Anna Giménez-Palomo, Mariona Guitart-Mampel, Ana Meseguer, Roger Borràs, Francesc Josep García-García, Esther Tobías, Laura Valls, Xavier Alsina-Restoy, Gemma Roqué, Ester Sánchez, Josep Roca, Gerard Anmella, Marc Valentí, Lorenzo Bracco, Helena Andreu, Sergi Salmerón, Lluc Colomer, Joaquim Radua, Norma Verdolini, Michael Berk, Eduard Vieta, Glòria Garrabou, Isabella Pacchiarotti
BACKGROUND: Bipolar disorder (BD) is a chronic and recurrent disease characterized by acute mood episodes and periods of euthymia. The available literature postulates that a biphasic dysregulation of mitochondrial bioenergetics might underpin the neurobiology of BD. However, most studies focused on inter-subject differences rather than intra-subject variations between different mood states. To test this hypothesis, in this preliminary proof-of-concept study, we measured in vivo mitochondrial respiration in patients with BD during a mood episode and investigated differences compared to healthy controls (HC) and to the same patients upon clinical remission...
November 29, 2023: Acta Psychiatrica Scandinavica