journal
https://read.qxmd.com/read/37871782/a-randomized-trial-of-expedited-intra-arrest-transfer-versus-more-extended-on-scene-resuscitation-for-refractory-out-of-hospital-cardiac-arrest-rationale-and-design-of-the-evidence-trial
#81
JOURNAL ARTICLE
Brian Burns, Ian Marschner, Renee Eggins, Hergen Buscher, Rachael L Morton, Jason Bendall, Anthony Keech, Mark Dennis
BACKGROUND: Refractory Out of Hospital Cardiac Arrest (r-OHCA) is common and the benefit versus harm of intra-arrest transport of patients to hospital is not clear. OBJECTIVE: To assess the rate of survival to hospital discharge in adult patients with r-OHCA, initial rhythm pulseless ventricular tachycardia (VT)/ventricular fibrillation (VF) or Pulseless Electrical Activity (PEA) treated with 1 of 2 locally accepted standards of care: (1) expedited transport from scene; or (2) ongoing advanced life support (ALS) resuscitation on-scene...
October 21, 2023: American Heart Journal
https://read.qxmd.com/read/37871781/effects-of-complete-revascularization-according-to-age-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease-complete-age
#82
JOURNAL ARTICLE
Kevin R Bainey, David A Wood, Matthias Bossard, Gianluca Campo, Warren J Cantor, Shahar Lavi, Mina Madan, Roxana Mehran, Natalia Pinilla-Echeverri, Sunil Rao, Jaydeep Sarma, Tej Sheth, Goran Stankovic, Phillipe Gabriel Steg, Robert F Storey, Jean-Francois Tanguay, James L Velianou, Robert C Welsh, Thenmozhi Mani, John A Cairns, Shamir R Mehta
BACKGROUND: In ST-segment elevation myocardial infarction (STEMI), complete revascularization with percutaneous coronary intervention (PCI) reduces major cardiovascular events compared with culprit-lesion-only PCI. Whether age influences these results remains unknown. METHODS: COMPLETE was a multinational, randomized trial evaluating a strategy of staged complete revascularization, consisting of angiography-guided PCI of all suitable non-culprit lesions, versus a strategy of culprit-lesion-only PCI...
October 21, 2023: American Heart Journal
https://read.qxmd.com/read/37805105/the-gut-microbiota-and-coronary-artery-calcification-in-japanese-men
#83
JOURNAL ARTICLE
Yukiko Okami, Hisatomi Arima, Keiko Kondo, Zhang Hexun, Yuichiro Yano, Aya Kadota, Sayuki Torii, Takashi Hisamatsu, Akira Fujiyoshi, Sayaka Kadowaki, Yoshiyuki Watanabe, Akira Andoh, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura
BACKGROUND: The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota associated with subclinical coronary artery calcification (CAC) in a Japanese population. METHODS: A total of 663 Japanese men were enrolled in this cross-sectional study. Computed tomography and gut microbiology tests were performed, and CAC scores were calculated using the Agatston method...
October 5, 2023: American Heart Journal
https://read.qxmd.com/read/37302738/the-left-atrial-appendage-closure-by-surgery-2-laacs-2-trial-protocol-rationale-and-design-of-a-randomized-multicenter-trial-investigating-if-left-atrial-appendage-closure-prevents-stroke-in-patients-undergoing-open-heart-surgery-irrespective-of-preoperative
#84
JOURNAL ARTICLE
Christoffer Læssøe Madsen, Jesper Park-Hansen, Akhmadjon Irmukhamedov, Christian Lildal Carranza, Sulman Rafiq, Rafael Rodriguez-Lecoq, Neiser Palmer-Camino, Ivy Susanne Modrau, Emma C Hansson, Anders Jeppsson, Rakin Hadad, Angel Moya-Mitjans, Anders Møller Greve, Robin Christensen, Helle Gervig Carstensen, Nis Baun Høst, Ulrik Dixen, Christian Torp-Pedersen, Lars Køber, Ismail Gögenur, Thomas Clement Truelsen, Christina Kruuse, Ahmad Sajadieh, Helena Domínguez
BACKGROUND: Current recommendations regarding the use of surgical left atrial appendage (LAA) closure to prevent thromboembolisms lack high-level evidence. Patients undergoing open-heart surgery often have several cardiovascular risk factors and a high occurrence of postoperative atrial fibrillation (AF)-with a high recurrence rate-and are thus at a high risk of stroke. Therefore, we hypothesized that concomitant LAA closure during open-heart surgery will reduce mid-term risk of stroke independently of preoperative AF status and CHA2 DS2 -VASc score...
