journal
https://read.qxmd.com/read/36928261/nomogram-analysis-of-the-influencing-factors-of-rapid-renal-decline-in-patients-with-biopsy-proven-diabetic-nephropathy-in-type-2-diabetes
#1
JOURNAL ARTICLE
Yan Ma, Yuqian Ren, Di Hui, Lihua Zhang, Chengfeng Jiao, Honglang Xie
BACKGROUND: HbA1c variability may be related to risk of poor prognoses in chronic kidney disease patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate whether HbA1c variability is associated with rapid renal function decline and the related risk factors in type 2 diabetic nephropathy (DN). MATERIALS AND METHODS: An observational analysis was performed on 387 DN patients who were diagnosed by kidney biopsy from January 2006 through January 2016 at the Department of Nephrology, Jinling Hospital Affiliated to Nanjing University...
March 17, 2023: Clinical Nephrology
https://read.qxmd.com/read/36928260/kidney-cysts-in-patients-with-hoga1-variants
#2
JOURNAL ARTICLE
Dipal M Patel, Nicolas Page, Neera K Dahl
In an era of increased accessibility to genetic testing, nephrologists may be able to better understand pathophysiologic mechanisms by which their patients develop specific conditions. In this study, we describe clinical and genetic findings of two patients with kidney cysts, who were found to have variants in HOGA1 , a mitochondrial 4-hydroxy-2-oxoglutarate aldolase enzyme associated with primary hyperoxaluria type 3 and the development of oxalate-containing kidney stones. We describe possible mechanisms by which mutations in this enzyme could result in the kidney cyst formation seen in our two patients...
March 17, 2023: Clinical Nephrology
https://read.qxmd.com/read/36881881/effect-of-kidney-transplantation-on-cyst-growth-in-autosomal-dominant-polycystic-kidney-disease
#3
JOURNAL ARTICLE
Jorge E Gaytan-Arocha, Aaron Pérez-Segovia, Estefania Reul-Linares, Elisa Naomi Hernández-Paredes, Mónica Chapa-Ibargüengoitia, Ricardo Correa-Rotter, Luis E Morales-Buenrostro, Juan C Ramirez-Sandoval
BACKGROUND: In patients with autosomal dominant polycystic kidney disease (ADPKD), there is limited evidence of the rate of cyst progression after kidney transplantation. AIMS: To compare the height-adjusted total kidney volume (Ht-TKV) before and after transplantation in kidney transplant recipients (KTR) with -ADPKD. MATERIALS AND METHODS: Retrospective cohort study. The estimate of Ht-TKV was calculated by the ellipsoid volume equation using measurements from CT or yearly MRI scans before and after transplantation...
March 7, 2023: Clinical Nephrology
https://read.qxmd.com/read/36881880/clinical-features-and-prognosis-of-autosomal-dominant-polycystic-kidney-disease-with-cerebrovascular-complications
#4
JOURNAL ARTICLE
Zhe Li, Song Luo, Yang Wang, Yuchao Zhou, Shutian Xu, Ke Zuo, Shijun Li
OBJECTIVES: This retrospective study was used to evaluate the clinical and imaging characteristics and the prognosis of autosomal dominant polycystic kidney disease (ADPKD) with cerebrovascular complications. MATERIALS AND METHODS: We retrospectively analyzed 30 patients with ADPKD complicated with intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), unruptured intracranial aneurysms (UIAs), or Moyamoya disease (MMD) who were admitted to Jinling Hospital from January 2001 to January 2022...
March 7, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871229/three-year-safety-observation-of-subcutaneous-administration-of-epoetin-zeta-in-patients-with-chronic-renal-anemia-results-from-pasco-ii-study
#5
JOURNAL ARTICLE
Stavros Patsialas, Heather Fowler, Ruffy Guilatco, Stephanie Salts, Feng Richard Xia, Sonja Gomez Perez, Andreas Iwanowitsch, Matthias Kohnle
Epoetin has been used to treat patients with renal anemia since 1988. Anti-erythropoietin antibody-mediated pure red cell aplasia (PRCA) has been associated with epoetin usage, and a PRCA incidence of 4.5 per 10,000 patient-years was observed for epoetin-α (Eprex) in 2002. The PASCO II study (post-authorization safety cohort observation of Retacrit and Silapo (epoetin-ζ) administered subcutaneously for the treatment of renal anemia) followed 6,346 patients (4,501 Retacrit (group R); 1,845 Silapo (group S)) for up to 3 years of subcutaneous treatment with the biosimilar epoetin-ζ...
