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Scandinavian Journal of Immunology

Gang Li, Lan Gao, Rufei Ma, Wenqian Tian, Ling Mingzhi
Several studies already explored associations between Fc gamma receptor (FCGR) polymorphisms and immune thrombocytopenia (ITP), but the results of these studies were not consistent. Consequently, we conducted a meta-analysis of relevant studies to better analyze the effects of FCGR polymorphisms on individual susceptibility to ITP. PubMed, Web of Science, Embase and CNKI were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Totally 17 studies were eligible for analyses (1,200 cases and 1,723 controls)...
February 20, 2019: Scandinavian Journal of Immunology
Hua Ma, Minwen Xu, Yuanyuan Song, Ting Zhang, Hanqiu Yin, Songlou Yin
BACKGROUND AND AIM: Interferon-γ (IFN-γ) is a versatile cytokine which broadly involves in the inflammatory diseases, mediating both immune activation and tolerance. Here, we aimed to investigate the role of IFN-γ in the initiation of adjuvant-induced arthritis (AIA). METHODS AND RESULTS: In an AIA mice model, increasing IFN-γ mRNA was observed at day 3 and peaked on day 7. At day 3, the majority of IFN-γ-producing cells were located around vessels observed by immunofluorescent staining...
February 9, 2019: Scandinavian Journal of Immunology
Hui-Qing Lu, Rong Hu
Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, however, the aetiology of preeclampsia still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents...
February 9, 2019: Scandinavian Journal of Immunology
H Kopřivová, M Hájková, M Koucký, K Malíčková, V Holáň, M Krulová
Regulatory T cells (Tregs) play a critical role in the maintenance of a pregnancy. While the kinetics of the number of peripheral blood Tregs has been satisfactorily described in mouse models, analysis of these cell populations in human pregnancy is complicated by high variability in the quantity of Tregs and inconsistencies in the markers used for detecting different types of Treg. In light of this, we set out to investigate the kinetics of various types of Treg, including CD45RA, GARP and PD-1(+) Tregs, in the peripheral blood of pregnant women in the first, second and third trimester, and at the time of delivery...
February 7, 2019: Scandinavian Journal of Immunology
Junyan Wang, Chan Li, Juanjuan Fu, Xia Wang, Xia Feng, Xiucheng Pan
Tim-3 is expressed on monocytes/macrophages, and is involved in the regulation of inflammatory responses. The aim of this study was to determine the effect of Tim-3 on inflammatory response triggered by peripheral monocytes from patients with chronic hepatitis B (CHB). Tim-3 expression on peripheral monocytes and frequency of Th17 cells in peripheral blood mononuclear cells (PBMCs) derived from CHB patients were detected. Followed by lipopolysaccharides (LPS) activation of circulating monocytes from CHB patients, expression of inflammatory cytokines including TNF-α,IL-1β and IL-6 were examined in the presence and absence of Galectin-9 which is the ligand for Tim-3...
February 7, 2019: Scandinavian Journal of Immunology
James Ding, Gisela Orozco
Over the past decade genome-wide association studies have contributed a wealth of knowledge to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of sample cohorts has improved so too have the computational and experimental methods used to robustly define variants associated with disease susceptibility. The challenge now remains to translate these finding into improved understanding of disease aetiology and patient care. Whilst much of the focus of translating the findings of genome-wide association studies has been on global analysis of all variants identified, careful functional study of individual disease susceptibility loci will be required in order to refine our understanding of how individual variants contribute to disease risk...
February 1, 2019: Scandinavian Journal of Immunology
Jie Wan, Yuwen Cao, Mohamed Hamed Abdelaziz, Lan Huang, Dinesh Kumar Kesavan, Zhaoliang Su, Shengjun Wang, Huaxi Xu
The accumulation of airway apoptotic cells may be an important factor causing airway hyper-responsiveness. Whether the apoptotic cells can be prompt removed is related to the occurrence and course of asthma. In recent years, studies have shown that Rac1 is involved in many cellular biological activities including the formation and elimination of apoptotic cells. In this study, based on analysis of airway local cells and related factors in asthmatic mice, we evaluated the expression of Rac1 in airway epithelial cells or phagocytes, and analyzed its relationship with the incidence of apoptosis or scavenging of apoptotic cells...
