Yingxian Pang, Jing Zhang, Jingjing Jiang, Christina Pamporaki, Minghao Li, Nicole Bechmann, Leah Meuter, Yongbao Wei, Haijian Huang, Shenghui Huang, Xunbin Yu, Mercedes Robledo, Miguel J Soria, Dewen Zhong, Shangyuan Xu, Henri J L M Timmers, Johan F Langenhuijsen, Xiaofeng Chen, Wanglong Deng, Timo Deutschbein, Hanna Remde, Long Wang, Hanyu Yao, Bin Yan, Annika M A Berends, Michiel N Kerstens, Yazhuo Jiang, Joakim Crona, Ning Xu, Hai Cai, Yanlin Wen, Anguo Wang, Ji Wu, Zongpin Zhang, Jinzhuo Ning, Fan Cheng, Xiang Chen, Jing Wang, Bin Xie, Danlei Chen, Yujun Liu, Longfei Liu, Karel Pacak, Graeme Eisenhofer, Jacques W M Lenders
OBJECTIVE: Paragangliomas of the urinary bladder (UBPGLs) are rare neuroendocrine tumours and pose a diagnostic and surgical challenge. It remains unclear what factors contribute to a timely presurgical diagnosis. The purpose of this study is to identify factors contributing to missing the diagnosis of UBPGLs before surgery. DESIGN, PATIENTS AND MEASUREMENTS: A total of 73 patients from 11 centres in China, and 51 patients from 6 centres in Europe and 1 center in the United States were included...
April 12, 2024: Clinical Endocrinology
Sarah R Catford, Darren Katz, Robert I McLachlan
OBJECTIVE: Idiopathic male infertility is common, yet there is no approved treatment. This study aimed to understand practice patterns towards empirical medical therapy (EMT) for idiopathic male infertility in Australia and New Zealand (NZ). DESIGN: Clinical members of the Endocrine Society of Australia, Fertility Society of Australia & NZ, and Urological Society of Australia & NZ were invited to complete a survey. Questions included demographics, EMT practice habits, and thoughts regarding infertility case scenarios...
April 12, 2024: Clinical Endocrinology
Lukas Ochsner Ridder, Camilla Mains Balle, Anne Skakkebæk, Marie Lind-Holst, Mette Mølby Nielsen, Pernille Hermann, Stinus Hansen, Dorte Guldbrand Nielsen, Sine Knorr, Niels Holmark Andersen, Mette Hansen Viuff, Agnethe Berglund, Claus Højbjerg Gravholt
OBJECTIVE: To investigate the metabolic, cardiovascular, and neuropsychological phenotype, quality of life (QoL), and hormonal regulation in individuals with congenital adrenal hyperplasia (CAH), a group of autosomal recessive disorders characterized by impaired synthesis of cortisol in the adrenal cortex and, if untreated compensatory hyperandrogenism. CAH is associated with an increased cardiovascular and metabolic morbidity, possibly due to overtreatment with glucocorticoids, leading to weight gain, insulin resistance, and metabolic syndrome...
April 4, 2024: Clinical Endocrinology
Clare Miller, Amna Al-Jabri, Liam O'Murchada, Mohamad Mustafa, Jennie Cooke, Niamh Phelan, Marie-Louise Healy
BACKGROUND: The optimal treatment strategy for radioiodine (RAI) treatment protocols for benign hyperthyroidism remains elusive. Although individualised activities are recommended in European Law, many centres continue to provide fixed activities. Our institution implemented a dosimetry protocol in 2016 following years of fixed dosing which facilitates the calculation of individualised activities based on thyroid volume and radioiodine uptake. METHODS: This was a retrospective study comparing success rates using a dosimetry protocol targeting an absorbed dose of 150 Gy for Graves' disease (GD) and 125 Gy for Toxic Multinodular Goiter (TMNG) with fixed dosing (200MBq for GD and 400MBq for TMNG) among 204 patients with hyperthyroidism...
