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Intervirology

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https://read.qxmd.com/read/30726837/iterative-excretion-of-human-cosaviruses-from-different-genotypes-associated-with-combined-immunodeficiency-disorder
#1
Asma Lamari, Henda Triki, Nadia Driss, Henda Touzi, Zina Meddeb, Ahlem Ben Yahia, Mohamed-Ridha Barbouche, Dorra Rezig
BACKGROUND: Human cosaviruses (HCoSVs) are newly discovered enteric viruses in the Picornaviridae family. They have been described in non-polio acute flaccid paralysis, diarrheal patients, and healthy individuals. They remain rarely documented in immunodeficient patients. OBJECTIVES: This study reports iterative excretion of HCoSVs in a patient with major histocompatibility complex (MHC) class II combined immunodeficiency, a relatively common primary immunodeficiency in consanguineous settings...
February 6, 2019: Intervirology
https://read.qxmd.com/read/30654371/the-hpv16-e1-carboxyl-domain-provides-a-helper-function-for-adeno-associated-virus-replication
#2
Maohua Cao, Sarmistha Bandyopadhyay, Hongqing Zhu, Hong You, Paul L Hermonat
BACKGROUND/AIMS: Recombinant adeno-associated virus (rAAV) is now in the clinic, yet production of rAAV remains problematic. We previously determined that human papillomavirus type 16 (HPV16) E1 protein boosts rAAV yields and E1 enhances AAV Rep78's replication-related biochemistries. Here, we deletion-mapped the helper domain within E1 to help glean its mechanism of action. METHODS: Rep78-E1 interaction was analyzed by Gal4-based yeast two-hybrid (Y2H)-cDNA assay...
January 17, 2019: Intervirology
https://read.qxmd.com/read/30654366/antiviral-activity-of-synthetic-peptides-derived-from-physiological-proteins
#3
Arianna Sala, Andrea Ardizzoni, Tecla Ciociola, Walter Magliani, Stefania Conti, Elisabetta Blasi, Claudio Cermelli
BACKGROUND/AIMS: New antivirals are needed to supplement or replace currently used drugs. The aim of this study was to evaluate the antiviral activity of synthetic peptides derived from physiological proteins. METHODS: Vero cell monolayers were infected with herpes simplex virus 1, vesicular stomatitis virus, adenovirus, and coxsackievirus B5 strains in the presence of different concentrations of the selected peptides and viral yield was determined by plaque reduction assays to evaluate the antiviral activity of the peptides...
January 17, 2019: Intervirology
https://read.qxmd.com/read/30654358/development-of-a-sybr-green-ii-real-time-polymerase-chain-reaction-for-the-clinical-detection-of-the-duck-origin-goose-parvovirus-in-china
#4
Qihui Luo, Bing Chen, Jing Xu, Wenjing Ma, Chengjie Lao, Yifan Li, Jinglong Tan, Yi Tang, Chao Huang, Wentao Liu, Zhengli Chen
OBJECTIVE: To establish an efficient, convenient and quantitative method for the clinical detection of the duck-origin goose parvovirus. METHOD: In the present study, a real-time polymerase chain reaction (PCR) method was established for detecting the duck-origin goose parvovirus using the fluorescent chimeric dye SYBR Green II. Specific primers were designed to target a highly conserved region of the VP3 gene of the duck-origin goose parvovirus. RESULTS: This method was able to detect a minimum of 19...
January 17, 2019: Intervirology
https://read.qxmd.com/read/30625488/viral-exploration-of-negative-acute-febrile-cases-observed-during-chikungunya-outbreaks-in-gabon
#5
Huguette Simo Tchetgna, Rita Sem Ouilibona, Andriniaina Andy Nkili-Meyong, Melanie Caron, Ingrid Labouba, Benjamin Selekon, Richard Njouom, Eric M Leroy, Emmanuel Nakoune, Nicolas Berthet
Non-malarial febrile illness outbreaks were documented in 2007 and 2010 in Gabon. After investigation, these outbreaks were attributed to the chikungunya and dengue viruses (CHIKV and DENV). However, for more than half of the samples analyzed, the causative agent was not identified. Given the geographical and ecological position of Gabon, where there is a great animal and microbial diversity, the circulation of other emerging viruses was suspected in these samples lacking aetiology. A total of 436 undiagnosed samples, collected between 2007 and 2013, and originating from 14 urban, suburban, and rural Gabonese locations were selected...
