Panpan Lu, Yingjuan Li, Guangchun Dai, Yuanwei Zhang, Liu Shi, Ming Zhang, Hao Wang, Yunfeng Rui
Tendinopathy describes a complex pathology of the tendon characterized by abnormalities in the microstructure, composition, and cellularity of the tendon, leading to pain, limitation of activity and reduced function. Nevertheless, the mechanism of tendinopathy has not been fully elucidated, and the treatment of tendinopathy remains a challenge. High mobility group box 1 (HMGB1), a highly conserved and multifaceted nuclear protein, exerts multiple roles and high functional variability and is involved in many biological and pathological processes...
April 9, 2023: Connective Tissue Research