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Acta Neurologica Scandinavica

Michael O Kinney, Gavin McCluskey, Daniel Friedman, Matthew C Walker, Josemir W Sander, Rohit Shankar
OBJECTIVES: Sudden death is a recognised consequence of epilepsy. Little is known about the practice of confirming the cause of sudden death from most nations. We sought to determine how often autopsy is undertaken, clinician confidence in cause of death, and identify the factors which may influence autopsy utilization. MATERIALS & METHODS: An online questionnaire survey was sent to all International League Against Epilepsy (ILAE) chapters chairpersons, asking them to complete the survey based on their perceptions in their country...
February 18, 2019: Acta Neurologica Scandinavica
Ho-Joon Lee, Kang Min Park
OBJECTIVES: We aimed to evaluate structural and functional connectivity of patients with newly diagnosed juvenile myoclonic epilepsy (JME) compared to healthy subjects. METHODS: We enrolled 36 patients with a diagnosis of JME, who were newly diagnosed and drug-naïve. They underwent T1-weighted imaging, and structural volumes were calculated using FreeSurfer software. In addition, EEG data were obtained from all of them. Structural and functional connectivity matrices were estimated by calculating the structural volumes and EEG amplitude correlation, respectively...
February 13, 2019: Acta Neurologica Scandinavica
Bo-Lin Ho, Ya-Ju Lin, Sheng-Feng Lin, Ping-Song Chou, Chien-Fu Chen, Ruey-Tay Lin, Han-Hwa Hu, A-Ching Chao
OBJECTIVES: Dabigatran etexilate is a direct thrombin inhibitor that clinicians increasingly prescribe to prevent stroke in patients with nonvalvular atrial fibrillation (NVAF). Clinicians also commonly prescribe statins for primary and secondary prevention of cardiovascular diseases. Little is known about the bleeding risk in patients taking a statin and dabigatran together. The aim of this study was to evaluate the safety and persistence of dabigatran after co-medication with statins...
February 11, 2019: Acta Neurologica Scandinavica
Pierre de Flon, Katarina Laurell, Peter Sundström, Kaj Blennow, Lars Söderström, Henrik Zetterberg, Martin Gunnarsson, Anders Svenningsson
OBJECTIVE: The main objective of this study was to evaluate the axonal component neurofilament light protein (NFL) in plasma and cerebrospinal fluid (CSF) as an outcome measure in a clinical trial on disease-modifying treatments in multiple sclerosis. MATERIALS & METHODS: Seventy-five patients with clinically stable relapsing-remitting multiple sclerosis (RRMS) participating in the clinical trial "Switch-To RItuXimab in MS" (STRIX-MS) were switched to rituximab from first-line injectable therapy and then followed for two years...
February 11, 2019: Acta Neurologica Scandinavica
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February 8, 2019: Acta Neurologica Scandinavica
Maddalena De Bernardo, Livio Vitiello, Nicola Rosa
we were really involved by the Candeliere Merlicco at al. article concerning the use of the transorbital ultrasonography for measuring optic nerve atrophy in multiple sclerosis. We would like to congratulate the authors for their interesting work, but we would like to comment the methods they used to measure the optic nerve (ON) diameter. The authors used the B scan technique, an examination broadly utilized to diagnose ocular diseases,2-7 that unfortunately is not sensitive enough in measuring orbital structures, as it is affected by the so-called blooming effect...
February 5, 2019: Acta Neurologica Scandinavica
Antonio Candeliere Merlicco, Laura Gabaldón Torres, Ramón Villaverde González, Isidoro Fernández Romero, Eladio Aparicio Castro, María Del Carmen Lastres Arias
We thank the authors for the comments on our recent work (1) and we would offer some clarification. The blooming effect is a doppler imaging artifact (2). In our work the doppler mode has not been used, so it is not possible that the blooming effect could artifact the images. On the other hand, we have already commented that, the difficulty in correctly visualizing all the structures that make up the optic nerve (ON) is one of the limitations of transorbital ultrasound, but we doubt that the use of the A-mode can be of any help...
February 5, 2019: Acta Neurologica Scandinavica
Fabiola De Marchi, Maria Francesca Sarnelli, Valentina Solara, Enrica Bersano, Roberto Cantello, Letizia Mazzini
OBJECTIVES: ALS is not only a motor disorder: more than 50% of patients have cognitive dysfunctions over the course of the disease. At the same time, mood disorders may also occur in ALS patients following diagnosis due to the fatal prognosis; however little data is available on any depression beforehand. Starting from these considerations, the aim of our study was to investigate the occurrence of depression in Italian ALS patients prior to diagnosis, evaluating its prevalence in the subjects who have developed cognitive dysfunctions and in those who did not...
