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Acta Oto-laryngologica

Xia Ling, Wenwen Sang, Bo Shen, Kangzhi Li, Lihong Si, Xu Yang
OBJECTIVE: To evaluate the diagnostic value of eye movements and vestibular function tests in PCI patients. METHODS: Thirty-eight PCI patients and 31 patients with unilateral vestibular neuritis (UVN) were enrolled and underwent eye movement tests and vestibular function tests (spontaneous nystagmus [SN], head-shaking nystagmus [HSN]). RESULTS: The rates of eye movement abnormality were 78.9% and 41.9% in PCI and UVN patients, respectively...
February 15, 2019: Acta Oto-laryngologica
Hongcun Sun, Jiandao Hu, Zhenyu Mao, ZhaoXin Ma
BACKGROUND: Combination therapy is the first-line option for total-deafness sudden sensorineural hearing loss (SSNHL). Age may act as a crucial prognostic factor. OBJECTIVE: The aim of this study was to compare efficacy of combination therapy between adolescent and adult patients with total-deafness SSNHL. MATERIALS AND METHODS: Twenty-five adolescent patients (adolescent group) and 106 adult patients (adult group) with total-deafness SSNHL were recruited...
February 14, 2019: Acta Oto-laryngologica
Artur Lorens, Marika Kruszyńska, Anita Obrycka, Piotr Henryk Skarzynski, Blake Wilson, Henryk Skarzynski
BACKGROUND: Recent studies of cochlear implants (CIs) in profound unilateral hearing loss (UHL) patients have demonstrated a restoration of some binaural hearing. AIMS/OBJECTIVES: The objective was to evaluate three possible advantages of binaural hearing in CIs adult users with UHL including single-side deafness (SSD) and asymmetric hearing loss (AHL) subgroups. MATERIAL AND METHODS: A prospective study was conducted that included 70 sequentially implanted patients...
February 14, 2019: Acta Oto-laryngologica
Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Xiaodong Luo, Peng Xu, Daowen Wang, Xuanfen Zhang
BACKGROUND: The prognostic factors of facial paralysis complicated by middle ear cholesteatoma (MEC) are largely unknown due to limited reports and smaller sample size. OBJECTIVES: This study aimed to analyze prognostic factors of postoperative outcomes of facial paralysis complicated by MEC. MATERIAL AND METHODS: Clinical data of 48 patients (48 ears) with facial paralysis complicated by MEC were retrospectively reviewed and analyzed. The outcomes of facial paralysis were compared between different groups...
February 14, 2019: Acta Oto-laryngologica
Suyang Wang, Wenjuan Ding, Chi Chen, Baicheng Xu, Xiaowen Liu, Panpan Bian, Yufen Guo
BACKGROUND: The clinical characteristics of LVAS have attracted more and more attention, its audiology and imaging features have also been deeply studied. OBJECTIVE: To analyze phenotypes, genotypes of EVA, and find out the relationship between them. METHODS: Sixty EVA patients were tested by audiometry, temporal bone high-resolution CT and inner ear MRI. SNPscan technology were carried out after the patients signed informed consent. SPSS19...
February 14, 2019: Acta Oto-laryngologica
Kimitaka Kaga, Yusuke Kimura, Shujiro Minami
Background: The function of common cavity deformity demonstrated by temporal bone CT and MRI has been unknown. AIM/OBJECTIVE: To investigate the developmental changes of vestibular ocular reflex and acquisition of postural control in infants with common cavity deformity. MATERIAL AND METHODS: Eight infants who were congenitally deaf complicated by common cavity deformity were studied. The damped rotational chair test was carried out to evaluate vestibular ocular reflex...
February 14, 2019: Acta Oto-laryngologica
Xiaohui Wu, Xingqiang Gao, Peng Han, Yulin Zhou
BACKGROUND: Due to extreme genetic heterogeneity, targeted next-generation sequencing (NGS) can be an efficient tool for rapid genetic diagnosis of hereditary non-syndromic hearing loss (NSHL). AIMS/OBJECTIVES: This study was aiming to identify causative variants in NSHL patients from the Minnan region through targeted NGS. MATERIAL AND METHODS: Genomic DNA samples from 90 NSHL subjects were extracted and subjected to SureSelect target enrichment system to capture the entire coding exons and flanking intronic regions of gene GJB2, SLC26A4, and MT-RNR1...
