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American Journal of the Medical Sciences

https://read.qxmd.com/read/38795968/recognizing-the-roles-of-fever-in-host-survival-and-in-medical-intervention-in-infectious-diseases
#1
REVIEW
Norbert J Roberts, Juan C Sarria
Fever has roles both in host defense against infectious challenges and in guidance of medical intervention. These roles remain insufficiently acknowledged and considered by both health care providers and patients and their families. This review cites reports in support of both roles and provides recommendations regarding the clinician's approach to fever, as well as points relevant for education of patients and their families.
May 23, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38795967/cryptosporidium-induced-acute-kidney-injury-in-a-patient-with-acquired-immunodeficiency-syndrome
#2
REVIEW
Yi-Hsin Chou, Hung-Ju Fan
Cryptosporidium is a pathogen that can cause infectious enteritis especially in immunocompromised patients. Acute kidney injury, electrolyte imbalance, and acid-base disorders may occur as a result of high volumes of intestinal fluid loss, which has not been previously reported to be a common manifestation of cryptosporidiosis. Numerous antigen detection methods can be used to ensure early diagnosis of Cryptosporidium infection, which is crucial to prevent morbidities. We report a unique case of cryptosporidiosis in a 33-year-old male patient with acute kidney injury and profound hypokalemia, hyponatremia, hypocalcemia, hypophosphatemia, hypomagnesemia, and metabolic acidosis...
May 23, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38795966/homeobox-b4-optimizes-the-therapeutic-effect-of-bone-marrow-mesenchymal-stem-cells-on-endotoxin-associated-acute-lung-injury-in-rats
#3
JOURNAL ARTICLE
Shan Lin, Yuling Luo, Xueyan Mao, Wanmei He, Caixia Xu, Mian Zeng
BACKGROUND: Alveolar capillary endothelial cell (EC) injury has a pivotal role in driving acute respiratory distress syndrome (ARDS) progression and maintaining endothelial homeostasis. A previous ex vivo study revealed that overexpression of homeobox B4 (HOXB4) in bone marrow mesenchymal stem cells (BMSCs) enhanced protection against lipopolysaccharide (LPS)-induced EC injury by activating the Wnt/β-catenin pathway. This in vivo study was performed to verify whether BMSCs overexpressing HOXB4 exert similar protective effects on LPS-induced acute lung injury (ALI) in an animal model...
May 23, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38795965/giant-pelvic-malignant-solitary-fibrous-tumor-with-heart-failure-a-treatment-dilemma
#4
LETTER
Hong-Chen Song, Meng-Hua Wu, Xuan-Hao Li
No abstract text is available yet for this article.
May 23, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38788927/low-attenuation-clusters-with-reduced-fractal-dimension-due-to-bronchial-atresia
#5
LETTER
Hiroki Takahashi, Michihiro Kunishige, Tsutomu Shinohara
No abstract text is available yet for this article.
May 22, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38788926/high-dose-vitamin-c-intake-and-covid-19-related-symptoms-during-the-sars-cov-2-pandemic
#6
LETTER
Mingcheng Guan, Yibo Zuo, Yukang Yuan, Hong Zhu, Hui Zheng
No abstract text is available yet for this article.
May 22, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38788925/d-dimers-in-advanced-liver-cirrhosis-useful-biomarker-or-not
#7
REVIEW
Lavinia Alice Balaceanu, Ion Dina
In clinical practice, the D-dimer levels rule out venous thromboembolism and diagnose disseminated intravascular coagulation. D-dimers increase in both physiological and pathological conditions. Liver cirrhosis, especially in the final stages, is characterized by complex coagulation and fibrinolysis factor disorders. Multiple mechanisms tried to explain the increased D-dimer levels in patients with liver cirrhosis and ascites. The D-dimer cut-off level used to rule out venous thromboembolism in cirrhosis is higher than that used to confirm the diagnosis of VTE or DIC in noncirrhotic patients...