October 2023: American Heart Journal
https://read.qxmd.com/read/37279840/rationale-and-design-of-a-randomized-study-comparing-the-watchman-flx-device-to-doacs-in-patients-with-atrial-fibrillation
#85
JOURNAL ARTICLE
Saibal Kar, Shephal K Doshi, Mohamad Alkhouli, A John Camm, Megan Coylewright, Michael C Gibson, Christopher B Granger, Mahmut E Gurol, Kenneth Huber, Moussa Mansour, Devi G Nair, Andrea Natale, Stuart J Pocock, Vivek R Reddy, Walid Saliba, Thomas Christen, Dominic J Allocco, Kenneth A Ellenbogen, Martin B Leon
BACKGROUND: Percutaneous left atrial appendage (LAA) closure (LAAC) was developed as a nonpharmacologic alternative to oral anticoagulants (OACs) in patients with atrial fibrillation (AF) who are at an increased risk for stroke or systemic embolism. The Watchman device permanently seals off the LAA to prevent thrombi from escaping into the circulation. Previous randomized trials have established the safety and efficacy of LAAC compared to warfarin. However, direct OACs (DOACs) have become the preferred pharmacologic strategy for stroke prevention in patients with AF, and there is limited data comparing Watchman FLX to DOACs in a broad AF patient population...
October 2023: American Heart Journal
https://read.qxmd.com/read/37271356/preventive-pci-or-medical-therapy-alone-for-vulnerable-atherosclerotic-coronary-plaque-rationale-and-design-of-the-randomized-controlled-prevent-trial
#86
RANDOMIZED CONTROLLED TRIAL
Jung-Min Ahn, Do-Yoon Kang, Pil Hyung Lee, Young-Keun Ahn, Won-Jang Kim, Chang-Wook Nam, Jin-Ok Jeong, In-Ho Chae, Hiroki Shiomi, Paul Hsien Li Kao, Joo-Yong Hahn, Sung-Ho Her, Bong-Ki Lee, Tae Hoon Ahn, Kiyuk Chang, Jei Keon Chae, David Smyth, Gregg W Stone, Duk-Woo Park, Seung-Jung Park
BACKGROUND: Acute coronary syndromes are commonly caused by the rupture of vulnerable plaque, which often appear angiographically not severe. Although pharmacologic management is considered standard therapy for stabilizing plaque vulnerability, the potential role of preventive local treatment for vulnerable plaque has not yet been determined. The PREVENT trial was designed to compare preventive percutaneous coronary intervention (PCI) plus optimal medical therapy (OMT) with OMT alone in patients with functionally nonsignificant high-risk vulnerable plaques...
October 2023: American Heart Journal
https://read.qxmd.com/read/37709109/early-computed-tomography-coronary-angiography-and-preventative-treatment-in-patients-with-suspected-acute-coronary-syndrome-a-secondary-analysis-of-the-rapid-ctca-trial
#87
JOURNAL ARTICLE
Kang-Ling Wang, Mohammed N Meah, Anda Bularga, Katherine Oatey, Rachel O'Brien, Jason E Smith, Nick Curzen, Attila Kardos, Liza Keating, Dirk Felmeden, Robert F Storey, Steve Goodacre, Carl Roobottom, David E Newby, Alasdair J Gray
BACKGROUND: Computed tomography coronary angiography (CTCA) offers detailed assessment of the presence of coronary atherosclerosis and helps guide patient management. We investigated influences of early CTCA on the subsequent use of preventative treatment in patients with suspected acute coronary syndrome. METHODS: In this secondary analysis of a multicentre randomised controlled trial of early CTCA in intermediate-risk patients with suspected acute coronary syndrome, prescription of aspirin, P2Y12 receptor antagonist, statin, renin-angiotensin system blocker, and beta-blocker therapies from randomisation to discharge were compared within then between those randomised to early CTCA or to standard of care only...
September 12, 2023: American Heart Journal
https://read.qxmd.com/read/37709108/a-cross-stakeholder-approach-to-improving-out-of-hospital-cardiac-arrest-survival
#88
JOURNAL ARTICLE
Timothy C Guetterman, Jane Forman, Sydney Fouche, Kaitlyn Simpson, Michael D Fetters, Christopher Nelson, Peter Mendel, Antony Hsu, Jessica A Flohr, Robert Domeier, Rebal Rahim, Brahmajee K Nallamothu, Mahshid Abir
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) affects over 300,000 individuals per year in the U.S. with poor survival rates overall. A remarkable five-fold difference in survival-to-hospital discharge rates exist across U.S. communities. METHOD: We conducted a study using qualitative research methods comparing the system of care across sites in Michigan communities with varying OHCA survival outcomes, as measured by return to spontaneous circulation with pulse upon emergency department arrival...
