Arinola O Lampejo, Suzanne E Lightsey, Maria C Gomes, Christian M Nguyen, Dietmar W Siemann, Blanka Sharma, Walter L Murfee
Biomimetic tumor microenvironment models bridge the gap between in vitro and in vivo systems and serve as a useful way to address the modeling challenge of how to recreate the cell and system complexity associated with real tissues. Our laboratory has developed an ex vivo rat mesentery culture model, which allows for simultaneous investigation of blood and lymphatic microvascular network remodeling in an intact tissue environment. Given that angiogenesis and lymphangiogenesis are key contributors to the progression of cancer, the objective of this study was to combine tissue and tumor spheroid culture methods to establish a novel ex vivo tumor spheroid-tissue model by verifying its use for evaluating the effects of cancer cell behavior on the local microvascular environment...
May 25, 2024: Annals of Biomedical Engineering
Yuan Shi, Xiaotian Wu, Joseph A Paydarfar, Ryan J Halter
This study aimed to develop and validate a Computed Tomography (CT)/Magnetic Resonance Imaging (MRI)-compatible polymer oral retractor system to enable intraoperative image guidance for transoral robotic surgery (TORS). The retractor was designed based on standard-of-care metallic retractors and 3D (three-dimensional) printed with carbon fiber composite and nylon. The system was comprehensively evaluated in bench-top and cadaveric experiments in terms of its ability to enable intraoperative CT/MR images during TORS, functionality including surgical exposure and working volume, usability, compatibility with da Vinci surgical systems, feasibility for disinfection or sterilization, and robustness over an extended period of time...
May 25, 2024: Annals of Biomedical Engineering
Drew DiSerafino, Derek A Jones, Zachary S Hostetler, Alex Kalmar-Gonzalo, Lance L Frazer, Daniel P Nicolella, Matthew L Davis
Military personnel are commonly at risk of lower back pain and thoracolumbar spine injury. Human volunteers and postmortem human subjects have been used to understand the scenarios where injury can occur and the tolerance of the warfighter to these loading regimes. Finite element human body models (HBMs) can accurately simulate the mechanics of the human body and are a useful tool for understanding injury. In this study, a HBM thoracolumbar spine was developed and hierarchically validated as part of the Incapacitation Prediction for Readiness in Expeditionary Domains: an Integrated Computational Tool (I-PREDICT) program...
May 23, 2024: Annals of Biomedical Engineering
Danilo V Rogayan
It is crucial to equip our next-generation healthcare professionals with futures thinking and strategic foresight skills as they confront the demands and challenges of the volatile, uncertain, complex, ambiguous, diverse, and disruptive (VUCAD2) world. In this paper, I contend that such skills must be embedded in health education curricula, part of the qualification standards in hiring healthcare professionals, and be integrated in health licensure requirements. The crucial role of health workers in the future in addressing the complex challenges and opportunities in public healthcare cannot be overstated...
May 21, 2024: Annals of Biomedical Engineering
Angela Straccia, Michael C Barbour, Fanette Chassagne, David Bass, Guilherme Barros, Daniel Leotta, Florence Sheehan, Deepak Sharma, Michael R Levitt, Alberto Aliseda
The Circle of Willis (CoW) is a ring-like network of blood vessels that perfuses the brain. Flow in the collateral pathways that connect major arterial inputs in the CoW change dynamically in response to vessel narrowing or occlusion. Vasospasm is an involuntary constriction of blood vessels following subarachnoid hemorrhage (SAH), which can lead to stroke. This study investigated interactions between localization of vasospasm in the CoW, vasospasm severity, anatomical variations, and changes in collateral flow directions...
May 17, 2024: Annals of Biomedical Engineering
Véronique Bouvette, Y Petit, L De Beaumont, S Guay, S A Vinet, E Wagnac
Recorded head kinematics from head-impact measurement devices (HIMd) are pivotal for evaluating brain stress and strain through head finite element models (hFEM). The variability in kinematic recording windows across HIMd presents challenges as they yield inconsistent hFEM responses. Despite establishing an ideal recording window for maximum principal strain (MPS) in brain tissue, uncertainties persist about the impact characteristics influencing vulnerability when this window is shortened. This study aimed to scrutinize factors within impact kinematics affecting the reliability of different recording windows on whole-brain peak MPS using a validated hFEM...
May 17, 2024: Annals of Biomedical Engineering
Claudia Serrano-Amenos, Frank Hu, Po T Wang, Payam Heydari, An H Do, Zoran Nenadic
This study aims to estimate the maximum power consumption that guarantees a thermally safe operation for a titanium-enclosed chest wall unit (CWU) subcutaneously implanted in the pre-pectoral area. This unit is a central piece of an envisioned fully-implantable bi-directional brain-computer interface (BD-BCI). To this end, we created a thermal simulation model using the finite element method implemented in COMSOL. We also performed a sensitivity analysis to ensure that our predictions were robust against the natural variation of physiological and environmental parameters...
