Laura Bergantini, Miriana d'Alessandro, Dalila Cavallaro, Elena Pordon, Lucia Cassai, Sara Gangi, Federica Meloni, Francesca Montagnani, Piero Paladini, Rosa Metella Refini, Luca Luzzi, Antonella Fossi, Elena Bargagli, David Bennett
INTRODUCTION: Lung transplant (LTX) patients are at high risk of cytomegalovirus (CMV) infection, which is often associated with high mortality and morbidity. Reactivation of CMV causes cell injury due to the cytopathic effect of viral replication and triggering of T cell immunity. The aim of this study was to compare expression of Immune checkpoints (ICs) (PD-1, CTLA-4, LAG-3 and TIGIT) in CD4, CD8 and CD56 and activation markers CD137, CD154 and CD69 of end-stage patients awaiting lung transplant...
December 27, 2022: Scandinavian Journal of Immunology