Adam B Marstrand-Jørgensen, Frederikke Emilie Sembach, Stine Thorhauge Bak, Maria Ougaard, Mikkel Christensen-Dalsgaard, Martin Rønn Madsen, Ditte Marie Jensen, Thomas Secher, Sebastian Møller Nguyen Heimbürger, Lisbeth N Fink, Ditte Hansen, Henrik H Hansen, Mette Viberg Østergaard, Michael Christensen, Louise S Dalbøge
INTRODUCTION: Several mouse models with diverse disease etiologies are used in preclinical research for chronic kidney disease (CKD). Here, we performed a head-to-head comparison of renal transcriptome signatures in standard mouse models of CKD to assess shared and distinct molecular changes in three mouse models commonly employed in preclinical CKD research and drug discovery. METHODS: All experiments were conducted on male C57BL/6J mice. Mice underwent sham, unilateral ureter obstruction (UUO) or unilateral ischemic reperfusion injury (uIRI) surgery and were terminated two- and six-weeks post-surgery, respectively...
February 14, 2024: Nephron