Journals Current Medical Research and O...

Current Medical Research and Opinion
Ruolin Jia, Zhen Li, Yichun Guan, Wen Zhang, Kexin Wang, Zhuolin Yao
OBJECTIVE: To explore a non-routine method of oocyte retrieval in patients with difficulty in obtaining oocytes via the vagina during a cycle of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)-embryo transfer (ET). METHODS: We report the clinical data of one case of combined transabdominal and transvaginal egg retrieval with a vaginal ultrasound probe in a patient with adenomyosis undergoing IVF/ICSI for fertilization. RESULTS: A patient with infertility due to adenomyosis desired fertility...
April 5, 2023: Current Medical Research and Opinion
Ewa Mrukwa-Komine, Marta Misiuk-Hojlo, Adrienne Csutak, Ingeborg Stalmans, Gerhard Garhofer
Objective: To compare the efficacy and safety of two fixed combination, preservative-free eye drops (bimatoprost 0.01% in combination with either timolol 0.1% or 0.5%) in a gel formulation, with bimatoprost 0.03%/timolol 0.5% in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods: Phase II, randomized, investigator-masked, multicenter, 3-arm parallel group (Eudract No. 2017-002823-46). Eighty-six patients aged ≥18 years with OAG or OHT, with intraocular pressure (IOP) initially controlled for at least 6 months by a combination therapy of a dual prostaglandin and timolol or insufficiently controlled by first-line monotherapy were included...
April 4, 2023: Current Medical Research and Opinion
Waqar Ali, Mohammad Ismail Tajik, Iftikhar Ali, Alia Gul, Jehan Zeb Khan
BACKGROUND: Rabies vaccines are conventionally given via the intramuscular (IM) route; however, switching the route of administration from IM to intradermal (ID) without affecting efficacy can be advantageous in terms of cost, dosing, and time. Hence, it is indispensable to evaluate its safety along different routes. This study was carried out to ascertain the frequency of adverse drug events (ADEs) and associated factors, as well as to compare safety based on the IM and ID routes. METHODS: A prospective observational study was carried out on 184 individuals with rabies exposure...
April 3, 2023: Current Medical Research and Opinion
Ogechukwu N Iloanusi, Nneka I Iloanusi, Arun A Ross
OBJECTIVES: A world-wide immunization project was launched at the peak of COVID-19 pandemic to contain and minimize the adverse effects of SARS-CoV-2 virus. We carried out a series of statistical analyses in this paper to determine, confirm and quantify the impact of the vaccinations on COVID-19 cases and mortalities, amidst critical confounding factors - temperature and solar irradiance. METHODS: The experiments in this paper were carried out on the world data, data from 21 countries and the five major continents...
April 3, 2023: Current Medical Research and Opinion
Francesco Lapi, Ettore Marconi, Gaetano Piccinocchi, Iacopo Cricelli, Gerardo Medea, Claudio Cricelli
Chronic kidney disease (CKD) is a global public health issue that can lead to several complications such as, kidney failure, cerebro/cardiovascular disease, and death.There is a well-documented "awareness gap" among general practitioners (GPs) to recognize CKD. As shown by estimates stemming from the Health Search Database (HSD) of the Italian College of General Practitioners and Primary Care (SIMG), no substantial changes were observed in terms of the incident rate of CKD over the last 10 years. Namely, 10...
April 2, 2023: Current Medical Research and Opinion
Mikkel H Pedersen, Anne Danø, Ebbe Englev, Lisbeth Kattenhøj, Emma Munk
BACKGROUND: Sedation is common practice in endoscopic procedures to suppress a patient's level of consciousness while maintaining the cardio-respiratory function. Midazolam and propofol are the sedatives most frequently used for procedural sedation at the hospitals in Scandinavia. Remimazolam is a new ultra-short-acting benzodiazepine sedative and the present analysis aimed at estimating the economic benefits of introducing remimazolam for procedural sedation in colonoscopies and bronchoscopies in hospitals in Scandinavia...
March 31, 2023: Current Medical Research and Opinion
Veena Hoffman, Kyra Mulder, Ia Topuria, Anna K Gawlicka, James E Kallman
OBJECTIVE: To investigate the impact of steroid-eluting implants after endoscopic sinus surgery (ESS) on health care resource use (HCRU) in chronic rhinosinusitis patients with (CRSwNP) and without (CRSsNP) nasal polyps. METHODS: This retrospective, observational cohort study using real-world evidence data included adult patients with CRS who underwent ESS in 2015-2019 with at least 24 months of data before and after ESS. Patients who received implants were matched to patients who did not based on a propensity score developed using baseline characteristics and NP status...
