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Journals Naunyn-Schmiedeberg's Archives...

Naunyn-Schmiedeberg's Archives of Pharmacology

https://read.qxmd.com/read/38652282/2-methoxyestradiol-ameliorates-doxorubicin-induced-cardiotoxicity-by-regulating-the-expression-of-glut4-and-cpt-1b-in-female-rats
#1
JOURNAL ARTICLE
Mohamed H Sobhy, Ahmed Ismail, Mohammed S Abdel-Hamid, Mohamed Wagih, Marwa Kamel
The clinical usage of doxorubicin (DOX) is hampered due to cardiomyopathy. Studies reveal that estrogen (E2) modulates DOX-induced cardiotoxicity. Yet, the exact mechanism is unclear. The objective of the current study is to evaluate the influence of E2 and more specifically its metabolite 2-methoxyestradiol (2ME) on cardiac remodeling and the reprogramming of cardiac metabolism in rats subjected to DOX cardiotoxicity. Seventy-two female rats were divided into groups. Cardiotoxicity was induced by administering DOX (2...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652281/examining-the-contribution-of-notch-signaling-to-lung-disease-development
#2
REVIEW
Samar A Antar, Mohamed Kh ElMahdy, Ahmed G Darwish
Notch pathway is a widely observed signaling system that holds pivotal functions in regulating various developmental cellular functions and operations. The Notch signaling mechanism is crucial for lung homeostasis, damage, and restoration. Based on increasing evidence, the Notch pathway has been identified, as critical for fibrosis and subsequently, the development of chronic fibroproliferative conditions in various organs and tissues. Recent research indicates that deregulation of Notch signaling correlates with the pathogenesis of significant pulmonary conditions, particularly chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, asthma, pulmonary arterial hypertension (PAH), lung carcinoma, and pulmonary abnormalities in some hereditary disorders...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652280/bibliometric-comparison-of-nobel-prize-laureates-in-physiology-or-medicine-and-chemistry
#3
JOURNAL ARTICLE
Severin Bünemann, Roland Seifert
The Nobel Prize is an annual honor awarded to the researchers who have made the greatest contribution to humanity with their work in the year in question. Nobel Prizes for physiology or medicine and chemistry most often have direct or indirect pharmacological relevance. In this study, we performed a bibliometric analysis of Nobel Prize laureates from 2006 to 2022. The parameters include the nationalities and age of the laureates, age at their productivity peaks, the research locations, the H-index, the age-adjusted H-index, and the number of citations and publications, and, for each parameter, a comparison of female and male award laureates...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652279/ischemia-does-not-provoke-the-full-immune-training-repertoire-in-human-cardiac-fibroblasts
#4
JOURNAL ARTICLE
Constantin Mann, Carolin van Alst, Simone Gorressen, Rachel Nega, Dobromir Dobrev, Maria Grandoch, Anke C Fender
Trained immunity of monocytes, endothelial, and smooth muscle cells augments the cytokine response to secondary stimuli. Immune training is characterized by stabilization of hypoxia-inducible factor (HIF)-1α, mTOR activation, and aerobic glycolysis. Cardiac fibroblast (CF)-myofibroblast transition upon myocardial ischemia/reperfusion (I/R) features epigenetic and metabolic adaptations reminiscent of trained immunity. We assessed the impact of I/R on characteristics of immune training in human CF and mouse myocardium...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652278/bibliometric-analysis-of-naunyn-schmiedeberg-s-archives-of-pharmacology-1947-1974
#5
JOURNAL ARTICLE
Mert Erkan Basol, Roland Seifert
Naunyn-Schmiedeberg's Archives of Pharmacology is the oldest pharmacological journal, founded in 1873. This bibliometric analysis examines the pivotal transformations within Naunyn-Schmiedeberg's Archives of Pharmacology from 1947 to 1974, identifying significant shifts from a national focus to a period of extensive internationalization and English-language adoption. Employing Python and Beautiful Soup for data extraction from SpringerLink, the study maps the journal's trajectory through post-World War II development, highlighting the decline in publication rates due to its initial emphasis on German-language articles predominantly from Germany...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652277/arnicolide-d-a-multi-targeted-anticancer-sesquiterpene-lactone-preclinical-efficacy-and-mechanistic-insights
