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Journals Current Medical Research and O...

Current Medical Research and Opinion

https://read.qxmd.com/read/38779703/extemporaneous-combination-therapy-with-nebivolol-valsartan-for-the-treatment-of-hypertension-a-study-of-real-world-evidence-in-europe
#1
JOURNAL ARTICLE
Giovambattista Desideri, Valeria Pegoraro, Riccardo Cipelli, Claudio Ripellino, Marco Miroddi, Suada Meto, Mario Gori, Paolo Fabrizzi
OBJECTIVE: To explore real-life use of the extemporaneous combination of nebivolol and valsartan (NV-EXC) in adult hypertensive patients in Europe. METHODS: Retrospective analysis of patients starting NV-EXC treatment conducted using prescription databases in Italy, Germany, Hungary, and Poland. The selection period during which study patients were identified covered a time span ranging from 3 to 9 years (until June 30, 2020) according to availability of the different data sources...
May 23, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38773792/statement-of-retraction-a-review-of-translational-medicine-the-future-paradigm-how-can-we-connect-the-orthopedic-dots-better
#2
(no author information available yet)
No abstract text is available yet for this article.
May 21, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38773739/management-of-hepatorenal-syndrome-and-treatment-related-adverse-events
#3
JOURNAL ARTICLE
Lorenzo Peluso, Marzia Savi, Giacomo Coppalini, Deliana Veliaj, Nicola Villari, Giovanni Albano, Stephen Petrou, Maria C Pace, Marco Fiore
Hepatorenal Syndrome is a critical complication of liver failure, mainly in cirrhotic patients and rarely in patients with acute liver disease. It is a complex spectrum of conditions that leads to renal dysfunction in the liver cirrhosis population; the pathophysiology is characterized by a specific triad: circulatory dysfunction, nitric oxide (NO) dysfunction and systemic inflammation but a specific kidney damage has never been demonstrated, in a clinicopathological study, kidney biopsies of patients with cirrhosis showed a wide spectrum of kidney damage...
May 21, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38771729/therapeutic-potential-of-acarbose-in-ameliorating-the-metabolic-and-endocrinological-complications-of-polycystic-ovarian-syndrome-a-review
#4
REVIEW
Marina Andavar, Raju Kamaraj, Thangavel Mahalingam Vijayakumar, Anuradha Murugesan
Polycystic ovarian syndrome is a perplexed condition addressing endocrinal, cardiometabolic and gynaecological issues. It affects women of adolescent age and is drastically increasing in the Indo-Asian ethnicity over the recent years. According to Rotterdam criteria, PCOS is characterized by clinical or biochemical excess androgen and polycystic ovarian morphology; however, it has been established in the recent years that PCOS exacerbates to further serious metabolic conditions on the long term. This is a narrative literature review and not systematic review and is based on PubMed searches with relevant keywords "Polycystic ovarian syndrome AND acarbose OR metformin OR myoinositol; PCOS AND metabolic syndrome OR cardiovascular disease OR menstrual irregularity OR infertility OR chronic anovulation OR clinical hyperandrogenism" used in the title and are limited to articles published in English language with no time limits...
May 21, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38756086/a-survey-on-the-short-to-medium-term-satisfaction-of-neurological-patients-treated-by-functional-surgery-for-the-correction-of-limb-deformities
#5
JOURNAL ARTICLE
Paolo Zerbinati, Davide Mazzoli, Martina Galletti, Giacomo Basini, Chiara Rambelli, Francesca Mascioli, Maria Chiara Bò, Caterina Delia, Ludovica Petroselli, Maria Chiara Vulpiani, Paolo Prati, Jonathan Bemporad, Andrea Merlo
OBJECTIVES: Functional surgery (FS) is often used to correct congenital or acquired deformities in neurological patients. Along with functional results, short- and medium-term patient satisfaction should always be considered a key goal of surgery and rehabilitation. The aim of this study is to assess the short to medium-term satisfaction of patients who underwent FS and its correlation with perceived improvements. METHODS: Invitation to an anonymous online survey was sent via e-mail to all neurological adult patients or caregivers of children who underwent lower or upper limb FS over the 2018 - 2020 period...