January 9, 2019: Intervirology
https://read.qxmd.com/read/30541013/loss-of-transfected-human-brain-micro-vascular-endothelial-cell-integrity-during-herpes-simplex-virus-infection
#6
Sau Har Lee, Nadia Atiya, Seok Mui Wang, Rishya Manikam, Chandramathi Samudi Raju, Shamala Devi Sekaran
OBJECTIVE: Herpes simplex virus infection through the neuronal route is the most well-studied mode of viral encephalitis that can persists in a human host for a lifetime. However, the involvement of other possible infection mechanisms by the virus remains underexplored. Therefore, this study aims to determine the temporal effects and mechanisms by which the virus breaches the human brain micro-vascular endothelial cells of the blood-brain barrier. METHOD: An electrical cell-substrate impedance-sensing tool was utilized to study the real-time cell-cell barrier or morphological changes in response to the virus infection...
December 12, 2018: Intervirology
https://read.qxmd.com/read/30448834/high-herpesvirus-diversity-in-wild-rodent-and-shrew-species-in-central-africa
#7
Nkom Felix Ntumvi, Placide Mbala Kingebeni, Ubald Tamoufe, Charles Kumakamba, Valentine Ndze, Ipos Ngay Lukusa, Matthew LeBreton, Joseph Atibu Losoma, Joseph Le Doux Diffo, Frida N'Kawa, Jean-Michel Takuo, Prime Mulembakani, Julius Nwobegahay, Maria Makuwa, Jean J Muyembe Tamfum, Amethyst Gillis, Stephen Harris, Anne W Rimoin, Nicole A Hoff, Joseph M Fair, Corina Monagin, James Ayukekbong, Edward M Rubin, Nathan D Wolfe, Christian E Lange
OBJECTIVE: Herpesviruses belong to a diverse order of large DNA viruses that can cause diseases in humans and animals. With the goal of gathering information about the distribution and diversity of herpesviruses in wild rodent and shrew species in central Africa, animals in Cameroon and the Democratic Republic of the Congo were sampled and tested by PCR for the presence of herpesvirus DNA. METHODS: A broad range PCRs targeting either the Polymerase or the terminase gene were used for virus detection...
November 16, 2018: Intervirology
https://read.qxmd.com/read/29316545/survival-of-viruses-in-water
#8
Anthony Pinon, Michèle Vialette
Water, a frequent vehicle for the transmission of viruses, may permit their survival, but many environmental factors will have an adverse effect on the viral population. Risk evaluation requires identification of these factors and assessment of the inactivation rate of infectious viruses. A higher temperature means a faster reduction of the viral population, as do increased sunlight, higher antimicrobial concentration, or higher oxygen levels. Another documented impact is linked to the presence of indigenous microbial populations: virus survival is higher in sterile water...
January 10, 2018: Intervirology
https://read.qxmd.com/read/30404089/high-throughput-sequencing-of-putative-novel-micrornas-in-rhesus-monkey-peripheral-blood-mononuclear-cells-following-ev71-and-ca16-infection
#9
Jie Song, Xi Jiang, Yajie Hu, Hui Li, Xuemei Zhang, Jingwen Xu, Weiyu Li, Xuelin Zheng, Shaozhong Dong
OBJECTIVES: Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) remain the major pathogens in hand, foot, and mouth disease (HFMD) cases, but the mechanisms of the different pathogeneses that follow EV71 and CA16 infection remain largely unknown. METHODS: Herein, we utilized microRNA (miRNA) deep sequencing to investigate the roles of novel differentially expressed miRNAs in peripheral blood mononuclear cells (PBMCs) infected with EV71 and CA16. RESULTS: The results identified 13 novel differentially expressed miRNAs in each group...
2018: Intervirology
https://read.qxmd.com/read/30404084/a-molecular-epidemiological-investigation-of-carriage-of-the-adeno-associated-virus-in-murine-rodents-and-house-shrews-in-china
#10
Yi-Quan Xiong, Min-Yi Zhang, Jun-Hua Zhou, Yong-Zhi Li, Fang-Fei You, Yu-Qi Wen, Wen-Qiao He, Qing Chen
OBJECTIVE: To investigate the prevalence of the adeno-associated virus (AAV) in murine rodents and house shrews in 4 provinces of China. METHODS: A total of 469 murine rodents and 19 house shrews were captured between May 2015 and May 2017. Cap gene of AAV sequences was obtained to evaluate the genetic characteristics of rat AAV. RESULTS: Rat AAVs were found in 54.7% (267/488) of throat swabs, 14.3% (70/488) of fecal samples, and 18.4% (41/223) of serum samples...
