Lauren Madden Doyle, S Faisal Ahmed, Jessica Davis, Sue Elford, Yasir S Elhassan, Lynette James, Neil Lawrence, Sofia Llahana, Grace Okoro, D Aled Rees, Jeremy W Tomlinson, Michael W O'Reilly, Nils P Krone
BACKGROUND: Congenital adrenal hyperplasia (CAH) encompasses a rare group of autosomal recessive disorders, characterised by enzymatic defects in steroidogenesis. Heterogeneity in management practices has been observed internationally. The International Congenital Adrenal Hyperplasia registry (I-CAH, was established to enable insights into CAH management and outcomes, yet its global adoption by endocrine centres remains unclear. DESIGN: We sought (1) to assess current practices amongst clinicians managing patients with CAH in the United Kingdom and Ireland, with a focus on choice of glucocorticoid, monitoring practices and screening for associated co-morbidities, and (2) to assess use of the I-CAH registry...
March 17, 2024: Clinical Endocrinology
Herborg Líggjasardóttir Johannesen, Anna Sofía Veyhe, Jens Andreassen, Pál Weihe, Marin Strøm, Guðrið Andorsdóttir, Aase Krogh Rasmussen, Ulla Feldt-Rasmussen, Allan Carlé, Stig Andersen
OBJECTIVE: The occurrence of thyroid disease varies among populations. While the iodine nutrition level of the Faroese seems to have been decreasing over the past decades, there is no systematic evaluation of the thyroid disease pattern in the Faroe Islands. Such knowledge of thyroid disease occurrence in the North Atlantic region may support healthcare planning and prevention. To investigate incidence rates, including subtypes of thyroid diseases, and demographic characteristics of thyroid disease patients in the Faroe Islands, to improve understanding of the patterns and trends of these disorders...
March 13, 2024: Clinical Endocrinology
Oded Cohen, Sharon Tzelnick, Gregory Randolph, Alessandra Rinaldo, Fernando Álvarez, Juan P Rodrigo, Nabil F Saba, Sandra Nuyts, June Corry, Antti A Mäkitie, Vincent Vander Poorten, Cherie-Ann Nathan, Cesare Piazza, Alfio Ferlito
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor from parafollicular cells that produce calcitonin (Ct). Despite several existing guidelines for the surgical management of sporadic MTC (sMTC), optimal initial surgical management of the thyroid, the central and the lateral neck remains a matter of debate. METHODS: A systematic review in PubMed and Scopus for current guidelines addressing the surgical management of sMTC and its referenced citations was conducted as per the PRISMA guidelines...
March 12, 2024: Clinical Endocrinology
Sabine E Hannema, Katja P Wolffenbuttel, Yolande van Bever, Hennie T Bruggenwirth, Remko Hersmus, J Wolter Oosterhuis, Leendert H J Looijenga
No abstract text is available yet for this article.
March 12, 2024: Clinical Endocrinology
Rohan K Henry, Leena Mamilly, Monika Chaudhari, Brett G Klamer, Melica Nikahd, Amy L Pyle-Eilola
OBJECTIVES: Various biases pertaining to stature account for a male sex predominance in growth hormone deficiency (GHD) cases diagnosed by endocrinology clinics. This manuscript will assess the sex distribution when biases are minimised. METHODS: Retrospective chart review was conducted on patients diagnosed with GHD between 3 and 16 years of age. The sex distribution of cases was ascertained according to: (1) peak GH (pGH) by groups; based on growth hormone provocative testing, (2) pituitary gland imaging results, and (3) isolated GHD (IGHD) versus multiple pituitary hormone deficiencies (MPHD)...
March 11, 2024: Clinical Endocrinology
Nicole Lafontaine, Suzanne J Brown, Petros Perros, Enrico Papini, Endre V Nagy, Roberto Attanasio, Laszlo Hegedüs, John P Walsh
OBJECTIVE: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. DESIGN AND PARTICIPANTS: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire...
