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Clinical Endocrinology

Eirini Kostopoulou, Antonia Dastamani, Silvana Caiulo, Hannah Antell, Sarah E Flanagan, Pratik Shah
16p11.2 microdeletion syndrome is a recognisable chromosomal anomaly caused by microdeletions in the 16p11.2 locus. It is characterised by developmental delay, intellectual disability and social impairments or susceptibility to autism spectrum disorder. It also involves mild variable dysmorphism and predisposition to obesity. Motor skills, cognitive function and expressive language are mainly impaired and 20% of affected individuals present with epilepsy. There also appears to be an increase of all types of birth defects, particularly vertebral anomalies...
February 18, 2019: Clinical Endocrinology
Jing Wang, Xuena Wang, Yeqing Gu, Mingyue Liu, Thi Quynh Chi Vu, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Xue Bao, Shunming Zhang, Yanyan Wang, Zuolin Lu, Liu Wang, Lixiao Zheng, Xiaona Wang, Chunling Tian, Jingzhu Fu, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Jian Huang, Junsheng Huo, Bing Zhang, Gangqiang Ding, Kaijun Niu
OBJECTIVE: Handgrip strength (HGS) begins an accelerating decline around 50y. Many of the studies performed in old adults have demonstrated a significant relationship between vitamin D and HGS, but the studies performed in participants with a broad age range have yielded conflicting results. The purpose of the study was to investigate the relationship between vitamin D and HGS using age 50 as a specific cutoff. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: 5,102 participants (2,911 males, 2,191 females) from the TCLSIH Cohort...
February 18, 2019: Clinical Endocrinology
Ravindra Shukla, M K Garg, Biplab Mandal, Praveen Devrabhai
We read with interest article by Crowley et al (1). The authors a found an apparent decrease in 11 β HSD- 1 expression in subcutaneous adipose tissue (SAT) of deteriorators as compared to improvers. They explained it as compensatory decrease of 11 β HSD- 1 activity as consequence of overall adverse metabolic phenotype. It remained speculative whether visceral adipose tissue (VAT) 11 β HSD1 was increased in deteriorators. While this is consistent with recently published study by us (2), in which we found liver/portal circulation 11 β HSD1 activity to be increased in diabetics as compared to controls...
February 15, 2019: Clinical Endocrinology
Pierpaolo Trimboli, Arnoldo Piccardo, Maria Alevizaki, Camilla Virili, Mehrdad Naseri, Simona Sola, Gaetano Paone, Gilles Russ, Luca Giovanella
BACKGROUND: Several ultrasound (US) risk stratification systems have been proposed for the assessment of thyroid nodules, and their performance was shown as good. However, the rate of nodules assessed at intermediate risk is not negligible and whether they should be submitted or not to further examination is still under debate. The present study aimed to evaluate the reliability of 18 F-FDG PET/CT in stratifying the risk of malignancy in these lesions. METHODS: Two institutions participated to this retrospective study in which a dedicated 18 F-FDG PET/CT was proposed to patients having a thyroid nodule with US assessment of EU-TIRADS 4 or 5...
February 11, 2019: Clinical Endocrinology
Ye Hong, Sarah E Maessen, Guanping Dong, Ke Huang, Wei Wu, Liang Li, Chunlin Wang, Xiaochun Chen, John D Gibbins, Wayne S Cutfield, José G B Derraik, JunFen Fu
OBJECTIVE: We examined the associations between maternal age at menarche and anthropometry and metabolism in adolescent offspring. METHODS: Anthropometric, metabolic, and blood pressure data were obtained from 304 girls and 190 boys aged 11-16 years attending school in Hangzhou (China). Age at menarche for both mothers and daughters was self-reported. Fasting blood samples were obtained and all participants underwent clinical examinations. Obesity was defined as BMI ≥95th percentile for age and sex...
February 9, 2019: Clinical Endocrinology
Jing Song, Zhongyan Shan, Jinyuan Mao, Weiping Teng
OBJECTIVE: Polyamines are indispensable polycations and play important physiological roles in living cells. Some polyamine metabolites have been associated with autoimmune disorders. The aims of this study were to profile polyamine metabolites in autoimmune thyroid disease (AITD) and predict whether polyamine metabolites are associated with thyroid hormone, thyroid autoantibodies or disease progression. DESIGN, PATIENTS AND MEASUREMENTS: A total of 136 participants were recruited, including Graves' disease (GD) (n=36), Hashimoto's thyroiditis (HT) (n=33) and thyroid autoantibody-positive (pTAb) (n=29) patients and 38 age- and sex-matched healthy controls (HCs)...
February 6, 2019: Clinical Endocrinology
Ziyun Pan, Tingkai Cui, Wen Chen, Shu Gao, Elizabeth N Pearce, Wei Wang, Yanting Chen, Wenxing Guo, Long Tan, Jun Shen, Wanqi Zhang
OBJECTIVE: This study aims to evaluate the association of serum iodine concentration (SIC) with urinary iodine concentration (UIC) and thyroid function in pregnant women, as well as to provide the reference range of SIC of pregnant women in iodine-sufficiency area. METHODS: Pregnant women were enrolled in the Department of Obstetrics, Tanggu Maternity Hospital, Tianjin from March 2016 to May 2017. Fasting venous blood and spot urine samples were collected. Serum free-triiodothyronine (FT3), free-thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), UIC, and serum iodine concentration (SIC) were measured...
