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Documenta Ophthalmologica. Advances in Ophthalmology

Linlin Li, Jie Qin, Tingting Fu, Jiaxiang Shen
PURPOSE: Glaucoma is a common chronic neurodegenerative disease, which could lead to visual loss. In this study, we aimed to investigate whether fisetin, a natural flavone with anti-inflammatory and antioxidant properties, is able to alleviate glaucoma. METHODS: We employed a DBA/2J mouse model which was treated with or without fisetin. Pattern electroretinogram (P-ERG), visual evoked potentials (VEPs) and intraocular pressure (IOP) were evaluated. Quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA) were used to measure the expression levels of TNF-α, IL-1β and IL-6...
February 11, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Haijun Gong, Yuanlin Tang, Jianhui Xiao, Yimin Liu, Rui Zeng, Zijing Li, Si Zhang, Yuqing Lan
OBJECTIVE: To assess the role of multifocal electroretinograms (mfERGs) and optical coherence tomography (OCT) for detecting early changes in macular functions of patients with nasopharyngeal carcinoma (NPC) after radiotherapy. METHODS: mfERGs and OCT were used to examine a NPC group (36 NPC patients after radiotherapy without clinically visible radiation retinopathy, 36 eyes) and a normal control group (25 healthy individuals, 25 eyes) with the same procedure and parameters...
February 9, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
F Nasser, L Mulahasanovic, M Alkhateeb, S Biskup, K Stingl, E Zrenner
PURPOSE: To investigate a very rare case of hypotrichosis with cone-rod dystrophy caused by a P-cadherin CDH3 mutation. METHODS: A 16-year-old Syrian girl was examined at age 9 and 14 years with an ophthalmological examination, fundus imaging, OCT and electrophysiological recordings (ERG and PERG). A disease-targeted gene panel sequencing was performed. RESULTS: Fundus images showed pigmentations at the posterior eye pole to the mid periphery, as well as vessel tortuosity...
February 1, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Dylan Vatcher, Allison L Dorfman, Youjia Shen, Jia Yue You, Vincent Sun, Ayesha Khan, Robert C Polomeno, Pierre Lachapelle
PURPOSE: We have previously shown that the amplitude of the mfERG response obtained to a single (large) hexagon is significantly smaller than that obtained when summating all the mfERG responses evoked to an array of 7-61 hexagons covering the same retinal area. The purpose of this study was to confirm our initial findings in normal subjects of different ages and in selected patients. METHODS: Binocular mfERGs (1, 7, 19, 37 and 61 hexagon arrays; Espion V6.0.54 Diagnosys LLC) were recorded from 40 normal subjects (25 aged 18-25, and 15 aged 3-12)...
January 31, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Kenji Ozawa, Kiyofumi Mochizuki, Yusuke Manabe, Nobuaki Yoshikura, Takayoshi Shimohata, Ichizo Nishino, Yu-Ichi Goto
PURPOSE: Mitochondrial encephalopathy with lactic acid and stroke-like episodes (MELAS) is caused by mutations in the mitochondrial DNA. Approximately 80% of MELAS patients have an A > G transition mutation at nucleotide pair 3243 in the mitochondrial DNA, m.3243A > G. There are also MELAS patients with a one-base deletion at nucleotide pair 3271 in the mitochondrial DNA, m.3271delT, but these cases are very rare. We report a case of MELAS with the m.3271delT and describe the retinal structure and electrophysiological alterations...
January 30, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Torsten Strasser, Fadi Nasser, Hana Langrová, Ditta Zobor, Łukasz Lisowski, Dominic Hillerkuss, Carla Sailer, Anne Kurtenbach, Eberhart Zrenner
PURPOSE: The aim of this study was to develop a simple and reliable method for the objective assessment of visual acuity by optimizing the stimulus used in commercially available systems and by improving the methods of evaluation using a nonlinear function, the modified Ricker model. METHODS: Subjective visual acuity in the normal subjects was measured with Snellen targets, best-corrected, and in some cases also uncorrected and with plus lenses (+ 1 D, + 2 D, + 3 D)...
