Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S Bhatt, Daniel Modin, Safia Chatur, Brian L Claggett, Kira Hyldekær Janstrup, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Lars Køber, Scott D Solomon, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Tyra Grove Krause, Tor Biering-Sørensen
BACKGROUND: Yearly influenza vaccination is strongly recommended for older adults and patients with chronic diseases including cardiovascular disease (CVD); however, vaccination rates remain suboptimal, particularly among younger patients. Electronic letters incorporating behavioral nudges are highly scalable public health interventions which can potentially increase vaccination, but further research is needed to determine the most effective strategies and to assess effectiveness across different populations...
March 7, 2024: American Heart Journal
Jianhua Wu, Ramesh Nadarajah, Yoko M Nakao, Kazuhiro Nakao, Ronen Arbel, Moti Haim, Doron Zahger, Gregory Y H Lip, Campbell Cowan, Chris P Gale
BACKGROUND: The increasing burden of atrial fibrillation (AF) emphasizes the need to identify high-risk individuals for enrolment in clinical trials of AF screening and primary prevention. We aimed to develop prediction models to identify individuals at high-risk of AF across prediction horizons from 6-months to 10-years. METHODS: We used secondary-care linked primary care electronic health record data from individuals aged ≥30 years without known AF in the UK Clinical Practice Research Datalink-GOLD dataset between Jan 2, 1998 and Nov 30, 2018; randomly divided into derivation (80%) and validation (20%) datasets...
March 6, 2024: American Heart Journal
Mitchell Krucoff, Alessandro Spirito, Usman Baber, Samantha Sartori, Dominick J Angiolillo, Carlo Briguori, David J Cohen, Timothy Collier, George Dangas, Dariusz Dudek, Javier Escaned, C Michael Gibson, Ya-Ling Han, Kurt Huber, Adnan Kastrati, Upendra Kaul, Ran Kornowski, Vijay Kunadian, Birgit Vogel, Shamir R Mehta, David Moliterno, Gennaro Sardella, Richard A Shlofmitz, Samin Sharma, Philippe Gabriel Steg, Stuart Pocock, Roxana Mehran
BACKGROUND: The optimal antiplatelet regimen after percutaneous coronary intervention (PCI) in patients with peripheral artery disease (PAD) is still debated. This analysis aimed to compare the effect of ticagrelor monotherapy versus ticagrelor plus aspirin in patients with PAD undergoing PCI. METHODS: In the TWILIGHT trial, patients at high ischemic or bleeding risk that underwent PCI were randomized after 3 months of dual antiplatelet therapy (DAPT) to aspirin or matching placebo in addition to open-label ticagrelor for 12 additional months...
March 6, 2024: American Heart Journal
Dou Dou, Su Yuan, Yuan Jia, Yang Wang, Yinan Li, Hongbai Wang, Jie Ding, Xie Wu, Dongyun Bie, Qiao Liu, Ran An, Haoqi Yan, Fuxia Yan
BACKGROUND: The Enhanced Recovery After Cardiac Surgery is a bundle of measurements from preoperative to postoperative phases to improve patients' recovery. METHODS: This study is a multicenter, stepwise design, cluster randomized controlled trial. 3600 patients presenting during control and intervention periods are eligible if they are aged from 18 to 80 years old awaiting elective cardiac surgery with cardiopulmonary bypass (CPB). 5 centers are randomly assigned to staggered start dates for one-way crossover from the control phase to the intervention phase...
March 2, 2024: American Heart Journal
Ghazaleh Mehdipoor, Björn Redfors, Shmuel Chen, Fotios Gkargkoulas, Zixuan Zhang, Manesh R Patel, Christopher B Granger, E Magnus Ohman, Akiko Maehara, Ingo Eitel, Ori Ben-Yehuda, Suzanne de Waha-Thiele, Holger Thiele, Gregg W Stone
INTRODUCTION: Mortality after ST-segment elevation myocardial infarction (STEMI) is increased in patients with hypertension. The mechanisms underlying this association are uncertain. We sought to investigate whether patients with STEMI and prior hypertension have greater microvascular obstruction (MVO) and infarct size (IS) compared with those without hypertension. METHODS: We pooled individual patient data from 7 randomized trials of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) in whom cardiac magnetic resonance imaging was performed within 1 month after reperfusion...