February 14, 2019: Acta Oto-laryngologica
Su Jin Kim, Sun Ae Shin, Ho Yun Lee, Yong-Ho Park
BACKGROUND: Paper patching, a method that places cigarette paper over the most mobile quadrants of the tympanic membrane, is one of the treatment options for patulous eustachian tube (PET). AIMS/OBJECTIVES: The objective of this study was to compare the outcomes of two different treatment strategies for PET. MATERIAL AND METHODS: Twenty-three patients underwent paper patching of the tympanic membrane and 16 patients were treated with nasal saline irrigation with or without ipratropium bromide nasal spray...
February 14, 2019: Acta Oto-laryngologica
Manabu Komori, Takeshi Tada, Hiromi Koizumi, Masahiro Takahashi, Sayaka Sanpei, Tsunetaro Morino, Masaomi Motegi, Masahiro Miura, Kazuhisa Yamamoto, Yuika Sakurai, Yuichiro Yaguchi, Yutaka Yamamoto, Hiromi Kojima
BACKGROUND: The Japan Otology Society (JOS) proposed the classification and staging system for middle ear cholesteatoma. However, there was little analysis of the pathology of cholesteatoma using this staging system. AIMS/OBJECTIVES: To analyze the pathology of pars flaccida cholesteatoma using the staging system by JOS. MATERIAL AND METHODS: A total of 183 cases of fresh pars flaccida cholesteatoma treated between January 2009 and December 2015 were included...
February 11, 2019: Acta Oto-laryngologica
Jian Zhou, Liang Zhou, Lei Tao, Ming Zhang, Haitao Wu, Xiaoling Chen, Xiaoming Li, Cai Li, Hongli Gong
BACKGROUND: T3 supraglottic laryngeal carcinoma (LC) is a common advanced laryngeal cancer. OBJECTIVE: This study was conducted to assess the clinical results of pathological T3 (pT3) supraglottic LC patients who were amenable to laryngectomy treated with primary surgery and postoperative therapy. METHODS: Retrospective review of 202 pT3 cases of supraglottic laryngeal squamous cell carcinoma. RESULTS: The five-year cancer specific survival (CSS) rate was 63...
February 8, 2019: Acta Oto-laryngologica
Marcos V Goycoolea, Raquel Levy, Maria Paz Bustamante, Constanza Pacheco, Ximena Balmaceda
BACKGROUND: This prospective study evaluated the effectiveness of a rehabilitation program in vulnerable children with language deficits. AIMS/OBJECTIVES: Evaluating reversibility of a sensory understimulation. MATERIAL/METHODS: Two groups of five students, each, (sensory and not sensory deprived) were evaluated at ages 5 and 11. Both groups were taught the compulsory national educational program. The sensory deprived group also had a 5-year rehabilitation program...
February 8, 2019: Acta Oto-laryngologica
Stefan Kristiansson, Johan Reizenstein, Mathias von Beckerath, Fredrik Landström
BACKGROUND: Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field. AIMS/OBJECTIVES: To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent. MATERIALS AND METHODS: Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration...
February 8, 2019: Acta Oto-laryngologica
Minmin Li, Tao Zhang, Benxu Tan, Min Yu, Binglan Zhang
BACKGROUND: Studies have shown mixed results on the role of postoperative adjuvant radiotherapy (PORT) in surgically managed locally advanced laryngeal cancer. OBJECTIVES: The aim of this study is to review and investigate the role of PORT in patients with locally advanced laryngeal cancer using meta-analysis. MATERIALS AND METHODS: Relevant studies were searched using PubMed and eligible information has been extracted. Then, meta-analysis of hazard ratio (HR) was performed to evaluate the role of PORT in locally advanced laryngeal cancer...