January 29, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Abbas Azimi, Shokoufeh Bonakdaran, Javad Heravian, Parvin Layegh, Negareh Yazdani, Maryam Alborzi
PURPOSE: To investigate the functional integrity of visual pathway in hypothyroid patients by pattern visual evoked potential (PVEP). METHODS: We enrolled 36 female patients with history of hypothyroidism (18 overt and 18 subclinical) aged 20 to 60 years and 36 healthy women of similar age (control group). All subjects had a complete ophthalmic examination. For VEP testing, subjects were exposed to checks subtending a visual angle of 15 and 60 min of arc. RESULTS: For the 15 min of arc check size, the mean P100 latency was significantly delayed (113 milliseconds (ms)) and amplitude significantly reduced (9...
January 24, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Lisa-Marie Anders, Sven P Heinrich, Wolf A Lagrèze, Lutz Joachimsen
PURPOSE: Daily administration of 0.01% atropine eye drops is a promising approach for myopia control. The mechanism of action is believed to involve the dopaminergic system of the retina, triggering an increased release of dopamine. Previous studies in psychiatric condition such as major depression suggest that pattern electroretinogram (PERG) amplitudes are modulated by changes in retinal dopamine. It is thus plausible that atropine eye drops could have an effect on PERG amplitudes. The present study was designed to test this, assessing the difference in amplitude between contrast levels and the ratio of amplitudes between check sizes as primary endpoints...
January 24, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Aniruddha Banerjee, Mona Khurana, Ramya Sachidanandam, Parveen Sen
PURPOSE: A prospective, cross-sectional, case-control study was conducted to investigate the role of broadband and monochromatic photopic negative response (PhNR) of the full-field flash electroretinogram (ERG) in the evaluation of ganglion cell damage in primary open-angle glaucoma (POAG) subjects. METHODS: Subjects with POAG and age-matched normal subjects were recruited from the outpatient department of a tertiary eye care center in South India. A total of 25 patients with POAG and 50 age-matched normal subjects were recruited...
January 12, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Railson Cruz Salomão, Isabelle Christine Vieira da Silva Martins, Bárbara Begot Oliveira Risuenho, Diego Leite Guimarães, Luiz Carlos Lima Silveira, Dora Fix Ventura, Givago Silva Souza
PURPOSE: Visual evoked cortical potentials (VECPs) are useful for investigating the mechanisms and dysfunctions of color vision. Chromatic sinusoidal gratings are generally used to elicit VECPs, but they require long psychophysical measurements to match the perceptual luminance between their stripes. An alternative method is to use pseudoisochromatic stimuli, which makes use of luminance noise to mask luminance clues and force the target perception to be dependent on chromatic contrast...
January 7, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
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No abstract text is available yet for this article.
December 28, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Carla Rocio Perez-Montaño, Jose Luis Palomares-Ordoñez, Abel Ramirez-Estudillo, Jorge Sanchez-Ramos, Gerardo González-Saldivar
PURPOSE: To describe the first case of a combined sub-hyaloid and sub-internal limiting membrane macular hemorrhage after recreational laser exposure. METHODS: A 23-year-old patient presented with an acute loss of vision in his right eye (OD) immediately after a brief exposure to a laser beam at a music festival. Color photography, spectral-domain optical coherence tomography (SD-OCT), and multifocal electroretinogram (mfERG) were performed for diagnosis and follow-up...
