journal
https://read.qxmd.com/read/38860316/metabolic-acidosis-and-sexual-dysfunction-in-chronic-kidney-disease-in-predialysis-group-cross-sectional-study-from-a-single-center
#1
JOURNAL ARTICLE
Elif Ilhan, Sibel G Bek, Irem Sarıoglu, Sibel Balcı, Ozge Tekdemir, Metin Ergül, Erkan Dervisoglu, Betul Kalender
OBJECTIVES: This study aimed to investigate the prevalence of sexual disorders in stage 2 - 5 chronic kidney disease (CKD) during predialysis and its relationship with laboratory parameters. METHODS AND RESULTS: This cross-sectional study included 110 predialysis patients and 110 healthy controls admitted to clinics. The International Index of Erectile Function (IIEF) and Female Sexual Function Index (FSFI) were used. Sexual dysfunction was detected in 76% of female patients and 31...
June 11, 2024: Clinical Nephrology
https://read.qxmd.com/read/38856027/decreased-iga-binding-levels-were-accompanied-by-increased-igg-sialylation-in-iga-nephropathy
#2
JOURNAL ARTICLE
Youxia Liu, Hongshan Chen, Hongfen Li, Fanghao Wang, Yue Xing, Zhanfei Wu, Wenying Li, Junya Jia, Tiekun Yan
INTRODUCTION: IgA nephropathy (IgAN) is a kidney disorder characterized by the deposition of circulating immune complexes of IgG bound to galactose-deficient IgA1 (Gd-IgA1) in the mesangial glomeruli. However, limited research has been conducted on the levels of IgA binding in relation to the various sialylation profiles of IgG in IgAN. MATERIALS AND METHODS: Sialylated IgG (SA-IgG) and desialylated IgG (DSA-IgG) were isolated from IgAN patients. The IgG-IgA immune complex (IgG-IgA-IC) was detected using two customized commercial ELISA kits...
June 10, 2024: Clinical Nephrology
https://read.qxmd.com/read/38845461/hypercalcemia-of-malignancy-cancer-treatment-can-be-a-cause-as-well
#3
JOURNAL ARTICLE
Hassan Izzedine, Rose Mary Attieh, Farhana Begum, Yee-Ming Melody Cheung, Kenar D Jhaveri
While the incidence of hypercalcemia of malignancy (HCM) is on the decline, it still occurs in up to 30% of patients with cancer. Immune checkpoint inhibitor (ICI)-related hypercalcemia is becoming increasingly recognized. We describe a case of cemiplimab-induced hypercalcemia in a patient with metastatic squamous cell carcinoma of the earlobe and discuss a management algorithm for HCM. Timely diagnosis and management of HCM is critical for optimal care and the prevention of complications.
June 7, 2024: Clinical Nephrology
https://read.qxmd.com/read/38836368/sagliker-syndrome-in-a-patient-with-end-stage-renal-disease-and-uncontrolled-secondary-hyperparathyroidism
#4
JOURNAL ARTICLE
Yuefang Ru, Lingjie Xue, Min-Gang Zhu, Xiaolan Ye, Er-Min Gu
No abstract text is available yet for this article.
June 5, 2024: Clinical Nephrology
https://read.qxmd.com/read/38836367/phosphorus-chronicles-of-the-epistemology-of-a-vital-element
#5
JOURNAL ARTICLE
Garabed Eknoyan, Eleanor D Lederer
It was in the philosopher's stone quest that the alchemist Hennig Brand isolated chemiluminescent white phosphorus (P), Greek for "light bearer", from urine in 1669. By 1771 phosphorus was isolated from bone, and in 1777 it was identified by Antoine Lavoisier as a highly reactive element that exists predominantly in nature as ionic phosphate (PO4 3- ) and in solution as phosphoric acid (H3 PO4 ). Early 20th century studies revealed phosphorylated biomolecules as essential components of replicative nuclear material (RNA, DNA), a metabolic source of energy (ATP), and structural components of cellular membrane (phospholipid bilayer)...
