journal
https://read.qxmd.com/read/37716449/prophylactic-corticosteroids-for-cardiac-surgery-in-children-a-systematic-review-and-meta-analysis
#1
REVIEW
Huzaifa Ahmad Cheema, Arsalan Ali Khan, Awab Hussain Ahmad, Abdullah Ali Khan, Muhammad Amna Khalid, Abia Shahid, Alaa Hamza Hermis, Ali Syed, Neha Bansal, Koichi Yuki, Sunil J Ghelani, Sourbha S Dani
OBJECTIVE: Perioperative corticosteroids have been used for pediatric cardiac surgery for decades, but the underlying evidence is conflicting. We aimed to investigate the efficacy and safety of perioperative prophylactic corticosteroids in pediatric heart surgeries. METHODS: We searched electronic databases until March 2023 to retrieve all randomized controlled trials (RCTs) that administered perioperative prophylactic corticosteroids to children undergoing heart surgery...
September 14, 2023: American Heart Journal
https://read.qxmd.com/read/37716448/rationale-and-design-of-the-direct-oral-anticoagulants-for-prevention-of-left-ventricular-thrombus-after-anterior-acute-myocardial-infarction-aperitif-trial
#2
JOURNAL ARTICLE
Etienne Puymirat, Gilles Soulat, Antoine Fayol, Elie Mousseaux, Gilles Montalescot, Guillaume Cayla, Philippe Gabriel Steg, Laurence Berard, Alexandra Rousseau, Élodie Drouet, Tabassome Simon, Nicolas Danchin
BACKGROUND: Anterior acute myocardial infarction (AMI) is associated with an increased risk of left ventricular (LV) thrombus formation. We hypothesized that adding low-dose oral rivaroxaban to the usual antiplatelet regimen would reduce the risk of LV thrombus in patients with large AMI. STUDY DESIGN: APERITIF is an investigator-initiated, multicenter randomized open-label, blinded end-point (PROBE) trial, nested in the ongoing "FRENCHIE" registry, a French multicenter prospective observational study, in which all consecutive patients admitted within 48 hours of symptom onset in a cardiac Intensive Care Unit (ICU) for AMI are included (NCT04050956)...
September 14, 2023: American Heart Journal
https://read.qxmd.com/read/37709109/early-computed-tomography-coronary-angiography-and-preventative-treatment-in-patients-with-suspected-acute-coronary-syndrome-a-secondary-analysis-of-the-rapid-ctca-trial
#3
JOURNAL ARTICLE
Kang-Ling Wang, Mohammed N Meah, Anda Bularga, Katherine Oatey, Rachel O'Brien, Jason E Smith, Nick Curzen, Attila Kardos, Liza Keating, Dirk Felmeden, Robert F Storey, Steve Goodacre, Carl Roobottom, David E Newby, Alasdair J Gray
BACKGROUND: Computed tomography coronary angiography (CTCA) offers detailed assessment of the presence of coronary atherosclerosis and helps guide patient management. We investigated influences of early CTCA on the subsequent use of preventative treatment in patients with suspected acute coronary syndrome. METHODS: In this secondary analysis of a multicentre randomised controlled trial of early CTCA in intermediate-risk patients with suspected acute coronary syndrome, prescription of aspirin, P2Y12 receptor antagonist, statin, renin-angiotensin system blocker, and beta-blocker therapies from randomisation to discharge were compared within then between those randomised to early CTCA or to standard of care only...
September 12, 2023: American Heart Journal
https://read.qxmd.com/read/37709108/a-cross-stakeholder-approach-to-improving-out-of-hospital-cardiac-arrest-survival
#4
JOURNAL ARTICLE
Timothy C Guetterman, Jane Forman, Sydney Fouche, Kaitlyn Simpson, Michael D Fetters, Christopher Nelson, Peter Mendel, Antony Hsu, Jessica A Flohr, Robert Domeier, Rebal Rahim, Brahmajee K Nallamothu, Mahshid Abir
BACKGROUND: Out-of-hospital cardiac arrest (OHCA) affects over 300,000 individuals per year in the U.S. with poor survival rates overall. A remarkable five-fold difference in survival-to-hospital discharge rates exist across U.S. communities. METHOD: We conducted a study using qualitative research methods comparing the system of care across sites in Michigan communities with varying OHCA survival outcomes, as measured by return to spontaneous circulation with pulse upon emergency department arrival...