December 18, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Scott E Brodie
PURPOSE: To describe recent changes in the dimensions of the ERG-jet contact lens electrode, and to suggest corresponding changes in the dimensions of cylindrical stents to facilitate the use of ERG-jet contact lens electrodes in infants and small children. METHODS: Upon the observation that existing cylindrical stents no longer fit newly purchased ERG-jet contact lenses, the spacings between the "bumps" on the front surface of old and new electrodes were measured with calipers, and prototype stents were newly machined from acrylic plastic...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Maya Ross, Hen Honig, Raaya Ezra-Elia, Eyal Banin, Alexey Obolensky, Edward Averbukh, Alexander Rosov, Elisha Gootwine, Ron Ofri
PURPOSE: Our aim was to compare the electroretinographic (ERG) responses of two eyes obtained by consecutive unilateral recordings to those obtained by a simultaneous bilateral recording in sheep. METHODS: Eight sheep underwent two full-field ERG recordings, using two recording strategies of the standard ISCEV protocol: consecutive unilateral recordings of one eye after the other, and simultaneous bilateral recording of both eyes. The order of recording strategy within an animal (unilateral/bilateral), eye recording sequence in the unilateral session (OD/OS), and amplifier channel assignment for each eye were all randomized...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Ewelina Lachowicz, Wojciech Lubiński
BACKGROUND AND METHODS: Based on the available literature, it is suggested, in the clinical evaluation of the chiasmal tumors, that the following electrophysiological tests: visual evoked potentials to pattern-reversal stimulation, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (PERG) play an important role in the diagnosis of the optic nerve and retinal dysfunction in the course of pituitary tumors. RESULTS: Macroadenomas and also microadenomas may cause dysfunction of retinal ganglion cells (RGCs) and their axons, even in the absence of changes in the routine ophthalmological examination, retinal sensitivity in standard automated perimetry, and retinal nerve fiber layer thickness in optical coherent tomography...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Samaneh Chaychi, Anna Polosa, Sylvain Chemtob, Pierre Lachapelle
PURPOSE: To determine the neuroprotective effect of estrogen on the structure and function of the retina exposed to an oxidative stress. METHODS: Male Sprague-Dawley rat pups were exposed to either hyperoxia (O2 E: from P8 to P14) or bright light (LE: from P14 to P28) with or without 17 β-estradiol (βE2 ) treatment. Retinal structure (histology) and function (ERG) were assessed at selected time points. RESULTS: In the O2 E model, βE2 injections caused a significant reduction of the ERG and a significantly thinner OPL compared to untreated oxygen-exposed group (O2 -exposed) rats...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Henry Liu, Xiang Ji, Sabrina Dhaliwal, Syeda Naima Rahman, Michelle McFarlane, Anupreet Tumber, Jeff Locke, Tom Wright, Ajoy Vincent, Carol Westall
PURPOSE: The full-field electroretinogram (ff-ERG) is a widely used clinical tool to evaluate generalized retinal function by recording electrical potentials generated by the cells in the retina in response to flash stimuli and requires mydriasis. The purpose of this study was to determine the intra-visit reliability and diagnostic capability of a handheld, mydriasis-free ERG, RETeval (LKC Technologies, Gaithersburg, MD, USA), in comparison with the standard clinical ff-ERG by measuring responses recommended by the International Society for Clinical Electrophysiology of Vision (ISCEV)...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Mehmet Fatih Kağan Değirmenci, Sibel Demirel, Figen Batıoğlu, Emin Özmert
PURPOSE: To determine if the RETeval system can be used for the screening of diabetic retinopathy (DR) to provide early diagnosis. METHODS: The subjects were 42 diabetic patients selectively recruited by examination of their medical records to have varying severities of DR. The severity of DR was classified into four groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale. Full-field electroretinograms (ERG) without mydriasis were obtained by the DR assessment protocol of the RETeval system...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Wendy Harrison, Kaila Osmotherly, Nathan Biancardi, Jamison Langston, Russell Gray, Taylor Kneip, Reese Loveless
PURPOSE: The clinical standards for multifocal electroretinograms (mfERG) call for adaption to normal room lighting before the mfERG begins. They specify that any assessments where bright lights are used, should be done after the mfERG to prevent excess stimulation of retinal cells. However, full-field electroretinograms (FFERG) are performed prior to mfERGs in some clinical settings. It is unclear from the literature whether the FFERG has an impact on the mfERG. This study seeks to examine the effect of the FFERG on the mfERG when performed sequentially...
December 2018: Documenta Ophthalmologica. Advances in Ophthalmology
Dorota Pojda-Wilczek, Wojciech Maruszczyk, Sebastian Sirek
AIM: To compare flash visual evoked potentials (FVEP) elicited using a Ganzfeld bowl (G), Mini Ganzfeld (MG) and Flash Goggles (GG) with eyes open and closed. PATIENTS AND METHOD: The study group comprised 17 volunteers with mean age of 30 years; all of them were examined with the Roland Consult electrophysiological diagnostic system. Active electrodes were placed at O1 and O2 . With the G and MG stimulators, the flash generated by white-light-emitting diodes (LEDs) presented standard flash of 3 cd s m-2 ...
November 23, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
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