February 29, 2024: American Heart Journal
Emelie Dillenbeck, Jacob Hollenberg, Michael Holzer, Hans-Jörg Busch, Graham Nichol, Peter Radsel, Jan Belohlavec, Ervigio Corral Torres, Esteban López-de-Sa, Fernando Rosell, Giuseppe Ristagno, Sune Forsberg, Filippo Annoni, Leif Svensson, Martin Jonsson, Denise Bäckström, Mikael Gellerfors, Akil Awad, Fabio S Taccone, Per Nordberg
BACKGROUND: Delayed hypothermia, initiated after hospital arrival, several hours after cardiac arrest with 8-10 hours to reach the target temperature, is likely to have limited impact on overall survival. However, the effect of ultrafast hypothermia, i.e., delivered intra-arrest or immediately after return of spontaneous circulation (ROSC), on functional neurologic outcome after out-of-hospital cardiac arrest (OHCA) is unclear. In two prior trials, prehospital trans-nasal evaporative intra-arrest cooling was safe, feasible and reduced time to target temperature compared to delayed cooling...
February 28, 2024: American Heart Journal
Marco Spagnolo, Davide Capodanno
Despite a perceived increase in attention to gender differences in medicine, a comprehensive assessment of gender equality research, particularly in cardiology, remains underexplored. This observational retrospective study, focusing on documents related to "Gender Equality" according to the Sustainable Development Goals, reveals cardiology as a significant area for gender equality research, albeit with a decline in publications post-2018. The analysis highlighted a concentrated effort in the United States and a considerable impact gap between gender-focused and general cardiology research...
June 2024: American Heart Journal
Robert S Zhang, Muhammad H Maqsood, Allison A Greco, Radu Postelnicu, Vikramjit Mukherjee, Carlos L Alviar, Sripal Bangalore
Data comparing catheter-based thrombectomy (CBT) and catheter-directed thrombolysis (CDT) in acute pulmonary embolism are lacking. To address this, we performed a meta-analysis of prospective and retrospective studies of CBT and compared it to performance goal rates of mortality and major bleeding from a recently published network meta-analysis. When compared with performance goal for CDT based on historical studies, CBT was noninferior for all-cause mortality (6.0% vs 6.87%; P-valueNI < .001), non-inferior and superior for major bleeding (4...
June 2024: American Heart Journal
Jamie G Cooper, James Ferguson, Lorna A Donaldson, Kim M M Black, Kate J Livock, Judith L Horrill, Elaine M Davidson, Neil W Scott, Amanda J Lee, Takeshi Fujisawa, Kuan Ken Lee, Atul Anand, Anoop S V Shah, Nicholas L Mills
In the Emergency Department, patients with suspected myocardial infarction can be risk stratified using the HEART pathway, which has recently been amended for prehospital use and modified for the incorporation of a high-sensitivity cardiac troponin test. In a prospective analysis, the performance of both HEART pathways in the prehospital setting, with a high-sensitivity cardiac troponin test using 3 different thresholds, was evaluated for major adverse cardiac events at 30 days. We found that both low-risk HEART pathways, when using the most conservative cardiac troponin thresholds, approached but did not reach accepted rule-out performance in the Emergency Department...
May 2024: American Heart Journal
Veraprapas Kittipibul, Dmitry M Yaranov, Jan Biegus, James Matthew Gray, Jeroen Molinger, Marc A Silver, Marat Fudim
The prognostic implications of intravascular volume status assessed by blood volume analysis (BVA) in ambulatory heart failure (HF) remain uncertain. The incremental benefits of assessing volume status, beyond the well-established filling pressures, in predicting HF outcomes are unknown.
