journal
https://read.qxmd.com/read/38773691/mucosal-associated-invariant-t-cells-modulate-innate-immune-cells-and-inhibit-colon-cancer-growth
#1
JOURNAL ARTICLE
Olivia J Cheng, Eric J Lebish, Owen Jensen, Damian Jacenik, Shubhanshi Trivedi, Jackson G Cacioppo, Jeffrey Aubé, Ellen J Beswick, Daniel T Leung
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited. Using an animal model of colon cancer, we showed that peritumoral injection of in vivo-expanded MAIT cells into RAG1-/- mice with MC38-derived tumours inhibits tumour growth compared to control...
May 21, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38769661/role-of-akr1b10-in-inflammatory-diseases
#2
REVIEW
Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao
Inflammation is an important pathophysiological process in many diseases; it has beneficial and harmful effects. When exposed to various stimuli, the body triggers an inflammatory response to eliminate invaded pathogens and damaged tissues to maintain homeostasis. However, uncontrollable persistent or excessive inflammatory responses may damage tissues and induce various diseases, such as metabolic diseases (e.g. diabetes), autoimmune diseases, nervous system-related diseases, digestive system-related diseases, and even tumours...
May 20, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38757311/ifih1-loss-of-function-predisposes-to-inflammatory-and-sars-cov-2-related-infectious-diseases
#3
JOURNAL ARTICLE
Rania Najm, Lemis Yavuz, Ruchi Jain, Maha El Naofal, Sathishkumar Ramaswamy, Walid Abuhammour, Tom Loney, Norbert Nowotny, Alawi Alsheikh-Ali, Ahmad Abou Tayoun, Richard K Kandasamy
The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation in weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-function of the IFIH1 gene has been associated with multisystem disorders, namely Aicardi-Goutieres and Singleton-Merten syndromes, while biallelic loss causes immunodeficiency...
May 16, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38750640/genetic-polymorphisms-in-il-2-il-10-and-foxp3-are-associated-with-autoimmune-neutropaenia-in-early-childhood-and-autoantibody-specificity-in-a-danish-cohort
#4
JOURNAL ARTICLE
Kirstine Kløve-Mogensen, Rudi Steffensen, Tania Nicole Masmas, Andreas Glenthøj, Christina Friis Jensen, Paul Ratcliffe, Petter Höglund, Henrik Hasle, Kaspar René Nielsen, Thure Mors Haunstrup
Autoimmune neutropaenia (AIN) in early childhood is characterized by chronic neutropaenia and positivity for human neutrophil antibodies (HNA), resulting in the excessive destruction of neutrophils. The association between regulatory T cells (Tregs) and AIN has been described, and in this study, we investigated three Treg-associated genes, IL-2, IL-10 and FOXP3. The frequencies of three single nucleotide polymorphisms (SNPs) in IL-2 -330T>G (rs2069762), +114G>T (rs2069763) and IVS3-116 A>G (rs2069772), four SNPs in IL-10 -3575T>A (rs1800890), -1082G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872) and three SNPs in FOXP3 -3499 A>G (rs3761547), -3279 C>A (rs3761548) and -924 A>G (rs2232365) were compared between 166 Danish AIN patients and 358 healthy controls...
May 15, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38750629/the-quantum-model-of-t-cell-activation-revisiting-immune-response-theories
#5
JOURNAL ARTICLE
Masoud H Manjili, Saeed H Manjili
Our understanding of the immune response is far from complete, missing out on more detailed explanations that could be provided by molecular insights. To bridge this gap, we introduce the quantum model of T-cell activation. This model suggests that the transfer of energy during protein phosphorylation within T cells is not a continuous flow but occurs in discrete bursts, or 'quanta', of phosphates. This quantized energy transfer is mediated by oscillating cycles of receptor phosphorylation and dephosphorylation, initiated by dynamic 'catch-slip' pulses in the peptide-major histocompatibility complex-T-cell receptor (pMHC-TcR) interactions...
May 15, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38741164/sirolimus-is-effective-and-safe-in-childhood-relapsed-refractory-autoimmune-cytopenias-a-multicentre-study
#6
JOURNAL ARTICLE
Sultan Okur Acar, Neryal Tahta, Işık Odaman Al, Melek Erdem, Salih Gözmen, Tuba Hilkay Karapınar, Burcu Kılınç, Tiraje Celkan, Serap Kirkiz, Ülker Koçak, Hale Ören, Ayşen Türedi Yıldırım, Esra Arslantaş, Aylin Canbolat Ayhan, Yeşim Oymak
Autoimmune cytopenias are a heterogeneous group of disorders characterized by immune-mediated destruction of haematopoietic cell lines. Effective and well-tolerated treatment options for relapsed-refractory immune cytopenias are limited. In this study, the aim was to evaluate the efficacy and safety of sirolimus in this disease group within the paediatric age group. The study enrolled patients in the paediatric age group who used sirolimus with a diagnosis of immune cytopenia between December 2010 and December 2020, followed at six centres in Turkey...