June 5, 2024: Clinical Nephrology
https://read.qxmd.com/read/38836366/igg4-associated-disease-with-systemic-lupus-erythematosus-a-case-report-and-review
#6
JOURNAL ARTICLE
Ruyi Xie, Huimin Li, Xian Wang, Xiaowei Li
We report a 67-year-old man who presented with poor dietary intake and fatigue. Laboratory tests showed leukopenia, antinuclear antibody (ANA) positivity, anti-dsDNA antibody (A-dsDNA) and anti-Smith antibody (anti-Sm) negativity, decreased C3 and C4, elevated serum immunoglobulin G (IgG), IgG4, and creatinine, and 1.25 g urinary protein at 24 hours. As his condition worsened, re-examination showed thrombocytopenia and A-dsDNA positivity, and renal biopsy pathology showed IgG4-related tubulointerstitial nephritis...
June 5, 2024: Clinical Nephrology
https://read.qxmd.com/read/38836365/membranous-like-glomerulopathy-with%C3%A2-masked-monotypic-igg-deposits-a%C3%A2-single-center-case-series
#7
JOURNAL ARTICLE
Rosemary Attieh, Kumail Merchant, Yihe Yang, Christine Sethna, Kenar D Jhaveri
BACKGROUND: Membranous-like glomerulopathy with masked monoclonal IgG deposits (MGMID) is a newly recognized condition predominantly observed in young females, and its understanding in the pediatric population remains limited. MATERIALS AND METHODS: Four cases of MGMID are reported, including three pediatric patients. RESULTS: All patients were female, with ages ranging from 12 to 26 years. None of the patients had malignancies. They presented with kidney dysfunction, proteinuria, or hematuria...
June 5, 2024: Clinical Nephrology
https://read.qxmd.com/read/38818714/mind-the-gap-in-kidney-care-translating-what-we-know-into-what-we-do
#8
JOURNAL ARTICLE
Valerie A Luyckx, Katherine R Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W S Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, Alessandro Balducci
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target...
May 31, 2024: Clinical Nephrology
https://read.qxmd.com/read/38726574/first-episode-of-febrile-urinary-tract%C3%A2-infection-in-children-detection-and-risk-factors-of-kidney-scarring-a%C3%A2-prospective-cohort-study
#9
JOURNAL ARTICLE
Despoina Tramma, Vaia Dokousli, Despoina Samourkasidou, Nikolaos Gkiourtzis
AIMS: This prospective study aimed to evaluate the characteristics and findings of children who presented with acute pyelonephritis (APN) and to determine the independent risk factors for kidney scarring. MATERIAL AND METHODS: Patients who satisfied the following criteria were enrolled in the study: first known episode of APN; at least two of the following findings: fever ≥ 38.5 °C, white blood cell count ≥ 10,000/mm3 , erythrocyte sedimentation rate ≥ 20 mm/h, C-reactive protein ≥ 20 mg/dL; absence of congenital abnormalities or other kidney and systemic diseases, except vesicoureteral reflux (VUR); no APN relapses until the time of kidney scar detection...
May 10, 2024: Clinical Nephrology
https://read.qxmd.com/read/38699986/variable-phenotype-and-genotype-of-pediatric-patients-with-hnf1b-nephropathy
#10
JOURNAL ARTICLE
Bora Gülhan, Ozan Ekici, İsmail Dursun, Nilüfer Göknar, Selçuk Yüksel, Demet Alaygut, Zeynep Birsin Özçakar, Hülya Nalçacıoğlu, Beltinge Demircioğlu Kılıç, Oğuz Söylemezoğlu, Ali Duzova, Rezan Topaloglu, Fatih Ozaltin
AIMS: Hepatocyte nuclear factor 1β ( HNF1B ) mutations are the most common monogenic cause of congenital anomalies of the kidney and urinary tract (CAKUT). We aimed to investigate clinical and genetic characteristics of patients with HNF1B nephropathy to expand its phenotypic and genetic spectrum. MATERIALS AND METHODS: This retrospective cohort study included 16 unrelated pediatric patients (6 females, 10 males) from 13 families with genetically confirmed HNF1B -related nephropathy...