February 6, 2019: Clinical Endocrinology
Jakub Mesinovic, Lachlan B McMillan, Catherine Shore-Lorenti, Ayse Zengin, Barbora De Courten, Peter R Ebeling, David Scott
OBJECTIVES: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography (pQCT) in overweight and obese community-dwelling older adults. STUDY DESIGN: Cross-sectional study of 79 community-dwelling overweight and obese adults (mean±SD age 62.8±7.9 years; BMI 32.3±6.1 kg/m2 ; 58% women). MAIN OUTCOME MEASURES: pQCT assessed distal radius and tibia trabecular volumetric bone mineral density (vBMD) and proximal radius and tibia cortical vBMD, periosteal circumference, endosteal circumference and stress-strain index (SSI)...
February 6, 2019: Clinical Endocrinology
Moran Shemesh-Iron, Liora Lazar, Yael Lebenthal, Nessia Nagelberg, Ariel Tenenbaum, Revital Ezra, Nir Leffler, Michal Yackobovitch-Gavan, Michal Schoenberg-Taz, Moshe Phillip
CONTEXT: Growth hormone (GH) treatment of short healthy children is based on the belief that short stature is associated with psychosocial problems and a diminished quality of life. OBJECTIVE: To determine the impact of GH therapy on psychosocial well-being and the ability of psychological metrics to define short stature-related distress. METHODS: Sixty prepubertal boys with idiopathic short stature (age: 10.0±1.4yrs, height-SDS: -2.38±0...
February 5, 2019: Clinical Endocrinology
Paula M O'Shea, Darragh O'Donoghue, Waiel Bashari, Russell Senanayake, Mary B Joyce, Andrew Powlson, Darragh Browne, Gerard J O'Sullivan, Heok Cheow, Iosif Mendichovszky, Denis Quill, Aoife Lowery, David Lappin, Mark Gurnell, Michael Conall Dennedy
OBJECTIVE: To describe clinical practice experience of 11 C-Metomidate PET/CT as an adjunct to adrenal vein sampling (AVS) in the lateralization of aldosterone producing adenomas (APA) in primary aldosteronism (PA). CONTEXT: Accurate lateralisation of aldosterone producing adenomas in the setting of primary aldosteronism (PA) offers the potential for surgical cure and improved long-term cardiovascular outcomes. Challenges associated with adrenal vein sampling, the current gold-standard lateralization modality, mean that only a small proportion of potentially eligible patients currently make it through to surgery...
February 5, 2019: Clinical Endocrinology
Sicen Wu, Jun Yang, Jinbo Hu, Ying Song, Wenwen He, Shumin Yang, Rong Luo, Qifu Li
OBJECTIVE: Saline infusion test (SIT), captopril challenge test (CCT), fludrocortisone suppression test (FST) and oral sodium loading test (SLT) are recommended by the Endocrine Society's clinical practice guidelines to diagnose primary aldosteronism, but which one is the best remains controversial. We aimed to summarize the available comparative data and evaluate the diagnostic accuracy of these four tests. DESIGN: We searched PubMed, Embase and the Cochrane Library for relevant studies published between January 1980 and January 2018...
February 5, 2019: Clinical Endocrinology
Mona M Sabra, Eric Sherman, R Michael Tuttle
PURPOSE: To assess molecular targeted therapy (MTT) 's ability to affect tumor volume doubling time (TVDT) and disease specific survival (DSS) in patients presenting with lung metastasis from radioactive iodine refractory progressive thyroid cancer. METHODS: In this retrospective study, we examined the clinical characteristics, average tumor volume doubling times of lung metastasis and disease specific survival of patients with lung metastasis from differentiated thyroid cancer who were treated with MTT...
January 31, 2019: Clinical Endocrinology
Rachel K Crowley, Conor P Woods, Beverly A Hughes, Joanna Gray, Theresa McCarthy, Angela E Taylor, Laura L Gathercole, Cedric Hl Shackleton, Nicola Crabtree, Wiebke Arlt, Paul M Stewart, Jeremy W Tomlinson
OBJECTIVE & CONTEXT: Increasing adiposity, aging and tissue-specific regeneration of cortisol through the activity of 11β-hydroxysteroid dehydrogenase type 1 have been associated with deterioration in glucose tolerance. We undertook a longitudinal, prospective clinical study to determine if alterations in local glucocorticoid metabolism track with changes in glucose tolerance. DESIGN, PATIENTS, MEASUREMENTS: 65 overweight/obese individuals (mean age 50.3±7...