May 22, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38777154/the-sign-of-pericardial-adhesions-as-described-by-nikolaus-friedreich
#8
LETTER
Steven H Yale, Halil Tekiner, Eileen S Yale
No abstract text is available yet for this article.
May 20, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38777153/the-role-of-serum-chloride-ion-in-the-prognosis-of-copd
#9
JOURNAL ARTICLE
Yiben Huang, Binbin Hu, Siyao Chen, Zerui Jiang, Zicong Dai, Zihan Jiang, Chunyan Liu, Yage Xu, Xianjing Chen, Wanzhong Jin, Beibei Yu, Xiaodiao Zhang
BACKGROUND: As exacerbations of chronic obstructive pulmonary disease (COPD) are one of the leading causes of hospitalization and are associated with significant mortality, it is particularly important to accurately assess the risk of exacerbations in COPD. Most of the current clinical biomarkers are related to inflammation and few consider how ion levels affect COPD. While chloride ions, the second most abundant serum electrolyte, have been shown to be associated with poor prognosis in several diseases, but their relationship with COPD remains unclear...
May 20, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38772441/salary-equity-in-academic-medicine-physicians
#10
LETTER
Ajay Malhotra, Dheeman Futela, Mihir Khunte, Nagaraj S Moily, Xiao Wu, Seyedmehdi Payabvash, Dheeraj Gandhi
No abstract text is available yet for this article.
May 19, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38768780/the-classic-rat-bite-erosions-in-gouty-arthritis-with-normal-uric-acid-levels
#11
LETTER
Rebekah Tanas, Viraj Shah, Carl Henderson
No abstract text is available yet for this article.
May 18, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38768779/utility-of-fractional-excretion-of-urea-in-acute-kidney-injury-with-comparison-to-fractional-excretion-of-sodium-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Mohammad O Abdelhafez, Asil A Alhroob, Mustafa O Abu Hawilla, Asmaa A Rjoob, Nasser M Abualia, Emily F Gorman, Abdurrahman M Hamadah, Kamel A Gharaibeh
BACKGROUND: Differentiating between intrinsic and prerenal acute kidney injury (AKI) presents a challenge. Here, we assessed the performance of the fractional excretion of urea (FEUrea) and compared it to the fractional excretion of sodium (FENa) in distinguishing intrinsic from prerenal AKI. METHODS: A thorough search was conducted in several databases until January 16, 2024. We included studies evaluating FEUrea, with or without FENa, for differentiating AKI etiologies in adults...
May 18, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38754779/association-between-neck-circumference-and-bone-mineral-loss-a-cross-sectional-study-in-sichuan-province-in-china
#13
JOURNAL ARTICLE
Qing Wen, Xiaoran Zhang, Yunjiao Yang, Huizhen Chen, Xuke Han, Qiu Chen
BACKGROUND: The associations of fat distribution with bone health are debatable. We aimed to investigate the associations between neck circumference (NC) and bone mineral loss among the adult Chinese population in Sichuan province. METHODS: We examined overall NC size and NC stratums (≤35cm, 35<NC≤38cm,>38cm) with bone mineral density (BMD) at the femoral neck, lumbar spine, total hip skeletal sites in 135 men and 479 women respectively, and assessed whether adiposity, lipids, and calcium and phosphorus levels, might have a biased role in the relationship of NC and bone mineral loss with linear regression, logistic regression, and restricted cubic spline models...
May 14, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38705462/majocchi-s-granuloma
#14
LETTER
Yanyang Liu, Junfeng Zhou, Yuanyuan Wang, Lei Yao
No abstract text is available yet for this article.
May 3, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38705461/tamponade-physiology-related-to-a-large-pleural-effusion
#15
LETTER
Madison S Tackett, Parijat Sen, Amartya Kundu, Taha Ahmed
No abstract text is available yet for this article.