September 12, 2023: American Heart Journal
https://read.qxmd.com/read/37703948/randomized-controlled-trial-of-mechanical-thrombectomy-versus-catheter-directed-thrombolysis-for-acute-hemodynamically-stable-pulmonary-embolism-rationale-and-design-of-the-peerless-study
#89
JOURNAL ARTICLE
Carin F Gonsalves, C Michael Gibson, Stefan Stortecky, Roger A Alvarez, Daren M Beam, James M Horowitz, Mitchell J Silver, Catalin Toma, John H Rundback, Stuart P Rosenberg, Craig D Markovitz, Thomas Tu, Wissam A Jaber
BACKGROUND: The identification of hemodynamically stable pulmonary embolism (PE) patients who may benefit from advanced treatment beyond anticoagulation is unclear. However, when intervention is deemed necessary by the PE patient's care team, data to select the most advantageous interventional treatment option are lacking. Limiting factors include major bleeding risks with systemic and locally delivered thrombolytics and the overall lack of randomized controlled trial (RCT) data for interventional treatment strategies...
September 11, 2023: American Heart Journal
https://read.qxmd.com/read/37703947/diagnostic-and-prognostic-impact-of-new-pathophysiology-based-categorization-of-type-1-and-type-2-myocardial-infarction-data-from-the-french-rico-survey
#90
JOURNAL ARTICLE
Hermann Yao, Yves Cottin, Frédéric Chagué, Maud Maza, Florence Bichat, Marianne Zeller, Alain Putot
BACKGROUND: A new classification of type 1 and 2 myocardial infarction (MI) derived from the fourth universal definition of MI (UDMI) has been recently proposed, based on pathophysiology of coronary artery disease (CAD). We assessed the impact of this new MI categorization on epidemiology and outcomes, considering type 1 MI (T1MI) and type 2 MI (T2MI), with and without CAD. METHODS: Retrospective study including all consecutive patients hospitalized for an acute MI in a multicenter database (RICO)...
September 11, 2023: American Heart Journal
https://read.qxmd.com/read/37369269/sociodemographic-disparities-in-the-use-of-cardiovascular-ambulatory-care-and-telemedicine-during-the-covid-19-pandemic
#91
JOURNAL ARTICLE
Esli Osmanlliu, Neil M Kalwani, Vijaya Parameswaran, Lubna Qureshi, Rajesh Dash, David Scheinker, Fatima Rodriguez
BACKGROUND: The COVID-19 pandemic accelerated adoption of telemedicine in cardiology clinics. Early in the pandemic, there were sociodemographic disparities in telemedicine use. It is unknown if these disparities persisted and whether they were associated with changes in the population of patients accessing care. METHODS: We examined all adult cardiology visits at an academic and an affiliated community practice in Northern California from March 2019 to February 2020 (pre-COVID) and March 2020 to February 2021 (COVID)...
September 2023: American Heart Journal
https://read.qxmd.com/read/37192698/proteus-study-a-prospective-randomized-controlled-trial-evaluating-the-use-of-artificial-intelligence-in-stress-echocardiography
#92
RANDOMIZED CONTROLLED TRIAL
Gary Woodward, Mamta Bajre, Sanjeev Bhattacharyya, Maria Breen, Virginia Chiocchia, Helen Dawes, Hakim-Moulay Dehbi, Tine Descamps, Elena Frangou, Carol-Ann Fazakarley, Victoria Harris, Will Hawkes, Oliver Hewer, Casey L Johnson, Samuel Krasner, Lynn Laidlaw, Jonathan Lau, Tom Marwick, Steffen E Petersen, Hania Piotrowska, Ged Ridgeway, David P Ripley, Emily Sanderson, Natalie Savage, Rizwan Sarwar, Louise Tetlow, Ben Thompson, Samantha Thulborn, Victoria Williamson, William Woodward, Ross Upton, Paul Leeson
BACKGROUND: Stress echocardiography (SE) is one of the most commonly used diagnostic imaging tests for coronary artery disease (CAD) but requires clinicians to visually assess scans to identify patients who may benefit from invasive investigation and treatment. EchoGo Pro provides an automated interpretation of SE based on artificial intelligence (AI) image analysis. In reader studies, use of EchoGo Pro when making clinical decisions improves diagnostic accuracy and confidence. Prospective evaluation in real world practice is now important to understand the impact of EchoGo Pro on the patient pathway and outcome...
