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Thrombosis Research

Xiaoling Xu, Liuhong Shi, Xiuqing Ma, Hua Su, Guofeng Ma, Xiaohong Wu, Kejing Ying, Ruifeng Zhang
INTRODUCTION: Acute pulmonary embolism (APE) is a cardiovascular disease with high morbidity and mortality. Although the anatomical obstruction of the pulmonary vascular bed initiates APE, recent studies have suggested that vasoconstrictors in the renin-angiotensin system (RAS) play a role in the severity of APE. MATERIALS AND METHODS: We performed a 5-year retrospective clinical study to analyze the key RAS components in APE patients, including angiotensin converting enzyme (ACE), ACE2, angiotensin II (Ang II) and angiotensin 1-7(Ang(1-7))...
February 15, 2019: Thrombosis Research
L Jara-Palomares, N van Es, J M Praena-Fernandez, G Le Gal, H M Otten, P Robin, A Piccioli, R Lecumberri, P Religa, V Rieu, M Rondina, M Beckers, P Prandoni, P Y Salaun, M Di Nisio, P M Bossuyt, N Kraaijpoel, H R Büller, M Carrier
BACKGROUND: Unprovoked venous thromboembolism (VTE) may be the first manifestation of an underlying cancer. We aimed to assess the period prevalence of occult cancer detection stratified by VTE location (deep vein thrombosis [DVT], pulmonary embolism [PE] or both) and the anatomical relationship between occult cancer and VTE. METHODS: Post-hoc analysis of a systematic review and individual patient data meta-analysis of adults with unprovoked VTE with at least 12 months of follow-up...
February 13, 2019: Thrombosis Research
Takeshi Ogura, Takaaki Eguchi, Mio Amano, Tatushi Sano, Nobu Nishioka, Akira Miyano, Masahiro Tsujimae, Hirohisa Tanimura, Tadahiro Yamada, Yoshihiko Terashima, Akihiko Okada, Kazuhide Higuchi
BACKGROUND: Severe acute cholecystitis (AC) is defined by the association of organ dysfunction, including hematological dysfunction, with AC. Severe AC is often complicated by disseminated intravascular coagulation (DIC), the diagnostic criteria of which overlap with AC-associated hematological dysfunction. Since the diagnosis of DIC often delays definitive surgical management of severe AC, treatment of DIC in this setting is clinically important. Recombinant human soluble thrombomodulin (rTM) is a new agent that has proven clinically useful for treating DIC...
February 13, 2019: Thrombosis Research
A M Münster, T B Rasmussen, A M Falstie-Jensen, L Harboe, G Stynes, L Dybro, M L Hansen, A Brandes, E L Grove, S P Johnsen
BACKGROUND: Venous thromboembolism (VTE) has major clinical and public health impact. However, only sparse data on calendar time trends in incidence from unselected populations reflecting current clinical practice are available. OBJECTIVES: To examine temporal trends in the incidence and characteristics of patients hospitalized with first-time VTE in Denmark between 2006 and 2015. PATIENTS/METHODS: Using nationwide health care registries, we calculated yearly hospitalization rates for first-time VTE from 2006 to 2015...
February 13, 2019: Thrombosis Research
Ivan D Tarandovskiy, Paul W Buehler, Fazoil I Ataullakhanov, Elena Karnaukhova
Package inserts for C1-esterase inhibitor (C1INH) products include warnings for an elevated risk of possible thrombosis in certain individuals, referring to thromboembolic events (TEEs) that were reported to occur after C1INH infusions. However, the mechanism(s) that could explain possible development of TEEs due to C1INH remains unknown. In this work, we evaluated plausible impact of C1INH on the protein C (PC) anticoagulant system. We performed thrombin generation (TG) assays (TGA) and analyzed spatial fibrin clot propagation using thrombodynamics in plasma of individual donors after the addition of thrombomodulin (TM) and C1INH...
