journal
https://read.qxmd.com/read/38126194/the-ratio-of-neutrophils-to-lymphocytes-effectively-predicts-clinical-outcomes-in-idiopathic-membranous-nephropathy
#21
JOURNAL ARTICLE
Qing Zhao, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Yang Huang, Yu Lin Huang, Feng Yong Jin, Qin Yi Wu, Gui Hua Wang, Xiong Zhong Ruan, Kun Ling Ma
BACKGROUND: Systemic inflammatory indicators are important in the prognoses of various diseases. Such indicators, including the neutrophil-to-lymphocyte ratio (NLR), can be meaningful in predicting the clinical outcome in patients diagnosed with idiopathic membranous nephropathy (IMN). MATERIALS AND METHODS: 112 IMN patients diagnosed by renal biopsy were recruited retrospectively. The endpoint was defined as a combination of partial and complete remission. Statistical analysis determined the independent factors associated with clinical remission and the predictive utility of NLR...
December 21, 2023: Clinical Nephrology
https://read.qxmd.com/read/38085074/determinants-of-the-serum-phosphate-concentration-in-chronic-kidney-disease
#22
JOURNAL ARTICLE
Elvira O Gosmanova, Darren E Gemoets, Sunny Dharia, Paul Der Mesropian, Gulvahid Shaikh, Csaba P Kovesdy, Kenneth R Phelps
If Ccr is creatinine clearance and EP and TRP are rates of phosphate excretion and reabsorption, the serum phosphate concentration (Ps ) is the sum of EP /Ccr and TRP /Ccr , i.e., the amounts of phosphate excreted and reabsorbed per volume of filtrate. At equilibrium, influx of phosphate into plasma determines EP , and EP /Ccr quantifies the contribution of phosphate influx to Ps . We used data obtained at 688 clinic visits of 387 patients to analyze the evolution of Ps in chronic kidney disease (CKD) stages G1 - 5 (dialysis excluded)...
December 12, 2023: Clinical Nephrology
https://read.qxmd.com/read/38050730/sarcopenia-an-overlooked-diagnosis-in%C3%A2-kidney-transplant-recipients
#23
JOURNAL ARTICLE
Seyda Gul Ozcan, Ozge Sonmez, Zeynep Atli, Cebrail Karaca, Selma Alagöz, Zafer Akman, Ali Egemen Koroglu, Salih Pekmezci, Sinan Trabulus, Nurhan Seyahi
Most studies of sarcopenia in renal transplant recipients (RTRs) have been hampered by a lack of standardization in the definitions of sarcopenia. In this study, we aimed to investigate the prevalence of sarcopenia and the associated factors in RTRs using the recently proposed criteria of the European Working Group on Sarcopenia in Older People 2018 (EWGSOP2), which included a standardized definition of sarcopenia. We examined 93 consecutive adult RTRs, 46 chronic kidney disease patients, and 46 healthy controls...
February 2024: Clinical Nephrology
https://read.qxmd.com/read/37969110/efficacy-of-roxadustat-in-maintenance-hemodialysis-patients-with-erythropoietin-hyporesponsive-anemia
#24
JOURNAL ARTICLE
Xiaoshuang Wang, Hezhou Cai, Haifan Xu, Liqun Chen
OBJECTIVE: To investigate the efficacy of roxadustat in hemodialysis patients with erythropoietin (EPO) hypo-responsive anemia. MATERIALS AND METHODS: This retrospective study included 55 hemodialysis patients with erythropoietin hypo-responsive anemia at the First Affiliated Hospital of Chongqing Medical University from January to December 2020. We observed their hemoglobin (Hb) changes, inflammatory factors, and adverse reactions before and after 12 weeks of roxadustat treatment...
January 2024: Clinical Nephrology
https://read.qxmd.com/read/37877297/comparative-analysis-of-roxadustat-efficacy-between-maintenance-hemodialysis-and-peritoneal-dialysis-patients
#25
JOURNAL ARTICLE
Liling Zhang, Yan Huang, Defeng Yin, Tingting Zhu, Qi Liu, Ying Li, Linwang Gan
BACKGROUND: This study evaluated the comparative efficacy of roxadustat for renal anemia between patients on maintenance hemodialysis (HD) and peritoneal dialysis (PD). MATERIALS AND METHODS: 93 maintenance dialysis patients who regularly followed up from August 2015 to June 2021 were enrolled. Despite receiving a therapeutic dose ≥ 12,000 U/week of erythropoiesis-stimulating agents (E+SA) in the past 12 weeks, this had not worked very well. Subjects were assigned to the HD group (n = 60) or the PD group (n = 33) based on their dialysis treatment modality...
January 2024: Clinical Nephrology
https://read.qxmd.com/read/37877298/pitfalls-in-anticoagulant-related-nephropathy
#26
JOURNAL ARTICLE
Romeo V Kock, Kenrick Berend, Sandrine Florquin, Hugo Ten Cate
Anticoagulant-related nephropathy (ARN) is a rare but important disease and often misdiagnosed. The hallmark of the diagnosis is acute kidney injury (AKI) superimposed on preexisting kidney disease due to anticoagulation-induced glomerular hemorrhage with histologic features of widespread tubular obstruction by red blood cells and red cell casts. As ARN is a diagnosis of exclusion only proven by renal biopsy, the diagnosis is often unlikely to be confirmed histologically because of fear of biopsy-related bleeding during anticoagulant therapy...