September 2023: American Heart Journal
https://read.qxmd.com/read/37169122/attributable-mortality-benefit-of-digoxin-treatment-in-hypoplastic-left-heart-syndrome-after-the-norwood-operation-an-instrumental-variable-based-analysis-using-data-from-the-pediatric-health-information-systems-database
#93
JOURNAL ARTICLE
Michael L O'Byrne, Lihai Song, Jing Huang, Bethan Lemley, David Goldberg, Monique M Gardner, Chitra Ravishankar, Jonathan J Rome, Andrew C Glatz
BACKGROUND: Observational studies have demonstrated an association between the use of digoxin and reduced interstage mortality after Norwood operation for hypoplastic left heart syndrome (HLHS). Digoxin use has increased significantly but remains variable between different hospitals, independent of case-mix. Instrumental variable analyses have the potential to overcome unmeasured confounding, the major limitation of previous observational studies and to generate an estimate of the attributable benefit of treatment with digoxin...
September 2023: American Heart Journal
https://read.qxmd.com/read/37164146/contemporary-use-of-cardiovascular-risk-reduction-strategies-in-type-2-diabetes-insights-from-the-diabetes-collaborative-registry
#94
JOURNAL ARTICLE
Suzanne V Arnold, Kensey Gosch, Mikhail Kosiborod, Nathan D Wong, Laurence S Sperling, Jonathan D Newman, Cory L Gamble, Carol Hamersky, Jigar Rajpura, Muthiah Vaduganathan
BACKGROUND: Cardiovascular disease remains the primary source of morbidity and mortality in type 2 diabetes (T2D). We characterized the change over time in the use of evidence-based therapies to reduce cardiovascular risk in US patients with T2D. METHODS: Data from a longitudinal outpatient diabetes registry were used to calculate the prescription of SGLT2i or GLP-1RA over time and among those with high-risk comorbidities (atherosclerotic cardiovascular disease [ASCVD], heart failure [HF], chronic kidney disease [CKD]) and a diabetes cardiovascular composite score (DCCS; calculated as: #eligible medications prescribed/#eligible medications x 100 for SGLT2i, GLP-1RA, statin, antiplatelet/anticoagulant therapy, ACEi/ARB/ARNI)...
September 2023: American Heart Journal
https://read.qxmd.com/read/37657594/rationale-and-design-of-the-ulyss-trial-a-randomized-multicenter-evaluation-of-the-efficacy-of-early-impella-cp-implantation-in-acute-coronary-syndrome-complicated-by-cardiogenic-shock
#95
JOURNAL ARTICLE
Clement Delmas, Marc Laine, Guillaume Schurtz, Francois Roubille, Pierre Coste, Guillaume Leurent, Sami Hraiech, Mathieu Pankert, Quaino Gonzalo, Thibaut Dabry, Vincent Letocart, Sandrine Loubière, Noémie Resseguier, Laurent Bonello
Despite 20 years of improvement in acute coronary syndromes care, patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) remains a major clinical challenge with a stable incidence and mortality. While intra-aortic balloon pump (IABP) did not meet its expectations, percutaneous mechanical circulatory supports (pMCS) with higher hemodynamic support, large availability and quick implementation may improve AMICS prognosis by enabling early hemodynamic stabilization and unloading. Both interventional and observational studies suggested a clinical benefit in selected patients of the IMPELLA® CP device within in a well-defined therapeutic strategy...
