trevisi, Massimo Di Maio, Giorgio Vittorio Scagliotti
INTRODUCTION: Neuroendocrine neoplasms (NENs) are a rare and heterogeneous group of tumors, with a variety of primary origins and variable aggressiveness. NENs with an atypical primary origin, such as breast and retroperitoneal NENs, are extremely rare. As a consequence, an established diagnostic and therapeutic strategy in this particular subgroup is lacking. The combination of capecitabineandtemozolomide, called CAPTEM regimen, has produced promising response rates in patients with grade1 or 2neuroendocrine tumors of multiple origins...
October 25, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30359461/endothelin-1-et-1-n-terminal-fragment-of-proatrial-natriuretic-peptide-ntpro-anp-and-tumor-necrosis-factor-alpha-tnf-%C3%AE-in-children-with-primary-hypertension-and-hypertension-of-renal-origin
#16
Beata Banaszak, Elżbieta Świętochowska, Paweł Banaszak, Katarzyna Ziora
Introduction Hypertension is regarded to be a condition of mild inflammation and endothelial imbalance. The aim of the study was to evaluate serum concentrations of biomarkers of inflammation and endothelial function: tumor necrosis factor alpha (TNF-α), endothelin-1 (ET-1) and N-terminal fragment of proatrial natriuretic peptide (NTpro-ANP) in hypertensive and normotensive children. Material and methods We studied 63 children aged 13,56 ± 3,73 years, divided into: group with primary hypertension (n=50) and group with renal hypertension (n=13)...
October 25, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30351443/intracerebral-hemorrhage-as-a-first-sign-of-pheochromocytoma-case-report-and-review-of-the-literature
#17
Sandra Pekic, Vladimir Jovanovic, Goran Tasic, Ivan Paunovic, Svetislav Tatic, Dusko Dundjerovic, Mirjana Doknic, Dragana Miljic, Marko Stojanovic, Marina Nikolic Djurovic, Milan Petakov, Vera Popovic
Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young, with only few cases reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He had a six months history of paroxysmal headache, palpitations and sweating. During examination he became somnolent and developed left-sided hemiplegia. A computed tomographic (CT) scan of the brain showed a right temporoparietal hematoma...
October 23, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30351442/treatment-of-severe-primary-igf-1-deficiency-using-rhigf-1-preparation-first-three-years-of-polish-experience
#18
Elżbieta Petriczko, Tomasz Jackowski, Anita Horodnicka-Józwa, Beata Wikiera, Anna Noczyńska, Maria Korpal-Szczyrska, Dorota Birkholz-Walerzak, Ewa Małecka-Tendera, Barbara Kalina-Fraska, Maria Kalina, Ewa Barg, Iwona Beń-Skowronek, Leszek Szewczyk, Maciej Hilczer, Joanna Smyczyńska, Renata Stawerska, Andrzej Lewiński, Katarzyna Ziora, Artur Bossowski, Edyta Pietrewicz, Beata Pyrżak, Andrzej Kędzia, Mieczysław Szalecki, Agnieszka Kilian, Mieczysław Walczak
INTRODUCTION: The objective of this study was to analyze the effects of the first three years of treatment with recombinant human insulin-like growth factor 1 (rhIGF-1) in patients from the Polish population. MATERIAL AND METHODS: Twenty-seven children (22 boys and 5 girls) aged 2.8 to 16.0 years old were qualified for treatment with rhIGF-1 (mecasermin) in different treatment centers, according to Polish criteria: body height below -3.0 SD and IGF-1 concentration below 2...
October 23, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30307028/sexual-function-and-depressive-symptoms-in-men-with-overt-hyperthyroidism
#19
Robert Krysiak, Bogdan Marek, Bogusław Okopień
INTRODUCTION: Although hyperthyroidism is characterized by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin. MATERIAL AND METHODS: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n=20), men with overt hyperthyroidism and toxic multinodular goiter or toxic adenoma (group B; n=21) and men with normal thyroid function (group C; n=23)...
October 11, 2018: Endokrynologia Polska
https://read.qxmd.com/read/30306537/false-positive-radioiodine-whole-body-scan-due-to-a-renal-cyst
#20
Adam Maciejewski, Rafał Czepczyński, Marek Ruchała
Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. Post-therapy whole body scan allows detecting thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. On post-therapy whole body scan, abnormal uptake in the left upper abdomen was found, although stimulated thyroglobulin level was not suggestive for distant metastases of differentiated thyroid carcinoma...
October 11, 2018: Endokrynologia Polska
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