journal
https://read.qxmd.com/read/38735167/pulmonary-vein-thrombosis-clinical-presentation-and-outcomes
#1
JOURNAL ARTICLE
Daniel Sykora, Robert A Churchill, David O Hodge, Steven Callori, Damon E Houghton, Robert D McBane, Waldemar E Wysokinski
BACKGROUND: Pulmonary vein thrombosis (PVT) is a rare thromboembolic disease with potential high-risk complications related to arterial embolization, but little is known regarding risk factors and outcomes. OBJECTIVE: To describe the etiology, management, and clinical course of PVT. METHODS: Institutional health records were queried (1/1/2001-12/30/2023) to identify patients ≥18 years of age diagnosed with PVT. Thrombosis, bleeding, respiratory failure, and all-cause mortality were analyzed...
May 10, 2024: Thrombosis Research
https://read.qxmd.com/read/38735166/risk-assessment-models-for-picc-related-venous-thrombosis-in-adult-patients-with-cancer-a-network-meta-analysis
#2
REVIEW
Zeyin Hu, Ruoying He, Yu Zhao, Mengna Luo, Yuying Fan, Jia Li
OBJECTIVES: This review aims to compare the performance of available risk assessment models (RAMs) for predicting peripherally inserted central catheter-related venous thrombosis (PICC-RVT) in adult patients with cancer. METHODS: A systematic search was conducted across ten databases from inception to October 20, 2023. Studies were eligible if they compared the accuracy of a RAM to that of another RAM for predicting the risk of PICC-RVT in adult patients with cancer...
May 9, 2024: Thrombosis Research
https://read.qxmd.com/read/38733694/subject-letter-to-the-editor-regarding-the-article-a-systematic-review-on-the-effects-of-direct-oral-anticoagulants-on-cancer-growth-and-metastasis-in-animal-models
#3
LETTER
Huda Moutaz Asmael Al-Azzawi, Antonio Celentano
No abstract text is available yet for this article.
May 8, 2024: Thrombosis Research
https://read.qxmd.com/read/38733692/reply-to-letter-to-the-editor
#4
LETTER
J T Buijs, S Najidh, H H Versteeg
No abstract text is available yet for this article.
May 8, 2024: Thrombosis Research
https://read.qxmd.com/read/38761550/the-doac-direct-oral-anticoagulant-dipstick-reliably-excludes-residual-fxa-inhibitors-levels-in-the-preoperative-setting
#5
LETTER
Julie Vassart, Alfonso Tafur, Marisa Durante, Anne-Yseult Boucher, Laure Morimont, Jeanine M Walenga, Job Harenberg, Jonathan Douxfils
No abstract text is available yet for this article.
May 7, 2024: Thrombosis Research
https://read.qxmd.com/read/38733695/detection-and-management-of-clinically-relevant-drug-drug-interactions-with-direct-oral-anticoagulants-an-intervention-study-in-community-pharmacies
#6
JOURNAL ARTICLE
Andreas Capiau, Els Mehuys, Maxim Grymonprez, Inge Van Tongelen, Thierry Christiaens, Eline Tommelein, Geneviève Philippe, Lies Lahousse, Tine De Backer, Koen Boussery
INTRODUCTION: Direct oral anticoagulants (DOACs) are increasingly used and can be involved in clinically relevant drug-drug interactions (DDIs) that increase the risk of major bleeding or thromboembolism. Skilled drug interaction management is essential to ensure safe and effective use of DOACs. In this study, we aimed to investigate the impact of the detection and management of DDIs with DOACs in a real-life community pharmacy setting on the pharmacotherapy of DOAC users. METHODS: We conducted an intervention study in 201 community pharmacies in Belgium...
May 7, 2024: Thrombosis Research
https://read.qxmd.com/read/38733691/venous-thromboembolism-in-black-covid-19-patients-in-a-minority-context-compared-to-white-asian-and-other-racialized-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Jude Mary Cénat, Elisabeth Dromer, Seyed Mohammad Mahdi Moshirian Farahi, Christa Masengesho Ndamage, Aiden Yun, Hannah Zuta, Jihane Mkhatri, Eden Samson, Raina Barara, Patrick R Labelle, Yan Xu
IMPORTANCE: COVID-19 has disproportionately affected racialized populations, with particular impact among individuals of Black individuals. However, it is unclear whether disparities in venous thromboembolic (VTE) complications exist between Black individuals and those belonging to other racial groups with confirmed SARS-CoV2 infections. OBJECTIVE: To summarize the prevalence and moderators associated with VTE among Black COVID-19 patients in minoritized settings, and to compare this to White and Asian COVID-19 patients according to sex, age, and comorbid health conditions (heart failure, cancer, obesity, hypertension)...