March 11, 2024: Clinical Endocrinology
Hanbing Li, Lingling Gao, Xiao Yang, Lu Chen
OBJECTIVES: This study aims to develop and validate a prediction model for preterm birth in women with gestational diabetes mellitus (GDM). DESIGN: We conducted a retrospective study on women with GDM who gave birth at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, between November 2017 and July 2021. We divided 1879 patients into a development set (n = 1346) and a validation set (n = 533). The development set was used to construct the prediction model for preterm birth using the stepwise logistic regression model...
March 11, 2024: Clinical Endocrinology
David J Handelsman, Amanda Idan, Reena Desai, Janelle Grainger, Catrin Goebel, Sue Sleiman, Sasha Savkovic, Dorothy Kouzios, Venna Jayadev, Ann J Conway
OBJECTIVE: Human choriogonadotrophin (hCG) treatment of gonadotrophin-deficient infertile men uses hCG of urinary (uhCG) or recombinant (rhCG) origin, but these treatments have not been compared nor are there studies defining rhCG dosing in men. DESIGN: hCG products were studied in randomized cross-over single-dose studies of standard (Study 1, 1500 IU and 62.5 µg, respectively) or high (Study 2, 5000 IU and 250 µg) dose and a multi-dose population pharmacology study of hCG use...
March 6, 2024: Clinical Endocrinology
Line T Møllehave, Nils Knudsen, Eva Prescott, Inge B Pedersen, Gitte Ravn-Haren, Allan Carlé, Allan Linneberg
OBJECTIVE: Iodine fortification (IF) induces an initial increase followed by a decrease in the incidence of hyperthyroidism in the general population. Within the population of hyperthyroid patients, the sex-, age- and subtype distribution changes after IF. The risk of atrial fibrillation (AF) in hyperthyroid patients may be influenced by these factors. Therefore, we aimed to examine how the association between incident hyperthyroidism and AF was affected by IF increasing the population iodine intake from moderate-mild iodine deficiency to low adequacy...
March 4, 2024: Clinical Endocrinology
Bassel H Al Wattar, Jhia Jiat Teh, Sophie Clarke, Ali Abbara, Rachel Morman, Alison Wilcox, Vikram Talaulikar
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a chronic lifelong condition affecting up to 20% of women worldwide. There is limited input from affected women to guide the provision of healthcare services and future research needs. Our objective was to scope the healthcare and research priorities of women with PCOS in the United Kingdom. DESIGN: A three-staged modified Delphi method, consisting of two questionnaires and a consensus meeting involving lay representatives and healthcare professionals...
February 29, 2024: Clinical Endocrinology
Sara S Berggren, Jovanna Dahlgren, Ola Andersson, Stefan Bergman, Josefine Roswall
OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA). DESIGN: Blood samples from 551 Swedish children were analysed at birth, 4, 12, 36 and 60 months of age...
February 22, 2024: Clinical Endocrinology
Vijayakumar Karthik, Puthiyaveetil Khadar Jabbar, Devadas Krishnadas, Abilash Nair, Geena Susan George, Chellamma Jayakumari, Sarayu Soumya, Arsha Asok, Shameer Basheer
BACKGROUND: There are no reliable methods in clinical practice to diagnose adrenal insufficiency (AI) in patients with cirrhosis owing to variable cortisol-binding protein levels. This leads to unreliable results in ACTH stimulated serum cortisol test. We aimed to estimate the long-acting porcine (LA)ACTH-stimulated serum and salivary cortisol levels of patients at different stages of cirrhosis using second generation electrochemiluminescence and to determine the prevalence of true adrenal insufficiency in these patients...