January 25, 2019: Scandinavian Journal of Immunology
Yiqing Tong, Xin Ku, Chunrong Wu, Jianjun Liu, Chunhui Yang, Wenzhi Tang, Wei Yan, Jianguo Tang
This study was aimed to uncover proteins that are differentially expressed in sepsis. Data Independent Acquisition (DIA) was used for analysis to identify differentially expressed proteins in peripheral blood mononuclear cells (PBMCs) of patients. A total of 24 non-septic Intensive Care Unit (ICU) patients, 11 septic shock patients and 27 patients diagnosed with sepsis were recruited for the Mass Spectrometry (MS) discovery. PBMCs were isolated from routine blood samples and digested into peptides. A DIA workflow was developed using a quadrupole-Orbitrap Liquid Chromatography (LC)-MS system, and mass spectra peaks were extracted by Skyline software...
January 22, 2019: Scandinavian Journal of Immunology
Wei Wang, Na Zhao, Baozhu Li, Haopeng Gao, Yongjia Yan, Hao Guo
Interleukin-35 (IL-35) is a cytokine recently discovered to play a potent immunosuppressive role by intensifying the functions of regulatory T cells and inhibiting the proliferation and functions of T helper 1 and T helper 17 cells. Mesenchymal stem cells (MSCs) have recently emerged as promising candidates for cell-based immune therapy, and our previous study showed that IL-35 gene modification can effectively enhance the therapeutic effect of MSCs in vitro. In this study, we isolated adipose tissue-derived MSCs in vitro and infected them with lentiviral vectors overexpressing the IL-35 gene, thereby creating IL-35-MSCs...
January 21, 2019: Scandinavian Journal of Immunology
Yousheng Lu, Yueran Xu, Shaopeng Zhang, Ji Gao, Xiaojie Gan, Ju Zheng, Jian Gu, Ling Lu
Current evidence indicates that inflammatory bowel disease (IBD) is caused primarily by impaired mucosal immunity, resulting in an imbalance between epithelial barrier function and tissue inflammation. Human gingiva-derived mesenchymal stem cells (GMSCs) exhibit immunomodulatory and anti-inflammatory effects in a variety of immunity- and inflammation-associated diseases. However, the role of GMSCs in treating IBD has not been elucidated. Our study, therefore, examined the therapeutic effect and mechanism of GMSCs in a murine colitis model of IBD...
January 21, 2019: Scandinavian Journal of Immunology
Jayesh Mudgal, Piya Paul Mudgal, Manas Kinra, Ritu Raval
Chitosan, the deacetylated form of chitin, a natural polysaccharide, is known for its various biomedical applications. The present study aimed at exploring the immunomodulatory properties of chitosan (CSNP) and gallic acid grafted chitosan (cGANP) nanoparticles in mice model of cyclophosphamide (CPA)-induced immunosuppression. In addition, chitooligosaccharides, the hydrolysed form of chitin and chitosan were also evaluated for its potential against immunosuppression in mice. CPA (80 mg/kg/i.p.) induced significant immunosuppression, which was reversed with cGANP treatment as indicated by a significant increase in the thymus and spleen indices compared to the CPA-treated group...
January 21, 2019: Scandinavian Journal of Immunology
Gholamreza Daryabor, Dieter Kabelitz, Kurosh Kalantar
Obesity is associated with chronic low-grade inflammation of the adipose tissue (AT) that might develop into systemic inflammation, insulin resistance (IR), and an increased risk of type 2 diabetes mellitus (T2DM) in severe obese rodents and humans. In the lean state, small normal adipocytes and AT macrophages interact with each other to maintain metabolic homeostasis but during obesity, enlarged adipocytes secrete inflammatory mediators and express immune receptors to recruit immune cells and aggravate the inflammation...
December 28, 2018: Scandinavian Journal of Immunology
Donald R Forsdyke
With the emergence of clonal selection ideas in the 1950s, the development of immune cell repertoires was seen to require the negative selection of self-reacting cells, with surviving cells exhibiting a broad range of specificities. Thus, confronting a universe of not-self antigens, a potential host organism spread its resources widely. In the 1960s the two signal hypothesis showed how this might work. However, in the 1970s an affinity/avidity model further proposed that, anticipating a pathogen strategy of exploiting "holes" in the repertoire created by negative selection, hosts should also positively select near-self-reacting cells...
December 28, 2018: Scandinavian Journal of Immunology
M Eberhardson, Crh Hedin, M Carlson, L Tarnawski, Y A Levine, P S Olofsson
Inflammatory bowel disease (IBD), is characterized by activation of both the innate and adaptive immune system in genetically susceptible individuals, resulting in chronic intestinal inflammation. The triggers that initiate and perpetuate this continuous inflammation are the subject of much speculation and research, although the central role of the intestinal microbiota is recognized and is even a target for treatment in some circumstances. The mainstay of modern IBD-treatment is suppression of the immune response towards as yet unspecified antigens, and conventional therapy includes corticosteroids, 5-aminosalicylic acid (5-ASA), thiopurines and methotrexate...