February 12, 2019: Thrombosis Research
Margaret R Passmore, Nchafatso G Obonyo, Liam Byrne, Ai-Ching Boon, Sara D Diab, Kimble R Dunster, Yoke L Fung, Michelle M Spanevello, Mohd H Fauzi, Sanne E Pedersen, Gabriela Simonova, Chris M Anstey, Kiran Shekar, John-Paul Tung, Kathryn Maitland, John F Fraser
INTRODUCTION: Fluid resuscitation is a cornerstone of severe sepsis management, however there are many uncertainties surrounding the type and volume of fluid that is administered. The entire spectrum of coagulopathies can be seen in sepsis, from asymptomatic aberrations to fulminant disseminated intravascular coagulation (DIC). The aim of this study was to determine if fluid resuscitation with saline contributes to the haemostatic derangements in an ovine model of endotoxemic shock. MATERIALS AND METHODS: Twenty-one adult female sheep were randomly divided into no endotoxemia (n = 5) or endotoxemia groups (n = 16) with an escalating dose of lipopolysaccharide (LPS) up to 4 μg/kg/h administered to achieve a mean arterial pressure below 60 mmHg...
February 12, 2019: Thrombosis Research
Jon Mabley, Jignesh P Patel, Abdelrahman Sayed, Roopen Arya, Greg Scutt
No abstract text is available yet for this article.
February 12, 2019: Thrombosis Research
Sarah Goldman-Mazur, Ewa Wypasek, Marek Karpiński, Andrzej Stanisz, Anetta Undas
INTRODUCTION: Thrombophilia screening has limited detection efficiency. We assessed the detection rate when a standardized approach to thrombophilia-screened outpatients was used. METHODS: We analyzed 1185 patients (36.5% males, median age: 43 years [IQR 33-54]) referred to a single center from January 2014 to October 2017 with 11 different clinical indications for thrombophilia screening, which was performed in the adherence to published guidelines. Factor V Leiden, prothrombin G20210A mutation, antithrombin (AT), protein C, protein S deficiencies and antiphospholipid syndrome (APS) were determined...
February 11, 2019: Thrombosis Research
Sheng Xu, Jerry Yongqiang Chen, Qishi Zheng, Ngai Nung Lo, Shi-Lu Chia, Keng Jin Darren Tay, Hee Nee Pang, Luming Shi, Edwin Shih Yen Chan, Seng Jin Yeo
INTRODUCTION: Blood loss in Total Joint Arthroplasty can be significant and often under-estimated. This study aims to investigate the safety and efficacy of different routes of tranexamic acid (TXA) administration in reducing blood transfusion after Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA). The secondary aim is to find the safest and most efficacious route and dose of TXA. MATERIAL AND METHODS: PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, and OpenGrey were systemically searched for randomised controlled trials investigating the efficacy and/or safety of TXA for THA and/or TKA...
February 11, 2019: Thrombosis Research
Christopher Beynon, Oliver W Sakowitz, Andreas W Unterberg
No abstract text is available yet for this article.
February 11, 2019: Thrombosis Research
E A Seregina, A V Poletaev, E V Bondar, T A Vuimo, F I Ataullakhanov, N S Smetanina
INTRODUCTION: Patients with hereditary spherocytosis (HS) are characterized by having an increased risk for thrombosis. An early manifestation of thrombotic complications can occur even in childhood, especially after surgery. Hypercoagulability can be associated with hemolytic crises. AIM: The aim of this study was to investigate the hemostatic state in children with HS using global hemostasis assays. METHODS: The hemostatic status of 62 children (38 boys and 24 girls; age range: 0...
February 5, 2019: Thrombosis Research
Harrish Nithianandan, Aoife Reilly, Philip Wells
No abstract text is available yet for this article.
February 5, 2019: Thrombosis Research
Kyle A Davis, Charles R Puleo, Alexander J Kovalic, Sarah A Nisly
No abstract text is available yet for this article.