May 3, 2024: Clinical Nephrology
https://read.qxmd.com/read/38699985/spectrum-of-renal-disease-in-scleroderma-other-than-scleroderma-renal-crisis-a-review-of-the-literature
#11
JOURNAL ARTICLE
Larabe Farrukh, Virginia Steen, Lee Shapiro, Geovani Faddoul, Swati Mehta
BACKGROUND: Systemic sclerosis (SSc) is a multi-system rheumatic disease characterized by vascular and fibrotic manifestations that can affect practically every organ. Scleroderma renal crisis (SRC) is the most common renal manifestation of SSc. However, with the use of angiotensin-converting enzyme inhibitors (ACEi), the morbidity and mortality associated with SRC has significantly reduced. Renal manifestations in SSc other than SRC have been generally under-recognized and can be left untreated, which can lead to grave consequences in this patient population...
May 3, 2024: Clinical Nephrology
https://read.qxmd.com/read/38699984/shorter-observation-times-and-smaller-gauge-needles-in-outpatient-kidney-biopsies
#12
JOURNAL ARTICLE
Larab L Giniyani, James McGee, Maria V DeVita, Revana T Rahman, Andrew A Moses, Jordan L Rosenstock
Controversy exists as to the optimal observational time (OT) after outpatient percutaneous kidney biopsy. Further, there is some uncertainty about the benefit of smaller (18-gauge) vs. larger (16-gauge) biopsy needles. At our institution, we have been lowering the OT after outpatient kidney biopsies. Initially in 2015, we were monitoring for 6 hours and gradually began to decrease the OT over time. From 2020, we have adopted an OT of less than 4 hours. During this time period (in 2018), we also began using a smaller gauge needle (18 gauge)...
May 3, 2024: Clinical Nephrology
https://read.qxmd.com/read/38699983/a-comparative-analysis-of-kidney-allograft-outcomes-in-steroid-use-versus-steroid-discontinuation-after-basiliximab-and-atg-induction-a%C3%A2-unos-database-study
#13
JOURNAL ARTICLE
Pitchaphon Nissaisorakarn, Het Patel, Francesca Cardarelli, Aala Amtul
BACKGROUND AND OBJECTIVES: The relative safety and efficacy of early steroid withdrawal in kidney transplant patients after basiliximab compared to anti-thymocyte globulin (ATG) induction therapy is unknown. We aimed to compare kidney allograft outcomes in steroid use versus steroid discontinuation after basiliximab and ATG induction from the United Network for Organ Sharing (UNOS) database. MATERIALS AND METHODS: We conducted a retrospective cohort analysis of the UNOS database and included first kidney transplant recipients who received ATG or basiliximab induction therapy...
May 3, 2024: Clinical Nephrology
https://read.qxmd.com/read/38660889/incorporating-genetic-testing-into-a-routine-kidney-clinic
#14
JOURNAL ARTICLE
Jingjing Zhang, Wing Zeng, Seyed Hamrahian, Omar H Maarouf
Incorporating genetic testing in routine outpatient nephrology clinic can improve on chronic kidney disease (CKD) diagnosis and utilization of precision medicine. We sent a genetic test on patients with atypical presentation of common kidney diseases, electrolytes derangements, and cystic kidney diseases. We were able to identify a gene variant contributing to patients' kidney disease in more than half of our cohort. We then showed that patients with ApoL1 risk allele have likely worse kidney disease, and we were able to confirm genetic focal segmental glomerulosclerosis (FSGS) in 2 patients and avoid unnecessary immunosuppression...
April 25, 2024: Clinical Nephrology
https://read.qxmd.com/read/38660888/rituximab-treatment-in-resistant-lupus%C3%A2-nephritis-a-single-center-prospective-study
#15
JOURNAL ARTICLE
Shahzad Alam, Mastakim Ahmed Mazumder, Manjuri Sharma, Pranab Jyoti Mahanta, Manzoor Ahmand Parry, Prodip Kumar Doley
BACKGROUND: Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE) and failure to respond to traditional immunosuppression increases morbidity and mortality. Rituximab has been considered a novel therapeutic option for the management of SLE. MATERIALS AND METHODS: We conducted a single-center, prospective, observational study from July 2018 to June 2019 to evaluate the effectiveness of rituximab in patients with resistant LN. Resistant LN was defined as the failure to respond to conventional immunosuppressive therapy including both cyclophosphamide and mycophenolate mofetil...
