Alessandro Spirito, Won-Joon Koh, Samantha Sartori, Birgit Vogel, Yihan Feng, Usman Baber, Johny Nicolas, Clayton Snyder, Karim Kamaleldin, Brunna Pileggi, Vahid Rezvanizadeh, Joseph Sweeny, Samin K Sharma, Annapoorna Kini, Stuart J Pocock, George Dangas, Roxana Mehran
AIMS: The TWILIGHT trial (NCT02270242) demonstrated that in selected high-risk patients undergoing percutaneous coronary intervention (PCI) ticagrelor monotherapy significantly reduced bleeding complications without ischemic harm as compared to ticagrelor plus aspirin after 3 month of dual antiplatelet therapy. The aim of this analysis was to assess the applicability of the findings TWILIGHT trial to a real-world population. METHODS AND RESULTS: Patients undergoing PCI at a tertiary center between 2012 and 2019 and not meeting any TWILIGHT exclusion criterion (oral anticoagulation treatment, ST-segment elevation myocardial infarction [MI], cardiogenic shock, dialysis, prior stroke, or thrombocytopenia) were included...
April 22, 2023: American Heart Journal
Simon Parlow, Pietro Di Santo, Lee H Sterling, Laura Goodliffe, Pouya Motazedian, Graeme Prosperi-Porta, Baylie Morgan, Zandra Koopman, Richard G Jung, Melissa Fay Lepage-Ratte, Lisa Robinson, Hannah Feagan, Trevor Simard, George A Wells, Kwadwo Kyeremanteng, Craig Ainsworth, Faizan Amin, Jeffrey A Marbach, Shannon M Fernando, Marino Labinaz, Emilie P Belley-Cote, Benjamin Hibbert, Rebecca Mathew
BACKGROUND: Cardiogenic shock (CS) is a state of end-organ hypoperfusion related to cardiac dysfunction. Current guidelines recommend consideration of inotrope therapy in patients with CS, however no robust data support their use. The purpose of the CAPITAL DOREMI2 trial is to examine the efficacy and safety of inotrope therapy against placebo in the initial resuscitation of patients with CS. METHODS AND DESIGN: This is a multi-center, double-blind, randomized, placebo-controlled trial comparing single-agent inotrope therapy to placebo in patients with CS...
April 22, 2023: American Heart Journal
Sem Aof Rikken, W L Bor, A Selvarajah, K L Zheng, A Hack, C M Gibson, C B Granger, O Bentur, B S Coller, Awj Van 't Hof, Jm Ten Berg
BACKGROUND: Zalunfiban (RUC-4) is a novel, subcutaneously administered glycoprotein IIb/IIIa inhibitor (GPI) designed for pre-hospital treatment to initiate reperfusion in the infarct-related artery (IRA) before primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction (STEMI). Since GPIs have been reported to rapidly reperfuse IRAs, we assessed whether there was a dose-dependent relationship between zalunfiban treatment and angiographic reperfusion indices and thrombus grade of the IRA at initial angiogram in patients with STEMI...
April 21, 2023: American Heart Journal
Simona Chiusolo, Christian Sørensen Bork, Francesco Gentile, Søren Lundbye-Christensen, William S Harris, Erik Berg Schmidt, Raffaele De Caterina
BACKGROUND: Tissue levels of n-3 polyunsaturated fatty acids (PUFAs) have been inversely related with risk of myocardial infarction (MI). Whether ratios of n-3 to n-6 PUFAs, reflecting both dietary intake of n-3 PUFAs and competing n-6 PUFAs, are better predictors of future MI than n-3 PUFA fractions is unclear. We aimed at investigating whether such ratios in adipose tissue better predict MI than n-3 PUFA fractions. METHODS: Subcutaneous adipose tissue biopsies were obtained in a random sample (n=3,500) of the Diet, Cancer and Health cohort (n=57,053)...