#6
REVIEW
Shivaprasad Shetty Mangalpady, Sheila I Peña-Corona, Fabiola Borbolla-Jiménez, Rajesh Kaverikana, Shobhitha Shetty, Vinayaka Babu Shet, Zainab M Almarhoon, Daniela Calina, Gerardo Leyva-Gómez, Javad Sharifi-Rad
Arnicolide D, a potent sesquiterpene lactone from Centipeda minima, has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delves into the molecular underpinnings of Arnicolide D's anticancer actions, emphasizing its impact on key signaling pathways such as PI3K/AKT/mTOR and STAT3, and its role in modulating cell cycle and survival mechanisms...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38652276/the-thrombin-receptor-par4-supports-visceral-adipose-tissue-inflammation
#7
JOURNAL ARTICLE
Sonja Kleeschulte, Vivien Fischinger, Lisa Öhlke, Johannes Bode, Markus Kamler, Dobromir Dobrev, Maria Grandoch, Anke C Fender
Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR-4-/- mice received a high fat diet (HFD) for 8 weeks, WT controls received standard chow. Body fat was quantified by NMR. Epididymal WAT was assessed by histology, immunohistochemistry, qPCR and lipase activity assay. 3T3-L1 preadipocytes were differentiated ± thrombin, acutely stimulated ± PAR4 activating peptide (AP) and assessed by immunoblot, qPCR and U937 monocyte adhesion...
April 23, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643455/estrone-mediated-lowering-of-ros-and-nox4-improves-endothelial-function-in-ovariectomized-wistar-rats
#8
JOURNAL ARTICLE
Thiago S Oliveira, Hericles M Campos, Rafael M Costa, Raphaela C Georg, Jacqueline A Leite, Rita C Tostes, Elson A Costa, Fernanda Cristina A Santos, Núbia S Lobato, Fernando P Filgueira, Paulo César Ghedini
Estrone (E1) constitutes the primary component in oral conjugated equine estrogens (CEEs) and serves as the principal estrogen precursor in the female circulation in the post-menopause. E1 induces endothelium-dependent vasodilation and activate PI3K/NO/cGMP signaling. To assess whether E1 mitigates vascular dysfunction associated with postmenopause and explore the underlying mechanisms, we examined the vascular effects of E1 in ovariectomized (OVX) rats, a postmenopausal experimental model. Blood pressure was measured using tail-cuff plethysmography, and aortic rings were isolated to assess responses to phenylephrine, acetylcholine (ACh), and sodium nitroprusside...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643454/the-prevelance-of-multidrug-resistance-in-uropathogens-of-patients-admitted-in-the-intensive-care-unit-of-a-tertiary-care-hospital
#9
JOURNAL ARTICLE
Shaista Ahmed, Neetu Shree, Ajit Singh Narula, Purushottam Kr Nirala, Haya Majid, Aakriti Garg, Uzma Nayeem, Mohd Ashif Khan
Urinary tract infections (UTIs) are among the most common bacterial infections, posing significant public health challenges due to increasing antimicrobial resistance (AMR). This study aims to assess the prevalence, demographic characteristics, microbial profile, and antimicrobial resistance patterns in Indian patients with UTIs admitted to intensive care unit. A total of 154 patients with positive UTIs were included in this cross-sectional study. The prevalence data including demographics, microbial isolates, and antimicrobial susceptibility patterns were collected...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643453/presentation-of-pharmacological-content-in-crime-novels-between-1890-and-2023
#10
JOURNAL ARTICLE
Iven H Möller, Roland Seifert
As there is lack of research on how drugs are presented in crime literature, we read nearly 25,000 pages of crime literature written between 1890 and 2023 to provide an overview on the pharmacological content in this genre. Correct presentation of pharmacological information decreased over time. Misconceptions about certain substances, especially narcotics and anesthetics appear in many of the analyzed examples. Also, in comparison with crime TV series, books are inferior in providing the reader with additional information and pharmacological plausibility...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643452/inflammatory-setting-therapeutic-strategies-targeting-some-pro-inflammatory-cytokines-and-pathways-in-mitigating-ischemia-reperfusion-induced-hepatic-injury-a-comprehensive-review
#11
REVIEW