May 3, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38701971/qtc-interval-a-frequently-unrecognized-electrocardiographic-interval
#16
REVIEW
Ali Osama Kamal Zaki Ibrahim, Akruti Patel Prabhakar, Angel Lopez-Candales
The QT interval, an electrocardiographic temporal representation of the ventricular depolarization and repolarization, is an integral parameter that must be carefully evaluated to gather critical information regarding electrical instability that may cause malignant ventricular dysrhythmias or sudden cardiac death. The QT interval is affected by several inheritable and acquired factors, such as genetic mutations, electrolyte disturbances, and medication interactions. We strongly believe that prompt and accurate recognition of any QT interval abnormalities is critical in many clinical settings...
May 1, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38701970/metformin-as-adjuvant-treatment-in-hepatitis-c-virus-infections-and-associated-complications
#17
REVIEW
Dylan Landis, Alex Sutter, Sachi Khemka, Busara Songtanin, Jacob Nichols, Kenneth Nugent
Hepatitis C virus is an important global cause of hepatitis and subsequently cirrhosis and hepatocellular carcinoma. These infections may also cause extrahepatic manifestations, including insulin resistance and type 2 diabetes mellitus. These two complications can potentially reduce sustained virologic responses (SVR) in some drug regimens for this infection. Metformin has important biochemical effects that can limit viral replication in cellular cultures and can improve the response to antiviral drug therapy based on ribavirin and interferon...
May 1, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38697477/perils-of-reduced-dose-apixaban-in-atrial-fibrillation-flutter-a-case-report-with-a-brief-literature-review
#18
REVIEW
Mohammed El Nayir, Karldon Iwuchukwu Nwaezeapu, John Oboseh Ogedegbe, Yash Bharatkumar Patel, Misha Aftab Khan, Javier Valle
Patients with atrial fibrillation/atrial flutter (AF) are notoriously predisposed to thromboembolic events secondary to the development of thrombi within the left atrium of the heart. AF accompanied by a fairly decent CHA2DS2-VASc score is a known indication for full anticoagulation, frequently with direct oral anticoagulants (DOACs), such as apixaban. Following extensive studies weighing the benefits of anticoagulation versus risks of major bleeding, patients meeting two or more of the dose-reduction criteria (age ≥80 years, weight ≤60 kg, and/or creatinine ≥ 1...
April 30, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38697476/syndecans-and-diabetic-complications-a-narrative-review
#19
REVIEW
Yasamin Rajabloo, Maryam Saberi-Karimian, Sara Saffar Soflaei, Gordon A Ferns, Majid Ghayour-Mobarhan
Syndecan (SDC) is a member of the heparan sulfate proteoglycan (HSPG) family. It appears to play a role in the aetiology of diabetic complications, with decreased levels of SDCs being reported in the kidney, retina, and cardiac muscle in models of diabetes mellitus (DM). The reduced levels of SDCs may play an important role in the development of albuminuria in DM. Some studies have provided the evidence supporting the mechanisms underlying the role of SDCs in DM. However, SDCs and the molecular mechanisms involved are complex and need to be further elucidated...
April 30, 2024: American Journal of the Medical Sciences
https://read.qxmd.com/read/38685353/serum-urea-increase-during-hospital-stay-is-associated-with-worse-outcomes-after-in-hospital-cardiac-arrest
#20
JOURNAL ARTICLE
João Carlos Clarck Barros, Gustavo Martins Ferreira, Isabelle de Almeida Souza, Asiya Shalova, Paula Schmidt Azevedo, Bertha Furlan Polegato, Leonardo Zornoff, Sergio Alberto Rupp de Paiva, Edson Luiz Favero, Taline Lazzarin, Marcos Ferreira Minicucci
BACKGROUND: Evaluate the association between serum urea at admission and during hospital stay with return of spontaneous circulation (ROSC) and in-hospital mortality in patients with in-hospital cardiac arrest (IHCA). METHODS: This retrospective study included patients over 18 years with IHCA attended from May 2018 to December 2022. The exclusion criteria were the absence of exams to calculate delta urea and the express order of "do-not-resuscitate". Data were collected from the electronic medical records...
April 27, 2024: American Journal of the Medical Sciences
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