May 17, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38745451/panel-interview-of-oncology-practices-with-emergent-experience-of-teclistamab-in-the-real-world-the-tecpioneer-study
#6
JOURNAL ARTICLE
Benjamin A Derman, Meaghan Roach, Dee Lin, Bingcao Wu, Richard Murphy, Nina Kim, Margaret Doyle, Nadya Prood, Jessica Fowler, Alexander Marshall, Amal Jamaleddine, Agne Paner-Straseviciute
OBJECTIVE: To understand providers' current teclistamab step-up dosing (SUD) model and how they envision future administration models, as well as perceived barriers and facilitators to these models in day-to-day clinical practice. METHODS: Interviews of clinicians with RW experience administering teclistamab, with a subsequent roundtable discussion to discuss interview findings. Topics of interest included managing adverse events (AE), and handling logistics of SUD and transition of care (ToC)...
May 14, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38745448/economic-burden-of-generalized-myasthenia-gravis-mg-in-the-united-states-and-the-impact-of-common-comorbidities-and-acute-mg-events
#7
JOURNAL ARTICLE
Maryia Zhdanava, Jacqueline Pesa, Porpong Boonmak, Qian Cai, Dominic Pilon, Zia Choudhry, Nizar Souayah
Introduction: This study assessed incremental healthcare costs and resource utilization (HRU) associated with generalized myasthenia gravis (gMG) as well as variability in these outcomes among patients with gMG and common comorbidities and acute MG-related events. Methods: Adults with gMG and without MG were identified from a large US database (2017-2021). The index date was the first MG diagnosis (gMG cohort) or random date (non-MG cohort). Cohorts were propensity score matched 1:1. The gMG cohort included subgroups of patients with a 12-month pre-index (baseline) cardiometabolic or psychiatric comorbidity, or a post-index MG exacerbation/crisis...
May 14, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38738706/real-world-outcomes-in-patients-with-chronic-spontaneous-urticaria-receiving-omalizumab-insights-from-a-clinical-practice-survey
#8
JOURNAL ARTICLE
Arpamas Seetasith, Michael Holden, James Hetherington, Aaron Keal, Phoebe Salmon, Jonathan A Bernstein, Thomas B Casale
Objective: Chronic spontaneous urticaria (CSU) is a debilitating inflammatory skin condition, often impacting quality of life. International guidelines recommend omalizumab, an anti-immunoglobulin E antibody, for second-line treatment. Our objective was to understand patient characteristics associated with prescription of omalizumab, and assess real-world outcomes in patients with CSU treated with omalizumab. Methods: We analyzed data from the Adelphi Real World CSU Disease Specific Programme™, a cross-sectional survey with retrospective data collection (December 2020-October 2021) from physicians and patients with CSU in the United States...
May 13, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38727420/exploring-treatment-strategies-for-paroxysmal-nocturnal-hemoglobinuria-an-overview-of-registered-clinical-trials
#9
REVIEW
Vanda P Peixoto, Cristina Prudêncio, Mónica Vieira
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease in which blood cells lack anchored proteins that regulate the complement system. The erythrocytes are then destroyed because of uncontrolled complement activity, leading to intravascular hemolysis (IVH) and a high risk of thrombosis outcome.A huge alteration in the treatment of the disease was the development of terminal complement inhibitors, with the achievement of IVH blockade, reduction or abolishment of red blood cell (RBC) transfusions, and thromboembolic events prevention...