May 2024: American Heart Journal
Veena Manja, Alexander Tarlochan Singh Sandhu, Steven Asch, Susan Frayne, Mark McGovern, Cheng Chen, Paul Heidenreich
BACKGROUND: Although methamphetamine use associated heart failure (MU-HF) is increasing, data on its clinical course are limited due to a preponderance of single center studies and significant heterogeneity in the definition of MU-HF in the published literature. Our objective was to evaluate left ventricular ejection fraction (LVEF) distribution, methamphetamine use treatment engagement and postdischarge healthcare utilization among Veterans with heart failure hospitalization in the department of Veterans Affairs (VA) medical centers for MU-HF versus HF not associated with methamphetamine use (other-HF)...
April 2024: American Heart Journal
Hiddo Jl Heerspink, Michele Provenzano, Priya Vart, Niels Jongs, Ricardo Correa-Rotter, Peter Rossing, Patrick B Mark, Roberto Pecoits-Filho, John Jv McMurray, Anna Maria Langkilde, David C Wheeler, Robert B Toto, Glenn M Chertow
BACKGROUND AND AIMS: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is unknown. We conducted a prespecified analysis of the DAPA-CKD trial to investigate the effect of dapagliflozin on systolic blood pressure (SBP) in patients with CKD, with and without type 2 diabetes. METHODS: A total of 4304 adults with baseline estimated glomerular filtration rate (eGFR) 25-75 mL/min/1...
April 2024: American Heart Journal
Elvin Kedhi, Andi Rroku, Rik S Hermanides, Jan Henk Dambrink, Sandeep Singh, Jurriën Ten Berg, Dirk-Jan van Ginkel, Martin Hudec, Giovanni Amoroso, Ignacio J Amat-Santos, Martin Andreas, Rui Campante Teles, Guillaume Bonnet, Eric Van Belle, Lenard Conradi, Leen van Garsse, Wojtek Wojakowski, Vasileious Voudris, Jerzy Sacha, Pavel Cervinka, Erik Lipsic, Samer Somi, Luis Nombela-Franco, Sonja Postma, Kerstin Piayda, Giuseppe De Luca, Krzysztof Malinofski, Thomas Modine
BACKGROUND: Patients with severe aortic stenosis (AS) frequently present with concomitant obstructive coronary artery disease (CAD). In those, current guidelines recommend combined coronary artery bypass grafting (CABG) and surgical aortic valve replacement (SAVR) as the preferred treatment option, although this surgical approach is associated with a high rate of clinical events. Combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) with or without FFR have evolved as a valid alternative for cardiac surgery in patients with AS and multivessel or advanced CAD...
April 2024: American Heart Journal
James E Ip, Hanh Bui, A John Camm, Benoit Coutu, Peter A Noseworthy, Maria Leonor Parody, Samuel F Sears, Narendra Singh, Juan Agudelo Uribe, John Vyselaar, Sarah Omodele, Silvia Shardonofsky, David B Bharucha, Bruce Stambler
BACKGROUND: Paroxysmal supraventricular tachycardia (PSVT) is a common episodic arrhythmia characterized by unpredictable onset and burdensome symptoms including palpitations, dizziness, chest pain, distress, and shortness of breath. Treatment of acute episodes of PSVT in the clinical setting consists of intravenous adenosine, beta-blockers, and calcium channel blockers (CCBs). Etripamil is an intranasally self-administered L-type CCB in development for acute treatment of AV-nodal dependent PSVT in a nonmedical supervised setting...
April 2024: American Heart Journal
Eishan Ashwat, James A Brown, Sarah Yousef, Danial Ahmad, Yisi Wang, Floyd W Thoma, Derek Serna-Gallegos, Pyongsoo Yoon, David West, Danny Chu, Johannes Bonatti, David Kaczorowski, Ibrahim Sultan
OBJECTIVE: To compare the clinical outcomes of radial artery (RA) grafts during CABG to those of right internal mammary artery (RIMA) grafts. METHODS: This was a retrospective, single-institution cohort study of isolated CABG with multiple grafts between 2010-2022. To balance graft cohorts, propensity score matching (PSM) was performed using a 1:1 match ratio. Long-term postoperative survival was compared among RA and RIMA groups. Similarly, major adverse cardiac and cerebrovascular events (MACCE) were compared among both cohorts, with MACCE comprising death, myocardial infarction (MI), coronary revascularization, and stroke...
