Isabel Valli, Alex Gonzalez Segura, Norma Verdolini, Clemente Garcia-Rizo, Daniel Berge, Inmaculada Baeza, Manuel J Cuesta, Ana Gonzalez-Pinto, Antonio Lobo, Anabel Martinez-Aran, Gisela Mezquida, Laura Pina-Camacho, Alexandra Roldan Bejarano, Sergi Mas, Philip McGuire, Miquel Bernardo, Eduard Vieta, Silvia Amoretti, Avila Parcet Aina, Vicent Balanzá-Martínez, Roger Borras, Anna Butjosa, Josefina Castro-Fornirles, Concepción De-la-Cámara, Elena De la Serna, Jon-Inaki Etxeandia-Pradera, Maria Florencia Forte, Paz García-Portilla, Jairo M González, Leticia González-Blanco, Itxaso Gonzalez-Ortega, Angela Ibañez, Santiago Madero, Laura Martínez-Sadurni, Juan Nacher, Rocío Panadero, Pomarol Clotet Edith, Mar Fatjó-Vilas, Roberto Rodriguez-Jimenez, Pedro Ruiz, Luis Sanchez-Pastor, Segarra Echevarría Rafael, Ana M Sánchez-Torres, Selma Gonzalez Judith, Amira Trabsa, Elena Urbiola, Judith Usall, Zabala Rabadán Arantzazu, Iñaki Zorrilla
BACKGROUND: Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosis proneness. We examined the role of distinct types of OCs in terms of psychosis risk and tested whether they interact differently with genetic vulnerability, whilst accounting for other known environmental risk factors. Study Design 405 participants (219 first episode psychosis patients and 186 healthy volunteers) underwent a comprehensive assessment of OCs, measured using the Lewis-Murray scale and divided into complications of pregnancy, abnormalities of fetal growth and development, and complications of delivery...
March 13, 2023: Acta Psychiatrica Scandinavica