May 10, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38720658/influence-of-tricuspid-regurgitation-on-the-prognosis-of-patients-with-cardiogenic-shock
#10
JOURNAL ARTICLE
Marinela Ruka, Tobias Schupp, Kathrin Weidner, Sascha Egner-Walter, Jan Forner, Kambis Mashayekhi, Péter Tajti, Mohamed Ayoub, Muharrem Akin, Michael Behnes, Ibrahim Akin, Jonas Rusnak
OBJECTIVE: Tricuspid regurgitation (TR) is associated with adverse prognosis in various patient populations. However, data regarding the prognostic impact in patients with cardiogenic shock (CS) is limited. The study investigates the prognostic impact of pre-existing TR in patients with CS. METHODS: Consecutive patients with CS from 2019 to 2021 were included in a monocentric registry. Every patient's medical history, including echocardiographic data, was recorded...
May 9, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38715458/real-world-effectiveness-of-cdk4-6-inhibitors-on-patients-with-hr-her2-advanced-breast-cancer-in-south-korea-focusing-on-underrepresented-patients
#11
JOURNAL ARTICLE
Hye-In Jung, Sun-Hong Kwon, Jin Hyun Nam, Jeong-Yeon Ch, Eui-Kyung Lee
Objective We assessed the real-world effectiveness of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors as first-line treatments in postmenopausal patients with HR+/HER2- advanced breast cancer, focusing on younger (<45 years) and older (>78 years) populations not considered in clinical trials. Methods We analyzed nationwide claims data from the Health Insurance Review and Assessment Service between November 2016 and February 2021. In this retrospective cohort study, patients using CDK4/6 inhibitors and aromatase inhibitors were selected and grouped by age as follows: 45-78 years (trial-enrolled), <45 years (younger), and >78 years (older)...
May 7, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38713585/a-study-of-hemodynamic-effects-postoperative-recovery-and-safety-of-esketamine-right-handed-during-flexible-bronchoscopy-under-general-anesthesia
#12
JOURNAL ARTICLE
Qin Ding, Suyang Yue
OBJECTIVE: Flexible bronchoscopy during general anesthesia has become an indispensable tool. Anesthetics are widely utilized in flexible bronchoscopy (FB). This study delved into the application value of a subanesthetic dose of esketamine (ES) (right handed) in flexible bronchoscopy during general anesthesia. METHODS: A sample of 160 patients who underwent flexible bronchoscopy during general anesthesia were selected as study subjects and were equally divided into the control and ES groups, with clinical baseline data (age, sex, body mass index, American Society of Anesthesiologists grading) collected...
May 7, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38709213/awareness-attitudes-and-practices-regarding-meningococcal-serogroup-b-vaccination-in-the-united-states-among-parents-of-older-adolescents-and-among-young-adults-a-plain-language-summary
#13
JOURNAL ARTICLE
Oscar Herrera-Restrepo, Zifan Zhou, Annie Krishnan, Wanda J Conley, Eni Oladele, Jasjit K Multani, Rifat Tuly, Liucheng Shi, Chi-Chang Chen, Scott Preiss, Diana E Clements
No abstract text is available yet for this article.
May 6, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38700245/beyond-disclaimers-the-need-for-a-curation-based-model-of-pubmed
#14
JOURNAL ARTICLE
Jaime A Teixeira da Silva, Helmar Bornemann-Cimenti, Timothy Daly, Jens C Türp
According to its own description, the biomedical meta-database PubMed exists "with the aim of improving health-both globally and personally." Unfortunately, PubMed contains an increasing amount of low-quality research that may detract from this goal. Currently, PubMed warns its users and protects itself from such problems with a disclaimer stating that the presence of any article, book, or document in PubMed does not imply an endorsement of, or concurrence with, its contents by the NLM, the National Institutes of Health (NIH), or the U...
May 3, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38700241/exploring-the-current-dynamics-of-preprints
#15
JOURNAL ARTICLE
Raj Rajeshwar Malinda, Dipika Mishra, Ruchika Bajaj, Alin Khaliduzzaman
Preprints are non-peer-reviewed and publicly available articles for open and transparent research communication. Preprint servers host the submission of such manuscripts, and despite the presence of established preprint servers, their numbers have continued to rise in recent times. A steep increasing pattern in posted preprints and their accommodating servers has been observed over the last decade. In this article, we explored the global trends in the preprint adoption and its involvement in promoting open and transparent research findings across various domains...
