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Current Medical Research and Opinion

Francis Vekeman, Jesus Eric Piña-Garza, Wendy Y Cheng, Edward Tuttle, Philippe Giguère-Duval, Arman Oganisian, Joseph Damron, Mei Sheng Duh, Vivienne Shen, Timothy B Saurer, Georgia D Montouris, Jouko Isojarvi
OBJECTIVE: Describe the development of a claims-based classifier utilizing machine learning to identify patients with probable Lennox-Gastaut syndrome (LGS) from 6 state Medicaid programs. METHODS: Patients were included if they had ≥2 medical claims ≥30 days apart for specified or unspecified epilepsy, excluding those with ≥1 claim for petit mal status. The LGS classifier utilized a random forest algorithm, a compilation of thousands of binary decision trees in which machine-generated predictor variables split the data set into branches that predict the presence or absence of LGS...
March 14, 2019: Current Medical Research and Opinion
Sigal Kaplan, Birgit Ehlken, Xenia Hamann
OBJECTIVES: This report characterizes flupirtine prescribing patterns before and after the implementation of risk minimization measures (RMM) in Germany as a complementary analysis to support previous study findings. METHODS: A retrospective analysis was conducted using a patient-level longitudinal prescription database (IMS® LRx) in Germany. The study population included patients who were prescribed flupirtine-containing products. One-year periods before (2012) and after (April 2015 - March 2016) RMM implementation were assessed for the following measures: flupirtine use of up to two weeks, flupirtine use when other analgesics are contraindicated, and concomitant use of drugs with a known potential to induce liver injury...
March 13, 2019: Current Medical Research and Opinion
Arndt van Ophoven, Kirsten Vonde, Winfried Koch, Günter Auerbach, Klaus P Maag
BACKGROUND: Among the numerous therapeutic approaches used in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) only few have been assessed with a sufficient level of evidence. Safety and efficacy of pentosan polysulfate sodium (PPS) has been shown in several open-label and comparative clinical trials with different populations including two meta-analyses. In the context of the approval procedure of PPS for the treatment of IC/BPS by the European Medicines Agency we updated the findings of the previous analyses by incorporating the results of the latest studies...
March 8, 2019: Current Medical Research and Opinion
Kazeem A Oshikoya, Ibrahim Abayomi Ogunyinka, Brian Godman
BACKGROUND AND AIMS: Pentazocine remains a widely used opioid pre-anesthetic medication and post-operative analgesic in low- and middle-income countries despite concerns. We assessed the adverse events (AEs) associated with off-label use of pentazocine in pediatric surgical patients and determined the possible risk factors associated with slow respiratory AEs. METHOD: Children ≤18 years old for surgery administered pentazocine IM/IV as a pre-anesthetic medication or post-operative analgesic...
March 5, 2019: Current Medical Research and Opinion
(no author information available yet)
No abstract text is available yet for this article.
March 5, 2019: Current Medical Research and Opinion
Kuat Oshakbayev, Bakytzhan Bimbetov, Kenzhegul Manekenova, Gulnara Bedelbayeva, Khalit Mustafin, Bibazhar Dukenbayeva
No abstract text is available yet for this article.
March 1, 2019: Current Medical Research and Opinion
Niki Katsiki, Vasilios G Athyros
No abstract text is available yet for this article.
March 1, 2019: Current Medical Research and Opinion
Vanessa Taieb, Hidetoshi Ikeoka, Fang-Fang Ma, Katarzyna Borkowska, Samuel Aballéa, Keiko Tone, Nobuo Hirotsu
OBJECTIVE: Baloxavir marboxil (baloxavir) is the first cap-dependent endonuclease inhibitor being studied for the treatment of influenza in single oral dosing regimen. This network meta-analysis (NMA) evaluated the efficacy and safety of baloxavir compared to other antivirals for influenza in otherwise healthy patients. METHODS: A systematic literature review was performed on November 14, 2016 in Medline, Embase, CENTRAL, and ICHUSHI to identify randomized controlled trials assessing antivirals for influenza...
February 27, 2019: Current Medical Research and Opinion
Mata Charokopou, Rebecca Harvey, Kunal Srivastava, Christian Brandt, Simon Borghs
OBJECTIVE: To estimate the relative efficacy, safety and tolerability of adjunctive brivaracetam and other antiepileptic drugs (AEDs) using a Bayesian network meta-analysis (NMA) approach. METHODS: A systematic literature review (SLR) identified randomized controlled trials of AEDs treating focal (partial-onset) seizures for ≥8 weeks and assessed them for inclusion in the NMA. Bayesian random-effects NMA was performed for several outcomes. All interventions within the licensed dose range were included in the network of evidence...
February 25, 2019: Current Medical Research and Opinion
Bailey Roberts, Reese Courington, Erik VerHage, Melissa Ward-Peterson, Juan Lozano
INTRODUCTION AND OBJECTIVES: Acute abdominal pain (AAP) is one of the most common complaints in the emergency department (ED). Rapid diagnosis is essential and is often achieved through imaging. Computed tomography (CT) is widely considered an exemplary test in the diagnosis of AAP in adult patients. As previous studies show disparities in healthcare treatment based on insurance status, our objective was to assess the association between insurance status and frequency of CT ordered for adult patients presenting to the ED with AAP from 2005-2014...
February 25, 2019: Current Medical Research and Opinion
Varun Vaidya, Meghan Hufstader Gabriel, Pranav Patel, Renuka Gupte, Cameron James
PURPOSE: The purpose of this study is to determine racial and ethnic disparities with the adherence to inhaled corticosteroids (ICSs) in adults with persistent asthma, and its association with healthcare expenditures. METHODS: A retrospective, cross-sectional study using the Medical Expenditure Panel Survey (MEPS) 2013-2014 data included patients ≥18 years with persistent asthma. Median medication possession ratio (MPR) was used to dichotomize adherence levels...
