Hecheng Wang, Jiatong Liu, Yanyan Fang, Xudan Shen, Hui Liu, Lushan Yu, Su Zeng, Sheng Cai, Jingjing Zhou, Zheyong Li
MicroRNAs (miRNAs) are potential biomarkers for cancer diagnosis and prognosis, methods for detecting miRNAs with high sensitivity, selectivity, and stability are urgently needed. Various nucleic acid probes that have traditionally been for this purpose suffer several drawbacks, including inefficient signal-to-noise ratios and intensities, high cost, and time-consuming method establishment. Computing tools used for investigating the thermodynamics of DNA hybridization reactions can accurately predict the secondary structure of DNA and the interactions between DNA molecules...
May 15, 2024: Analytica Chimica Acta