January 22, 2019: Clinical Endocrinology
Rosa Cervelli, Salvatore Mazzeo, Giuseppe Boni, Antonio Boccuzzi, Francesca Bianchi, Federica Brozzi, Pierina Santini, Paolo Vitti, Roberto Cioni, Davide Caramella
OBJECTIVE: To compare the efficacy of Radioiodine (RI) and Radiofrequency ablation (RFA) in the treatment of autonomously functioning thyroid nodules (AFTNs). END POINTS: nodule volume reduction (NVR) and thyroid function normalization. DESIGN, PATIENTS AND MEASUREMENTS: Twenty-two patients (2:20 M:F; 51.9±13.9 years) affected by 25 AFTNs, treated by RFA were retrospectively compared with 25 patients (8:17 M:F; 57.2±12.8 years) affected by a single AFTN treated by RI...
January 18, 2019: Clinical Endocrinology
Do Kyeong Song, Hyejin Lee, Young Sun Hong, Yeon-Ah Sung
OBJECTIVE: Hirsutism affects 5-10% of reproductive-aged women worldwide and exhibits clinical importance as a cutaneous manifestation of underlying hyperandrogenism. Racial and genetic factors play roles in manifestation of hirsutism, and the prevalence of hirsutism seems to be low in East Asians. However, the reference value of the modified Ferriman-Gallway (mFG) score to diagnose hirsutism and the prevalence of hirsutism have not been determined in Korean populations to date. We aimed to investigate the distribution of the mFG score and establish its reference value for defining hirsutism and to examine its relationship with metabolic and reproductive traits in reproductive-aged Korean women...
January 18, 2019: Clinical Endocrinology
Martin Cuesta, David Slattery, Eirena L Goulden, Saket Gupta, Elizabeth Tatro, Mark Sherlock, William Tormey, Shane O Neill, Christopher J Thompson
OBJECTIVE: Hyponatraemia is common in community acquired pneumonia (CAP) and is associated with increased mortality. The mechanism of hyponatraemia in CAP is not completely understood and treatment is therefore ill-defined. We aimed to define the causation of hyponatraemia in CAP. DESIGN: Prospective, single-centre, observational study of all patients with CAP and hyponatremia (≤ 130 mmol/L) during a 9-month period. PATIENTS: The prevalence of each subtype of hyponatraemia, and the associated mortality, was determined in 143 admissions with CAP (Study 1)...
January 18, 2019: Clinical Endocrinology
Mahaveer Singh, David D Chandy, Tamnay Bharani, Rungmei S K Marak, Subhash Yadav, Preeti Dabadghao, Sushil Gupta, Saroj K Sahoo, Rakesh Pandey, Eesh Bhatia
OBJECTIVE: Detailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy. DESIGN: Single-centre retrospective hospital-based study of 40 consecutive adults with AH [39 males; age (mean ± SD) 53 ± 11 years] was conducted between 2006 and 2018. The median duration of follow-up was 2.5 years (range 0.2-12 years)...
January 17, 2019: Clinical Endocrinology
Minh Tam Le, Viet Nguyen Sa Le, Dinh Duong Le, Vu Quoc Huy Nguyen, Chen Chen, Ngoc Thanh Cao
OBJECTIVE: This study explores the role of anti-Mullerian hormone (AMH) and LH/FSH ratio in diagnosis of polycystic ovary syndrome (PCOS). METHODS: In this multicenter cross-sectional descriptive study, a total of 863 infertile women between 18- 45 years were evaluated at 3 infertility centres in Vietnam and were recruited from June 2016 to June 2017. The patients were classified into two groups: Group I included 441 patients with PCOS (based on Rotterdam criteria consensus) and Group II included 422 non-PCOS women...
January 13, 2019: Clinical Endocrinology
Uche Ezeh, Ida Y-D Chen, Yen-Hao Chen, Ricardo Azziz
BACKGROUND: PCOS is a highly prevalent endocrine-metabolic disorder associated with insulin resistance (IR). In IR states noninsulin-mediated glucose uptake (NIMGU) may increase to compensate for declining insulin-mediated glucose uptake (IMGU), although this does not appear to be the case in PCOS. The underlying molecular mechanisms for this deficiency remains unclear. OBJECTIVES: To compare adipocyte glucose transporter 1 and 4 (GLUT-1 and GLUT-4) gene expression in PCOS women and matched controls, and to determine whether changes in GLUT-1 and GLUT-4 are associated with concomitant alterations in whole-body glucose uptake...
January 8, 2019: Clinical Endocrinology
Azita Goshtasebi, Tatjana Subotic Brajic, Delia Scholes, Tamara Beres Lederer Goldberg, Abbey Berenson, Jerilynn C Prior
OBJECTIVE: Many women use combined hormonal contraceptives (CHC) during adolescence during which they are accruing peak areal bone mineral density (BMD) that relates to lifetime fracture risk. To build BMD requires formation with which CHC-related exogenous oestrogen may interfere. We compared peak BMD accrual in adolescents using and not using CHC. DESIGN/PARTICIPANTS: We performed literature searches for prospective published peer-reviewed articles providing 12- to 24-month BMD change in adolescent (12- to 19-year-old) women using CHC vs CHC-unexposed control women...
January 7, 2019: Clinical Endocrinology
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