December 2023: Clinical Nephrology
https://read.qxmd.com/read/37870264/parakid-navigating-the-relation-between-paraproteins-and-kidney-lesions-a-multi-center-retrospective-observational-study
#27
MULTICENTER STUDY
Mythri Shankar, Urmila Anandh, Swarnalatha Guditi
INTRODUCTION: Monoclonal gammopathy is a heterogeneous group of disorders due to the clonal proliferation of immunoglobulin-producing plasma cells or B lymphocytes. Patients develop kidney disease not only due to malignant transformation but also due to the idiosyncratic properties of the M protein and the host factors. We aim to study the spectrum of kidney diseases in patients with paraproteinemia. MATERIALS AND METHODS: A retrospective observational study was performed at three tertiary care centers in Southern India...
December 2023: Clinical Nephrology
https://read.qxmd.com/read/38032142/renal-histology-of-fanconi-syndrome-associated-with-adefovir-dipivoxil-a%C3%A2-case-report
#28
JOURNAL ARTICLE
Shengchun Xu, Haifeng Ni, Min Wu, Xiaotong Xie, Bicheng Liu, Xiaoliang Zhang, Hong Liu
A sporadic occurrence of Fanconi syndrome associated with adefovir dipivoxil (ADV) has been reported, particularly when confirmed by renal biopsy. This study presents the case of a 53-year-old man who had been taking ADV 10 mg daily for 10 years to treat chronic hepatitis B (CHB) and subsequently developed Fanconi syndrome. The clinical manifestations included hypophosphatemic osteomalacia, glucosuria, renal tubular acidosis, low-molecular-weight proteinuria, and renal insufficiency. Renal biopsy revealed significant injury to proximal tubular epithelial cells, including vacuolar degeneration and regeneration of tubular epithelial cells...
November 30, 2023: Clinical Nephrology
https://read.qxmd.com/read/37997943/proteinuria-on-dipstick-urinalysis-in-a-woman-with-alkaline-urine
#29
JOURNAL ARTICLE
James Alstott
No abstract text is available yet for this article.
November 24, 2023: Clinical Nephrology
https://read.qxmd.com/read/37997942/body-composition-indices-as-predictors-of-humoral-response-to-mrna-vaccination-against-covid-19-in-patients-on-maintenance-hemodialysis
#30
JOURNAL ARTICLE
Konstantinos Tsiotsios, Anastasia Parthymou, Georgia Georgopoulou, Adamantia Mpratsiakou, George I Habeos, Dimitrios S Goumenos, Dionysios V Chartoumpekis, Evangelos Papachristou, Marios Papasotiriou
INTRODUCTION: Patients on maintenance hemodialysis show lower serological response to mRNA vaccines. Main causes that contribute to this phenomenon are uremic milieu and older age. However, there are no data on the impact of body composition parameters to humoral response. MATERIALS AND METHODS: In this retrospective study, we used data from adult patients on maintenance hemodialysis who received vaccination with 2 doses of BNT162b2. Quantitative determination of antibodies to SARS-CoV-2 spike (S) protein receptor binding domain was performed using the Elecsys immunoassay...
November 24, 2023: Clinical Nephrology
https://read.qxmd.com/read/37997941/insights-and-observations-from-a-multi-organ-nephrology-point-of-care-ultrasound-course
#31
JOURNAL ARTICLE
Abhilash Koratala, Nathaniel Reisinger
No abstract text is available yet for this article.
November 24, 2023: Clinical Nephrology
https://read.qxmd.com/read/37969111/characteristics-of-registered-research-in-peritoneal-dialysis-past-and-present
#32
JOURNAL ARTICLE
Martin L Li, Ankush Bajaj, Uttam Bhetuwal, Ankur D Shah
Recent national policy changes in the United States and the continued growth of peritoneal dialysis (PD) as a therapy for end-stage kidney disease has renewed interest in this modality. The objective of this study was to describe the current landscape of PD clinical trials to assess trends and gaps in clinical research. An advanced search was completed through ClinicalTrials.gov, yielding 248 studies. Descriptive statistics and Fisher exact tests were used for statistical analysis. Most studies were completed (197, 79...
November 16, 2023: Clinical Nephrology
https://read.qxmd.com/read/37942929/plasma-neutrophil-gelatinase-associated-lipocalin-predicts-renal-tubulointerstitial-injury-in-patients-with-iga-nephropathy
#33
JOURNAL ARTICLE
Wanwan Zhao, Jun Jiang, Wei Chen
OBJECTIVE: To investigate the relationship of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and urine neutrophil gelatinase-associated lipocalin (uNGAL) with clinical indicators and pathology in patients with IgA nephropathy (IgAN). MATERIALS AND METHODS: Clinical and pathological data of 36 patients with primary IgAN diagnosed by kidney biopsy were selected. The Oxford and Lee classifications were used to rank the pathology of IgAN patients and the particle-enhanced immunoturbidimetric method was adopted to measure pNGAL and uNGAL...
