journal
https://read.qxmd.com/read/36964024/clinical-presentation-treatment-patterns-and-outcomes-of-pulmonary-embolism-in-patients-with-chronic-myeloproliferative-neoplasms
#1
LETTER
Ivan Krečak, Dragana Grohovac, Nikolina Vučenović Bašić, Monika Čeko, Karla Nižetić, Anica Sabljić, Hrvoje Holik, Davor Galušić, Ivan Zekanović, Martina Morić Perić, Vlatka Periša, Marko Lucijanić
No abstract text is available yet for this article.
March 21, 2023: Thrombosis Research
https://read.qxmd.com/read/36948993/the-spleen-is-the-major-site-for-the-development-and-expansion-of-inhibitor-producing-cells-in-hemophilia-a-mice-upon-fviii-infusion-developing-high-titer-inhibitor
#2
JOURNAL ARTICLE
Akihisa Oda, Shoko Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima, Shota Sonobe, Kaoru Horiuchi, Yuto Nakajima, Kenichi Ogiwara, Ryo Goitsuka, Midori Shima, Toshihiro Ito, Keiji Nogami
BACKGROUND: Hemophilia A (HA) is a hereditary bleeding disorder caused by defects in endogenous factor (F)VIII. Approximately 30 % of patients with severe HA treated with FVIII develop neutralizing antibodies (inhibitors) against FVIII, which render the therapy ineffective. The managements of HA patients with high-titter inhibitors are especially challenging. Therefore, it is important to understand the mechanism(s) of high-titer inhibitor development and dynamics of FVIII-specific plasma cells (FVIII-PCs)...
March 17, 2023: Thrombosis Research
https://read.qxmd.com/read/36948020/pathway-driven-rare-germline-variants-associated-with-transplant-associated-thrombotic-microangiopathy-ta-tma
#3
JOURNAL ARTICLE
Zhihui Zhang, Wei Hong, Qian Wu, Spiridon Tsavachidis, Jian-Rong Li, Christopher I Amos, Chao Cheng, Sarah E Sartain, Vahid Afshar-Kharghan, Jing-Fei Dong, Pavan Bhatraju, Paul J Martin, Robert S Makar, Pavan K Bendapudi, Ang Li
The significance of rare germline mutations in transplant-associated thrombotic microangiopathy (TA-TMA) is not well studied. We performed a genetic association study in 100 adult TA-TMA patients vs. 98 post-transplant controls after matching by race, sex, and year. We focused on 5 pathways in complement, von Willebrand factor (VWF) function and related proteins, VWF clearance, ADAMTS13 function and related proteins, and endothelial activation (3641variants in 52 genes). In the primary analysis focused on 189 functional rare variants, no differential variant enrichment was observed in any of the pathways; specifically, 29 % TA-TMA and 33 % controls had at least 1 rare complement mutation...
March 15, 2023: Thrombosis Research
https://read.qxmd.com/read/36921435/age-versus-clinical-pretest-probability-adjusted-d-dimer-to-rule-out-lower-extremity-deep-vein-thrombosis-in-ambulatory-patients-with-active-cancer
#4
JOURNAL ARTICLE
Marcello Di Nisio, Matteo Candeloro, Nicola Potere, Camilla Federici, Anne W S Rutjes, Maria Domenica Guglielmi, Ettore Porreca
BACKGROUND: In patients with suspected deep vein thrombosis (DVT), D-dimer thresholds adjusted to age or clinical pretest probability (CPTP) increase the proportion of patients in whom DVT can be safely excluded compared to a standard approach using a fixed D-dimer threshold. Performance of these diagnostic strategies among cancer patients is uncertain. AIM: To compare the performance of age- and CPTP-adjusted D-dimer approaches among cancer outpatients with clinically suspected DVT, and derive a cancer-specific CPTP rule...
