Sabine E Hannema, Katja P Wolffenbuttel, Yolande van Bever, Hennie T Bruggenwirth, Sjoerd A A van den Berg, Remko Hersmus, J Wolter Oosterhuis, Leendert H J Looijenga
PURPOSE: Individuals with 45,X/46,XY or 46,XY gonadal dysgenesis are at increased risk of germ cell malignancies. Therefore, prophylactic bilateral gonadectomy is advised in girls and considered in boys with atypical genitalia for undescended, macroscopically abnormal gonads. However, severely dysgenetic gonads may not contain germ cells rendering gonadectomy unnecessary. Therefore, we investigate if undetectable pre-operative serum AMH and inhibin B can predict the absence of germ cells, (pre)malignant or otherwise...
March 10, 2023: Clinical Endocrinology