April 20, 2023: American Heart Journal
Sabrina J G C Welten, Sharon Remmelzwaal, Marieke T Blom, Amber A van der Heijden, Giel Nijpels, Hanno L Tan, Irene van Valkengoed, Jean-Philippe Empana, Xavier Jouven, Frederik Nybye Ågesen, Peder Emil Warming, Jacob Tfelt-Hansen, Eva Prescott, Reza Jabbari, Petra J M Elders
BACKGROUND: Sudden cardiac death is responsible for 10-20% of all deaths in Europe. The current study investigates how well the risk of sudden cardiac death can be predicted. To this end, we validated a previously developed prediction model for sudden cardiac death from the Atherosclerosis Risk in Communities study (USA). METHODS: Data from participants of the Copenhagen City Heart Study (CCHS) (n=9988) was used to externally validate the previously developed prediction model for sudden cardiac death...
April 19, 2023: American Heart Journal
Scott Cohen, Michelle Gurvitz, Kristin M Burns, Olivia Wheaton, Ashok Panigrahy, Laura Umfleet, Michelle Loman, Nicole Brown, Tim Cotts, Peter Ermis, Susan Fernandes, Stephanie Gaydos, Arvind Hoskoppal, Ian Lindsay, Larry W Markham, Annique Nyman, Fred H Rodriguez, Cynthia C Smith, Mario Stylianou, Felicia Trachtenberg, Ali N Zaidi
BACKGROUND: Neurocognitive dysfunction (NCD) is a common comorbidity among children with congenital heart disease (CHD). However, it is unclear how underlying CHD and its sequelae combine with genetics and acquired cardiovascular and neurological disease to impact NCD and outcomes across the lifespan in adults with CHD. METHODS: The Multi-Institutional Neurocognitive Discovery Study in Adults with Congenital Heart Disease (MINDS-ACHD) is a partnership between the Pediatric Heart Network (PHN) and the Adult Alliance for Research in Congenital Cardiology (AARCC) that examines objective and subjective neurocognitive function and genetics in young ACHD...
April 19, 2023: American Heart Journal
Patrick C Demkowicz, Sanket S Dhruva, Erica S Spatz, Alexis L Beatty, Joseph S Ross, Rohan Khera
BACKGROUND: While the US Food and Drug Administration (FDA) has cleared smartwatch software for detecting atrial fibrillation (AF), there is lack of guidance on management by physicians. We sought to evaluate the approach to management of Apple Watch alerts for AF by physicians and assess whether respondent and case characteristics were associated with their approach. METHODS: We conducted a case-based survey of physicians practicing primary care, emergency medicine, and cardiology at 2 large academic centers (Yale and University of California San Francisco) between September to December 2021...
April 19, 2023: American Heart Journal
Jonathan Y Brown, Sheila Drakeley, Madeline Duncan, William P Knapp, Zoë J Schefter, Nancy Barker, Caroline E Rouse, Bradley Maron, Elazer R Edelman, Anne Marie Valente, Katherine E Economy
BACKGROUND: Exercise in pregnancy has proven health benefits, yet the safety of exercise in patients with pre-existing cardiovascular disease (CVD) has not been established. Our aim was to determine the feasibility and safety profile of moderate intensity exercise during pregnancy in patients with CVD, compared with those without CVD. METHODS: This is a prospective single center pilot study of a moderate intensity exercise regimen, with data collection through wearable fitness trackers and personal exercise logs in pregnant patients with and without pre-existing CVD...
April 16, 2023: American Heart Journal
Dong Huang, Yanjun Gong, Yongzhen Fan, Bo Zheng, Zhibing Lu, Jianping Li, Yunlong Huo, Javier Escaned, Yong Huo, Junbo Ge
BACKGROUND: Assessing index of microcirculatory resistance (IMR) is customarily performed using intracoronary wires fitted with sensors by at least 3 intracoronary injections of 3-4 ml of room-temperature saline during sustained hyperemia, which is time- and cost-consuming. METHODS: The FLASH IMR study is a prospective, multicenter, randomized study to assess the diagnostic performance of coronary angiography-derived IMR (caIMR) in patients with suspected myocardial ischemia with non-obstructive coronary arteries using wire-based IMR as a reference...