February 8, 2019: Acta Oto-laryngologica
Qing-Qing Xu, Wei-Wei Guo, Xiangdong Wang, Suoqiang Zhai, Shiming Yang
BACKGROUND: Clinical trials of cell-based therapies using induced pluripotent stem (iPS) cells have already been started for several neurological diseases. OBJECTIVE: The purpose of the present study was to explore the characteristics and differentiation of somatic cells in vitro undergoing a low pH treatment, so as to provide new therapeutic strategies for treating sensorineural hearing loss. METHODS: Somatic cells were treated with low pH solution to alter their characteristics...
February 8, 2019: Acta Oto-laryngologica
Hilde Haave, Sahil Gulati, Jorunn Brekke, Stein Lybak, Olav K Vintermyr, Hans Jørgen Aarstad
BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/OBJECTIVES: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MATERIAL AND METHODS: Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE)...
February 8, 2019: Acta Oto-laryngologica
Kadri Ila, Emre Soylemez, Nihat Yilmaz, Seyit Ali Kayis, Adrien A Eshraghi
OBJECTIVE: Tinnitus is the perception of sound in the ears or head without any external or internal acoustic stimulation, and it is usually associated with hearing loss. In addition, it has been reported that there is a relationship between vestibular problems and sensorineural hearing loss. The aim of this study was to evaluate the vestibular function in patients with tinnitus without hearing loss. METHODS: A total of 32 patients who complained only of tinnitus without hearing loss and 30 control subjects without tinnitus or hearing loss were included in this study...
February 8, 2019: Acta Oto-laryngologica
Hamlet Suarez, Enrique Ferreira, Sofia Arocena, Belen Garcia Pintos, Maria Quinteros, Silvina Suarez, Maria Pia Gonzalez
BACKGROUND: Information about the role of auditory input and motor control is limited. OBJECTIVES: Assessment the relationship between auditory and vestibular information with specific motor and cognitive functions. METHODS: Posturography in 17 Pre-lingual Cochlear Implant Adolescents, (PCIA) age 14.06 ± 3.05 in four sensory conditions was analyzed: (A) eyes open, cochlear implant (CI) on, (B) eyes open, CI off, (C) eyes closed standing on a foam over a platform (ECFP) with CI on, and (D) ECFP, CI off...
February 7, 2019: Acta Oto-laryngologica
Pedro Clarós, Aleksandra Zofia Sobolewska, Antonio Cardesa, Marta Lopez-Fortuny, Andres Claros
BACKGROUND: Silent sinus syndrome (SSS) is defined as spontaneous, painless enophthalmos, hypoglobus with orbital floor resorption and maxillary sinus collapse on the ipsilateral side. Different methods of orbital floor reconstruction have been proposed. AIMS/OBJECTIVES: The purpose was to analyse the results of combined endoscopic sinus surgery (ESS) and reconstruction using orbital floor implant of 15 patients with SSS and to present recent histological findings...
February 3, 2019: Acta Oto-laryngologica
Lei Jin, Keyong Li, Xiaoyan Li
BACKGROUND: Diagnosis and treatment strategies for CP with OME and the timing of ear tube insertion remain controversial. OBJECTIVES: To analyze the clinical outcomes of otitis media with effusion in children with incomplete cleft palate after palatoplasty prospectively. METHODS: A total of 30 children (10 months-2 years old) with incomplete CP were enrolled in this study and received at least 6 months of follow-up evaluations after palatoplasty...
February 3, 2019: Acta Oto-laryngologica
Suvi Silén, Aaro Haapaniemi, Amy Dickinson, Karin Rönn, Antti Mäkitie
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is rare in the young. OBJECTIVES: We characterized the clinical behavior of LSCC and assessed the presentation of second primary tumors (SPCs) in this patient population. MATERIALS AND METHODS: Data from the Finnish Cancer Registry (FCR) were used to identify an epidemiological series of LSCC patients diagnosed at the age of 40 years or under, during 1953-2012 in Finland. Data regarding primary treatment, survival, and SPCs were available...
February 3, 2019: Acta Oto-laryngologica
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