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Clinical Nephrology

Shunsuke Kobayashi, Takeo Yasu, Kenji Momo
No abstract text is available yet for this article.
February 10, 2019: Clinical Nephrology
Deidra C Crews, Aminu K Bello, Gamal Saadi, For The World Kidney Day Steering Committee
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
February 1, 2019: Clinical Nephrology
Rhian L Clissold, Coralie Bingham, Charles Shaw-Smith
No abstract text is available yet for this article.
January 28, 2019: Clinical Nephrology
Anders Helldén, Ulf Bergman, Ingegerd Odar-Cederlöf
AIM: To compare renal function by several GFR formulas (particularly cystatin C eGFR-"CAPA") in relation to renal risk drugs (RRDs) in patients admitted to two geriatric wards in a university geriatric department. MATERIALS AND METHODS: This was a prospective quality improvement study including 108 patients, 2/3 women, age ≥ 75 years, admitted with multimorbidity. Renal function tests were performed with Cockcroft & Gault with uncalibrated (C&Guc) and calibrated creatinine (C&Gcc), and 3 - 4 points' iohexol clearance (mGFR) in mL/min, and eGFR with MDRD4, CKD-EPI, CAPA, and BIS2 clearance in mL/min/1...
January 28, 2019: Clinical Nephrology
Ertugrul Erken, Orcun Altunoren, Mahmut Egemen Senel, Deniz Tuncel, Tugba Yilmaz, Safa Ersen Ganidagli, Didem Demircioglu, Ozkan Gungor
BACKGROUND: Cognitive impairment is common among hemodialysis (HD) patients and is associated with poor treatment compliance and mortality. The aim of this study is to evaluate relatively young HD patients with less comorbidities using the Montreal Cognitive Assessment (MoCA) and identify clues for earlier detection of cognitive impairment with the help of cognitive subscale scores. MATERIALS AND METHODS: A total of 103 chronic HD patients (mean age 48.3 years) and 37 stage-3 to 5 chronic kidney disease (CKD) patients with similar demographics were included...
January 28, 2019: Clinical Nephrology
Jin Deng, Huan Xie, Lin Zhu, Lei Luo, Hongping Xie
AIM: Maintenance therapy for lupus nephritis (LN) remains controversial. This meta-analysis of randomized controlled trials (RCTs) describes the comparative benefits and safety of mycophenolate mofetil (MMF) versus azathioprine (AZA) as maintenance therapy in patients with LN. MATERIALS AND METHODS: RCTs that compared the maintenance regimens of MMF and AZA in the treatment of LN were included. Outcomes were mortality, end-stage renal disease (ESRD), renal relapse, doubling of serum creatinine, and adverse effects...
January 28, 2019: Clinical Nephrology
Jan Schiefer, Christos Chatzikyrkou, Peter R Mertens, Vassilios Liakopoulos
No abstract text is available yet for this article.
January 21, 2019: Clinical Nephrology
Keng-Thye Woo, Choong-Meng Chan, Cynthia Lim, Jason Choo, Yoke Mooi Chin, Wei Ling Teng, Alwin H L Loh, Hui-Lin Choong, Han-Kim Tan, Kok-Seng Wong, Grace S L Lee, Evan J C Lee, Stephanie Fook-Chong, Puay Hoon Tan, Marjorie Foo
This review of 3,289 native kidney biopsies over the past four decades in Singapore documents the changing pattern of biopsy-proven glomerulonephritis (GN)from that of a third world country to that of a developed nation. In the 1st decade, mesangial proliferative GN was the most common form of primary GN, similar to the Asian region. In the 2nd decade, the percentage of mesangial proliferative GN decreased, but membranous GN became more common, as was seen in China and Thailand. In the 3rd decade, focal segmental glomerulosclerosis (FSGS) and membranous nephropathy continued to rise, but it was only recently, in the 4th decade, that FSGS prevalence increased dramatically, although membranous nephropathy continues to increase in some Asian countries...
January 21, 2019: Clinical Nephrology
Fahad Saeed, Muhammad Adil Sardar, Sara N Davison, Haris Murad, Paul R Duberstein, Timothy Edward Quill
BACKGROUND: Few studies have explored dialysis patients' perspectives on dialysis decision-making and end-of-life-care (EoLC) preferences. We surveyed a racially diverse cohort of maintenance dialysis patients in the Cleveland, OH, USA, metropolitan area. MATERIALS AND METHODS: In this cross-sectional study, we administered a 41-item questionnaire to 450 adult chronic dialysis patients. Items assessed patients' knowledge of their kidney disease as well as their attitudes toward chronic kidney disease (CKD) treatment issues and EoLC issues...
January 21, 2019: Clinical Nephrology
Maggie Ming Yee Mok, Christopher T Chan
BACKGROUND AND AIMS: Intensive hemodialysis is associated with more frequent arteriovenous (AV) access complications. We performed a retrospective cohort study to ascertain potential risk factors associated with access dysfunction in a cohort of nocturnal home hemodialysis (HHD) patients. MATERIAL AND METHODS: Consecutive patients undergoing HHD from October 1999 to November 2015 using an AV access were included. Patient demographics and clinical variables were collected...