May 16, 2024: Annals of Biomedical Engineering
A Sahni, L Marshall, M A Cetatoiu, J Davee, N Schulz, E R Eickhoff, N St Clair, S Ghelani, A Prakash, P E Hammer, D M Hoganson, P J Del Nido, R H Rathod, Vijay Govindarajan
The hemodynamics in Fontan patients with single ventricles rely on favorable flow and energetics, especially in the absence of a subpulmonary ventricle. Age-related changes in energetics for extracardiac and lateral tunnel Fontan procedures are not well understood. Vorticity (VOR) and viscous dissipation rate (VDR) are two descriptors that can provide insights into flow dynamics and dissipative areas in Fontan pathways, potentially contributing to power loss. This study examined power loss and its correlation with spatio-temporal flow descriptors (vorticity and VDR)...
May 16, 2024: Annals of Biomedical Engineering
Concetta F Morino, Allison L Schmidt, Elizabeth Dimbath, Shea T Middleton, Jay K Shridharani, Jason R Kait, Maria A Ortiz-Paparoni, Josh Klinger, Joost Op 't Eynde, Cameron R Bass
Low back pain (LBP) affects 50-80% of adults at some point in their lifetime, yet the etiology of injury is not well understood. Those exposed to repeated flexion-compression are at a higher risk for LBP, such as helicopter pilots and motor vehicle operators. Animal injury models offer insight into in vivo injury mechanisms, but interspecies scaling is needed to relate animal results to human. Human (n = 16) and porcine (n = 20) lumbar functional spinal units (FSUs) were loaded in repeated flexion-compression (1 Hz) to determine endplate fracture risk over long loading exposures...
May 15, 2024: Annals of Biomedical Engineering
Zhehao Liu, Jiazi Gao, He Gong
Bone tissue is subjected to increased mechanical stress during high-intensity work. Inadequate bone remodeling reparability can result in the continuous accumulation of microdamage, leading to stress fractures. The aim of this work was to investigate the characteristics and repair mechanisms of tibial microdamage under several degrees of overload. Also, we aimed at better understanding the effects of overload on the multi-scale structure and mechanical properties of bone. Sixty 5-month female rats were divided into three groups with different time points...
May 14, 2024: Annals of Biomedical Engineering
Andrew M Ferguson, Alex C Lin
Three manufacturers sell artificial pancreas systems in the United States for management of Type 1 Diabetes. Given the life-saving task required of an artificial pancreas there needs to be a high level of trust and safety in the devices. This evaluation sought to find the adjusted safety event reporting rate and themes along with device-associated risk in events reported utilizing the MAUDE database. We searched device names in the MAUDE database over the period from 2016 until August 2023 (the date of retrieval)...
May 13, 2024: Annals of Biomedical Engineering
Tobia Sebastiano Nava, Maximilian Nussbaumer, James R Tysome, Michael P F Sutcliffe
This research aims to enhance the understanding of the acoustic processes occurring during sonotubometry, a method used to assess the Eustachian tube (ET) function. Recent advancements in digital signal processing enable a more comprehensive data analysis. In this project, a silicone model of the ET was developed to systematically study the existing noise and sound sources. These measurements were then compared with recordings from human subjects. Three distinct 'noise sources' were identified, which can influence the assessment of the ET opening using transmission measurements of the imposed signal: sound leakage from the speaker, a clicking noise at the initiation of ET opening, and rumbling/swallowing noise...
May 13, 2024: Annals of Biomedical Engineering
George Stilwell, Danyon Stitt, Keith Alexander, Nick Draper, Natalia Kabaliuk
In contact sports such as rugby, players are at risk of sustaining traumatic brain injuries (TBI) due to high-intensity head impacts that generate high linear and rotational accelerations of the head. Previous studies have established a clear link between high-intensity head impacts and brain strains that result in concussions. This study presents a novel approach to investigating the effect of a range of laboratory controlled drop test parameters on regional peak and mean maximum principal strain (MPS) predictions within the brain using a trained convolutional neural network (CNN)...
May 13, 2024: Annals of Biomedical Engineering
Breandan B Yeats, Dahlia Galvez, Sri Krishna Sivakumar, Kimberly Holst, Venkateshwar Polsani, Pradeep K Yadav, Vinod H Thourani, Ajit Yoganathan, Lakshmi P Dasi
Patients with bicuspid aortic valve (BAV) commonly have associated aortic stenosis and aortopathy. The geometry of the aortic arch and BAV is not well defined quantitatively, which makes clinical classifications subjective or reliant on limited 2D measurements. The goal of this study was to characterize the 3D geometry of the aortic arch and BAV using objective and quantitative techniques. Pre-TAVR computed tomography angiogram (CTA) in patients with BAV and aortic stenosis (AS) were analyzed (n = 59) by assessing valve commissural angle, presence of a fused region, percent of fusion, and calcium volume...