February 3, 2019: Acta Neurologica Scandinavica
Margrete Larsen Burns, Einar Kinge, Mimi Stokke Opdal, Svein I Johannessen, Cecilie Johannessen Landmark
OBJECTIVES: Gabapentin has been increasingly used in various indications in recent years. Despite variable pharmacokinetics, therapeutic drug monitoring (TDM) is scarcely described in other indications than epilepsy. The aim of the study was to investigate the use and pharmacokinetic variability of gabapentin in epilepsy and non-epilepsy indications, and to further evaluate the use of TDM in patients with restless legs syndrome (RLS). MATERIALS & METHODS: Population-based data from the Norwegian Prescription Database, retrospective TDM-data from the section for Clinical Pharmacology, the National Center for Epilepsy, Norway, and prospective observational data on patients with RLS were used...
February 1, 2019: Acta Neurologica Scandinavica
Signe Bruun Munksgaard, Samuel Kjaer Madsen, Troels Wienecke
Medication overuse headache (MOH) is the most prevalent chronic headache disorder with a prevalence between 1-2% worldwide. The disease has been acknowledged for almost 30 years, yet experts still disagree on how best to treat MOH. By performing a search in PubMed on the terms "medication overuse headache", "analgesics abuse headache", "rebound headache", "drug induced headache", and "headache AND drug misuse" limited to human studies published in English between January 1st 2004 and November 1st 2017, we aimed to evaluate current literature concerning predictors of treatment outcome, inpatient and outpatient treatment programs, initial versus latent administration of prophylactic medications, and to review the effect of prophylactic medications...
February 1, 2019: Acta Neurologica Scandinavica
Madhu Nagappa, Anita Mahadevan, Gangadhar Yashwanth, Shripad A Patil, Suresh Bokolia, Parayil S Bindu, Sanjib Sinha, Arun B Taly
BACKGROUND: Data on antibody profile in myasthenia gravis (MG) from India are limited. OBJECTIVES: To investigate antibody profile in patients with MG and their clinical correlates. PATIENTS AND METHODS: Patients of MG (n=85, M:F::1.1:1, mean age: 39.29±17.3 years, mean symptom-duration: 72.94±91.8 months) were evaluated for clinical features, MG foundation of America (MGFA) score, response to treatment and outcome at last follow-up. Antibodies to acetylcholine receptor (AChR), muscle-specific kinase (MUSK), titin and ryanodine-receptor (RYR) were analysed using ELISA...
January 28, 2019: Acta Neurologica Scandinavica
Melissa Song, Abraham Lieberman, Terry Fife, Megan Nielsen, Sharon Hayden, Marwan Sabbagh, Jiong Shi
OBJECT: We characterize idiopathic normal pressure hydrocephalus (NPH) following treatment with lumbar puncture (LP) and shunt placement through clinical evaluation and quantitative ProtoKinetics Zeno walkway assessments. We evaluate the symptomology by determining gait characteristics altered by treatment. METHODS: Patients at Barrow Neurological Institute (BNI) who underwent a lumbar puncture (LP, removing 30-32 ml cerebrospinal fluid) followed by ventriculoperitoneal shunt placement in February 2015 to February 2017 were analyzed for gait impairments...
January 24, 2019: Acta Neurologica Scandinavica
Annie Palstam, Emma Westerlind, Hanna C Persson, Katharina S Sunnerhagen
OBJECTIVES: Disability due to stroke imposes a large burden on individuals, and on society, in terms of impaired work ability and sick leave. The reported return to work (RTW) rate after stroke varies globally and is influenced by a range of different aspects. The aim of this study was to investigate the influence of work-related factors on time to RTW after stroke, and possible differences between the sexes. MATERIALS & METHODS: Data from 204 persons with first-time stroke in the years 2009-2010 in Gothenburg, Sweden, who were of working age and had worked prior to their stroke, were analysed...
