Marcus Buggert, Petter Höglund
No abstract text is available yet for this article.
December 2023: Scandinavian Journal of Immunology
Luana Amorim Hassun, Maria Luiza Ricarte Ruggeri, Stefany Alvino de Souza, Alice Mory Rossato, Gabriela Souza Chmieleski, Larissa Scarpini de Carvalho, Adriana Gut Lopes Riccetto, Giovanna Rosa Degasperi
Adiponectin and leptin are adipokines, secreted by white adipose tissue (WAT), which play an important role in energy homeostasis. Some evidence has shown that adipokine-producing adipose cells present in the bone marrow (BM) appear to exert an influence on hematopoiesis and B cell development. Common variable immunodeficiency (CVID) is one of the most common inborn errors of immunity in humans. In CVID, numerical and/or functional defects of B cells and their precursors result in hypogammaglobulinemia, usually Immunoglobulin (Ig) A and IgG...
September 2023: Scandinavian Journal of Immunology
Lasse Melvaer Giil, Silja Hanseth, Ognjen Bojovic, Jan Erik Nordrehaug, Per Magne Ueland, Klaus Meyer, Grethe S Tell
BACKGROUND: C-reactive protein (CRP) is lower in patients who carry the apolipoprotein E epsilon 4 allele variant (APOEε4) of the APOE gene. This could however be explained by other factors observed in APOEε4 carriers, such as lower body mass index (BMI), possibly less diabetes and more use of statins, all associated with CRP concentrations. OBJECTIVES: To assess the association between CRP and APOEε4 stratified by BMI, statin use and diabetes...
August 23, 2023: Scandinavian Journal of Immunology
Anran Liu, Songcheng Ying
Aicardi-Goutières syndrome (AGS) is a rare monogenic autoimmune disease that primarily affects the brains of children patients. Its main clinical features include encephalatrophy, basal ganglia calcification, leukoencephalopathy, lymphocytosis and increased interferon-α (IFN-α) levels in the patient's cerebrospinal fluid (CSF) and serum. AGS may be caused by mutations in any one of nine genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, IFIH1, LSM11 and RNU7-1) that result in accumulation of self-nucleic acids in the cytoplasm or aberrant sensing of self-nucleic acids...
July 29, 2023: Scandinavian Journal of Immunology
Magne Kristoffer Fagerhol, Nina Haagenrud Schultz, Mohammad Reza Mirlashari, Markus Karl Hermann Wiedmann, Lise Sofie Haug Nissen-Meyer, Arne Vasli Lund Søraas, Geir Hetland
Increased levels of neutrophil extracellular traps (NETs) have been detected in individuals with vaccine complications after the ChAdOx1 nCov vaccine with a correlation between the severity of vaccine side effects and the level of NETosis. DNases may disrupt NETs by degrading their content of DNA, and a balance has been reported between NETs and DNases. Because of this and since the inflammatory marker NETs may be used as a confirmatory test in diagnosing VITT, it is of interest to monitor levels of DNase in patients with increased NETs levels...
July 2023: Scandinavian Journal of Immunology
Radouan Fadi Ameur, Lilya Meriem Berkani, Brahim Belaid, Khadidja Habchi, Messaoud Saidani, Reda Djidjik
The introduction of the Luminex Crossmatch assay (LumXm) which uses Luminex bead technology, consists of extracting the donor's Human Leukocyte Antigen (HLA) molecules from their lymphocytes, and binding them to fluorescent beads that are put in contact with recipient's serum. HLA donor-specific antibodies (DSA) are detected using a fluorescent conjugate. The goal of our study is to determine the benefits of using LumXm in a renal transplantation algorithm. We tested 78 recipients' sera using the LumXm, and the results were compared with the Luminex single antigen bead assay (SAB) for all sera, as well as the Flow Cytometry Crossmatch (FCXM) for 46 sera...