April 3, 2024: Clinical Endocrinology
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Clinical Endocrinology
Pedro Marques, Inês Sapinho, Márta Korbonits
OBJECTIVE: Pseudoacromegaly encompasses conditions with features of acromegaly/gigantism, but no growth hormone (GH) or insulin-like growth factor-1 (IGF-1) excess. We aimed to review published pseudoacromegaly cases evaluated due to clinical suspicion of acromegaly. DESIGN/PATIENTS: PubMed/Medline search was conducted to identify reported pseudoacromegaly cases, which were systematically reviewed to ensure they met eligibility criteria: (1) presentation suggestive of acromegaly; (2) acromegaly excluded based on normal GH, IGF-1 and/or GH suppression on oral glucose tolerance test (OGTT-GH); (3) diagnosis of the pseudoacromegaly condition was established...
March 28, 2024: Clinical Endocrinology
Mark Livingston, Syeda F Hashmi, Sudarshan Ramachandran, Ian Laing, Adrian Heald
OBJECTIVE AND DESIGN: Macroprolactinemia may influence the interpretation of serum prolactin levels-a recognised phenomenon since 1981. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation) varied by analysing serial measurements in hyperprolactinaemic individuals over a period of 9 years. PATIENTS AND MEASUREMENTS: Results from 1810 individuals were included...
March 27, 2024: Clinical Endocrinology
Su Ann Tee, Hady Gad, Christopher Boot, Andy James, Yaasir Mamoojee
No abstract text is available yet for this article.
March 20, 2024: Clinical Endocrinology
Lauren Madden Doyle, S Faisal Ahmed, Jessica Davis, Sue Elford, Yasir S Elhassan, Lynette James, Neil Lawrence, Sofia Llahana, Grace Okoro, D Aled Rees, Jeremy W Tomlinson, Michael W O'Reilly, Nils P Krone
BACKGROUND: Congenital adrenal hyperplasia (CAH) encompasses a rare group of autosomal recessive disorders, characterised by enzymatic defects in steroidogenesis. Heterogeneity in management practices has been observed internationally. The International Congenital Adrenal Hyperplasia registry (I-CAH, was established to enable insights into CAH management and outcomes, yet its global adoption by endocrine centres remains unclear. DESIGN: We sought (1) to assess current practices amongst clinicians managing patients with CAH in the United Kingdom and Ireland, with a focus on choice of glucocorticoid, monitoring practices and screening for associated co-morbidities, and (2) to assess use of the I-CAH registry...
March 17, 2024: Clinical Endocrinology
Herborg Líggjasardóttir Johannesen, Anna Sofía Veyhe, Jens Andreassen, Pál Weihe, Marin Strøm, Guðrið Andorsdóttir, Aase Krogh Rasmussen, Ulla Feldt-Rasmussen, Allan Carlé, Stig Andersen
OBJECTIVE: The occurrence of thyroid disease varies among populations. While the iodine nutrition level of the Faroese seems to have been decreasing over the past decades, there is no systematic evaluation of the thyroid disease pattern in the Faroe Islands. Such knowledge of thyroid disease occurrence in the North Atlantic region may support healthcare planning and prevention. To investigate incidence rates, including subtypes of thyroid diseases, and demographic characteristics of thyroid disease patients in the Faroe Islands, to improve understanding of the patterns and trends of these disorders...
March 13, 2024: Clinical Endocrinology
Oded Cohen, Sharon Tzelnick, Gregory Randolph, Alessandra Rinaldo, Fernando Álvarez, Juan P Rodrigo, Nabil F Saba, Sandra Nuyts, June Corry, Antti A Mäkitie, Vincent Vander Poorten, Cherie-Ann Nathan, Cesare Piazza, Alfio Ferlito
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor from parafollicular cells that produce calcitonin (Ct). Despite several existing guidelines for the surgical management of sporadic MTC (sMTC), optimal initial surgical management of the thyroid, the central and the lateral neck remains a matter of debate. METHODS: A systematic review in PubMed and Scopus for current guidelines addressing the surgical management of sMTC and its referenced citations was conducted as per the PRISMA guidelines...
March 12, 2024: Clinical Endocrinology
Sabine E Hannema, Katja P Wolffenbuttel, Yolande van Bever, Hennie T Bruggenwirth, Remko Hersmus, J Wolter Oosterhuis, Leendert H J Looijenga
No abstract text is available yet for this article.