February 4, 2019: Thrombosis Research
Justyna Rosińska, Wojciech Ambrosius, Joanna Maciejewska, Robert Narożny, Wojciech Kozubski, Maria Łukasik
INTRODUCTION: Platelet-derived microvesicles (pMVs) exhibit procoagulant and proinflammatory properties and play a role in the development and progression of atherosclerosis. The study examined the association between the total number of pMVs and their phenotypes with carotid atherosclerosis and recurrent vascular events (VEs) in patients in the convalescent phase of ischemic stroke (IS). MATERIALS AND METHODS: The study group consisted of 72 patients with IS secondary to large artery atherosclerosis (LAA) (n = 40) and small arteries occlusion (SAO) (n = 32) and 69 matched cardiovascular disease risk-factor (RF) controls...
February 2, 2019: Thrombosis Research
Lauren E Amos, Michael Silvey, Matt Hall, Char M Witmer, Shannon L Carpenter
BACKGROUND/OBJECTIVES: Hospital acquired venous thromboembolism in children is associated with significant morbidity/mortality. Prevention strategies include sequential compression devices and prophylactic anticoagulation but these interventions carry risk and are poorly studied in children. Objectives were to evaluate primary thromboprophylaxis use in hospitalized children over time and the associated bleeding risk. MATERIALS AND METHODS: Retrospective study of hospitalized patients aged 10-18 years within the Pediatric Health Information System administrative database from January 2008-September 2015...
February 2, 2019: Thrombosis Research
José Luis Ferreiro, David Vivas, Jesús María De La Hera, Ana Lucrecia Marcano, Leslie Marisol Lugo, Juan Carlos Gómez-Polo, Iria Silva, Antonio Tello-Montoliu, Francisco Marín, Inmaculada Roldán
INTRODUCTION: There is compelling evidence supporting the association between high on-treatment platelet reactivity (HPR) and low on-treatment platelet reactivity (LPR) to clopidogrel with atherothrombotic and bleeding events, respectively. However, it is uncertain if current cutoff values should be used in prasugrel- or ticagrelor-treated subjects. The objective of this analysis was to evaluate the pharmacodynamic (PD) efficacy of P2Y12 antagonists in a contemporary real-world population...
January 31, 2019: Thrombosis Research
Alisa D Kjaergaard, Ole Halfdan Larsen, Anne-Mette Hvas, Peter H Nissen
INTRODUCTION: Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population. MATERIALS AND METHODS: We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification analyses, in 46 individuals (23 index cases) with and 9 relatives without antithrombin deficiency. Furthermore, in order to explore whether a combination of antithrombin type II heparin binding site (HBS) deficiency and factor V Leiden single nucleotide variant (SNV) conferred a higher risk of VTE than either risk factor alone, we performed genotyping for factor V Leiden in most of the carriers of type II HBS deficiency (n = 25)...
January 31, 2019: Thrombosis Research
D Little, C Chai-Adisaksopha, C Hillis, D M Witt, M Monreal, M A Crowther, D M Siegal
INTRODUCTION: Oral anticoagulation (OAC) is permanently discontinued in up to 50% of patients following a gastrointestinal (GI) bleed. A previous meta-analysis showed a reduced risk of thromboembolism and death, and a non-statistically significant increased risk of re-bleeding associated with resumption. We conducted an updated meta-analysis to determine the risks of recurrent GI bleeding, thromboembolism, and death in patients who resumed OAC compared to those who did not. MATERIALS AND METHODS: We searched EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials for new references from January 2014 to September 2017...
January 30, 2019: Thrombosis Research
Anne Winther-Larsen, Anne-Mette Hvas
INTRODUCTION: Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was evaluated. PATIENTS AND METHODS: Clinical data was systematically retrieved from medical records on all patients who had undergone a DOAC testing at Aarhus University Hospital, Denmark from 2014 until March 2018...
January 24, 2019: Thrombosis Research
Crispijn L van den Brand, Kelly A Foks, Korné Jellema, Diederik W J Dippel
No abstract text is available yet for this article.
January 24, 2019: Thrombosis Research
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