May 7, 2024: Thrombosis Research
https://read.qxmd.com/read/38729030/elevated-plasma-levels-of-factor-viii-enhance-arterial-thrombus-formation-on-erosive-smooth-muscle-cell-rich-neointima-but-not-normal-intima-in-rabbits
#8
JOURNAL ARTICLE
Chihiro Sugita, Kazunari Maekawa, Toshihiro Gi, Nobuyuki Oguri, Eriko Nakamura, Eiji Furukoji, Minako Azuma, Yujiro Asada, Atsushi Yamashita
BACKGROUND: Plaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels of coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute to thrombus formation on eroded plaques. AIMS: We aimed to elucidate the role of elevated FVIII in arterial thrombus formation within SMC-rich neointima in rabbits. METHODS AND RESULTS: We assessed the effect of recombinant human FVIII (rFVIII) on blood coagulation in vitro and platelet aggregation ex vivo...
May 6, 2024: Thrombosis Research
https://read.qxmd.com/read/38735165/management-options-for-pediatric-venous-thromboembolic-disease-beyond-anticoagulation-with-endovascular-therapies
#9
REVIEW
Priyanka Mitta, Jake DiFatta, Chase Mahler, Junjian Huang, Rachel Oser, Andrew John Gunn, Hope Wilson, Junaid Raja
Venous thromboembolism (VTE) in pediatric patients is an uncommon but serious diagnosis that has an array of therapeutic options and challenges. An assessment of the existing literature on management of pediatric patients with VTE was conducted. The interventions reviewed include anticoagulation, thrombolysis, thrombectomy, inferior vena cava (IVC) filters, and venous stenting. For each intervention, a discussion of mechanism of action, indications, contraindications, and potential complications was performed...
May 3, 2024: Thrombosis Research
https://read.qxmd.com/read/38723521/immunological-role-of-gas6-tam-signaling-in-hemostasis-and-thrombosis
#10
REVIEW
Fanshu Li, Liling Xu, Chun Li, Fanlei Hu, Yin Su
The immune system is an emerging regulator of hemostasis and thrombosis. The concept of immunothrombosis redefines the relationship between coagulation and immunomodulation, and the Gas6/Tyro3-Axl-MerTK (TAM) signaling pathway builds the bridge across them. During coagulation, Gas6/TAM signaling pathway not only activates platelets, but also promotes thrombosis through endothelial cells and vascular smooth muscle cells involved in inflammatory responses. Thrombosis appears to be a common result of a Gas6/TAM signaling pathway-mediated immune dysregulation...
May 3, 2024: Thrombosis Research
https://read.qxmd.com/read/38718473/aav-mediated-genome-engineering-with-a-bypass-coagulation-factor-alleviates-the-bleeding-phenotype-in-a-murine-model-of-hemophilia-b
#11
JOURNAL ARTICLE
Pratiksha Sarangi, Narendra Kumar, Ramkumar Sambasivan, Sivaprakash Ramalingam, Sonal Amit, Dinesh Chandra, Giridhara R Jayandharan
It is crucial to develop a long-term therapy that targets hemophilia A and B, including inhibitor-positive patients. We have developed an Adeno-associated virus (AAV) based strategy to integrate the bypass coagulation factor, activated FVII (murine, mFVIIa) gene into the Rosa26 locus using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 mediated gene-editing. AAV vectors designed for expression of guide RNA (AAV8-gRNA), Cas9 (AAV2 neddylation mutant-Cas9), and mFVIIa (AAV8-mFVIIa) flanked by homology arms of the target locus were validated in vitro...
May 3, 2024: Thrombosis Research
https://read.qxmd.com/read/38733693/neutrophil-extracellular-traps-formation-may-be-involved-in-the-association-of-propranolol-with-the-development-of-portal-vein-thrombosis
#12
JOURNAL ARTICLE
Xiangbo Xu, Shixue Xu, Yiyan Zhang, Le Wang, Chenghui Yan, Zihua Xu, Qingchun Zhao, Xingshun Qi
BACKGROUND & AIMS: Nonselective β blockers (NSBBs) facilitate the development of portal vein thrombosis (PVT) in liver cirrhosis. Considering the potential effect of NSBBs on neutrophils and neutrophil extracellular traps (NETs), we speculated that NSBBs might promote the development of PVT by stimulating neutrophils to release NETs. MATERIALS AND METHODS: Serum NETs biomarkers were measured, use of NSBBs was recorded, and PVT was evaluated in cirrhotic patients...
May 1, 2024: Thrombosis Research
https://read.qxmd.com/read/38718472/anticoagulation-in-covid-19-patients-an-updated-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Stefanie Reis, Amon Faske, Ina Monsef, Florian Langer, Oliver J Müller, Peter Kranke, Patrick Meybohm, Stephanie Weibel
BACKGROUND: Thromboembolic events are common complications of COVID-19. Clinical study results on safety and efficacy of anticoagulation in COVID-19 are controversial. MATERIAL AND METHODS: This report is the second update of our systematic review with meta-analysis on randomized controlled trials (RCTs) comparing standard thromboprophylaxis, intermediate or therapeutic dose anticoagulation or no anticoagulation in COVID-19 in- and outpatients. We searched eligible studies up to 5 October 2023...