May 13, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38671579/isoliquiritigenin-limits-inflammasome-activation-of-macrophage-via-docking-into-syk-to-alleviate-murine-non-alcoholic-fatty-liver-disease
#7
JOURNAL ARTICLE
Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong
Isoliquiritigenin (ISL) is a chalcone-type flavonoid derived from the root of licorice with antioxidant, anti-inflammatory, anti-tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL-1β, TNF-α and IL-6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL-1β, TNF-α and IL-6 expressions in lipopolysaccharide-stimulated macrophages ex vivo. ApoC3-transgenic (ApoC3TG ) mice had more activated macrophages...
April 26, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38654426/clinical-and-molecular-significance-of-flow-cytometric-analysis-for-reactive-oxygen-species-production-and-residual-p67-phox-expression-in-p67-phox-deficient-chronic-granulomatous-disease
#8
JOURNAL ARTICLE
Hanae Miyazawa, Masahiro Muraoka, Yusuke Matsuda, Tomoko Toma, Tomohiro Morio, Tomonari Shigemura, Kohei Haraguchi, Tadashi Matsubayashi, Toshinao Kawai, Yuya Shirai, Taizo Wada
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by molecular defects in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. p67phox -CGD is an autosomal recessive CGD, which is caused by a defect in the cytosolic components of NADPH oxidase, p67phox , encoded by NCF2. We previously established a flow cytometric analysis for p67phox expression, which allows accurate assessment of residual protein expression in p67phox -CGD. We evaluated the correlation between oxidase function and p67phox expression, and assessed the relevancy to genotypes and clinical phenotypes in 11 patients with p67phox -CGD...
April 23, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38584338/asymptomatic-sars-cov-2-infection-a-possible-role-of-platelet-hla-class-i-expression-level
#9
LETTER
Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta
No abstract text is available yet for this article.
April 7, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38566362/elevated-levels-of-anti-golgi-antibodies-an-early-sign-of-seronegative-rheumatoid-arthritis
#10
JOURNAL ARTICLE
Emrah Salman, Bedia Dinç
Anti-Golgi antibodies are uncommon antibodies that exhibit specific, polarized cytoplasmic staining on the Hep-2 substrate. The objective of our study was to identify the clinical and laboratory features associated with anti-Golgi antibodies. We examined 4.5 years of data from a Turkish tertiary hospital in this retrospective cohort analysis. The indirect immunofluorescence staining patterns, antinuclear antibody (ANA) titres and clinical data of all patients were obtained from the hospital record system...
April 2, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38556807/mite-negative-allergic-rhinitis-a-model-of-the-regulation-mechanism-of-atopy-onset
#11
LETTER
Yasuhiro Horiuchi
No abstract text is available yet for this article.
March 31, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38527944/major-low-energy-trauma-results-in-non-specific-immunoglobulin-generation-without-evidence-for-specific-autoantibody-production-a-prospective-cohort-study
#12
JOURNAL ARTICLE
Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova
Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control...
March 25, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38436518/the-presence-of-autoantibodies-as-a-potential-prognostic-biomarker-for-breast-cancer
#13
JOURNAL ARTICLE
Libo Ouyang, Keying Jing, Chunkai Zhu, Rong Wang, Peiming Zheng
The presence of autoantibodies is closely associated with the occurrence and development of cancer. Autoantibodies can be used as biomarkers for early breast cancer diagnosis. However, the relationship between autoantibodies and the prognosis of breast cancer patients remains elusive. This retrospective study aimed to investigate the correlation between the presence of autoantibodies and outcomes in breast cancer patients. This study included a total of 155 patients from People's Hospital of Henan University (Zhengzhou, China) who were diagnosed with breast cancer from January 2017 to December 2021...
February 28, 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38720521/systematic-analysis-of-mucosal-associated-invariant-t-cells-in-haematological-malignancies
#14
JOURNAL ARTICLE
Barbora Bacova, Jakub Cierny, Lucia Nemcekova, Jitka Smetanova/Brozova, Jan Novak
Mucosal-associated invariant T-cells (MAIT) are unconventional T-cells with cytotoxic and pro-inflammatory properties. Previous research has reported contradictory findings on their role in cancerogenesis with data being even scarcer in haematological malignancies. Here, we report the results of a systematic analysis of MAIT cells in treatment-naïve patients with a broad range of haematological malignancies. We analysed peripheral blood of 204 patients and 50 healthy subjects. The pool of haematological patients had a statistically significant lower both the absolute value (median values, 0...
June 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38720518/changes-in-serum-immunoglobulin-g-glycosylation-patterns-for-antiphospholipid-syndrome-patients-with-lectin-microarray
#15
JOURNAL ARTICLE
Yifei Wang, Siting Li, Jingjing Meng, Rui Yu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Jiulang Zhao, Chaojun Hu
Antiphospholipid syndrome is a rare autoimmune disease characterized by persistent antiphospholipid antibodies. Immunoglobulin G plays a vital role in disease progression, with its structure and function affected by glycosylation. We aimed to investigate the changes in the serum immunoglobulin G glycosylation pattern in antiphospholipid syndrome patients. We applied lectin microarray on samples from 178 antiphospholipid syndrome patients, 135 disease controls (including Takayasu arteritis, rheumatoid arthritis and cardiovascular disease) and 100 healthy controls...