Moustafa O Aboelez, Hend A A Ezelarab, Ghallab Alotaibi, Deiaa E Elsayed Abouzed
Ischemia/reperfusion injury (IRI) is a key determining agent in the pathophysiology of clinical organ dysfunction. It is characterized by an aseptic local inflammatory reaction due to a decrease in blood supply, hence deprivation of dependent oxygen and nutrients. In instances of liver transplantation, this injury may have irreversible implications, resulting in eventual organ rejection. The deterioration associated with IRI is affected by the hepatic health status and various factors such as alterations in metabolism, oxidative stress, and pro-inflammatory cytokines...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643451/empagliflozin-protective-effects-against-cisplatin-induced-acute-nephrotoxicity-by-interfering-with-oxidative-stress-and-inflammation-in-wistar-rats
#12
JOURNAL ARTICLE
Nika Farrokh-Eslamlou, Saeideh Momtaz, Amirhossein Niknejad, Yasamin Hosseini, Parvin Mahdaviani, Morteza Ghasemnejad-Berenji, Amir Hossein Abdolghaffari
Cisplatin (Cis) is a platinum-based antineoplastic drug used in various types of cancers. This drug can induce nephrotoxicity as a cause of acute kidney injury (AKI) by inducing oxidative stress and inflammation. Empagliflozin (Empa) is a newly developed inhibitor of sodium-glucose cotransporter-2 (SGLT2) approved as an antidiabetic medication for patients with type 2 diabetes mellitus. In addition to its blood glucose-lowering effect, Empa has been shown to exert anti-inflammatory and anti-oxidant properties...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643450/pharmacokinetics-and-safety-of-a-new-generic-lurasidone-a-phase-i-bioequivalence-study-in-healthy-chinese-subjects
#13
JOURNAL ARTICLE
Zhengzhi Liu, Jinling Xue, Qiaohuan Deng, Yanli Wang, Lixiu Zhang, Lang Liu, Nan Xiao, Tianying Chang, Yingzi Cui, Yang Cheng, Guangwen Liu, Wanhua Wang, Yannan Zhou, Wei Yang, Xinyao Qu, Jiahui Chen, Yicheng Zhao, Zeyu Wang, Haimiao Yang
Latuda®  is a novel antipsychotic drug for schizophrenia and bipolar depression. A bioequivalence trial was performed to investigate the bioequivalence of Latuda® and its generic drug lurasidone. Two independent trials were carried out, each involving 28 subjects. In the fasting trial, subjects were randomly assigned to two groups (1:1 ratio), receiving either 40 mg of generic lurasidone or Latuda® . After a 7-day washout period, subjects entered the second period with a crossover administration of 40 mg of generic lurasidone or Latuda® ...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38643449/kurarinone-a-flavonoid-from-radix-sophorae-flavescentis-inhibits-rankl-induced-osteoclastogenesis-in-mouse-bone-marrow-derived-monocyte-macrophages
#14
JOURNAL ARTICLE
Ling Long, Hao Luo, Yi Wang, Jiaxiang Gu, Jiachao Xiong, Xiaokai Tang, Hao Lv, Faxin Zhou, Kai Cao, Sijian Lin
Inflammation-induced osteoclast proliferation is a crucial contributor to impaired bone metabolism. Kurarinone (KR), a flavonoid extracted from the Radix Sophorae Flavescentis, exhibits notable anti-inflammatory properties. Nevertheless, the precise influence of KR on osteoclast formation remains unclear. This study's objective was to assess the impact of KR on osteoclast activity in vitro and unravel its underlying mechanism. Initially, a target network for KR-osteoclastogenesis-osteoporosis was constructed using network pharmacology...
April 21, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38639898/narrative-review-on-nanoparticles-based-on-current-evidence-therapeutic-agents-for-diabetic-foot-infection
#15
REVIEW
Mohd Saleem, Azharuddin Sajid Syed Khaja, Soha Moursi, Tahani Almofeed Altamimi, Mohammed Salem Alharbi, Kauser Usman, Mohd Shahid Khan, Alwaleed Alaskar, Mohammad Jahoor Alam
Diabetes's effects on wound healing present a major treatment challenge and increase the risk of amputation. When traditional therapies fail, new approaches must be investigated. With their submicron size and improved cellular internalisation, nanoparticles present a viable way to improve diabetic wound healing. They are attractive options because of their innate antibacterial qualities, biocompatibility, and biodegradability. Nanoparticles loaded with organic or inorganic compounds, or embedded in biomimetic matrices such as hydrogels, chitosan, and hyaluronic acid, exhibit excellent anti-inflammatory, antibacterial, and antioxidant properties...