September 12, 2023: American Heart Journal
https://read.qxmd.com/read/37703948/randomized-controlled-trial-of-mechanical-thrombectomy-versus-catheter-directed-thrombolysis-for-acute-hemodynamically-stable-pulmonary-embolism-rationale-and-design-of-the-peerless-study
#5
JOURNAL ARTICLE
Carin F Gonsalves, C Michael Gibson, Stefan Stortecky, Roger A Alvarez, Daren M Beam, James M Horowitz, Mitchell J Silver, Catalin Toma, John H Rundback, Stuart P Rosenberg, Craig D Markovitz, Thomas Tu, Wissam A Jaber
BACKGROUND: The identification of hemodynamically stable pulmonary embolism (PE) patients who may benefit from advanced treatment beyond anticoagulation is unclear. However, when intervention is deemed necessary by the PE patient's care team, data to select the most advantageous interventional treatment option are lacking. Limiting factors include major bleeding risks with systemic and locally delivered thrombolytics and the overall lack of randomized controlled trial (RCT) data for interventional treatment strategies...
September 11, 2023: American Heart Journal
https://read.qxmd.com/read/37703947/diagnostic-and-prognostic-impact-of-new-pathophysiology-based-categorization-of-type-1-and-type-2-myocardial-infarction-data-from-the-french-rico-survey
#6
JOURNAL ARTICLE
Hermann Yao, Yves Cottin, Frédéric Chague, Maud Maza, Florence Bichat, Marianne Zeller, Alain Putot
BACKGROUND: A new classification of type 1 and 2 myocardial infarction (MI) derived from the 4th universal definition of MI (UDMI) has been recently proposed, based on pathophysiology of coronary artery disease (CAD). We assessed the impact of this new MI categorization on epidemiology and outcomes, considering type 1 MI and type 2 MI, with and without CAD. METHODS: Retrospective study including all consecutive patients hospitalized for an acute MI in a multicenter database (RICO)...
September 11, 2023: American Heart Journal
https://read.qxmd.com/read/37657594/rationale-and-design-of-the-ulyss-trial-a-randomized-multicenter-evaluation-of-the-efficacy-of-early-impella-cp-implantation-in-acute-coronary-syndrome-complicated-by-cardiogenic-shock
#7
JOURNAL ARTICLE
Clement Delmas, Marc Laine, Guillaume Schurtz, Francois Roubille, Pierre Coste, Guillaume Leurent, Sami Hraiech, Mathieu Pankert, Quaino Gonzalo, Thibaut Dabry, Vincent Letocart, Sandrine Loubière, Noémie Resseguier, Laurent Bonello
Despite 20 years of improvement in acute coronary syndromes care, patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) remains a major clinical challenge with a stable incidence and mortality. While intra-aortic balloon pump (IABP) did not meet its expectations, percutaneous mechanical circulatory supports (pMCS) with higher hemodynamic support, large availability and quick implementation may improve AMICS prognosis by enabling early hemodynamic stabilization and unloading. Both interventional and observational studies suggested a clinical benefit in selected patients of the IMPELLA® CP device within in a well-defined therapeutic strategy...
August 30, 2023: American Heart Journal
https://read.qxmd.com/read/37657593/the-coronary-microvascular-angina-cardiovascular-magnetic-resonance-imaging-trial-rationale-and-design
#8
JOURNAL ARTICLE
Conor P Bradley, Vanessa Orchard, Gemma McKinley, Robert Heggie, Olivia Wu, Richard Good, Stuart Watkins, Mitchell Lindsay, Hany Eteiba, James McGowan, Ross McGeoch, David Corcoran, Peter Kellman, Alex McConnachie, Colin Berry
BACKGROUND: Coronary microvascular dysfunction may cause myocardial ischemia with no obstructive coronary artery disease (INOCA). If functional testing is not performed INOCA may pass undetected. Stress perfusion cardiovascular MRI (CMR) quantifies myocardial blood flow (MBF) but the clinical utility of stress CMR in the management of patients with suspected angina with no obstructive coronary arteries (ANOCA) is uncertain. OBJECTIVES: First, to undertake a diagnostic study using stress CMR in patients with ANOCA following invasive coronary angiography and, second, in a nested, double-blind, randomized, controlled trial to assess the effect of disclosure on the final diagnosis and health status in the longer term...