June 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38605563/oxidized-low-density-lipoproteins-impair-the-pro-atherosclerotic-effect-of-granulocyte-macrophage-colony-stimulating-factor-producing-t-helper-cells-on-macrophages
#16
JOURNAL ARTICLE
Xiaofang Xiong, Zheng Yan, Long Yan, Xuexue Yang, Dongsheng Li, Guizhen Lin
T cells contribute to the pathogenesis of atherosclerosis. However, the presence and function of granulocyte-macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in atherosclerosis development is unknown. This study aims to characterize the phenotype and function of ThGM cells in experimental atherosclerosis. Atherosclerosis was induced by feeding apolipoprotein E knockout (ApoE-/- ) mice with a high-fat diet. Aortic ThGM cells were detected and sorted by flow cytometry. The effect of oxidized low-density lipoprotein (oxLDL) on ThGM cells and the impact of ThGM cells on macrophages were evaluated by flow cytometry, quantitative RT-PCR, oxLDL binding/uptake assay, immunoblotting and foam cell formation assay...
May 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38605549/unlocking-pd-1-antibody-resistance-the-muc1-dna-vaccine-augments-cd8-t-cell-infiltration-and-attenuates-tumour-suppression
#17
JOURNAL ARTICLE
Xiaoqin Wang, Yinsha Miao, Jinghui Shen, Dandan Li, Xinyue Deng, Chengcheng Yang, Yanhong Ji, ZhiJun Dai, Yunfeng Ma
In light of increasing resistance to PD1 antibody therapy among certain patient populations, there is a critical need for in-depth research. Our study assesses the synergistic effects of a MUC1 DNA vaccine and PD1 antibody for surmounting PD1 resistance, employing a murine CT26/MUC1 colon carcinoma model for this purpose. When given as a standalone treatment, PD1 antibodies showed no impact on tumour growth. Additionally, there was no change observed in the intra-tumoural T-cell ratios or in the functionality of T-cells...
May 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38605547/markedly-upregulated-serum-semaphorin-4a-as-a-novel-activity-marker-of-myasthenia-gravis
#18
JOURNAL ARTICLE
Akiyuki Uzawa, Manato Yasuda, Hiroyuki Akamine, Yosuke Onishi, Hideo Handa, Etsuko Ogaya, Yukiko Ozawa, Hiroki Masuda, Masahiro Mori, Satoshi Kuwabara
Myasthenia gravis (MG) is an autoantibody-mediated disease of the neuromuscular junction. Semaphorin 4A (Sema4A) is involved in the activation of T cells in various inflammatory disorders. In this study, we aimed to investigate whether Sema4A is involved in the pathogenesis of MG. We measured serum Sema4A concentrations in 30 treatment-naïve MG patients with acetylcholine receptor (AChR) antibodies, 7 with muscle-specific tyrosine kinase (MuSK) antibodies and 21 normal controls. As a result, serum Sema4A levels were significantly higher in patients with AChR antibody-positive MG and MuSK antibody-positive MG than in controls (p ≤ 0...
May 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38605535/interaction-of-t-cell-specific-adapter-protein-with-src-and-tec-family-kinases
#19
JOURNAL ARTICLE
Zsuzsa Huszenicza, Brian C Gilmour, Lise Koll, Hanna Kjelstrup, Hanna Chan, Vibeke Sundvold, Stine Granum, Anne Spurkland
Adapter proteins are flexible and dynamic modulators of cellular signalling that are important for immune cell function. One of these, the T-cell-specific adapter protein (TSAd), interacts with the non-receptor tyrosine kinases Src and Lck of the Src family kinases (SFKs) and Itk of the Tec family kinases (TFKs). Three tyrosine residues in the TSAd C-terminus are phosphorylated by Lck and serve as docking sites for the Src homology 2 (SH2) domains of Src and Lck. The TSAd proline-rich region (PRR) binds to the Src homology 3 (SH3) domains found in Lck, Src and Itk...
May 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38605529/blood-defense-system-proposal-for-a-new-concept-of-an-immune-system-against-blood-borne-pathogens-comprising-the-liver-spleen-and-bone-marrow
#20
REVIEW
Makoto Kashimura
Blood-borne pathogen (BBP) infections can rapidly progress to life-threatening sepsis and must therefore be promptly eliminated by the host's immune system. Intravascular macrophages of the liver sinusoid, splenic marginal zone and red pulp and perisinusoidal macrophage protrusions in the bone marrow (BM) directly phagocytose BBPs in the blood as an innate immune response. The liver, spleen and BM thereby work together as the blood defence system (BDS) in response to BBPs by exerting their different immunological roles...
May 2024: Scandinavian Journal of Immunology
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