March 13, 2023: Thrombosis Research
https://read.qxmd.com/read/36898171/low-serum-albumin-is-associated-with-mortality-and-arterial-and-venous-ischemic-events-in-acutely-ill-medical-patients-results-of-a-retrospective-observational-study
#5
JOURNAL ARTICLE
Francesco Violi, Alessio Novella, Pasquale Pignatelli, Valentina Castellani, Mauro Tettamanti, Pier Mannuccio Mannucci, Alessandro Nobili
BACKGROUND: In general population hypoalbuminemia is associated with poor survival. Aim of this study was to assess the impact of hypoalbuminemia on mortality and venous and arterial ischemic events in hospitalized acutely ill medical patients. PATIENTS AND METHODS: Retrospective observational analysis from the "REgistro POliterapie SIMI" (REPOSI). Patients were followed up to 12 months. Serum albumin was obtained in each patient. Mortality and ischemic events were registered throughout the follow-up period...
March 7, 2023: Thrombosis Research
https://read.qxmd.com/read/36934482/low-dose-immune-tolerance-induction-therapy-in-severe-hemophilia-a-children-in-china-starting-earlier-resulted-in-better-inhibitor-eradication-outcomes
#6
JOURNAL ARTICLE
Zhengping Li, Jie Sun, Zekun Li, Zhenping Chen, Guoqing Liu, Wanru Yao, Gang Li, Yingzi Zhen, Xiaoling Cheng, Di Ai, Kun Huang, Man-Chiu Poon, Runhui Wu
BACKGROUND: Shorter interval-time from inhibitor detection to starting immune tolerance induction (ITI) might predict better ITI outcomes for severe Hemophilia A (SHA) patients with high-risk-inhibitors. However, the prediction-impact of interval-time for these patients on low-dose ITI strategy remained unclear. OBJECTIVES: To explore the relationship between interval-time and low-dose ITI outcomes in Chinese SHA children with high-risk-inhibitors. METHODS: This was a single-center, retrospective study on SHA children with high-risk-inhibitors (each with immediate pre-ITI inhibitor titer>10 Bethesda Units/mL) undergoing low-dose ITI strategy for ≥24 months...
March 5, 2023: Thrombosis Research
https://read.qxmd.com/read/36906474/doacs-plasma-levels-in-relation-to-clinical-outcome-how-far-have-we-come
#7
LETTER
Rosa Talerico, Roberto Pola, Menno Volkert Huisman, Frederikus Albertus Klok
No abstract text is available yet for this article.
March 5, 2023: Thrombosis Research
https://read.qxmd.com/read/36871347/eculizumab-in-the-management-of-drug-induced-thrombotic-microangiopathy-a-scoping-review-of-the-literature
#8
JOURNAL ARTICLE
Aneeqa Zafar, Ming Yeong Lim, Mouhamed Yazan Abou-Ismail
Drug-induced TMA (DI-TMA) is a thrombotic microangiopathy (TMA) caused by certain drugs, usually managed by drug discontinuation and supportive measures. Data on the use of complement-inhibition with eculizumab in DI-TMA is scarce, and its benefit in cases of severe or refractory DI-TMA is unclear. We conducted a comprehensive search in PubMed, Embase and MEDLINE databases (2007-2021). We included articles that reported on DI-TMA patients treated with eculizumab and its clinical outcomes. All other causes of TMA were excluded...
March 2, 2023: Thrombosis Research
https://read.qxmd.com/read/36933476/acute-venous-thromboembolic-events-in-patients-with-monoclonal-gammopathy-of-undetermined-significance-an-analysis-of-the-national-inpatient-sample
#9
JOURNAL ARTICLE
Ali Abdelhay, Amir A Mahmoud, Mariam Mostafa, Omar Al Ali, Simrat Gill, Saad Jamshed
BACKGROUND: Monoclonal Gammopathy of Undetermined Significance (MGUS) is a premalignant plasma cell disorder which despite being clinically silent carries an increased risk of venous thromboembolism (VTE). We conducted a population-based study to investigate the risk of VTE in these patients. METHODS: We utilized the National Inpatient Sample (NIS) for the year 2016 to compare the incidence of acute VTE between patients who carry the diagnosis of MGUS and those who don't...
March 1, 2023: Thrombosis Research
https://read.qxmd.com/read/36863259/the-efficacy-of-sequential-mmf-rescue-regimen-to-eradicate-inhibitors-for-refractory-severe-hemophilia-a-inhibitor-children-in-china
#10
LETTER
Zhengping Li, Zekun Li, Jie Sun, Xiaoling Cheng, Guoqing Liu, Wanru Yao, Kun Huang, Di Ai, Zhenping Chen, Gang Li, Yingzi Zhen, Man-Chiu Poon, Runhui Wu
No abstract text is available yet for this article.