August 30, 2023: American Heart Journal
https://read.qxmd.com/read/37648579/rationale-and-design-of-the-dapa-mi-trial-dapagliflozin-in-patients-without-diabetes-mellitus-with-acute-myocardial-infarction
#9
JOURNAL ARTICLE
Stefan James, David Erlinge, Robert F Storey, Darren K McGuire, Mark de Belder, Ida Björkgren, Peter A Johansson, Anna Maria Langkilde, Wilhelm Ridderstråle, Ehsan Parvaresh Rizi, John Deanfield, Jonas Oldgren
BACKGROUND: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. METHODS: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or established HF, presenting with MI and impaired left ventricular systolic function or Q-wave MI...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37634656/a-review-of-polypills-for-the-prevention-of-atherosclerotic-cardiovascular-disease
#10
REVIEW
Federica Agnello, Simone Finocchiaro, Claudio Laudani, Marco Legnazzi, Maria Sara Mauro, Carla Rochira, Lorenzo Scalia, Davide Capodanno
Atherosclerotic cardiovascular disease (ASCVD) is a prevalent chronic condition managed through pharmacotherapy targeting modifiable risk factors. However, ASCVD patients often face poor medication adherence due to a high pill burden from multiple oral drugs, contributing to cardiovascular events. Recent evidence indicates that polypills combining anti-hypertensive and statin medications effectively control risk factors and improve adherence in various ASCVD risk patients. Randomized clinical trials demonstrate polypill efficacy in reducing major cardiovascular events, making them a convenient strategy for both established ASCVD patients and those without ASCVD...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37634655/an-investigator-sponsored-pragmatic-randomised-controlled-trial-of-anticoagulation-versus-acetylsalicylic-acid-after-transcatheter-aortic-valve-implantation-rationale-and-design-of-acasa-tavi-blinded-outcome-adjudication
#11
JOURNAL ARTICLE
Christopher A S Dodgson, Jan Otto Beitnes, Sophie F Kløve, Jon Herstad, Anders Opdahl, Ragnhild Undseth, Christian H Eek, Kaspar Broch, Lars Gullestad, Lars Aaberge, Ketil Lunde, Bjørn Bendz, Øyvind H Lie
The optimal antithrombotic therapy after transcatheter aortic valve implantation (TAVI) is unknown. Bioprosthetic valve dysfunction (BVD) is associated with adverse outcomes and may be prevented by anticoagulation therapy. A dedicated randomized trial comparing monotherapy NOAC to single antiplatelet therapy has not been performed previously. We hypothesize that therapy with any anti-factor Xa NOAC will reduce BVD compared to antiplatelet therapy, without compromising safety. ACASA-TAVI is a multicentre, prospective, randomised, open-label, blinded endpoint, all-comers trial comparing a monotherapy anti-factor Xa NOAC strategy (intervention arm) with a single antiplatelet therapy strategy (control arm) after successful TAVI...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37634654/coronary-artery-calcium-scoring-for-cardiovascular-risk-assessment-in-patients-with-inflammatory-bowel-disease
#12
JOURNAL ARTICLE
Robert Naami, Nour Tashtish, Ian J Neeland, Jeffry Katz, Preetika Sinh, Khurram Nasir, Vibhu Chittajallu, Emad Mansoor, Sanjay Rajagopalan, Sadeer Al-Kindi
BACKGROUND: Inflammatory bowel disease (IBD) is associated with higher incidence of atherosclerotic cardiovascular disease (ASCVD). Data investigating the role of coronary artery calcium (CAC) scoring in identifying subclinical atherosclerotic disease in IBD patients is scarce. METHODS: Using data obtained from the CLARIFY registry, a prospective study of no-charge coronary artery calcium (CAC) testing at University Hospitals, we reviewed patients with ulcerative colitis (UC) or Crohn's disease (CD) who underwent CAC scoring from 2014 to 2020...