August 30, 2023: American Heart Journal
https://read.qxmd.com/read/37634656/a-review-of-polypills-for-the-prevention-of-atherosclerotic-cardiovascular-disease
#96
REVIEW
Federica Agnello, Simone Finocchiaro, Claudio Laudani, Marco Legnazzi, Maria Sara Mauro, Carla Rochira, Lorenzo Scalia, Davide Capodanno
Atherosclerotic cardiovascular disease (ASCVD) is a prevalent chronic condition managed through pharmacotherapy targeting modifiable risk factors. However, ASCVD patients often face poor medication adherence due to a high pill burden from multiple oral drugs, contributing to cardiovascular events. Recent evidence indicates that polypills combining anti-hypertensive and statin medications effectively control risk factors and improve adherence in various ASCVD risk patients. Randomized clinical trials demonstrate polypill efficacy in reducing major cardiovascular events, making them a convenient strategy for both established ASCVD patients and those without ASCVD...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37634655/an-investigator-sponsored-pragmatic-randomised-controlled-trial-of-anticoagulation-versus-acetylsalicylic-acid-after-transcatheter-aortic-valve-implantation-rationale-and-design-of-acasa-tavi-blinded-outcome-adjudication
#97
JOURNAL ARTICLE
Christopher A S Dodgson, Jan Otto Beitnes, Sophie F Kløve, Jon Herstad, Anders Opdahl, Ragnhild Undseth, Christian H Eek, Kaspar Broch, Lars Gullestad, Lars Aaberge, Ketil Lunde, Bjørn Bendz, Øyvind H Lie
The optimal antithrombotic therapy after transcatheter aortic valve implantation (TAVI) is unknown. Bioprosthetic valve dysfunction (BVD) is associated with adverse outcomes and may be prevented by anticoagulation therapy. A dedicated randomized trial comparing monotherapy NOAC to single antiplatelet therapy has not been performed previously. We hypothesize that therapy with any anti-factor Xa NOAC will reduce BVD compared to antiplatelet therapy, without compromising safety. ACASA-TAVI is a multicentre, prospective, randomised, open-label, blinded endpoint, all-comers trial comparing a monotherapy anti-factor Xa NOAC strategy (intervention arm) with a single antiplatelet therapy strategy (control arm) after successful TAVI...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37634654/coronary-artery-calcium-scoring-for-cardiovascular-risk-assessment-in-patients-with-inflammatory-bowel-disease
#98
JOURNAL ARTICLE
Robert Naami, Nour Tashtish, Ian J Neeland, Jeffry Katz, Preetika Sinh, Khurram Nasir, Vibhu Chittajallu, Emad Mansoor, Sanjay Rajagopalan, Sadeer Al-Kindi
BACKGROUND: Inflammatory bowel disease (IBD) is associated with higher incidence of atherosclerotic cardiovascular disease (ASCVD). Data investigating the role of coronary artery calcium (CAC) scoring in identifying subclinical atherosclerotic disease in IBD patients is scarce. METHODS: Using data obtained from the CLARIFY registry, a prospective study of no-charge coronary artery calcium (CAC) testing at University Hospitals, we reviewed patients with ulcerative colitis (UC) or Crohn's disease (CD) who underwent CAC scoring from 2014 to 2020...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37611857/rationale-and-design-of-the-pullback-pressure-gradient-ppg-global-registry
#99
JOURNAL ARTICLE
Daniel Munhoz, Carlos Collet, Takuya Mizukami, Andy Yong, Antonio Maria Leone, Ashkan Eftekhari, Brian Ko, Bruno R da Costa, Colin Berry, Damien Collison, Divaka Perera, Evald Høj Christiansen, Fernando Rivero, Frederik M Zimmermann, Hirohiko Ando, Hitoshi Matsuo, Masafumi Nakayama, Javier Escaned, Jeroen Sonck, Koshiro Sakai, Julien Adjedj, Liyew Desta, Lokien X van Nunen, Nick E J West, Stephane Fournier, Tatyana Storozhenko, Tetsuya Amano, Thomas Engstrøm, Thomas Johnson, Toshiro Shinke, Simone Biscaglia, William F Fearon, Ziad Ali, Bernard De Bruyne, Nils P Johnson
INTRODUCTION: Diffuse disease has been identified as one of the main reasons leading to low post-PCI fractional flow reserve (FFR) and residual angina after PCI. Coronary pressure pullbacks allow for the evaluation of hemodynamic coronary artery disease (CAD) patterns. The pullback pressure gradient (PPG) is a novel metric that quantifies the distribution and magnitude of pressure losses along the coronary artery in a focal-to-diffuse continuum. AIM: The primary objective is to determine the predictive capacity of the PPG for post-PCI FFR...
August 21, 2023: American Heart Journal
https://read.qxmd.com/read/37611856/diagnostic-performance-of-a-novel-automated-ct-derived-ffr-technology-in-detecting-hemodynamically-significant-coronary-artery-stenoses-a-multicenter-trial-in-china
#100
JOURNAL ARTICLE
Quan Li, Yaodong Ding, QiLiang Chen, Yida Tang, Haitao Zhang, Yong He, Guosheng Fu, Qing Yang, Xiling Shou, Yicong Ye, Xiliang Zhao, Yang Zhang, Yu Li, Xiaoling Zhang, Changyan Wu, Rui Wang, Lei Xu, Ren Zhang, Alan Yeung, Yong Zeng, Xiang Qian
BACKGROUND AND AIMS: Computed tomography-derived fractional flow reserve (CT-derived FFR) algorithms have emerged as promising non-invasive methods for identifying hemodynamically significant coronary artery disease (CAD). However, its broad adaption is limited by the complex workflow, slow processing, and supercomputer requirement. Therefore, CT-derived FFR solutions capable of producing fast and accurate results could help deliver time-sensitive results rapidly and potentially alter patient management...
August 21, 2023: American Heart Journal
journal
journal
23294
5
6
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.