July 2023: Scandinavian Journal of Immunology
Meizhen Xu, Jinfeng Ren, Wenyu Jia, Siyu Wang, Yuting Liu, Xinzhu Chen, Jianhong Shi, Hui Wang
T and B lymphocytes are crucial players in cellular and humoral immune responses. The development, activation and differentiation of T and B lymphocytes are regulated by the best characterized PI3K-PI (3,4,5) P3-AKT phosphoinositide signalling pathway. As a branch of the phosphoinositide signalling pathway, the lipid phosphatase INPP4B inhibits AKT activation through degrading the phosphoinositide signalling messenger PI (3,4) P2. However, the role of Inpp4b in T and B lymphocytes remains elusive. Here, we reported that Inpp4b was highly expressed in human and murine T- and B-1 lymphocytes...
June 30, 2023: Scandinavian Journal of Immunology
Jiajun Wang, Sihong Zhang, Ying Wang, Yanjun Zhu, Xianglai Xu, Jianming Guo
No abstract text is available yet for this article.
June 9, 2023: Scandinavian Journal of Immunology
Lijun Tian, Junxian Xu, Cong Chen, Jinfeng Lin, Linling Ju, Lin Chen, Yufeng Zhang, Xudong Han, Lijun Liu
Mucosal-associated invariant T (MAIT) cells are important in antibacterial immune responses; however, during sepsis, they are few in number and exhibit highly activated phenotypes. The relationship between MAIT cells in peripheral blood and the prognosis of sepsis is not well understood. Thus, this study aimed to examine the levels and phenotypes of MAIT cells in early sepsis, evaluate their clinical relevance, and investigate their association with patient prognosis. This prospective observational study enrolled 72 septic patients defined according to the Sepsis 3...
May 10, 2023: Scandinavian Journal of Immunology
Florian G Scurt, Verena Hirschfeld, Leon Schubert, Peter R Mertens, Christos Chatzikyrkou
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) comprises a group of multisystem disorders with alternating periods of relapse and remission. Beyond that, a smoldering progress during apparently clinically silent phases often develops. AAVs are subgrouped in microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA) and renal limited vasculitis (RLV). ANCA are hallmark of this disease entity, although they are not always present...
May 3, 2023: Scandinavian Journal of Immunology
Mouldy Sioud
Besides being the physical link between DNA and proteins, RNAs play several other key roles, including RNA catalysis and gene regulation. Recent advances in the design of lipid nanoparticles have facilitated the development of RNA-based therapeutics. However, chemically and in vitro transcribed RNAs can activate innate immunity, leading to the production of proinflammatory cytokines and interferons, a response similar to the one induced by viral infections. Since these responses are undesirable for certain therapeutic applications, it is important to develop ways to block the sensing of exogenous RNAs by immune cells, such as monocytes, macrophages and dendritic cells...
May 3, 2023: Scandinavian Journal of Immunology
Joshua M Mutiso, Ciriaka M Gitonga, Michael M Gicheru
No abstract text is available yet for this article.
May 3, 2023: Scandinavian Journal of Immunology
Mingjie Gao, Denglu Zhang, Ruirong Xu
Aplastic anaemia (AA) is an autoimmune disease characterized by haematopoietic failure in the bone marrow. Abnormal activation and hyperfunction of T lymphocytes are believed to cause bone marrow damage, which plays a major role in AA pathogenesis. Dendritic cells (DCs) play a vital role in the immune system by processing antigens for presentation to T cells and regulating their differentiation and function. DC dysfunction may cause abnormal T-cell activation. Recent studies have associated the occurrence and development of AA with DC function...
May 2023: Scandinavian Journal of Immunology
Shaghayegh Tajik, Mohsen Badalzadeh, Massoud Houshmand, Zahra Alizadeh, Leila Moradi, Amir Ali Hamidieh, Alireza Shafiei, Javad Ahmadiani Heris, Seiamak Bahram, Anne Molitor, Raphael Carapito, Mostafa Moin, Mohammad Reza Fazlollahi, Zahra Pourpak
Griscelli syndrome type 2 (GS2) is an autosomal recessive immunodeficiency characterized by hair hypopigmentation, recurrent fever, hepatosplenomegaly and pancytopenia. This study aims to find new genetic changes and clinical features in 18 children with GS2 caused by the RAB27A gene defect. In all, 18 Iranian children with GS2 who presented with silver grey hair and frequent pyogenic infection were included in this study. After recording demographic and clinical data, PCR sequencing of the RAB27A gene was performed for all exons and exon-intron boundaries...