January 18, 2019: Acta Neurologica Scandinavica
Trine Apostolaki-Hansson, Teresa Ullberg, Bo Norrving, Jesper Petersson
BACKGROUND: Intracerebral hemorrhage (ICH) is the most serious adverse effect of treatment with oral anticoagulants. Prognostic data after ICH associated with Non-Vitamin K Antagonist oral anticoagulants (NOAC) compared to vitamin-K antagonists (VKA) are sparse. We compared 90-day survival and functional outcome following NOAC-ICH versus VKA-ICH using data from the Swedish Stroke Register (Riksstroke). METHODS: Using data from Riksstroke and the Swedish Causes of Death Register between 2012 and 2016, we compared all-cause 90-day mortality for patients with NOAC-ICH versus VKA-ICH using Kaplan-Meier survival analysis and Log-rank test...
January 18, 2019: Acta Neurologica Scandinavica
Markus Axelsson, Nicolas Dubuisson, Lenka Novakova-Nyren, Clas Malmeström, Gavin Giovannoni, Jan Lycke, Sharmilee Gnanapavan
BACKGROUND: Little is known about what leads to recovery between relapses in multiple sclerosis (MS), particularly following treatment. In the past, it has been demonstrated thatsoluble neural cell adhesion molecule (sNCAM), a putative biomarker of neuroplasticity, increased following steroid treatment in the CSF of MS subjects undergoing acute relapses. Taking this a step further, we have evaluated the effect of disease-modifying treatment (DMTs) on CSF sNCAM levels in various subtypes of MS...
January 18, 2019: Acta Neurologica Scandinavica
Johannes Drescher, Florian Wogenstein, Charly Gaul, Peter Kropp, Dirk Reinel, Yannic Siebenhaar, Jörg Scheidt
OBJECTIVES: The purpose of this work is the analysis of migraine attack reports collected online within the project Migraine Radar in respect to the distribution of the migraine attacks over the week on a single-participant level. MATERIALS & METHODS: Recording data using a web app as well as smartphone apps made it possible to collect data of 44,639 migraine attacks of 1,085 participants who reported 7 or more attacks over a participation period of at least 90 days...
January 12, 2019: Acta Neurologica Scandinavica
Nurettin Özgür Doğan, Murat Pekdemir, Serkan Yilmaz, Elif Yaka, Adnan Karadaş, Uğur Durmuş, Nazire Avcu, Esra Koçkan
OBJECTIVES: The present study aimed to evaluate the efficacy and safety of intravenous metoclopramide for acute migraine treatment. MATERIALS & METHODS: A double-blind, randomized, parallel-group, placebo-controlled trial was carried out in an academic emergency department. After the patients were assessed for eligibility via the International Headache Society criteria for migraines, they were randomized into 10 mg intravenous metoclopramide and normal saline groups...
January 10, 2019: Acta Neurologica Scandinavica
Adam Strzelczyk, Susanne Knake, Reetta Kälviäinen, Estevo Santamarina, Manuel Toledo, Sophia Willig, Alexandra Rohracher, Eugen Trinka, Felix Rosenow
OBJECTIVE: Novel treatments are needed to control treatment-resistant status epilepticus (SE). We report a summary of clinical cases where perampanel was used in established SE, refractory SE (RSE), or super-refractory SE (SRSE). METHODS: Medical records were retrospectively reviewed for perampanel administration in SE at five European hospitals between 2011 and 2015. RESULTS: Of 1319 patients identified as experiencing SE, 52 (3.9%) received perampanel...
January 4, 2019: Acta Neurologica Scandinavica
Anthony Lamanna, Julian Maingard, Christen Barras, Hong Kuan Kok, Guy Handelman, Ronil V Chandra, Vincent Thijs, Duncan Mark Brooks, Hamed Asadi
Both carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for carotid artery stenosis. Several randomised controlled trials (RCTs) have compared CEA to CAS in the treatment of carotid artery stenosis. These studies have suggested that CAS is more strongly associated with periprocedural stroke, however CEA is more strongly associated with myocardial infarction. Published long-term outcomes report that CAS and CEA are similar. A reduction in complications associated with CAS has also been demonstrated over time...
January 4, 2019: Acta Neurologica Scandinavica
Dmitriy Viderman, Philip la Fleur, Federico Bilotta, Agzam Zhumadilov
BACKGROUND: Hemofiltration reduces blood levels of cytokines, glutamate and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients. METHODS: 37 patients (mean age 56±16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n=19) or standard treatment (n=18). The primary outcome of interest was the occurrence of adverse events during the 28 day period following the stroke symptom onset...
December 13, 2018: Acta Neurologica Scandinavica
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