May 11, 2024: Annals of Biomedical Engineering
Nettie E Brown, Lela R Ellerbe, Scott J Hollister, Johnna S Temenoff
Regeneration of cartilage and bone tissues remains challenging in tissue engineering due to their complex structures, and the need for both mechanical support and delivery of biological repair stimuli. Therefore, the goal of this study was to develop a composite scaffold platform for anatomic chondral and osteochondral repair using heparin-based hydrogels to deliver small molecules within 3D-printed porous scaffolds that provide structure, stiffness, and controlled biologic delivery. We designed a mold-injection system to combine hydrolytically degradable hydrogels and 3D-printed scaffolds that could be employed rapidly (< 30 min) in operating room settings (~23 °C)...
May 11, 2024: Annals of Biomedical Engineering
Jianming Zhu, Ziming Wang, Chunyan Lv, Mengtian Li, Kaiyi Wang, Zhencheng Chen
Advanced glycation end products (AGEs) have garnered significant attention due to their association with chronic diseases and the aging process. The prevalence of geriatric diseases among young individuals has witnessed a notable surge in recent years, potentially attributed to the accelerated pace of modern life. The accumulation of AGEs is primarily attributed to their inherent difficulty in metabolism, which makes them promising biomarkers for chronic disease detection. This review aims to provide a comprehensive overview of the recent advancements and findings in AGE research...
May 5, 2024: Annals of Biomedical Engineering
Anna Corti, Matilde Marradi, Cemre Çelikbudak Orhon, Francesca Boccafoschi, Philippe Büchler, Jose F Rodriguez Matas, Claudio Chiastra
Multiscale agent-based modeling frameworks have recently emerged as promising mechanobiological models to capture the interplay between biomechanical forces, cellular behavior, and molecular pathways underlying restenosis following percutaneous transluminal angioplasty (PTA). However, their applications are mainly limited to idealized scenarios. Herein, a multiscale agent-based modeling framework for investigating restenosis following PTA in a patient-specific superficial femoral artery (SFA) is proposed. The framework replicates the 2-month arterial wall remodeling in response to the PTA-induced injury and altered hemodynamics, by combining three modules: (i) the PTA module, consisting in a finite element structural mechanics simulation of PTA, featuring anisotropic hyperelastic material models coupled with a damage formulation for fibrous soft tissue and the element deletion strategy, providing the arterial wall damage and post-intervention configuration, (ii) the hemodynamics module, quantifying the post-intervention hemodynamics through computational fluid dynamics simulations, and (iii) the tissue remodeling module, based on an agent-based model of cellular dynamics...
May 3, 2024: Annals of Biomedical Engineering
Zi'an Xu, Yin Dai, Fayu Liu, Siqi Li, Sheng Liu, Lifu Shi, Jun Fu
Parotid gland tumors account for approximately 2% to 10% of head and neck tumors. Segmentation of parotid glands and tumors on magnetic resonance images is essential in accurately diagnosing and selecting appropriate surgical plans. However, segmentation of parotid glands is particularly challenging due to their variable shape and low contrast with surrounding structures. Recently, deep learning has developed rapidly, and Transformer-based networks have performed well on many computer vision tasks. However, Transformer-based networks have yet to be well used in parotid gland segmentation tasks...
May 1, 2024: Annals of Biomedical Engineering
Kevin N Eckstein, John E Hergert, Asais Camila Uzcategui, Sarah A Schoonraad, Stephanie J Bryant, Robert R McLeod, Virginia L Ferguson
Tissue engineered scaffolds are needed to support physiological loads and emulate the micrometer-scale strain gradients within tissues that guide cell mechanobiological responses. We designed and fabricated micro-truss structures to possess spatially varying geometry and controlled stiffness gradients. Using a custom projection microstereolithography (μSLA) system, using digital light projection (DLP), and photopolymerizable poly(ethylene glycol) diacrylate (PEGDA) hydrogel monomers, three designs with feature sizes < 200 μm were formed: (1) uniform structure with 1 MPa structural modulus ( <mml:math xmlns:mml="https://www...
April 29, 2024: Annals of Biomedical Engineering
Wenxin Liang, Beibei Liang, Kaicheng Yan, Guanxuanzi Zhang, Jiaju Zhuo, Yun Cai
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, many in vitro and in vivo studies have shown that LIPUS may play its anti-inflammatory role by activating signaling pathways such as integrin/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt), Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS), or inhibiting signaling pathways such as Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-κB) and p38-Mitogen-activated protein kinase (MAPK)...
April 29, 2024: Annals of Biomedical Engineering
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