March 30, 2023: Current Medical Research and Opinion
Xiaoxuan Meng, Siyuan Li, Wenting Shen, Dongyan Li, Qingyun Lv, Xiaoxu Wang, Yan Wang, Xiaoying Zang, Qing Zhang, Lan Wang
OBJECTIVE: Many related scales have been developed and applied to measure patients' medication adherence, but the research on the psychometric characteristics of the scale still requires further studies. This study aims to provide further validation of the GMAS scale by using Rasch analysis and to make targeted recommendations for scale improvement. METHODS: This is a cross-sectional study using secondary data. 312 Chinese adult patients were recruited from two tertiary hospitals and one community health service center in Tianjin to complete a questionnaire containing the GMAS, from January to June 2020...
March 27, 2023: Current Medical Research and Opinion
James O Lindsay, Nils Picker, Daniel Kromer, Michael Smyth, Haridarshan Patel
OBJECTIVE: A considerable proportion of patients with moderate-to-severe ulcerative colitis (UC) treated with advanced therapies do not achieve remission, even after one year of treatment, and suboptimal response to advanced therapies is frequently observed in clinical practice. This study aims to analyze clinical practice data in the United Kingdom (UK) and assess the rates of clinical remission and inadequate response with advanced therapies among patients with UC. METHODS: This retrospective chart review included patients with UC who initiated a new advanced therapy (i...
March 23, 2023: Current Medical Research and Opinion
Massimo Volpe, Valeria Pegoraro, Franca Heiman, Riccardo Cipelli
Objectives To provide clinical characteristics and to quantify the number of patients receiving the extemporaneous combination of the calcium channel blocker amlodipine and the angiotensin converting enzyme inhibitor zofenopril in a real-world setting. This evidence can provide a snapshot of the potential users of the two molecules in a single pill combination (SPC). Methods Retrospective observational study using data from the IQVIA Italian Longitudinal Patient Database. Adult patients firstly prescribed with amlodipine and zofenopril between 1 July 2011 and 30 June 2020 were identified and demographic and clinical characteristics were extracted...
March 22, 2023: Current Medical Research and Opinion
John Diaz-Decaro, Evan Myers, Jacek Mucha, Monika Neumann, Witold Lewandowski, Magdalena Kaczanowska, Elvira Schmidt, Andrew Natenshon, Carla Talarico, Philip O Buck
OBJECTIVE: Cytomegalovirus (CMV) infection is typically asymptomatic in healthy individuals; however, certain populations are vulnerable to infection and may develop serious sequelae. CMV infection may also have a broad impact on humanistic outcomes, including patient health status and quality of life (QoL). We conducted a systematic literature review (SLR) to describe the global humanistic burden of CMV and congenital CMV (cCMV) infections across all age groups. METHODS: Medline, Embase, and LILACS were searched to identify studies on humanistic outcomes following CMV infection, including health status/QoL and any outcomes in domains such as auditory, cognitive ability, developmental status, intelligence, language, memory, mental health, motor performance, social communication, speech, and vocabulary...
March 20, 2023: Current Medical Research and Opinion
Mengyao Sun, Jing Huang, Jianwei Dong, Zhuo Li, Chaofan Li, Shasha Zhang, Bing Chen
BACKGROUND: This study aimed to explore the clinical efficacy of different treatment regimens for idiopathic membranous nephropathy (IMN). METHODS: Patients with IMN were retrospectively analyzed by dividing into two groups: glucocorticoids combined with cyclophosphamide group (GC + CYC) and glucocorticoids combined with calcineurin inhibitor group (GC + CNIs). After 1 year of treatment, those who found that the initial treatment was not effective were switched to another regimen...
March 20, 2023: Current Medical Research and Opinion
Louise Clarkson, Laura Hart, Alfred K Lam, Tien K Khoo
OBJECTIVE: Polypharmacy is associated with negative clinical consequences. The efficacy of deprescribing interventions within medical specialist outpatient clinics remains unclear. Here, we reviewed the research on the effectiveness of deprescribing interventions implemented within specialist outpatient clinics for patients ≥ 60 years. METHODS: Systematic searches of key databases were undertaken for studies published between January 1990 and October 2021...
March 20, 2023: Current Medical Research and Opinion
Ruggero Lasala, Andrea Zovi, Valentina Isgrò, Alessia Romagnoli, Felice Musicco, Fiorenzo Santoleri
OBJECTIVE: Time To Discontinuation (TTD) is defined as the time from the start of treatment to the end of treatment, usually occurring due to loss of efficacy or occurrence of adverse events. It has become an important surrogate efficacy endpoint especially in real-world studies due to its correlation with endpoints such as Progression Free Survival (PFS). The aim of the study is to conduct a literature review of all studies reporting TTD in first-line therapy of Non-Small Cell Lung Cancer (NSCLC)...