August 25, 2023: American Heart Journal
https://read.qxmd.com/read/37611857/rationale-and-design-of-the-pullback-pressure-gradient-ppg-global-registry
#13
JOURNAL ARTICLE
Daniel Munhoz, Carlos Collet, Takuya Mizukami, Andy Yong, Antonio Maria Leone, Ashkan Eftekhari, Brian Ko, Bruno R da Costa, Colin Berry, Damien Collison, Divaka Perera, Evald Høj Christiansen, Fernando Rivero, Frederik M Zimmermann, Hirohiko Ando, Hitoshi Matsuo, Masafumi Nakayama, Javier Escaned, Jeroen Sonck, Koshiro Sakai, Julien Adjedj, Liyew Desta, Lokien X van Nunen, Nick E J West, Stephane Fournier, Tatyana Storozhenko, Tetsuya Amano, Thomas Engstrøm, Thomas Johnson, Toshiro Shinke, Simone Biscaglia, William F Fearon, Ziad Ali, Bernard De Bruyne, Nils P Johnson
INTRODUCTION: Diffuse disease has been identified as one of the main reasons leading to low post-PCI fractional flow reserve (FFR) and residual angina after PCI. Coronary pressure pullbacks allow for the evaluation of hemodynamic coronary artery disease (CAD) patterns. The pullback pressure gradient (PPG) is a novel metric that quantifies the distribution and magnitude of pressure losses along the coronary artery in a focal-to-diffuse continuum. AIM: The primary objective is to determine the predictive capacity of the PPG for post-PCI FFR...
August 21, 2023: American Heart Journal
https://read.qxmd.com/read/37611856/diagnostic-performance-of-a-novel-automated-ct-derived-ffr-technology-in-detecting-hemodynamically-significant-coronary-artery-stenoses-a-multicenter-trial-in-china
#14
JOURNAL ARTICLE
Quan Li, Yaodong Ding, QiLiang Chen, Yida Tang, Haitao Zhang, Yong He, Guosheng Fu, Qing Yang, Xiling Shou, Yicong Ye, Xiliang Zhao, Yang Zhang, Yu Li, Xiaoling Zhang, Changyan Wu, Rui Wang, Lei Xu, Ren Zhang, Alan Yeung, Yong Zeng, Xiang Qian
BACKGROUND AND AIMS: Computed tomography-derived fractional flow reserve (CT-derived FFR) algorithms have emerged as promising non-invasive methods for identifying hemodynamically significant coronary artery disease (CAD). However, its broad adaption is limited by the complex workflow, slow processing, and supercomputer requirement. Therefore, CT-derived FFR solutions capable of producing fast and accurate results could help deliver time-sensitive results rapidly and potentially alter patient management...
August 21, 2023: American Heart Journal
https://read.qxmd.com/read/37604357/biomarkers-and-cardiovascular-events-in-patients-with-stable-coronary-disease-in-the-ischemia-trials-biomarkers-and-risk-prediction-in-stable-coronary-artery-disease-a-post-hoc-secondary-analysis-from-the-ischemia-randomized-clinical-trial-biorepository
#15
JOURNAL ARTICLE
Jonathan D Newman, Rebecca Anthopolos, Kelly V Ruggles, Macintosh Cornwell, Harmony R Reynolds, Sripal Bangalore, Kreton Mavromatis, Claes Held, Lars Wallentin, Iftikar J Kullo, Bruce McManus, L Kristin K Newby, Yves Rosenberg, Judith S Hochman, David J Maron, Jeffrey S Berger
IMPORTANCE: Biomarkers may improve prediction of cardiovascular events for patients with stable coronary artery disease (CAD), but their importance in addition to clinical tests of inducible ischemia and CAD severity is unknown. OBJECTIVES: To evaluate the prognostic value of multiple biomarkers in stable outpatients with obstructive CAD and moderate or severe inducible ischemia. DESIGN AND SETTING: The ISCHEMIA and ISCHEMIA CKD trials randomized 5,956 participants with CAD to invasive or conservative management from July 2012 to January 2018; 1,064 participated in the biorepository...
August 19, 2023: American Heart Journal
https://read.qxmd.com/read/37598795/baseline-characteristics-of-patients-in-the-randomized-study-to-investigate-the-efficacy-and-safety-of-ferric-carboxymaltose-as-treatment-for-heart-failure-with-iron-deficiency-heart-fid-trial
#16
JOURNAL ARTICLE
Josephine Harrington, Robert J Mentz, Frank W Rockhold, Jyotsna Garg, Javed Butler, Carmine G De Pasquale, Justin A Ezekowitz, Gregory D Lewis, Eileen O'Meara, Piotr Ponikowski, Richard W Troughton, Yee Weng Wong, Robert Adamczyk, Nicole Blackman, Adrian F Hernandez
BACKGROUND: Prior clinical trials have investigated intravenous iron in patients with heart failure (HF) and iron deficiency, but the safety and efficacy of this therapy remains unclear METHODS: We report the baseline demographics and clinical characteristics of patients enrolled in the HEART-FID study and compare HEART-FID participants with patients within other contemporary clinical trials of patients with HF with reduced ejection fraction (HFrEF), including other intravenous iron trials...