April 19, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38639897/mer-activation-ameliorates-nerve-injury-induced-neuropathic-pain-by-regulating-microglial-polarization-and-neuroinflammation-via-socs3-in-male-rats
#16
JOURNAL ARTICLE
Jingqiong Wang, Xuanzhi Zhu, Yaohua Wu
Accumulating evidence has demonstrated that M1 microglial polarization and neuroinflammation worsen the development of neuropathic pain. However, the mechanisms underlying microglial activation during neuropathic pain remain incompletely understood. Myeloid-epithelial-reproductive tyrosine kinase (Mer), which is a member of the Tyro-Axl-Mer (TAM) family of receptor tyrosine kinases, plays a crucial role in the regulation of microglial polarization. However, the effect of Mer on microglial polarization during neuropathic pain has not been determined...
April 19, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38630255/editorial-expression-of-concern-ellagic-acid-prevents-dementia-through-modulation-of-pi3-kinase-endothelial-nitric-oxide-synthase-signaling-in-streptozotocin-treated-rats
#17
Manish Kumar, Nitin Bansal
No abstract text is available yet for this article.
April 17, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38630254/exploring-the-potential-of-silymarin-loaded-nanovesicles-as-an-effective-drug-delivery-system-for-cancer-therapy-in-vivo-in-vitro-and-in-silico-experiments
#18
JOURNAL ARTICLE
Mohammad Reza Hajinezhad, Maryam Roostaee, Zahra Nikfarjam, Sanaz Rastegar, Ghasem Sargazi, Mahmood Barani, Saman Sargazi
We aimed to perform a comprehensive study on the development and characterization of silymarin (Syl)-loaded niosomes as potential drug delivery systems. The results demonstrate significant novelty and promising outcomes in terms of morphology, size distribution, encapsulation efficiency, in vitro release behavior, free energy profiles of Syl across the niosome bilayer, hydrogen bonding interactions, antimicrobial properties, cytotoxicity, and in vivo evaluations. The physical appearance, size, and morphology assessment of free niosomes and Syl-loaded niosomes indicated stable and well-formed vesicular structures suitable for drug delivery...
April 17, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38625553/polymeric-micelle-gel-with-luliconazole-in-vivo-efficacy-against-cutaneous-candidiasis-in-wistar-rats
#19
JOURNAL ARTICLE
Gurmeet Singh, Raj Kumar Narang
The objective of this research was focused on the design and development of luliconazole-loaded polymeric micelle hydrogel (LUL-PM-CHG) using quality by design (QbD) principle to improve the penetration and retention of LUL in the skin. The optimization of the formulation involved the utilization of a Box-Behnken design with three factors and three levels. The impact of specific formulation variables, namely the ratio of poloxamer P123 and F127, sonication time, and the quantity of drug, was investigated in terms of particle size, micellar incorporation efficiency, and polydispersity index...
April 16, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38625552/neuroprotective-effects-of-chlorogenic-acid-against-oxidative-stress-in-rats-subjected-to-lithium-pilocarpine-induced-status-epilepticus
#20
JOURNAL ARTICLE
Alberth Jonnathan Carreño-González, José Luiz Liberato, Marcus Vinicius Batista Celani, Norberto Peporine Lopes, João Luís Callegari Lopes, Leonardo Gobbo-Neto, Andreia Cristina Karklin Fontana, Wagner Ferreira Dos Santos
Epilepsy is a condition marked by sudden, self-sustained, and recurring brain events, showcasing unique electro-clinical and neuropathological phenomena that can alter the structure and functioning of the brain, resulting in diverse manifestations. Antiepileptic drugs (AEDs) can be very effective in 30% of patients in controlling seizures. Several factors contribute to this: drug resistance, individual variability, side effects, complexity of epilepsy, incomplete understanding, comorbidities, drug interactions, and no adherence to treatment...
April 16, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
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