March 12, 2024: Clinical Endocrinology
Rohan K Henry, Leena Mamilly, Monika Chaudhari, Brett G Klamer, Melica Nikahd, Amy L Pyle-Eilola
OBJECTIVES: Various biases pertaining to stature account for a male sex predominance in growth hormone deficiency (GHD) cases diagnosed by endocrinology clinics. This manuscript will assess the sex distribution when biases are minimised. METHODS: Retrospective chart review was conducted on patients diagnosed with GHD between 3 and 16 years of age. The sex distribution of cases was ascertained according to: (1) peak GH (pGH) by groups; based on growth hormone provocative testing, (2) pituitary gland imaging results, and (3) isolated GHD (IGHD) versus multiple pituitary hormone deficiencies (MPHD)...
March 11, 2024: Clinical Endocrinology
Nicole Lafontaine, Suzanne J Brown, Petros Perros, Enrico Papini, Endre V Nagy, Roberto Attanasio, Laszlo Hegedüs, John P Walsh
OBJECTIVE: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. DESIGN AND PARTICIPANTS: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire...
March 11, 2024: Clinical Endocrinology
Hanbing Li, Lingling Gao, Xiao Yang, Lu Chen
OBJECTIVES: This study aims to develop and validate a prediction model for preterm birth in women with gestational diabetes mellitus (GDM). DESIGN: We conducted a retrospective study on women with GDM who gave birth at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, between November 2017 and July 2021. We divided 1879 patients into a development set (n = 1346) and a validation set (n = 533). The development set was used to construct the prediction model for preterm birth using the stepwise logistic regression model...
March 11, 2024: Clinical Endocrinology
David J Handelsman, Amanda Idan, Reena Desai, Janelle Grainger, Catrin Goebel, Sue Sleiman, Sasha Savkovic, Dorothy Kouzios, Venna Jayadev, Ann J Conway
OBJECTIVE: Human choriogonadotrophin (hCG) treatment of gonadotrophin-deficient infertile men uses hCG of urinary (uhCG) or recombinant (rhCG) origin, but these treatments have not been compared nor are there studies defining rhCG dosing in men. DESIGN: hCG products were studied in randomized cross-over single-dose studies of standard (Study 1, 1500 IU and 62.5 µg, respectively) or high (Study 2, 5000 IU and 250 µg) dose and a multi-dose population pharmacology study of hCG use...
March 6, 2024: Clinical Endocrinology
Line T Møllehave, Nils Knudsen, Eva Prescott, Inge B Pedersen, Gitte Ravn-Haren, Allan Carlé, Allan Linneberg
OBJECTIVE: Iodine fortification (IF) induces an initial increase followed by a decrease in the incidence of hyperthyroidism in the general population. Within the population of hyperthyroid patients, the sex-, age- and subtype distribution changes after IF. The risk of atrial fibrillation (AF) in hyperthyroid patients may be influenced by these factors. Therefore, we aimed to examine how the association between incident hyperthyroidism and AF was affected by IF increasing the population iodine intake from moderate-mild iodine deficiency to low adequacy...
March 4, 2024: Clinical Endocrinology
Bassel H Al Wattar, Jhia Jiat Teh, Sophie Clarke, Ali Abbara, Rachel Morman, Alison Wilcox, Vikram Talaulikar
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a chronic lifelong condition affecting up to 20% of women worldwide. There is limited input from affected women to guide the provision of healthcare services and future research needs. Our objective was to scope the healthcare and research priorities of women with PCOS in the United Kingdom. DESIGN: A three-staged modified Delphi method, consisting of two questionnaires and a consensus meeting involving lay representatives and healthcare professionals...
February 29, 2024: Clinical Endocrinology
Sara S Berggren, Jovanna Dahlgren, Ola Andersson, Stefan Bergman, Josefine Roswall
OBJECTIVE: The longitudinal variations in serum levels of the hormone osteocalcin is largely unknown during infancy and early childhood. Our aim was to establish reference limits for total serum osteocalcin during specific time points from birth until 5 years of age and present those in the context of sex, breastfeeding practices and gestational age (GA). DESIGN: Blood samples from 551 Swedish children were analysed at birth, 4, 12, 36 and 60 months of age...
February 22, 2024: Clinical Endocrinology
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