May 2024: Clinical Endocrinology
Rasmus Reinke, Sebastian Udholm, Christian Fynbo Christiansen, Martin Almquist, Stefano Londero, Lars Rejnmark, Thomas Bøjer Rasmussen, Lars Rolighed
OBJECTIVE: Total thyroidectomy (TT) carries a risk of hypoparathyroidism (hypoPT). Recently, hypoPT has been associated with higher overall mortality rates. We aimed to evaluate the frequency of hypoPT and mortality in patients undergoing TT in Denmark covering 20 years. DESIGN: Retrospective Cohort study. PATIENTS AND MEASUREMENTS: Using population-based registries, we identified all Danish individuals who had undergone TT between January 1998 and December 2017...
April 2024: Clinical Endocrinology
İlkay N Yılmazer, Sema Nilay Abseyi, Gizem Şenyazar, Merih Berberoğlu, Zeynep Şıklar, Zehra Aycan
OBJECTIVE: This study aimed to investigate the quality of life of patients with central precocious puberty (CPP) who required treatment and premature thelarche (PT) followed up without treatment and to compare the groups with and without treatment among themselves and with healthy children. DESIGN, PATIENTS AND MEASUREMENT: This study is designed as a case-control study. A total of 193 children including 59 children with CPP, 53 children with PT, 81 healthy children and their parents were included in the study...
April 2024: Clinical Endocrinology
Natee Sakornyutthadej, Pat Mahachoklertwattana, Somboon Wankanit, Preamrudee Poomthavorn
OBJECTIVE: Serum luteinising hormone (LH) concentration has been reported to be lower in girls with overweight and obesity (OW/OB) as compared with girls with normal weight (NW). This study aimed to evaluate peak serum LH concentration during gonadotropin-releasing hormone analogue (GnRHa) test in girls with OW/OB and NW who had central precocious puberty (CPP) and to determine peak serum LH cut-off for diagnosing CPP in girls with OW/OB. DESIGN, PATIENTS AND MEASUREMENTS: Medical records of 971 girls with premature breast development who underwent subcutaneous GnRHa (100 µg of triptorelin acetate) test were reviewed...
April 2024: Clinical Endocrinology
Ye Lu, Ping Lu, Lixian Lin, Hang Chen, Feifei Zhang, Xin Li
OBJECTIVE: Bone mineral density (BMD) is typically reduced in patients with female athlete triad (FAT) and anorexia nervosa (AN). However, bone health in most patients with functional hypothalamic amenorrhoea (FHA), who may not suffer from severe energy deficiency, has not received adequate attention in clinical practice. This study aimed to investigate BMD and its association with clinical and endocrine features in individuals with FHA and to provide clinical evidence for improving bone loss and preventing osteoporosis in FHA...
April 2024: Clinical Endocrinology
Francis de Zegher, Lourdes Ibáñez
No abstract text is available yet for this article.
March 2024: Clinical Endocrinology
Matilde Calanchini, James Bradley-Watson, Fiona McMillan, Saul Myerson, Andrea Fabbri, Helen E Turner, Elizabeth Orchard
OBJECTIVE: The risk of aortic dissection (AoD) is increased in Turner syndrome (TS) but predicting those at risk is difficult. Based on scarce evidence, preventive aortic surgery is recommended when aortic diameter increases >5 mm/year. To investigate the aortic growth rate in TS and TS-related conditions associated with aortic growth. We also reported our experience of women who suffered aortic dissection (AoD), and who had preventive aortic replacement. METHODS: 151 adult TS were retrospectively identified...
March 2024: Clinical Endocrinology
Jasmine Saini, Raul Gregg Garcia, Justine Herndon, Dana Erickson, Lucinda Gruber, Irina Bancos
OBJECTIVE: Overnight metyrapone test (OMT) is a dynamic test used to diagnose secondary adrenal insufficiency (SAI). Data on OMT use and its safety are scarce. We aimed to describe the indications and safety of outpatient OMT and compare OMT to the cosyntropin stimulation test (CST). DESIGN: Single-centre retrospective study of adult patients undergoing OMT between 1 April 2018 and 27 January 2023. MEASUREMENTS: OMT-related adverse events, post-OMT diagnosis of SAI, and OMT comparison to CST...
March 2024: Clinical Endocrinology
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