April 2024: American Heart Journal
Carlos L Alviar, Boyangzi K Li, Norma M Keller, Erin Bohula-May, Christopher Barnett, David D Berg, James A Burke, Sunit-Preet Chaudhry, Lori B Daniels, Andrew P DeFilippis, Daniel Gerber, James Horowitz, Jacob C Jentzer, Praneeth Katrapati, Ellen Keeley, Patrick R Lawler, Jeong-Gun Park, Shashank S Sinha, Jeffrey Snell, Michael A Solomon, Jeffrey Teuteberg, Jason N Katz, Sean van Diepen, David A Morrow
BACKGROUND: Risk stratification has potential to guide triage and decision-making in cardiogenic shock (CS). We assessed the prognostic performance of the IABP-SHOCK II score, derived in Europe for acute myocardial infarct-related CS (AMI-CS), in a contemporary North American cohort, including different CS phenotypes. METHODS: The critical care cardiology trials network (CCCTN) coordinated by the TIMI study group is a multicenter network of cardiac intensive care units (CICU)...
April 2024: American Heart Journal
Thalys Sampaio Rodrigues, Levindo Jose Garcia Quarto, Savio Carvalho Nogueira, James D Theuerle, Omar Farouque, Louise M Burrell, Anoop N Koshy
Early decongestion therapy with intravenous diuretics may be associated with improved outcomes in acute heart failure (AHF), however data is conflicting. This meta-analysis sought to evaluate the impact of door-to-IV diuretic (D2D) time on mortality in patients with AHF. Pooled estimates from observational studies comprising 28,124 patients, early IV diuresis (reference time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in AHF (OR 0.77; 95% CI 0.64-0.93), despite no significant in-hospital death reduction (OR 0...
March 2024: American Heart Journal
Romy R M J J Hegeman, Dirk-Jan van Ginkel, Severin Laengle, Leo Timmers, Benno J W M Rensing, Thomas L de Kroon, Uday Sonker, Johannes C Kelder, Markus Mach, Martin Andreas, Martin J Swaans, Jurriën M Ten Berg, Patrick Klein
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an established treatment option for patients with severe aortic valve stenosis, but is still associated with relatively high rates of pacemaker implantation and paravalvular regurgitation. Routine preoperative computed tomography (CT) combined with patient-specific computer modelling can predict the interaction between the TAVI device and the patient's unique anatomy, allowing physicians to assess the risk for paravalvular regurgitation and conduction disorders in advance to the procedure...
March 2024: American Heart Journal
Erin A Bohula, Nicholas A Marston, Andrea Ruzza, Sabina A Murphy, Gaetano M De Ferrari, Rafael Diaz, Lawrence A Leiter, Mary Elliott-Davey, Huei Wang, Ajay K Bhatia, Robert P Giugliano, Marc S Sabatine
BACKGROUND: The reduction of low-density lipoprotein cholesterol (LDL-C) with evolocumab, a fully human monoclonal antibody inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9i), reduces the risk of major adverse cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD) with a prior MI, prior stroke, or symptomatic peripheral artery disease, with no offsetting safety concerns. The effect of evolocumab on CV outcomes in lower risk patients without a history of MI or stroke has not been explored...
March 2024: American Heart Journal
Pedro Rvo Salerno, Zhuo Chen, Sojin Wass, Issam Motairek, Chantal Elamm, Lúcia Mvo Salerno, Neda Shafiabadi Hassani, Salil V Deo, Sadeer G Al-Kindi
BACKGROUND: Heart failure (HF) has unique aspects that vary by biological sex. Thus, understanding sex-specific trends of HF in the US population is crucial to develop targeted interventions. We aimed to analyze the burden of HF in female and male patients across the US, from 1990 to 2019. METHODS: Using the Global Burden of Disease (GBD) study data from 2019, we performed an analysis of the burden of HF from 1990-2019, across US states and regions. The GBD defined HF through studies that used symptom-based criteria and expressed the burden of HF as the age-adjusted prevalence and years lived with disability (YLDs) rates per 100,000 individuals...
March 2024: American Heart Journal
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