May 3, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38700234/evaluating-unmet-needs-in-large-volume-subcutaneous-drug-delivery-u-s-payer-perspectives-on-a-novel-large-volume-on-body-delivery-system
#16
REVIEW
Mehul Desai, James Kenney, Edmund Pezalla
Existing healthcare systems face finite resource allocation and budgetary constraints, resulting in a substantial need for innovative solutions to enhance service delivery at reduced costs. A novel, user-friendly on-body delivery system (OBDS) was developed which enables administration of large-volume subcutaneous (SC) drugs in both clinical and home-based settings (at-home HCP administration or at-home self-administration). This research sought to evaluate the potential economic impact of at-home self- or HCP- administration with the OBDS through a comprehensive review of published literature and semi-structured interviews with 17 US payers representing approximately 227 million covered lives...
May 3, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38693906/characterizing-the-treatment-patterns-medication-burden-and-patient-demographics-of-older-adults-with-major-depressive-disorder-treated-with-antidepressants-with-or-without-selected-comorbidities
#17
JOURNAL ARTICLE
Laxmi Gann, Francesca Devine, Lyuba Popadic, Sagar Lal, Michael Witte, Marci Potter, Steve Hass
Objective: Evaluate clinical characteristics, comorbidity burden, major depressive disorder (MDD)-related healthcare resource utilization (HCRU), medication burden, and antidepressant treatment (ADT) patterns among older adults with MDD with and without selected comorbidities. Methods: Using Komodo's Healthcare Map claims data (1/1/2016-9/30/2022), patients with MDD (≥65 years) treated with ADTs were assessed 24 months preceding (baseline) and 12 months following (follow-up) first observed ADT prescription fill (index)...
May 2, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38683759/indonesia-s-healthcare-landscape-embracing-innovation-in-the-new-health-regime
#18
JOURNAL ARTICLE
Ferry Fadzlul Rahman
The comment highlights the intricate health issues in Indonesia, emphasizing urban-rural gaps, healthcare financing challenges, and the government's dedication to Universal Health Coverage (UHC). The country's geographical layout amplifies the struggle of providing healthcare to rural areas, resulting in substantial health concerns like high tuberculosis rates and financial vulnerability for the impoverished. The concern raised underscores the paradox of low state healthcare spending despite high household expenditures, leading to individual payment reliance and underutilization of insurance...
April 29, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38646669/perception-gaps-of-patient-engagement-for-patient-safety-between-healthcare-professionals-and-the-public-in-korea
#19
JOURNAL ARTICLE
Hyeran Jeong, Won Lee, Seung Gyeong Jang, Jeehee Pyo, Eun Young Choi, Seung Ju Baek, Minsu Ock
BACKGROUND: To ensure effective patient engagement, patients' efforts, partnerships with healthcare professionals, and the organisation's role in providing safe healthcare settings must be emphasised. Perception gaps regarding patient engagement between the public and healthcare professionals could prevent healthy partnerships from forming and hinder patient engagement activities. This study examined healthcare professionals' perception of patient engagement and compared the findings with that determined for the public in a previous study...
April 22, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38646665/unmet-needs-in-phenylketonuria-an-exploratory-italian-survey-among-patients-and-caregivers
#20
JOURNAL ARTICLE
Valentina Rovelli, Annamaria Dicintio, Chiara Cazzorla
OBJECTIVE: Patients with phenylketonuria (PKU) require a strict diet to maintain phenylalanine (Phe) levels within the desired range. However, the diet can be onerous, resulting in poor adherence. We carried out the first online national survey in Italy to better understand the perceptions, knowledge, and experiences of both patients with PKU and caregivers with the goal of improving patient outcomes. METHODS: An online survey of 35 questions to patients and 36 questions to caregivers was distributed in September 2022 through physicians and relevant Italian associations...
April 22, 2024: Current Medical Research and Opinion
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