January 21, 2019: Clinical Nephrology
Corey Cavanaugh, Gilbert W Moeckel, Mark A Perazella
Telavancin is a lipoglycopeptide semi-synthetic derivative of vancomycin used for select infections caused by Gram-positive bacteria including Staphylococcus aureus . Human clinical trials suggest that telavancin is potentially nephrotoxic, however there is no histopathologic description of acute kidney injury (AKI) in humans. An animal model has recently characterized the histologic changes associated with telavancin-induced AKI as proximal tubular injury with numerous phagolysosomes. We present a case of a 47-year-old man with methicillin-resistant Staphylococcus aureus bacteremia treated with telavancin, who developed AKI after 5 weeks of intravenous therapy...
January 7, 2019: Clinical Nephrology
Yanan Lv, Xiaomei Li, Shaoshan Liang, Dandan Liang, Feng Xu, Xiaodong Zhu, Caihong Zeng
AIMS: To investigate the clinicopathological features and outcomes of adefovir dipivoxil (ADV)-related renal impairment in Chinese patients. MATERIALS AND METHODS: Clinical, pathological, and follow-up data from 15 patients with ADV-related renal impairment were studied. Proximal renal tubular dysfunction (PRTD) was defined by the presence of at least two of the following four abnormalities: hypophosphatemia, hypouricemia, nondiabetic glucosuria, and proteinuria...
January 7, 2019: Clinical Nephrology
Gert Jensen, Lasse G Gøransson, Anders Fernström, Hans Furuland, Jeppe H Christensen
AIMS: Iron deficiency is common in patients with chronic kidney disease (CKD). Appropriate iron substitution is critical and intravenous iron is an established therapy for these patients. The objective of this study was to assess treatment routine, -effectiveness, and safety of iron isomaltoside (Monofer® (Pharma-cosmos A/S, Holbaek, Denmark) in CKD patients in clinical practice. MATERIALS AND METHODS: This was a prospective observational study conducted in predialysis CKD patients treated with iron isomaltoside according to the product label and to routine clinical care...
January 7, 2019: Clinical Nephrology
Amrit Kirpalani, Lana Rothfels, Ajay P Sharma, Carmen Rodriguez Cuellar, Guido Filler
BACKGROUND: Several factors may decrease plasma protein binding of mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), and potentially enhance its clearance. It is unclear if MMF dose adjustments are required for the treatment of steroid-resistant nephrotic syndrome (SRNS). Therapeutic drug monitoring of MPA levels is not widely utilized in the treatment of steroid-resistant nephrotic syndrome (SRNS). MATERIALS AND METHODS: In this retrospective cohort study, the authors measured 182 MPA predose trough levels (1 - 45/patient, HPLC/MS/MS) in 10 patients aged 0...
December 21, 2018: Clinical Nephrology
Alicia Molina-Andújar, Jacqueline Del Carpio, Adriana García-Herrera, Yolanda Arce, Jordi Bover
No abstract text is available yet for this article.
December 21, 2018: Clinical Nephrology
Abhilash Koratala, Deepti Bhattacharya, Amir Kazory
No abstract text is available yet for this article.
December 19, 2018: Clinical Nephrology
Mary Hammes, Rita L McGill, Anindita Basu, Tom Blicharski, Kristie Delaney
AIM: Arteriovenous fistulas (AVF) are the optimal vascular access for hemodialysis although many fistulas fail. The impetus to increase hemodialyzer blood flow (QB) in order to maximize solute clearances may be counterbalanced if AVF suffer adverse hemodynamic effects from accelerated pump flows. The optimal QB to maintain adequate hemodialysis without potentially contributing to AVF dysfunction is unknown. The aim of this study was to measure the hemodynamic effects of increased QB on AVF...
December 11, 2018: Clinical Nephrology
Amir Hossein Goudarzian, Azar Jafari, Belgüzar Kara, Mozhgan Taebi, Hedayat Jafari
BACKGROUND: Patients on hemodialysis can experience thirst distress. However, there is no valid and reliable Persian instrument to measure this condition in such patients. The present study aims to determine the psychometric properties of the Persian version of the thirst distress scale (TDS) for patients on hemodialysis. MATERIALS AND METHODS: Our sample consisted of 142 hemodialysis patients completed the TDS Persian version. The face, content, and construct validity of the scale were ascertained...
December 11, 2018: Clinical Nephrology
Thomas A Mavrakanas, Karl Asfour, Murray Vasilevsky, Paul E Barré, Ahsan Alam
AIMS: Different prediction models have been established to estimate mortality in the dialysis population. This study aims to externally validate the different available mortality prediction models in an incident dialysis population. MATERIALS: This was a retrospective cohort study of incident hemodialysis and peritoneal dialysis patients at two academic tertiary care centers. METHODS: Three previously published prediction models were used: the Liu index, the Urea5 score, and a predictive model estimating the survival probability by Hemke et al...
December 11, 2018: Clinical Nephrology
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