February 24, 2023: Thrombosis Research
https://read.qxmd.com/read/36827954/lupus-anticoagulant-laboratory-diagnosis-by-applying-the-2020-isth-ssc-guidelines
#11
JOURNAL ARTICLE
L Talon, V Fourneyron, S Senectaire, M Tardieu, M Tillier, A Trapani, A Trayaud, A Vaissade, A F Sapin, A Lebreton, T Sinegre
BACKGROUND: The ISTH-SSC guidelines for lupus anticoagulant (LA) testing recommend using in-house determined cut-off values, pooled normal plasma (PNP) for ratio normalization, and a ratio for the mixing test interpretation. They strongly support the mixing step role in the diagnostic process. OBJECTIVES: To investigate and compare the LA testing results and interpretations obtained following the ISTH-SSC guidelines or the available alternatives. PATIENTS/METHODS: Blood samples for LA testing from 462 consecutive patients were evaluated for screening, mixing and confirmatory tests...
February 18, 2023: Thrombosis Research
https://read.qxmd.com/read/36841157/differential-prognosis-of-patients-that-are-candidates-for-standard-short-or-prolonged-dual-antiplatelet-treatment-discharged-after-an-acute-coronary-syndrome
#12
JOURNAL ARTICLE
Alberto Cordero, David Escribano, José Mª García-Acuña, Belén Alvarez-Alvarez, Belén Cid-Alvarez, Moisés Rodriguez-Mañero, Rosa Agra-Bermejo, Mª Amparo Quintanilla, Pilar Zuazola, José R González-Juanatey
BACKGROUND: Current evidence supports the efficacy of prolonged dual antiplatelet treatment (DAPT) for patients at high-ischemic risk and low bleeding risk as well as the efficacy and safety of short DAPT in high-bleeding risk (HBR) patients. METHODS: We evaluated patterns of DAPT candidates in all patients discharged in 2 hospitals after an acute coronary syndrome (ACS). Patients categorized in 3 groups: 1) short-DAPT candidates if they met 1 major o 2 minor criteria for HBR, by the 2019 ARC-HBR criteria; 2) prolonged-DAPT candidates if were not HBR and had recurrent ACS, complex percutaneous coronary interventions or diabetes; 3) standard 12 months DAPT if were not include in the previous 2 groups...
February 16, 2023: Thrombosis Research
https://read.qxmd.com/read/36848784/trends-and-factors-associated-with-outpatient-anticoagulant-treatment-initiation-among-vte-patients-with-active-cancer
#13
JOURNAL ARTICLE
Amol D Dhamane, Shrushti Shah, Virginia Noxon, Robert Bruette, Mauricio Ferri, Xuejun Liu, Jenny Jiang, Xuemei Luo
BACKGROUND: Patients with venous thromboembolism (VTE) and cancer are at higher risk of recurrent VTE and mortality. Clinical guidelines recommend anticoagulant treatment for these patients. This study assessed trends in outpatient anticoagulant treatment and factors associated with this treatment initiation in outpatient setting among this high-risk patient population. OBJECTIVE: To study trends and factors associated with anticoagulant treatment initiation among patients with VTE and cancer...
February 15, 2023: Thrombosis Research
https://read.qxmd.com/read/36812877/estimating-the-measurement-uncertainties-of-the-international-sensitivity-index-of-12-thromboplastins-through-monte-carlo-simulation
#14
JOURNAL ARTICLE
Yong Kwan Lim, Oh Joo Kweon, Mi-Kyung Lee, Hye Ryoun Kim
BACKGROUND: Measurement uncertainty (MU) estimation has become an important process in clinical laboratories; however, calculating the MUs of the international sensitivity index (ISI) of thromboplastins is difficult because of the complex mathematical calculations required in calibration. Therefore, this study quantifies the MUs of ISIs through the Monte Carlo simulation (MCS), which involves random sampling of numerical values to solve a complex mathematical calculation. METHODS: Eighty blood plasmas and commercially available certified plasmas (ISI Calibrate) were used to assign the ISIs of each thromboplastin...