February 22, 2019: Current Medical Research and Opinion
Ben Hoskin, Benjamin Ortiz, Brandee Paknis, Abhishek Kavati
INTRODUCTION: Chronic idiopathic/spontaneous urticaria (CIU/CSU) is a debilitating skin condition that is burdensome for patients and healthcare providers. We aimed to describe clinical characteristics, consultation patterns, and healthcare resource utilization in real-world US patients with refractory and non-refractory CIU/CSU. METHODS: Data were collected from the Adelphi Real World 2015 Urticaria Disease Specific Programme. Physicians completed patient record forms (PRFs) for the next 4 patients consulting with non-refractory CIU/CSU and the next 6 with refractory CIU/CSU; patients were considered refractory if symptomatic and on treatment step ≥2...
February 22, 2019: Current Medical Research and Opinion
Andrea Berardi, Mohd Kashif Siddiqui, Catrin Treharne, Gerard Harty, Schiffon L Wong
OBJECTIVES: To estimate the comparative efficacy of cladribine tablets versus alternative disease modifying therapies (DMTs) - fingolimod, natalizumab, alemtuzumab and ocrelizumab - in adults with active relapsing-remitting multiple sclerosis (RRMS), using meta-regression to provide subpopulation-specific estimates of drug effect. Additionally, to determine the feasibility of conducting a matching-adjusted indirect comparison (MAIC) to validate the meta-regression results. METHODS: A published systematic literature review (SLR) identified studies evaluating the efficacy of cladribine tablets and alternative DMTs in the management of active RRMS...
February 20, 2019: Current Medical Research and Opinion
Ernst Yorke, Folaju O Oyebola, Samuel Anaja Otene, Axel Klein
OBJECTIVE: Pain management is unsatisfactory worldwide, particularly in developing countries where access to opioids is restricted and cost is an issue. It is a major concern in West Africa and we therefore undertook a survey of pain experts to obtain a better understanding of the problems in the region. METHODS: Medical practitioners involved in pain management, identified via professional networks, were interviewed to share their experience in treating moderate-to-severe pain in West Africa...
February 20, 2019: Current Medical Research and Opinion
Jeffrey R Curtis, Cecilie H Brahe, Mikkel Østergaard, Merete Lund Hetland, Karen Hambardzumyan, Saedis Saevarsdottir, Xingbin Wang, Darl D Flake, Eric H Sasso, T W Huizinga
OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: <30, 30-44, >44), DAS28-CRP (low/moderate/high: ≤2...
February 19, 2019: Current Medical Research and Opinion
Vincent Woo, Kim Connelly, Peter Lin, Philip McFarlane
BACKGROUND: Heart failure (HF) and chronic kidney disease (CKD) are responsible for substantial morbidity and mortality in individuals with type 2 diabetes (T2D). METHODS: This review discusses the significance of these comorbidities of T2D and current options for managing them, with a focus on sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Based on a focused literature search of cardiovascular outcomes trials (CVOTs), this review assessed the effects of SGLT-2 inhibitors in individuals with T2D with or without established cardiovascular disease (CVD)...
February 15, 2019: Current Medical Research and Opinion
Min Ji Kwak, Viraj Bhise, Mark T Warner, Prakash Balan, Tom C Nguyen, Anthony L Estrera, Richard W Smalling, Abhijeet Dhoble
OBJECTIVES: We aimed to trend the utilization of transcatheter aortic valve replacement (TAVR) among COPD patients, compare its outcomes to surgical aortic valve replacement (SAVR), and assess any social disparities of its outcomes. BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) have been increasingly undergoing TAVR, but studies to evaluate the national trend of TAVR utilization and outcome still are lacking. METHODS: We conducted a retrospective observational study using a nationally representative data, National Inpatient Sample (NIS)...
February 14, 2019: Current Medical Research and Opinion
Priscilla Hollander, Julie Hill, Jeremy Johnson, Zhi Wei Jiang, Gregory Golm, Susan Huyck, Steven G Terra, James P Mancuso, Samuel S Engel, Brett Lauring, Jie Liu
OBJECTIVE: To assess the safety and efficacy of ertugliflozin over 104 weeks in patients with type 2 diabetes mellitus (T2DM) inadequately controlled on metformin. METHODS: In this double-blind, multicenter, randomized, Phase III study (VERTIS SU; NCT01999218), adults with T2DM and glycated hemoglobin (HbA1c) 7.0-9.0% on metformin ≥1500 mg/day received ertugliflozin 5 mg, 15 mg, or glimepiride. The primary efficacy time point was Week 52; double-blinded treatment continued until Week 104...
February 14, 2019: Current Medical Research and Opinion
Sebastiano Leone, Marco Cascella, Ilaria Pezone, Marco Fiore
Nowadays, the infections of patients admitted to Intensive Care Units (ICUs) are one of the major public health problems; this is due to several factors, in primis an increase in antibiotic resistance and the inappropriate use of antibiotics. This editorial focuses on both new antibiotics approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in the last decade (2010-2019), and on agents in advanced phase of development that have been developed, or are already approved, for the treatment of serious infections due to multidrug-resistant (MDR) bacteria, both Gram-positive (GPB) and Gram-negative (GNB) bacteria...
February 14, 2019: Current Medical Research and Opinion
(no author information available yet)
No abstract text is available yet for this article.
February 13, 2019: Current Medical Research and Opinion
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