Journals Current Medical Research and O...

Current Medical Research and Opinion
Constantine S Tam, Nicole Lamanna, Susan M O'Brien, Lugui Qiu, Keri Yang, Gisoo Barnes, Ken Wu, Tommi Salmi, Jennifer R Brown
OBJECTIVE: The purpose of this analysis was to assess health-related quality of life (HRQoL) in patients treated with zanubrutinib and ibrutinib in the ALPINE trial (NCT03734016). METHODS: HRQoL was measured by the EORTC QLQ-C30 and EQ-5D-5L at baseline, cycle 1, and every third cycle until end of treatment. Key patient-reported outcome (PRO) endpoints included global health status (GHS), physical and role functioning, as well as symptoms of fatigue, pain, diarrhea, and nausea/vomiting...
September 27, 2023: Current Medical Research and Opinion
Paolo Ghia, Gisoo Barnes, Keri Yang, Constantine S Tam, Tadeusz Robak, Jennifer R Brown, Brad S Kahl, Tian Tian, Andy Szeto, Jason C Paik, Mazyar Shadman
OBJECTIVE: Zanubrutinib is a highly selective, next-generation Bruton's tyrosine kinase inhibitor. In the phase 3 SEQUOIA trial (NCT03336333), treatment with zanubrutinib resulted in significantly improved progression-free survival compared to bendamustine plus rituximab (BR) in adult patients with treatment-naïve chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) without del(17p). The current analysis compared the effects of zanubrutinib versus BR on patients' health-related quality of life (HRQoL)...
September 27, 2023: Current Medical Research and Opinion
Abdulmajeed Alharbi, Halah Alfatlawi, Clarrisa Pena, Tahrima Ferdous, Abdulaziz Aldhafeeri, Mohammad Alqadi, Zeid Nesheiwat, Ragheb Assaly
BACKGROUND: Cardiovascular disease, particularly acute coronary syndromes (ACS), is the leading cause of death in the United States. Minor fluctuations in hospital admissions for different conditions, including ACS, can be seen throughout the year. This study focuses on the impact of admission month on outcomes of acute coronary syndromes during the first year of the COVID-19 pandemic. METHODS: This was a retrospective observational study of patients hospitalized with ACS from the National Inpatient Sample, during the years 2020 (n = 779,895) and 2019 (n = 935,975)...
September 25, 2023: Current Medical Research and Opinion
Jesse Fishman, Elliot B Tapper, Stephen Dodge, Keith Miller, Dave Lewandowski, Alina Bogdanov, Machaon Bonafede
BACKGROUND: Non-alcoholic steatohepatitis (NASH) and type 2 diabetes (T2D) are both linked to substantial healthcare costs and are often co-occurring. We aim to quantify the incremental cost of NASH and T2D using real-world data. METHODS: Adults (≥18 years old) with ≥2 diagnosis codes for NASH and/or ≥2 diagnosis codes for T2D between 1/1/2016 and 12/31/2021 and ≥24 months of continuous claims enrollment (study period) were identified in electronic health records or claims in the Veradigm Integrated Dataset...
September 22, 2023: Current Medical Research and Opinion
Ercüment Öztürk, Sencer Ganidağlı, Zeynel Abidin Öztürk
OBJECTIVES: We aimed to investigate the risk factors of colistin-associated nephrotoxicity in patients older than 65 years treated in the palliative care unit. METHODS: 119 palliative care patients who received intravenous colistimethate for at least 7 days were included in the study. Estimated glomerular filtration rate (GFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2021 equation. Data were obtained from the hospital information system...
September 22, 2023: Current Medical Research and Opinion
Peter V Dicpinigaitis, Kenneth W Altman, Isil Ulger Isci, Xuehua Ke, Michael Blaiss
Chronic cough (CC) is associated with many conditions, so identifying contributing causes poses a diagnostic challenge. However, guidelines written for US physicians do not explicitly outline suggested roles for primary care providers (PCPs) in the approach to patients with CC, including refractory or unexplained CC. The objective of this review is to describe the role of PCPs in the diagnosis and treatment of CC in adults. This narrative review draws upon literature (identified via a PubMed search performed January 9, 2023, using primary care/disease state-related terms) and expertise from specialist physicians to provide recommendations for CC management in primary care...