November 9, 2023: Clinical Nephrology
https://read.qxmd.com/read/37779451/hospital-at-home-meets-need-for-new-dialysis-patients
#34
JOURNAL ARTICLE
Justin Smith, Ayako Mayo, Susan B Gurley, Raghav Wusirika
The COVID-19 pandemic has had lingering effects in healthcare. During the pandemic, inpatient bed shortages became a major barrier to providing care, and access to outpatient dialysis was delayed due to a shortage of staff. This resulted in lengthy admissions to the hospital while awaiting outpatient dialysis placement in a time when hospital bedspace was a scarce resource. In this report we describe the use of the Hospital at Home program for inpatient dialysis care as a novel method to both provide high quality patient care at home and also open inpatient beds in the hospital...
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37779450/does-hydration-status-influence-kidney-volume-in-autosomal-dominant-polycystic-kidney-disease
#35
RANDOMIZED CONTROLLED TRIAL
Signe Vinsand Naver, Anja Møller Jensen, Martin Egfjord, Bjarne Ørskov, Maria Grostøl Ørnhøj Østergaard, Anne Dorte Blankholm, Eva Fallentin, Michael Pedersen, Jens Dam Jensen
Autosomal dominant polycystic kidney disease (ADPKD) is a progressive kidney disease where the size of the kidneys is correlated to the stage of kidney failure. Total kidney volume (TKV) is used as a prognostic marker to determine disease stage, progression, and possible effect of treatment. It has been shown that water restriction is associated with reduced kidney volume in healthy subjects. The aim of this study was to evaluate the relationship between TKV and hydration status in ADPKD patients. 40 ADPKD patients with chronic kidney disease stage 1 - 3 were randomized to either 3 hours of water restriction (n = 21) or 1 hour of water loading (n = 19; intake: 20 mL/kg)...
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37779449/risk-factors-for-low-humoral-response-to-bnt-162b2-in-hemodialysis-patients
#36
JOURNAL ARTICLE
Rui Duarte, Ivan Luz, Francisco Ferrer, Hernâni Gonçalves, Flora Sofia, Karina Lopes, Ana Vila Lobos
INTRODUCTION: Maintenance hemodialysis (HD) patients are at higher risk of both infection and mortality associated with the new SARS-CoV-2. Immunization through large-scale vaccination is the cornerstone of infection prevention in this population. This study aims to identify risk factors for low response to the BNT-162b2 (Pfizer BioNTech) vaccine in an HD cohort. MATERIALS AND METHODS: Observational prospective study of an HD group followed in a Portuguese Public Founded Hemodialysis Center who received BNT-162b2 vaccination...
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37675489/elevated-tacrolimus-levels-among-covid-19-kidney-transplant-recipients-are-associated-with-worse-disease-severity-and-clinical-outcomes
#37
JOURNAL ARTICLE
Angelito Yango, Bipin Bista, Bernard Fischbach, Shana Machado, Alexandra Clark, Sanna Khoja, Nicole Dion, Giovana Saracino, Jessica Taylor, Hoylan Fernandez, Sathishkumar Seeliyur Duraiswamy, Giuliano Testa
BACKGROUND: The therapeutic effects of immunosuppressive drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections causing coronavirus disease 2019 (COVID-19) are being actively investigated. However, COVID-19's potential effects on serum calcineurin inhibitor levels have only been described recently. This study aimed to evaluate COVID-19's effect on tacrolimus levels in renal transplant recipients with moderate to severe symptoms and to assess their potential correlation with disease severity...
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37577768/one-case-two-unequally-spectacular-and-life-threatening-critical-conditions
#38
JOURNAL ARTICLE
Florian G Scurt, Felix A Büstgens, Antonios Katsounas, Christos Chatzikyrkou
No abstract text is available yet for this article.
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37548466/a-subtle-presentation-of-acute-interstitial-nephritis-with-a-peculiar-etiology
#39
JOURNAL ARTICLE
Oluwadamilola Adisa, Neev Patel, Phani Morisetti, Karina Sulaiman
No abstract text is available yet for this article.
November 2023: Clinical Nephrology
https://read.qxmd.com/read/37877300/the-reasons-for-comparative-effectiveness-clinical-trials-of-arteriovenous-fistula-versus-graft-strategy-in-older-adults-on-hemodialysis-with-a-catheter
#40
JOURNAL ARTICLE
Mariana Murea, Michael Allon
Clinicians and patients are guided by observational studies to make one of the most consequential decisions for patients with advanced kidney disease: the selection of the "right" hemodialysis vascular access. More than a decade ago, a call for randomized clinical trials was made to equitably compare clinical outcomes between arteriovenous (AV) fistulas (AVFs) and AV grafts (AVGs). Mounting evidence suggests that trade-offs between AVF- and AVGrelated outcomes are context dependent. In this article, we summarize four streams of evidence that collectively underpin the burden of equipoise between the two types of AV access in older adults with comorbidities who are on hemodialysis with a central venous catheter...
October 25, 2023: Clinical Nephrology
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