Hong Jiang, Meng Zhang, Hui-Qin Wang, Ning-Ning Zhang, Xin-Mu Li, Xue-Ying Yang, Ai-Ping Chen, Xu Yan, Zhao Zhang, Shi-Feng Chu, Zhen-Zhen Wang, Nai-Hong Chen
Depression is a major chronic mental illness worldwide, characterized by anhedonia and pessimism. Exposed to the same stressful stimuli, some people behave normally, while others exhibit negative behaviors and psychology. The exact molecular mechanisms linking stress-induced depressive susceptibility and resilience remain unclear. Connexin 43 (Cx43) forms gap junction channels between the astrocytes, acting as a crucial role in the pathogenesis of depression. Cx43 dysfunction could lead to depressive behaviors, and depression down-regulates the expression of Cx43 in the prefrontal cortex (PFC)...
April 2, 2024: Pharmacology, Biochemistry, and Behavior