September 22, 2023: Current Medical Research and Opinion
Mohamed Abuelazm, Ahmed K Awad, Islam Mohamed, Abdelrahman Mahmoud, Hosam Shaikhkhalil, Nour Shaheen, Omar Abdelwahab, Ahmed M Afifi, Basel Abdelazeem, Mohamed O Othman
OBJECTIVE: In the management of small and diminutive polyps, cold polypectomy is favored over electrocautery polypectomy. However, the optimal cold polypectomy technique is still controversial. Hence, this review aims to investigate the most effective cold technique for small and diminutive colorectal polyps. METHODS: We conducted a systematic review and network meta-analysis synthesizing randomized controlled trials (RCTs) which were retrieved by systematically searching PubMed, EMBASE, Web of Science, SCOPUS, and Cochrane through February 10th , 2023...
September 22, 2023: Current Medical Research and Opinion
Georg Seifert, Laura Upstone, Christopher P Watling, Christian Vogelberg
OBJECTIVES: EA 575 (Prospan) is a herbal medicine containing a dried extract of ivy leaves (drug extract ratio 5-7.5:1; extraction solvent, 30% ethanol). Although widely used for the treatment of cough, there remains a lack of clarity on the effects of EA 575 in children. This study aimed to evaluate the efficacy and tolerability of EA 575 in pediatric patients with cough, via a literature review and expert survey. METHODS: A MEDLINE/PubMed database search was performed to identify articles evaluating the efficacy and tolerability of EA 575 in pediatric patients with cough...
September 21, 2023: Current Medical Research and Opinion
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No abstract text is available yet for this article.
September 20, 2023: Current Medical Research and Opinion
Funda Tamer, Yusuf Can Edek, Ahmet Burhan Aksakal
OBJECTIVE: High serum uric acid levels have been associated with psoriasis as well as cardiovascular diseases and metabolic syndrome. The aim of this study was to evaluate the effect of biologic agent treatment on serum uric acid levels in patients with psoriasis. METHODS: Between April 2019 and September 2022, serum uric acid levels were retrospectively evaluated in patients with psoriasis before and three months after biologic agent treatment. RESULTS: This study included 224 patients, 100 females and 124 males who were treated with TNF-α, IL-17, IL-12/23 and IL-23 inhibitors...
September 19, 2023: Current Medical Research and Opinion
Timothy Daly
It is still not known what causes Alzheimer's Disease (AD). In this period of uncertainty, an emerging literature on risk factors suggests that the concept of "stimulation" is a useful pragmatic tool both before and after diagnosis to improve cognitive health. Before diagnosis of AD, stimulation of the brain through education, exercise, and social stimulation provides fortification against later cognitive decline. After diagnosis, specific electrical stimulation of brain circuits may protect cognitive function, and non-specific stimulation through different kinds of environmental enrichment may help to compensate for cognitive decline...
September 19, 2023: Current Medical Research and Opinion
Şükrü Alperen Korkmaz, Sadice Kızgın
Objective: Recent studies show that inflammation is related to the pathogenesis of acute mania of bipolar disorder. Neutrophil/high-density lipoprotein (HDL) ratio (NHR), lymphocyte/HDL ratio (LHR), monocyte/HDL ratio (MHR) and platelet/HDL ratio (PHR) have recently been investigated as novel markers of inflammation. In addition, the atherogenic index of plasma (AIP) and atherogenic coefficient (AC) are the leading atherogenic indices. The study aimed to investigate these inflammation and atherogenic index markers in acute mania of bipolar disorder...
September 19, 2023: Current Medical Research and Opinion
Saumitra Ray, Tiny Nair, J P S Sawhney, Erwinanto, Azhari Rosman, Eugene Reyes, Loewe Go, Apichard Sukonthasarn, Aekarach Ariyachaipanich, Phạm Manh Hung, Harshal Chaudhari, Harshveer Singh Malhi
OBJECTIVE: This Delphi method of consensus was designed to develop scientific statements for β-blockers in the continuum of cardiovascular diseases with a special focus on the role of bisoprolol. METHODS: Eleven experienced cardiologists from across the Asia-Pacific countries participated in two rounds of the survey. In the first round, experts were asked to rate agreement/disagreement with 35 statements across seven domains regarding the use of β-blockers for treating hypertension, heart failure, coronary artery diseases, co-morbidities as well as their safety profile, usage pattern, and pharmacokinetic variability...
September 11, 2023: Current Medical Research and Opinion
Jin Yan, Feihong Deng, Yuyong Tan, Bingyi Zhou, Deliang Liu
OBJECTIVE: The treat-to-target strategy is recommended by Selecting Therapeutic Targets in Inflammatory Bowel Disease II (STRIDE-II) for treating ulcerative colitis (UC), and monitoring remission status is crucial during this management. The systemic immune-inflammation index (SII), defined as platelet * neutrophil/lymphocyte, is a complete blood count-based index reflecting the balance of immune and inflammatory status. This study aims to investigate the feasibility of SII for diagnosing UC and monitoring UC disease activity...