2018: Intervirology
https://read.qxmd.com/read/30368502/high-prevalence-of-hbv-lamivudine-resistant-mutations-in-hbv-hiv-co-infected-patients-on-antiretroviral-therapy-in-the-area-with-the-highest-prevalence-of-hiv-hbv-co-infection-in-china
#11
Hui-Hua Jia, Kai-Wen Li, Qin-Yan Chen, Xue-Yan Wang, Tim J Harrison, Shu-Jia Liang, Qing-Li Yang, Chao Wang, Li-Ping Hu, Chuang-Chuang Ren, Zhong-Liao Fang
OBJECTIVES: We aimed to determine the prevalence of hepatitis B virus (HBV) drug-resistant mutations in patients co- infected with HBV/human immunodeficiency virus (HIV), including both drug-naïve subjects and those who received antiretroviral therapy (ART) in Guangxi, where the prevalence of HIV/HBV co-infection is highest in China. METHODS: Two hundred and three subjects co-infected with HBV/HIV were recruited, including 123 drug-naïve patients (group 1) and 80 who received ART (group 2)...
2018: Intervirology
https://read.qxmd.com/read/30336455/the-effects-of-il10-and-nk-cells-on-the-susceptibility-to-mouse-cytomegalovirus-in-balb-c-mice-despite-the-compensation-of-ifn%C3%AE
#12
Yuanyuan Lu, Xinglou Liu, Yuan Huang, Yi Liao, Ting Xi, Yanan Zhang, Sainan Shu, Feng Fang
OBJECTIVE: The aim of this study was to determine which factors lead to the susceptibility to mouse cytomegalovirus (MCMV) in the spleens of BALB/c mice. METHODS: BALB/c and C57BL/6 mice were randomly divided into a control group and an infection group and sacrificed on day 0, 1, 3, 7, 14, and 28 postinfection. The cytotoxicity of NK cells was determined by evaluating lactate dehydrogenase contents. Flow cytometry was used to analyze activated NK cells, IFNγ+ NK cells, and total NK cells in the spleen...
2018: Intervirology
https://read.qxmd.com/read/30278455/hepatitis-e-virus-genotype-1-and-hepatitis-a-virus-dual-infection-in-pediatric-patients-with-a-low-socioeconomic-status-from-mexico
#13
Mauricio Realpe-Quintero, Santiago Mirazo, Oliver Viera-Segura, Edgar D Copado-Villagrana, Arturo Panduro, Sonia Roman, Juan Arbiza, Nora A Fierro
OBJECTIVE: We aimed to detect and characterize hepatitis E virus (HEV) RNA in sera samples from a pediatric population infected with the hepatitis A virus (HAV) exhibiting acute hepatitis and to correlate the infection status with the clinical outcome. METHODS: Seventy-five ELISA-positive samples from children containing anti-HAV and anti-HEV IgM were used to amplify and characterize partial regions within HEV ORF2. A statistical comparison of clinical data between HEV IgM-positive/HEV RNA-positive patients and HEV IgM-positive/HEV RNA-negative patients was performed...
2018: Intervirology
https://read.qxmd.com/read/30278453/hepatitis-e-virus-genotype-3-genomes-from-rna-positive-but-serologically-negative-plasma-donors-have-cug-as-the-start-codon-for-orf3
#14
Heléne Norder, Cristina Galli, Ellen Magnil, Per Sikora, Elisabet Ekvärn, Kristina Nyström, Lars O Magnius
Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have identified HEV RNA in blood products although its significance is not understood. This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p < 0...
2018: Intervirology
https://read.qxmd.com/read/30253401/expression-of-duplex-shrnas-through-a-lentiviral-vector-against-cellular-and-viral-genes-inflicts-sustained-inhibition-of-hepatitis-c-virus-replication
#15
Anirban Mandal, Binay Chaubey
BACKGROUND: The RNAi-based transient therapeutic approach has been well explored for its potential against the hepatitis V virus (HCV). However, to achieve a sustained virological response, a consistent presence of siRNA is needed and it can be achieved by constitutively expressing shRNAs. In this context, the lentiviral vector has emerged as an attractive tool for shRNA delivery against HCV. METHODS: We monitored HCV inhibition after single and multiple rounds of siRNA treatments against La autoantigen and HCV-NS5B in Huh-7...