February 14, 2023: Thrombosis Research
https://read.qxmd.com/read/36801650/the-value-of-the-chap-model-for-prediction-of-the-bleeding-risk-in-patients-with-unprovoked-venous-thromboembolism-findings-from-the-riete-registry
#15
LETTER
Paolo Prandoni, Franca Bilora, Isabelle Mahé, José F Varona, José María Pedrajas, Jose Meireles, Raffaele Pesavento, Manuel Monreal
No abstract text is available yet for this article.
February 14, 2023: Thrombosis Research
https://read.qxmd.com/read/36801649/effect-of-therapeutic-anticoagulation-on-gas-exchange-in-mechanically-ventilated-covid-19-patients-a-secondary-analysis-of-the-covid-hep-trial
#16
LETTER
Olivier Pantet, Christophe Combescure, Zied Ltaief, Lucia Mazzolai, Séverin Jeanneret, Sara Manzocchi-Besson, Hans Stricker, Sara Cereghetti, Jérôme Pugin, Alexandra Calmy, Christophe Marti, Helia Robert-Ebadi, Pierre Fontana, Marc Righini, Alessandro Casini, Marc Blondon
No abstract text is available yet for this article.
February 10, 2023: Thrombosis Research
https://read.qxmd.com/read/36774701/characteristics-associated-with-diagnostic-yield-of-imaging-for-deep-venous-thrombosis-and-pulmonary-embolism-in-the-emergency-department-hospital-and-office-settings-an-optum-clinformatics-claims-database-study-2015-2019
#17
JOURNAL ARTICLE
Nidhi Rohatgi, Alex Dahlen, Caroline Berube, Yingjie Weng, Max Wintermark, Neera Ahuja
BACKGROUND: Different patient characteristics influence the decision to order diagnostic imaging for deep venous thrombosis (DVT) and pulmonary embolism (PE) in different settings (emergency department (ED), hospital, and office). Diagnostic yield is defined as the proportion of tests that report positive results. We hypothesize different patient characteristics are associated with higher or lower diagnostic yield of imaging for DVT and PE in different settings. METHODS: We used Optum Clinformatics™ national claims database (2015-2019) to assess the diagnostic yield of imaging for DVT and PE in three settings: (a) ED discharge, (b) Hospitalized, and (c) Office...
February 10, 2023: Thrombosis Research
https://read.qxmd.com/read/36774700/recurrent-thrombotic-events-after-disappearance-of-antiphospholipid-autoantibodies-a-long-term-longitudinal-study-in-patients-with-antiphospholipid-syndrome
#18
LETTER
Thomas Ballul, Arthur Mageau, Pascale Roland Nicaise, Nadine Ajzenberg, Andrey Strukov, Antoine Dossier, Diane Rouzaud, Thomas Papo, Karim Sacré
No abstract text is available yet for this article.
February 10, 2023: Thrombosis Research
https://read.qxmd.com/read/36805800/a-nomogram-model-to-predict-the-acute-venous-thromboembolism-risk-after-surgery-in-patients-with-glioma
#19
JOURNAL ARTICLE
Chuanhao Zhang, Zhenghai Deng, Zuocheng Yang, Jian Xie, Zonggang Hou
INTRODUCTION: Postoperative venous thromboembolism (VTE) is a common complication for glioma patients, with an incidence rate of about 20 %. The purpose of this study was to explore the risk factors of acute VTE after glioma surgery, which may provide an essential reference for clinical guidance on the prevention of acute VTE. MATERIALS AND METHODS: A total of 435 patients who underwent glioma surgery from 2012 to 2021 were included in this study. Duplex ultrasonography was performed routinely 3-5 days after the surgery to define VTE...
February 9, 2023: Thrombosis Research
https://read.qxmd.com/read/36801079/calculate-incidence-rates-of-bnt162b2-related-arterial-or-venous-thrombosis-only-from-the-entire-cohort-of-interest
#20
LETTER
Josef Finsterer
No abstract text is available yet for this article.
February 4, 2023: Thrombosis Research
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