May 2023: Scandinavian Journal of Immunology
Vijaya Gowri, Akshaya Chougule, Maya Gupta, Prasad Taur, Vaishnavi V Iyengar, Meena Sivasankaran, Deenadayalan Munirathnam, Sushma Krishna, Umair A Bargir, Aparna Dalvi, Priyanka Setia, Neha Jodhawat, Shweta Shinde, Shakuntala S Prabhu, Minnie Bodhanwala, Manisha R Madkaikar, Mukesh M Desai
DOCK8 deficiency affects various cell subsets belonging to both innate and adaptive immune systems. Clinical diagnosis is challenging as many cases present with severe atopic dermatitis as the only initial manifestation. Though flow cytometry helps in presumptive diagnosis of DOCK8 deficient patients by evaluating their DOCK8 protein expression, it requires subsequent confirmation by molecular genetic analysis. Currently, hematopoietic stem cell transplantation (HSCT) is the only curative treatment option available for these patients...
April 28, 2023: Scandinavian Journal of Immunology
Haijuan Xiao, Wenjun Mou, Rui Zhang, Xin Guo, Heying Chen, Liqiang Zhang, Gang Liu, Jingang Gui
B cell expansion with NF-κB and T cell anergy (BENTA) is a disease genetically linked with heterozygous gain-of-function (GOF) mutations in the CARD11 gene with an autosomal dominant expression. Hemophagocytic lymphohistiocytosis (HLH) is a heterogeneous group of disorders characterized by systemic inflammation and hypercytokinaemia. Some BENTA patients share similar clinical manifestations as HLH in various aspects, including fever and splenomegaly. In this study, we reported a 15-month-old boy diagnosed as BENTA meeting with diagnostic criteria of HLH...
April 2023: Scandinavian Journal of Immunology
Charles W Armitage, Alison J Carey, Emily R Bryan, Avinash Kollipara, Logan K Trim, Kenneth W Beagley
Urogenital chlamydial infections continue to increase with over 127 million people affected annually, causing significant economic and public health pressures. Whilst the role of traditional MHCI and II peptide presentation is well defined in chlamydial infections, the role of lipid antigens in immunity remains unclear. Natural killer (NK) T cells are important effector cells that recognise and respond to lipid antigens during infections. Chlamydial infection of antigen-presenting cells facilitates presentation of lipid on the MHCI-like protein, CD1d, which stimulates NKT cells to respond...
March 5, 2023: Scandinavian Journal of Immunology
Meenakshi Sachdeva, Aman Sharma, Sunil K Arora
Reservoirs of HIV remain a major obstacle to the complete eradication of virus despite regular anti-retroviral therapy (ART). Memory stem cells (Tscm), one of the major reservoirs are relatively less studied owing to their presence in lower numbers and inaccessible anatomical locations. We have evaluated the molecular characteristics of Tscms in patients with ART interruption (n=15) versus patients on uninterrupted ART (n=12) using flowcytometry. RNA sequencing was done in the sorted Tscms to study the differential gene expression...
February 28, 2023: Scandinavian Journal of Immunology
Masoud H Manjili
Current research and drug development for multiple sclerosis (MS) is fully influenced by the self-nonself (SNS) model of immunity, suggesting that breakage of immunological tolerance towards self-antigens expressed in the central nervous system (CNS) is responsible for pathogenesis of MS; thus, immune suppressive drugs are recommended for the management of the disease. However, this model provides incomplete understanding of the causes and pathways involved in the onset and progression of MS and limits our ability to effectively treat this neurological disease...
January 20, 2023: Scandinavian Journal of Immunology
Yanan Gu, Si Li, Zhen Wang, Dong Yang
The study aimed to investigate the clinical significance of anti-rods and rings (anti-RR) antibodies in antinuclear antibodies (ANAs) test samples retrospectively. The laboratory data and clinical details of patients with positive anti-RR antibodies were collected and analysed between December 2017 and May 2022 in the First Affiliated Hospital of Dalian Medical University. A total of 72 665 patients were tested for ANAs. There were 45 632 patients discovered with positive ANAs (62.80%), only 131 patients presented with anti-RR antibodies (0...
January 10, 2023: Scandinavian Journal of Immunology
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