December 23, 2018: Scandinavian Journal of Immunology
Hakan Köksal, Elisabeth Müller, Else Marit Inderberg, Øyvind Bruland, Sébastien Wälchli
Novel therapies to treat patients with solid cancers that have developed resistance to chemotherapy represent unmet needs of considerable dimensions. In the present review, we will address the attempts to develop Chimeric Antigen Receptor (CAR) targeted immunotherapy against osteosarcoma (OS). This aggressive cancer displays its peak incidence in children and young adults. The main cause of patient death is lung metastases with a 5-year survival as low as 5-10% in the primary metastatic setting and 30% in the relapse situation, respectively...
December 14, 2018: Scandinavian Journal of Immunology
Ritu Khosla, Ashish Kumar Vyas, Nirupma Trehanpati
Notch signaling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. However, although in some cancers Notch signaling acts as a tumor-promoter, in others it is reported to suppress tumor growth and progression. Accumulating evidence suggests the involvement of both the innate and adaptive immune system in the development of various tumors...
December 13, 2018: Scandinavian Journal of Immunology
Chang-Hyun Kim, Jung Ki Yoo, Seong Ho Jeon, Chi-Yeon Lim, Ju-Hee Lee, Deog-Bon Koo, Mi-Young Park
Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Our results showed that administration of MDSCs (1×106 or 2×106 cells) suppressed the development of IMQ-induced skin inflammation in mice as exemplified by a significant reduction in clinical severity scores and was associated with a reduction of histopathological changes, including inflammatory infiltration, epidermal hyperplasia, and hyperkeratosis...
December 13, 2018: Scandinavian Journal of Immunology
Dulce Adriana Mata-Espinosa, Alejandro Francisco-Cruz, Brenda Marquina-Castillo, Jorge Barrios-Payan, Octavio Ramos-Espinosa, Estela Isabel Bini, Zhou Xing, Rogelio Hernández-Pando
High dose of Mycobacterium tuberculosis (Mtb) strain H37Rv administered by intratracheal injection in BALB/c mice induce progressive tuberculosis (TB). In this model, during the first month there is a temporal control of bacillary growth, in coexistence with macrophage activation, granuloma formation and Th-1 response. Then, bacterial proliferation recommences, accompanied by progressive pneumonia and decreasing expression of protective cytokines (IFN-γ and TNF-α). In this model, we studied the IL-12 gene expression kinetics and cellular source...
December 13, 2018: Scandinavian Journal of Immunology
Manal S Fawzy, Mona G Elgazzaz, Ahmed Ibrahim, Mohammad H Hussein, Motaz S Khashana, Eman A Toraih
Several studies have investigated the association of Group-specific Component (GC) gene, also known as vitamin D binding protein (VDBP), and various respiratory disorder susceptibility with conflicting results. In this sense, we aimed to investigate whether rs7041 and rs4588 variants confer susceptibility to bronchial asthma in a sample of an Egyptian population and to elucidate by in silico analysis the structural and functional impact of these variants. GC polymorphisms rs7041 and rs4588 were genotyped in 192 Egyptian children and adolescents (96 with asthma and 96 healthy controls) by TaqMan single nucleotide polymorphism genotyping assay...
December 12, 2018: Scandinavian Journal of Immunology
Jiang Cao, Changxiao Zhang, Xiao Han, Hai Cheng, Wei Chen, Kunming Qi, Jianlin Qiao, Zengtian Sun, Qingyun Wu, Lingyu Zeng, Mingshan Niu, Li Li, Kailin Xu
Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by autoantibody-mediated platelet destruction. Multiple factors have been implicated in ITP pathogenesis, including T-lymphocyte dysfunctions. Increasing studies have indicated that stem cell memory-like T cell (TSCM) plays an important role in the development of multiple autoimmune diseases. This study aimed to explore the clinical correlation between the TSCM subset and ITP. The percentages of peripheral blood naïve T cells (TNs), TSCMs, central memory T cells (TCMs), effector memory T cells (TEMs) and effector T cells (TEs) among CD4+ and CD8+ T cells in 20 ITP patients before and after treatment were detected using flow cytometry...
December 1, 2018: Scandinavian Journal of Immunology
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