April 11, 2023: American Heart Journal
Sueli Ferreira da Fonseca, Antonio Luiz Pinho Ribeiro, Christiane Corrêa Rodrigues Cimini, Thiago Barbabela de Castro Soares, Polianna Delfino Pereira, Lucas Tavares Nogueira, Regina Márcia Faria de Moura, Daisy Motta Santos, Leonardo Bonisson Ribeiro, Márcia Cristiane Souza Camargos, Maria Cristina da Paixão, Magda Carvalho Pires, James Batchelor, Milena Soriano Marcolino
BACKGROUND: Hypertension and diabetes mellitus (DM) are highly prevalent in low and middle-income countries (LMICs), and the proportion of patients with uncontrolled diseases is higher than in high-income countries. Innovative strategies are required to surpass barriers of low sources, distance and quality of healthcare. Our aim is to assess the uptake and effectiveness of the implementation of an integrated multidimensional strategy in the primary care setting, for the management of people with hypertension and diabetes mellitus in Brazil...
April 10, 2023: American Heart Journal
Won-Jung Shin, Hye-Mee Kwon, Sung-Hoon Kim, Hwa-Young Jang, Yong-Seok Park, Jae-Hwan Kim, Kyoung-Sun Kim, Young-Jin Moon, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Diastolic dysfunction is regarded as an important predictor of outcome after liver transplantation (LT). We investigated the influence of liver disease severity on left ventricular diastolic properties using end-diastolic pressure-volume relationship (EDPVR) analysis in patients with end-stage liver disease (ESLD). Association between alterations of the EDPVR and mortality after LT was evaluated. METHODS: In this observational retrospective cohort study, 3211 patients who underwent LT for ESLD were included in analysis...
April 10, 2023: American Heart Journal
Breda Hennessey, John C Messenger, Ajay J Kirtane, Manish Parikh, Haim Danenberg, Frédéric De Vroey, Alejandro Curcio, Peter Eshuis, Javier Escaned
BACKGROUND: The clinical and anatomic complexity of patients undergoing percutaneous coronary interventions (PCI) has increased significantly over the past two decades. Contrast induced nephropathy (CIN) significantly impacts prognosis after PCI, therefore minimising the risk of CIN is important in improving clinical outcomes. Dynamic Coronary Roadmap (DCR) is a PCI navigation support tool which may decrease CIN by projecting a virtual coronary roadmap on the moving angiogram, potentially reducing iodinated contrast volume during PCI...
April 9, 2023: American Heart Journal
Takashi Araki, Toru Kondo, Takahiro Imaizumi, Yoko Sumita, Michikazu Nakai, Akihito Tanaka, Takahiro Okumura, Mingming Yang, Jawad H Butt, Mark C Petrie, Toyoaki Murohara
BACKGROUND: We examined the relationship between annual case volume at each hospital and outcome in cardiogenic shock (CS) patients receiving mechanical circulatory support (MCS) devices. METHODS: This cross-sectional study used the Japanese nationwide database to identify patients receiving short-term MCS for CS between April 2012 and March 2020. Of 65,837 patients, three sub-cohorts were created; the intra-aortic balloon pump (IABP) alone (n=48,643), the extracorporeal membrane oxygenation (ECMO) (n=16,871), and the Impella cohorts (n=696)...
April 7, 2023: American Heart Journal
Laura Willinger, Renate Oberhoffer-Fritz, Peter Ewert, Jan Müller
OBJECTIVE: Digital nudging is a modern e-health approach to increase physical activity (PA) in younger age groups. As activity promotion is particularly important in adolescents with congenital heart disease (CHD) this randomized-controlled trail examines if Digital Health Nudging via daily smartphone messages increases PA, activity-related self-efficacy (ArSE) and health-related quality of life (HrQoL) in adolescents with CHD. METHODS: From May 2021 to April 2022, 97 patients (15...
April 6, 2023: American Heart Journal
Krishna Pundi, Alexander C Perino, Jun Fan, Natasha Din, Karolina Szummer, Paul Heidenreich, Mintu P Turakhia
BACKGROUND: Morbidity and mortality associated with high CHA2 DS2 -VASc and HAS-BLED scores is not specific to atrial fibrillation (AF). Frailty could be an important contributor to this morbidity and mortality while being mechanistically independent from AF. We sought to evaluate the association of stroke and bleeding risk to non-cardiovascular frail events and the association of stroke prevention therapy to outcomes in frail patients with atrial fibrillation. METHODS: Using the TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF) study from the Veterans Health Administration, we identified patients with newly diagnosed AF from 2004-2014...