April 25, 2024: Clinical Nephrology
https://read.qxmd.com/read/38629745/physical-functional-capacity-assessment-in-children-with-chronic-kidney-disease-a-cross-sectional-observational-study
#16
JOURNAL ARTICLE
Himani Goswami, Harda Shah, Kinnari Vala, Shahenaz Kapadia, Bharat Tiwari, Anshuman Saha
BACKGROUND: Chronic kidney disease (CKD) leads to reduced muscle mass and strength in children resulting in a decrease in functional capacity. The objectives of this cross-sectional observational study were to evaluate and compare the functional capacity and muscle strength in children with CKD stage I - V (group A), on dialysis (stage VD) (group B), and kidney transplant recipients (KTR) (group C) in Indian children. MATERIALS AND METHODS: 60 children, 20 each in groups A, B, and C were enrolled...
April 17, 2024: Clinical Nephrology
https://read.qxmd.com/read/38629744/application-of-improved-glomerular-filtration-rate-estimation-by-a-neural-network-model-in-patients-with-neurogenic-lower-urinary-tract-dysfunction
#17
JOURNAL ARTICLE
Ying-Chun Ma, Yang Xie, Limin Liao
BACKGROUND: Previous studies have indicated that creatinine (Cr)-based glomerular filtration rate (GFR) estimating equations - including the new Chronic Kidney Disease Epidemiology creatinine (CKD-EPIcr ) equation without race and the estimated glomerular filtration rate (eGFR) equation developed for the Chinese population - displayed suboptimal performance in patients with neurogenic lower urinary tract dysfunction (NLUTD), which limited their clinical application for detecting changes in GFR levels in all cohorts...
April 17, 2024: Clinical Nephrology
https://read.qxmd.com/read/38606849/effect-of-cyclophosphamide-combined-with-glucocorticoid-therapy-on-idiopathic-membranous-nephropathy-a-multicenter-open-label-randomized-controlled-trial
#18
JOURNAL ARTICLE
Jianlin Wang, Dong Bian, Jian Sun
OBJECTIVE: We aimed to evaluate the effect of cyclophosphamide combined with glucocorticoid therapy on idiopathic membranous nephropathy through a multicenter open-label randomized controlled trial. MATERIALS AND METHODS: 92 patients with idiopathic membranous nephropathy admitted from March 2020 to September 2022 were included and assigned to a control group (n = 46) and a research group (n = 46) using a random number table. The control group was given glucocorticoid, and the research group was given cyclophosphamide combined with glucocorticoid...
April 12, 2024: Clinical Nephrology
https://read.qxmd.com/read/38606848/evaluating-prescription-of-angiotensin-converting-enzyme-inhibitors-or-angiotensin-ii-receptor-blockers-in-patients-with-diabetes-and-albuminuria
#19
JOURNAL ARTICLE
Kittiphan Chienwichai, Phirada Chaloemwa, Sorawat Sangkaew, Arunchai Chang
AIM: Although guidelines recommend the use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) in patients with diabetes, hypertension, and albuminuria, their use remains suboptimal in several developed countries. Limited data are available on ACEi/ARB use in developing countries. Here, we assessed the use of ACEi/ARB and identified factors contributing to their underutilization at Hatyai Hospital, Thailand. MATERIALS AND METHODS: This retrospective cross-sectional study was conducted using data from the Hatyai Hospital database...
April 12, 2024: Clinical Nephrology
https://read.qxmd.com/read/38577748/tolvaptan-therapy-for-edema-in-patients-with-chronic-kidney-disease
#20
JOURNAL ARTICLE
Li Zhou, Qianqian Xu, Xuehua Xi, Xueying Yu, Wenge Li
OBJECTIVE: Tolvaptan is a vasopressin V2 receptor antagonist that is commonly prescribed to alleviate edema associated with renal diseases. However, the clinical benefits of tolvaptan in chronic kidney disease (CKD) remain unclear. This study aimed to evaluate the effectiveness of tolvaptan in managing edema caused by CKD. MATERIALS AND METHODS: The efficacy and treatment regimen of tolvaptan were assessed in a cohort of 96 patients with renal edema and CKD. During the treatment, the patients' creatinine (CR), uric acid (UA), and estimated glomerular filtration rate (eGFR) were monitored as important indicators of kidney function...
April 5, 2024: Clinical Nephrology
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