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871228/creatinine-based-equations-to-estimate-glomerular-filtration-rate-should-be-used-with-caution-in-patients-with-neurogenic-bladder
#6
JOURNAL ARTICLE
Yingchun Ma, Tianyu Xiang, Peng Wang, Limin Liao
BACKGROUND: Patients with neurogenic bladder (NGB) are at an increased risk of developing chronic kidney disease (CKD). However, data related to the real performance of the serum creatinine (Cr)-based estimated glomerular filtration rate (eGFR) equation in patients with NGB are limited. This study is to evaluate the performance of new Cr-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation without race and the GFR estimation equation for Chinese CKD patients for the estimation of GFR in Chinese patients with NGB...
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871227/mycophenolate-mofetil-associated-collagenous-ileitis-in-a-kidney-transplant-recipient-a-case-report
#7
JOURNAL ARTICLE
Boya Wang, Weiwei Xi, Hua Li
We report a case of mycophenolate mofetil-induced collagenous ileitis in a kidney transplant patient. A 38-year-old Chinese man who had received a kidney transplant 3 years earlier was admitted to our department for severe diarrhea and rapid weight loss. Infection studies were negative, and tumors were ruled out, so drug-induced factors were suspected. He had been taking mycophenolate mofetil for immunosuppression, which was then suspended, and he had a rapid resolution of diarrhea. Pathological findings of gastrointestinal endoscopy biopsy showed the presence of thickened collagen bands in the subepithelium of the terminal ileum...
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871226/persistent-acidosis-and-chronic-kidney-disease-in-a-patient-with-type-1-glycogen-storage-disease
#8
JOURNAL ARTICLE
Kai Xiong Lim, Yan Mee Law, Weiwen Guo
Type 1 glycogen storage disease (GSDI) is a rare autosomal recessive disorder caused by glucose-6-phosphatase (G6Pase) deficiency. We discuss a case of a 29-year-old gentleman who had GSDI with metabolic complications of hypoglycemia, hypertriglyceridemia, hyperuricemia, and short stature. He also suffered from advanced chronic kidney disease, nephrotic range proteinuria, and hepatic adenomas. He presented with acute pneumonia and refractory metabolic acidosis despite treatment with isotonic bicarbonate infusion, reversal of hypoglycemia, and lactic acidosis...
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871225/a-case-of-acute-oxalate-nephropathy-after-colonoscopy
#9
JOURNAL ARTICLE
Jianping Xiao, Dandan Li, Guiling Liu, Deguang Wang
No abstract text is available yet for this article.
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36871224/validity-of-estimated-glomerular-filtration-rate-equations-in-stage-5-chronic-kidney-disease-patients-a-cross-sectional-study
#10
JOURNAL ARTICLE
Kullaya Takkavatakarn, Tawatchai Chaiwatanarat, Paweena Susantitaphong, Pisut Katavetin, Kearkiat Praditpornsilpa
No abstract text is available yet for this article.
March 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36734158/renal-involvement-in-familial-mediterranean-fever-in-an-algerian-population
#11
JOURNAL ARTICLE
Ghalia Khellaf, Ali Benziane, Louiza Kaci, Djouher Ait-Idir, Soumia Missoum, Mohamed Benabadji
The objectives of this study were to investigate the clinical biological and histological renal involvement secondary to familial Mediterranean fever (FMF), the epidemiological data, genetics of our patients and their evolution under treatment. We prospectively studied 58 Algerian patients admitted in our nephrology department from January 2012 to January 2021. The diagnosis of nephropathy was suspected clinically and biologically and confirmed histologically. All our patients were tested for MEFV mutations...