August 18, 2023: American Heart Journal
https://read.qxmd.com/read/37595659/prediction-of-early-death-after-atrial-fibrillation-diagnosis-using-a-machine-learning-approach-a-french-nationwide-cohort-study
#17
JOURNAL ARTICLE
Arnaud Bisson, Yassine Lemrini, Giulio Francesco Romiti, Marco Proietti, Denis Angoulvant, Sidahmed Bentounes, Wahbi El-Bouri, Gregory Y H Lip, Laurent Fauchier
AIMS: Atrial fibrillation is associated with important mortality but the usual clinical risk factor based scores only modestly predict mortality. This study aimed to develop machine learning models for the prediction of death occurrence within the year following atrial fibrillation diagnosis and compare predictive ability against usual clinical risk scores. METHODS AND RESULTS: We used a nationwide cohort of 2,435,541 newly diagnosed atrial fibrillation patients seen in French hospitals from 2011 to 2019...
August 16, 2023: American Heart Journal
https://read.qxmd.com/read/37595658/effectiveness-of-the-risk-stratification-proposed-by-the-2022-european-heart-rhythm-association-expert-consensus-statement-on-arrhythmic-mitral-valve-prolapse
#18
JOURNAL ARTICLE
Wouter L'Hoyes, Tomas Robyns, Sara Moura-Fereira, Pieter De Meester, Tom Dresselaers, Marie-Christine Herregods, Filip Rega, Pier Giorgio Masci, Rik Willems, Jan Bogaert, Bert Vandenberk
BACKGROUND: Recently, an expert consensus statement proposed indications where implantation of a primary prevention implantable cardioverter-defibrillator (ICD) may be reasonable in patients with mitral valve prolapse (MVP). The objective was to evaluate the proposed risk stratification by the expert consensus statement. METHODS: Consecutive patients with MVP without alternative arrhythmic substrates with cardiac magnetic resonance imaging (CMR) were included in a single-center retrospective registry...
August 16, 2023: American Heart Journal
https://read.qxmd.com/read/37591368/network-meta-analysis-of-temporary-mechanical-circulatory-support-in-acute-myocardial-infarction-cardiogenic-shock
#19
JOURNAL ARTICLE
Jacob C Jentzer, Atsuyuki Watanabe, Toshiki Kuno, Sripal Bangalore, Carlos L Alviar
We performed a network meta-analysis of 11 published randomized clinical trials examining the use of temporary mechanical circulatory support (MCS) devices in adults with acute myocardial infarction cardiogenic shock (AMICS), including 1053 total patients with an observed in-hospital or 30-day mortality of 40.4%. None of the temporary MCS devices was associated with lower in-hospital or 30-day mortality compared with initial medical therapy or any other MCS device, either individually or in combination...
August 15, 2023: American Heart Journal
https://read.qxmd.com/read/37572785/rationale-and-design-of-the-parthenope-trial-a-two-by-two-factorial-comparison-of-polymer-free-vs-biodegradable-polymer-drug-eluting-stents-and-personalized-vs-standard-duration-of-dual-antiplatelet-therapy-in-all-comers-undergoing-pci
#20
JOURNAL ARTICLE
Raffaele Piccolo, Paolo Calabrò, Attilio Varricchio, Cesare Baldi, Giovanni Napolitano, Ciro De Simone, Ciro Mauro, Eugenio Stabile, Gianluca Caiazzo, Tullio Tesorio, Marco Boccalatte, Bernardino Tuccillo, Giuseppe Bottiglieri, Enrico Russolillo, Emilio Di Lorenzo, Greta Carrara, Salvatore Cassese, Sergio Leonardi, Simone Biscaglia, Francesco Costa, Eugene McFadden, Dik Heg, Anna Franzone, Giulio G Stefanini, Davide Capodanno, Giovanni Esposito
BACKGROUND: Over the past few decades, percutaneous coronary intervention (PCI) has undergone significant advancements as a result of the combination of device-based and drug-based therapies. These iterations have led to the development of polymer-free drug-eluting stents. However, there is a scarcity of data regarding their clinical performance. Furthermore, while various risk scores have been proposed to determine the optimal duration of dual antiplatelet therapy (DAPT), none of them have undergone prospective validation within the context of randomized trials...
August 10, 2023: American Heart Journal
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