March 17, 2023: Current Medical Research and Opinion
Sencer Ganidagli, Ercument Ozturk, Zeynel Abidin Ozturk
OBJECTIVES: Sleep quality is associated with many diseases and conditions that affect individuals' health in various ways. We aimed to investigate the association between sleep quality and common geriatric conditions in older adults. METHODS: The study included 237 older adults admitted to the geriatric outpatient clinic of a university hospital. All patients underwent comprehensive geriatric assessment (CGA). Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), European Quality of Life (EQ-5D), Pittsburgh Sleep Quality Index (PSQI), Katz Index of Independence in Activities of Daily Living (ADL) and Lawton and Brody Instrumental Activities of Daily Living (IADL) questionnaires, Tinetti Balance and Gait Assessment (TBGA) and Mini Nutritional Assessment (MNA) were performed on the participants...
March 16, 2023: Current Medical Research and Opinion
Purnima Pathak, Leiyu Yue, Shaloo Gupta, Juanzhi Fang, M Andy Cheadle, Santosh Tiwari, Matias Ferraris, Parth Joshi, Jeffrey Thompson, Roshani Shah, Pamela Vo
OBJECTIVE: The treatment landscape for the prevention of migraine has rapidly evolved in recent years with the advent of calcitonin gene-related peptide therapy, including erenumab. The objective of this study was to assess patient-reported treatment satisfaction among erenumab users. METHODS: This retrospective, cross-sectional study used data from the 2019 US National Health and Wellness Survey collected during March-July 2019. Respondents self-reporting physician-diagnosed migraine and currently using erenumab were analyzed...
March 15, 2023: Current Medical Research and Opinion
Hongli Dong, Ping Hu, Jie Wang, Nan Lu
OBJECTIVE: Scarce data examined the associations of circulating calcium (Ca) and magnesium (Mg) with high sensitivity C-reactive protein (hsCRP) in humans. We conducted a hospital-based cross-sectional study to evaluate the associations of serum Ca, Mg and Ca/Mg ratio with hsCRP and examine the mediating roles of body mass index (BMI). METHODS: A total of 7203 patients with coronary artery disease (CAD) (average age: 61.0 years) were included. Serum concentrations of Ca, Mg and hsCRP were measured...
March 13, 2023: Current Medical Research and Opinion
Jullye Campos Mendes, Maria das Graças Braga, Adriano Max Moreira Reis, Micheline Rosa Silveira
OBJECTIVE: To measure the incidence of neuropsychiatric adverse drug reactions (ADRs) in individuals living with HIV who initiated antiretroviral therapy (ART) with first-line regimens containing dolutegravir (DTG) or efavirenz (EFV) and associated factors. METHODS: Prospective cohort study with individuals living with HIV who started ART with DTG or EFV associated with tenofovir disoproxil and lamivudine in Belo Horizonte, Brazil. Sociodemographic, clinical, and laboratory data were collected from September/2015 to October/2018 in three specialized HIV care services through interviews, clinical records, and computerized systems...
March 13, 2023: Current Medical Research and Opinion
Robert L Boggs, Samuel Engel, Tongtong Wang, Tracey Jean Weiss, Ashley A Martin, Austin Yue, Nate Way, Bryan Ricker, Swapnil N Rajpathak, Dominik Lautsch
BACKGROUND: Oral medications for chronic conditions often involve a variety of instructions, including time of day/dosing, drug interactions, and food intake restrictions. However, the extent to which patients are differentially aware of and able to follow these instructions is unclear. METHODS: We surveyed patients from the US and Europe (UK, France, Germany, Italy, Spain) who were prescribed sulfonylureas (SU) for diabetes or levothyroxine for hypothyroidism. SUs included glimepiride (US/Europe), glipizide (US) or gliclazide (Europe)...
March 13, 2023: Current Medical Research and Opinion
Carlos Escobar Cervantes, Alberto Esteban Fernández, Alejandro Recio Mayoral, Sonia Mirabet, José González Costello, Jorge Rubio Gracia, Julio Núñez Villota, Álvaro González Franco, Juan Luis Bonilla Palomas
The pathophysiology of heart failure with reduced ejection fraction (HFrEF) is a complex process in which a number of neurohormonal systems are involved. Targeting only some of these systems, but not all, translates into a partial benefit of HF treatment. The nitric oxide-soluble guanylate cyclase (sGC)-cGMP pathway is impaired in HF, leading to cardiac, vascular and renal disturbances. Vericiguat is a once-daily oral stimulator of sGC that restores this system. No other disease-modifying HF drugs act on this system...
March 10, 2023: Current Medical Research and Opinion
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