September 10, 2023: Current Medical Research and Opinion
Jonathan I Silverberg, Yael A Leshem, Brian M Calimlim, Jeffrey McDonald, Leighann Litcher-Kelly
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, skin pain, and sleep impacts, which are only reportable by patients themselves. The goal of this research is to evaluate the reliability, validity, and interpretability of the scores from three patient-reported outcome measures within the context of a clinical trial for adolescents and adults with moderate to severe AD. METHODS: Data from a Phase 3 randomized, double-blind, placebo-controlled, multinational clinical trial for individuals 12 to 75 years of age with moderate to severe AD (AD Up [ClinicalTrials...
September 10, 2023: Current Medical Research and Opinion
Irene Marcilla-Toribio, Maria Martinez-Andres, Maria Leopolda Moratalla-Cebrian, Ravi Jandhyala, Omolade Femi-Ajao, Eva Maria Galan-Moya
Introduction: The post-acute (long) COVID-19 Quality of Life instrument is the only specific instrument designed to assess quality of life in long COVID patients. The present study aims to make a transcultural adaptation and validation into Spanish of the disease-specific (long COVID) quality of life instrument, post-acute (long) COVID-19 Quality of Life, to have a tool for objective measurement of quality of life in this population. Methods: A descriptive cross-sectional study was divided into two phases. In phase one, the translation and cultural adaptation of the questionnaire was performed, while in phase two, the questionnaire was validated...
September 7, 2023: Current Medical Research and Opinion
Helmut Butzkueven, Jan Hillert, Merja Soilu-Hänninen, Tjalf Ziemssen, Jens Kuhle, Stig Wergeland, Melinda Magyari, Joseph R Berger, Nicholas Moore, Aida Aydemir, Irene Bezemer, Meritxell Sabidó
Objectives: As part of the CLARION study: (1) characterize the incidence of severe infections, herpes zoster, and malignancies in patients newly initiating cladribine or fingolimod for relapsing multiple sclerosis (MS); (2) estimate the incidence of severe lymphopenia among cladribine users; and (3) describe prior/subsequent disease-modifying therapy (DMT) in both cohorts. Methods: Patients were identified from seven participating MS registries/data sources. The incidence rate (IR) of each outcome per 1000 patient-years and its 95% confidence interval (95%CI) were estimated for cohorts using Poisson regression...
September 7, 2023: Current Medical Research and Opinion
Steve Freedman, Enrique de-Madaria, Eric Bruckert, Matthias Löhr, Vinciane Rebours, Ravi Jandhyala
BACKGROUND: In the study on triglyceride-induced pancreatitis (TG-IAP) (Freedman et al, 2022), a core clinical dataset using the Jandhyala method was developed to collect the minimum amount of information for each patient presenting with TG-IAP globally. This approach offered a unified framework for observing multiple populations of TG-IAP patients using the same set of indicators, resulting in a considerably larger and uniform real-world population. It was understood that when this core dataset is implemented in a patient registry it could address the issue of missing data in observational studies and produce higher-quality research...
September 4, 2023: Current Medical Research and Opinion
Kym Michelle McCormick, Sneha Sethi, Dandara Haag, Davi Manzini Macedo, Joanne Hedges, Adrian Quintero, Lisa Smithers, Rachel Roberts, Gregory Zimet, Lisa Jamieson, Pedro Henrique Ribeiro Santiago
Objective: The COVID-19 pandemic significantly impacted and continues to impact the health and well-being of Australian adults. However, there has been no instrument validated to comprehensively measure how the COVID-19 pandemic impacted adults in Australia across several domains (e.g. fear of COVID-19, attitudes towards vaccination, psychosocial impact of lockdowns).The current study conducted a rigorous psychometric process to develop and validate an instrument to measure the impact of the COVID-19 pandemic in Australia, the COVID-19 Impact Scale (CIS)...
September 1, 2023: Current Medical Research and Opinion
Sarah Cotton, Jeffrey S Andrews, Russell M Nichols, James Jackson, Antje Tockhorn-Heidenreich, Gary Milligan, James M Martinez
OBJECTIVE: To describe clinical characteristics and regional treatment patterns of episodic cluster headache (CH). METHODS: A point-in-time survey of physicians and their patients with CH was conducted in the United States, United Kingdom and Germany in 2017. RESULTS: Overall, 1012 patients with episodic CH were analyzed. Demographic and clinical findings were generally consistent across regions. Most patients were men (66.6%) and the mean age was 40...
August 24, 2023: Current Medical Research and Opinion
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