Shariq S Raza, Danielle Tatum, Kristen D Nordham, Jacob M Broome, Jane Keating, Zoe Maher, Amy J Goldberg, Grace Chang, Michelle Mendiola Pla, Elliott R Haut, Leah Tatebe, Eman Toraih, Christofer Anderson, Scott Ninokawa, Patrick Maluso, Sigrid Burruss, Matthew Reeves, Lauren E Coleman, David V Shatz, Anna Goldenberg-Sandau, Apoorva Bhupathi, Chance Spalding, Aimee LaRiccia, Emily Bird, Matthew R Noorbakhsh, James Babowice, Marsha C Nelson, Lewis E Jacobson, Jamie Williams, Michael Vella, Kate Dellonte, Thomas Z Hayward, Emma Holler, Mark J Lieser, John D Berne, Dalier R Mederos, Reza Askari, Barbara Okafor, Eric Etchill, Raymond Fang, Samantha L Roche, Laura Whittenburg, Andrew C Bernard, James M Haan, Kelly L Lightwine, Scott H Norwood, Jason Murry, Mark A Gamber, Matthew M Carrick, Nikolay Bugaev, Antony Tatar, Juan Duchesne, Sharven S Taghavi
BACKGROUND: Anti-inflammatory effects of tranexamic acid (TXA) in reducing trauma endotheliopathy may protect from acute lung injury. Clinical data showing this benefit in trauma patients is lacking. We hypothesized that TXA administration mitigates pulmonary complications in penetrating trauma patients. MATERIALS AND METHODS: This is a post-hoc analysis of a multicenter, prospective, observational study of adults (18+ years) with penetrating torso and/or proximal extremity injury presenting at 25 urban trauma centers...
August 7, 2024: American Surgeon