February 3, 2023: Clinical Nephrology
https://read.qxmd.com/read/36708206/a-case-of-membranous-nephropathy-with-microspherular-deposits-progressing-to-collapsing-nephropathy-and-dialysis-dependency-but-with-full-recovery-following-immunosuppression
#12
JOURNAL ARTICLE
Matthew Sayer, Samuel Pattle, Paul J Phelan, Christopher O C Bellamy
Membranous nephropathy with microspherular deposits is a rare renal condition associated with sub-nephrotic or nephrotic-range proteinuria. We report a case presenting with severe nephrotic syndrome and pathological features of collapsing glomerulopathy. This is the first case we are aware of that progressed to requiring dialysis. The patient received rituximab and corticosteroids. She has now been off dialysis for over a year with both serum creatinine and urine protein-creatinine ratio returning to baseline...
January 28, 2023: Clinical Nephrology
https://read.qxmd.com/read/36683556/prevalence-and-outcomes-of-hypothyroidism-induced-acute-kidney%C3%A2-injury
#13
JOURNAL ARTICLE
Naga Sai Sri Harsha Narilla, Spoorthi Ramineni, Sirisha Yarlagadda, Varun Kumar Bandi
INTRODUCTION: Hypothyroidism is an important reversible cause of acute kidney injury (AKI), acting through various mechanisms, including rhabdomyolysis, metabolic, and systemic effects. MATERIALS AND METHODS: We screened all patients presenting with AKI for hypothyroidism, and suspected hypothyroid-induced AKI patients were followed up. RESULTS: The prevalence of hypothyroidism-induced AKI was 1.9%, with the commonest presenting symptom being pedal edema...
January 23, 2023: Clinical Nephrology
https://read.qxmd.com/read/36683555/low-immunoglobulin-g-concentrations-are-not-associated-with-an-increased-risk-of-peritoneal-dialysis-related-peritonitis
#14
JOURNAL ARTICLE
Geertje K M Biebuyck, Lily Jakulj, Aegida Neradova, Raymond T Krediet
BACKGROUND: Peritonitis is a common and severe complication of peritoneal dialysis (PD) and is associated with high morbidity and sometimes also with mortality. Identification of risk factors, as well as protective mechanisms for peritonitis, is important to reduce peritonitis-induced morbidity. According to the current literature, IgG concentrations might be associated with peritonitis in PD-treated patients. In this study, we aimed to investigate possible associations between dialysate or serum IgG concentration and peritonitis risk in a longitudinal cohort of PD-treated patients...
January 23, 2023: Clinical Nephrology
https://read.qxmd.com/read/36683554/urinary-biomarkers-to-predict-acute-kidney-damage-and-mortality-in-covid-19
#15
JOURNAL ARTICLE
Diana Racovitan, Maximilian Hogeweg, Adrian A Doevelaar, Maximilian Seidel, Benjamin Rohn, Sebastian Bettag, Sonja Rieckmann, Nina Babel, Felix S Seibert, Timm H Westhoff
INTRODUCTION: Acute kidney injury (AKI) is a frequent condition in patients hospitalized for COVID-19. There are only a few reports on the use of urinary biomarkers in COVID-19 and no data so far comparing the prognostic use of individual biomarkers in the prediction of adverse outcomes. MATERIALS AND METHODS: We performed a prospective mono-centric study on the value of urinary biomarkers in predicting the composite endpoint of a transfer to the intensive care unit, the need for renal replacement therapy, mechanical ventilation, and in-hospital mortality...
January 23, 2023: Clinical Nephrology
https://read.qxmd.com/read/36633377/impact-of-focal-segmental-glomerulosclerosis-over-the-past-decade
#16
JOURNAL ARTICLE
Keng Thye Woo, Choong Meng Chan, Marjorie Foo, Cynthia Lim, Jason Choo, Yok Mooi Chin, Esther Wei Ling Teng, Irene Mok, Jia Liang Kwek, Hui Zhuan Tan, Alwin H L Loh, Jiunn Wong, Terence Kee, Hui Lin Choong, Han Khim Tan, Kok Seng Wong, Puay Hoon Tan, Chieh Suai Tan
OBJECTIVE: This is a study on the demographics and clinical outcomes including the response to therapy of patients with focal segmental glomerulosclerosis (FSGS) over the past decade. MATERIALS AND METHODS: All histologically proven FSGS cases diagnosed between 2008 and 2018 were analyzed for their clinical, laboratory, and histological characteristics including treatment that could influence the disease progression and renal outcome of these patients. We used the Columbia Classification for FSGS for the renal biopsy...