2018: Intervirology
https://read.qxmd.com/read/30176660/three-main-inducers-of-alphacoronavirus-infection-of-enterocytes-sialic-acid-proteases-and-low-ph
#16
REVIEW
Peng Yuan, Zhou Yang, Han Song, Kai Wang, Yang Yang, Luyi Xie, Shilei Huang, Jia Liu, Lin Ran, Zhenhui Song
Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are similar coronaviruses, causing diseases characterized by vomiting, diarrhea, and death from severe dehydration in piglets. Thus, they have caused huge losses to the swine-breeding industry worldwide. Nowadays, they are easily transmitted among the continents via vehicles, equipment, and cargo. Both viruses establish an infection in porcine enterocytes in the small intestine, and their spike (S) proteins play a key role in the virus-cell binding process under unfavorable conditions when the intestine with a low pH is filled with a thick layer of mucus and proteases...
2018: Intervirology
https://read.qxmd.com/read/30145592/rnai-targeting-of-human-metapneumovirus-p-and-n-genes-inhibits-viral-growth
#17
Kathleen M Nitschinsk, Daniel T Clarke, Adi Idris, Nigel A McMillan
BACKGROUND/AIMS: Human metapneumovirus (hMPV) is an important human respiratory pathogen and is implicated in an array of respiratory illnesses, ranging from asymptomatic infection to severe bronchiolitis. Currently, there is no reliable vaccine or specific antiviral therapy for hMPV infection and treatment is supportive. The use of ribonucleic acid interference has the potential to change that with the targeting of essential viral genes via small interfering RNAs (siRNAs) offering the ability to directly and rapidly treat viral infections...
2018: Intervirology
https://read.qxmd.com/read/30121676/isolation-and-quantification-of-mimivirus-like-and-marseillevirus-like-viruses-from-soil-samples-in-an-aboriginal-orang-asli-village-in-peninsular-malaysia
#18
Yeh Fong Tan, Chai Ying Lim, Chun Wie Chong, Patricia Kim Chooi Lim, Ivan Kok Seng Yap, Pooi Pooi Leong, Kenny Voon
BACKGROUND: The giant amoebal viruses of Mimivirus and Marseillevirus are large DNA viruses and have been documented in water, soil, and sewage samples. The trend of discovering these giant amoebal viruses has been increasing throughout Asia with Japan, India, and Saudi Arabia being the latest countries to document the presence of these viruses. To date, there have been no reports of large amoebal viruses being isolated in South East Asia. OBJECTIVE: In this study, we aim to discover these viruses from soil samples in an aboriginal village (Serendah village) in Peninsular -Malaysia...
2018: Intervirology
https://read.qxmd.com/read/30114699/spontaneous-viral-clearance-in-sixteen-hiv-infected-patients-with-chronic-hepatitis-c
#19
Jorge Soares, João Vasco Santos, António Sarmento, Altamiro Costa-Pereira
BACKGROUND/AIMS: Spontaneous viral clearance of the chronic hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-infected patients is a rare event. We aimed to identify the clinical, therapeutic, demographic, and laboratory features associated with spontaneous HCV clearance in 16 HIV-infected patients with chronic hepatitis C (CHC, the largest case series, to our knowledge). METHODS: This case series study reports the findings from 16 HIV/HCV coinfected patients with CHC who experienced spontaneous clearance of HCV infection...
2018: Intervirology
https://read.qxmd.com/read/30110699/association-of-the-aquaporin-3-gene-polymorphism-rs2231231-with-epstein-barr-virus-associated-cancers-in-china
#20
Jiayi Wang, Wen Liu, Zhenzhen Zhao, Yan Zhang, Bing Luo
BACKGROUND/AIMS: Aquaporins are widely expressed in a variety of cancers and were found to play an important role in cell migration, angiogenesis, tumor formation, and tumor development. Thus, they have been proposed as a potential biomarker for some cancers. Accordingly, we analyzed the association between a single-nucleotide polymorphism locus of aquaporin 3 (rs2231231) and Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (EBVaNPC), lymphoma (EBVaL), and gastric carcinoma in China...
2018: Intervirology
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