May 1, 2024: Thrombosis Research
https://read.qxmd.com/read/38704897/oral-anticoagulants-and-cognitive-impairment-in-patients-with-atrial-fibrillation-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#14
JOURNAL ARTICLE
Kun-Han Lee, Jiunn-Tyng Yeh, Meng-Lun Wu, Wan-Yu Yeh, Gregory Y H Lip, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng
BACKGROUND: This systematic review assesses the likelihood of developing dementia and cognitive impairment in patients with atrial fibrillation (AF) receiving non-vitamin K antagonist oral anticoagulants (NOACs) as opposed to vitamin K antagonists (VKAs). METHODS: We performed a systematic review with meta-analysis and trial sequential analysis (TSA), which encompassed both randomized controlled trials (RCTs) and observational studies. The objective was to assess the impact of NOACs and VKAs on the incidence of dementia in individuals diagnosed with AF...
May 1, 2024: Thrombosis Research
https://read.qxmd.com/read/38703586/downregulation-of-protein-s-in-patients-with-severe-covid-19-augments-the-prothrombotic-state
#15
LETTER
Devin Melancon, Tina Nguyen, Verima Pereira, Jarrod Harman, Sabyasachi Chatterjee, Arnold H Zea, Samarpan Majumder, Rinku Majumder
No abstract text is available yet for this article.
May 1, 2024: Thrombosis Research
https://read.qxmd.com/read/38703585/myocardial-ischemia-reperfusion-injury-released-cellular-fibronectin-containing-domain-a-cfn-eda-a-destructive-positive-loop-amplifying-arterial-thrombosis-formation-and-exacerbating-myocardial-reperfusion-injury
#16
JOURNAL ARTICLE
Moh Uzair, Chahak Singhal, Azeem Ali, Sangam Rajak, Aditya Kapoor, Surendra Kumar Agarwal, Swasti Tiwari, Shantanu Pande, Prem Prakash
Previous research has identified intravascular platelet thrombi in regions affected by myocardial ischemia-reperfusion (MI/R) injury and neighbouring areas. However, the occurrence of arterial thrombosis in the context of MI/R injury remains unexplored. This study utilizes intravital microscopy to investigate carotid artery thrombosis during MI/R injury in rats, establishing a connection with the presence of prothrombotic cellular fibronectin containing extra domain A (CFN-EDA) protein. Additionally, the study examines samples from patients with coronary artery disease (CAD) both before and after coronary artery bypass grafting (CABG)...
April 30, 2024: Thrombosis Research
https://read.qxmd.com/read/38733696/the-course-of-pulmonary-embolism-in-individuals-recovered-from-covid-19
#17
LETTER
Coşkun Doğan, Samet Samanci
No abstract text is available yet for this article.
April 29, 2024: Thrombosis Research
https://read.qxmd.com/read/38701722/a-thromboembolic-event-as-the-first-presentation-of-essential-thrombocytosis-a-case-report
#18
EDITORIAL
Niloufar Joharivarnoosfaderani, Seyedeh Solaleh Abedi
No abstract text is available yet for this article.
April 29, 2024: Thrombosis Research
https://read.qxmd.com/read/38729029/-what-is-it-that-really-counts-response-to-concerns-regarding-the-applicability-of-d-dimer-point-of-care-devices-in-the-emergency-department
#19
LETTER
Jorn S Heerink
No abstract text is available yet for this article.
April 27, 2024: Thrombosis Research
https://read.qxmd.com/read/38696925/obese-patients-with-atrial-fibrillation-are-more-efficiently-protected-from-thrombosis-under-warfarin-or-xabans-compared-to-non-obese-patients-a-systematic-review-and-meta-analysis-of-six-randomized-controlled-trials
#20
JOURNAL ARTICLE
Lazaros Karatisidis, Konstantinos Zagoridis, Theodoros Mprotsis, Christina Misidou, Aikaterini Pentidou, George Vrachiolias, Zoi Bezirgianidou, Emmanouil Kontomanolis, Emmanouil Spanoudakis
INTRODUCTION: Recommendations about proper anticoagulation in obese patients, body mass index (BMI) > 30 kg/m2, are not yet clearly defined. Obese patients were included in randomized controlled trials comparing new anticoagulants (NOACs) with warfarin in patients with atrial fibrillation or thromboembolism. METHODS: We performed a medline search entering proper criteria and finally 6 post-hoc analysis of RCTs, reporting outcome according to BMI, were included in this meta-analysis...
April 24, 2024: Thrombosis Research
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