January 12, 2023: Clinical Nephrology
https://read.qxmd.com/read/36602281/renal-injury-associated-with-myh9-disorder-with-5773delg-mutation-a-case-report
#17
JOURNAL ARTICLE
Kazuhiro Yoshikawa, Shinji Kunishima, Hidetake Kurihara, Kei Takahashi, Azumi Fukuta, Kazunori Murai, Taketora Echizenya, Izaya Nakaya, Jun Soma
A 35-year-old man with persistent urine abnormalities and renal dysfunction was referred to our hospital. May-Hegglin anomaly was suspected, and a renal biopsy showed focal segmental glomerulosclerosis (FSGS) with IgA deposition. Electron microscopy revealed foot process effacements and intense bleb-like morphological changes in podocytes. Nonmuscle myosin heavy chain IIA (NMMHCIIA) staining of granulocytes revealed a localized, type II pattern, and genomic DNA sequencing of MYH9 exon 40 revealed MYH9 5773delG mutation (c...
January 5, 2023: Clinical Nephrology
https://read.qxmd.com/read/36633378/polypharmacy-in-cardiorenal-syndrome-patients
#18
JOURNAL ARTICLE
Shahrukh Hashmani, Rakesh Madhyastha, Wasim El Nekidy, Bassam Atallah, Feras Bader, Nizar Attallah
Cardiorenal syndrome (CRS) is a term defined as complex interactions between concomitant cardiac and renal dysfunction in which disease of one organ initiates, perpetuates, and/or accelerates the decline in the other. It accounts for a third of presentations with heart failure and is associated with poor clinical outcomes. Polypharmacy (defined as using five or more medications) is common in CRS patients and is associated with worst clinical outcomes. The risk for polypharmacy increases to several fold with associated comorbidities, poses risks to the overall health of the patient, and enhances non-compliance to essential medications...
March 2023: Clinical Nephrology
https://read.qxmd.com/read/36472405/incremental-peritoneal-dialysis-is-it-better-for-preservation-of-residual-kidney-function-and-clinical-outcomes
#19
JOURNAL ARTICLE
Adriana Fernandes, Patrícia Matias, Patrícia Branco
INTRODUCTION: Incremental peritoneal dialysis (IPD) is based on the prescription of a dose lower than the standard (SPD). The combination of residual kidney function (RKF) and peritoneal clearance achieves clearance goals. The aim of this study is to compare the outcomes of IPD with SPD. MATERIALS AND METHODS: This was a single-center, retrospective study that included a cohort of prevalent peritoneal dialysis (PD) adults. Patients were assigned according to their first PD protocol in two groups - group A: IPD protocol (continuous ambulatory PD: less than 4 dwells daily, less than 2 L dwell volume, and/or treatment less than 7 days/week; automated PD: without a long dwell, less than 10 L daily delivered, and/or treatment for less than 7 days/week); group B: SPD protocol...
January 2023: Clinical Nephrology
https://read.qxmd.com/read/36546764/familial-polycystic-kidneys-with-no-genetic-confirmation-are-we-sure-it-is%C3%A2-adpkd
#20
JOURNAL ARTICLE
Manuela Rizzo, Ilaria Pezone, Maria Amicone, Ivana Capuano, Pasquale Buonanno, Eleonora Riccio, Antonio Pisani
Autosomal dominant polycystic kidney disease (ADPKD) is the most common heritable multifocal cystic disease encountered in clinical practice, and it is usually diagnosed in patients with family history by the evidence of markedly enlarged kidneys with multiple bilateral cysts at ultrasound (U.S.), computed tomography (CT) scan, or magnetic resonance imaging (MRI). In most cases, genetic testing is not required. Though ADPKD diagnosis is often straightforward, misdiagnosis is possible. Here we present a case of ADPKD misdiagnosis, followed by a review of the most important kidney heritable multifocal cystic diseases...
December 22, 2022: Clinical Nephrology
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