Jia-Wei Lin, Chwen-Ming Shih, Yen-Chou Chen, Chien-Min Lin, Jo-Ting Tsai, Yung-Hsiao Chiang, Raymond Shih, Pei-Ling Chiu, Kuo-Sheng Hung, Yi-Shian Yeh, Li Wei, Wen-Ta Chiu, Liang-Yo Yang
BACKGROUND: Parkinson's disease, affecting at least 1% of population older than 65 years, is the most common neurodegenerative movement disorder. Up to now, no evidence has demonstrated that biochemical changes in CSF occur preceding the onset of Parkinson's symptoms. In this study, we tested the hypothesis that biochemical changes in CSF precede behavioral deficits in Parkinsonian animals. METHODS: We infused different doses of 6-OHDA into the MFB of rats bilaterally and examined the animals' movement behaviors, biochemical alterations in CSF, and dopaminergic neuronal number in the SNpc 1 week later...
December 2009: Surgical Neurology