April 4, 2023: American Heart Journal
Eric W Mills, Michael Cassidy, Tamar Sofer, Thomas Tadros, Paul Zei, William Sauer, Jorge Romero, David Martin, Elliott M Antman, Sogol Javaheri
ABBREVIATIONS: Obstructive sleep apnea (OSA), atrial fibrillation (AF), home sleep test (HST), apnea-hypopnea index (AHI), continuous positive airway pressure (CPAP), Epworth Sleepiness Scale (ESS), Center of Excellence (COE), Mayo AF-Specific Symptom Inventory (MAFSI), Atrial Fibrillation Effect Quality of Life (AFEQT), body-mass index (BMI), oxygen desaturation index (ODI) BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice and is associated with significant morbidity, mortality, and financial burden...
April 3, 2023: American Heart Journal
Robert I Griffiths, Rafael Cavalcante, Alysha M McGovern, Aparna Bhave, Liesl M Hargens, Craig A Solid, Amit P Amin
BACKGROUND: . Acute kidney injury (AKI), including contrast-induced AKI (CI-AKI), is an important complication of percutaneous coronary intervention (PCI), resulting in short- and long-term adverse clinical outcomes. While prior research has reported an increased cost burden to hospitals from CI-AKI, the incremental cost to payers remains unknown. Understanding this incremental cost may inform decisions and even policy in the future. The objective of this study was to estimate the short- and long-term cost to Medicare of AKI overall, and specifically CI-AKI, in PCI...
April 2, 2023: American Heart Journal
Caglayan Demirel, Daijiro Tomii, Dik Heg, Taishi Okuno, Fabian Wieser, Thomas M Suter, Christoph Gräni, Stephan Windecker, Thomas Pilgrim
The aim of this retrospective analysis was to investigate the prevalence and prognostic importance of incidental malignancy detected during pre-TAVI computed tomography. Among 579 patients, CT-work-up for TAVI exposed previously undetected malignancy in 4.5% of patients. TAVI patients with a new malignancy had a 2.9-fold increased risk of death at one year, and a 16 month shorter mean survival time compared to patients with no malignancy.
April 1, 2023: American Heart Journal
Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, Alexander P Benz, John H Alexander, Stuart J Connolly, John W Eikelboom, Christopher B Granger, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Decisions on stroke prevention strategies in patients with atrial fibrillation (AF) depend on the perceived risks of stroke and bleeding with different antithrombotic treatment strategies. The study objectives were to evaluate net clinical outcome with oral anticoagulation (OAC) for the individual patient with AF and to identify clinically relevant thresholds for OAC treatment. METHODS: Patients with AF receiving OAC treatment in the randomized ARISTOTLE and RE-LY trials, with available biomarkers for calculation of ABC-AF scores at baseline, were included (n=23,121)...
March 27, 2023: American Heart Journal
Demilade A Adedinsewo, Andrea Carolina Morales-Lara, Jennifer Dugan, Wendy T Garzon-Siatoya, Xiaoxi Yao, Patrick W Johnson, Erika J Douglass, Zachi I Attia, Sabrina D Phillips, Mohamad H Yamani, Yvonne Butler Tobah, Carl H Rose, Emily E Sharpe, Francisco Lopez-Jimenez, Paul A Friedman, Peter A Noseworthy, Rickey E Carter
BACKGROUND: Artificial intelligence (AI), and more specifically deep learning, models have demonstrated the potential to augment physician diagnostic capabilities and improve cardiovascular health if incorporated into routine clinical practice. However, many of these tools are yet to be evaluated prospectively in the setting of a rigorous clinical trial - a critical step prior to implementing broadly in routine clinical practice. OBJECTIVES: To describe the rationale and design of a proposed clinical trial aimed at evaluating an AI-enabled electrocardiogram (AI-ECG) for cardiomyopathy detection in an obstetric population in Nigeria...
March 24, 2023: American Heart Journal
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