Yaofeng Fang, Shengchen Lv, Shouchun Xiao, Haonan Hou, Jianing Yao, Yue Cao, Bingying He, Xueke Liu, Peng Wang, Donghui Liu, Zhiqiang Zhou
Sulfoxaflor is a widely used fourth-generation neonicotinoid pesticide, which has been detected in biological and environmental samples. Sulfoxaflor can potentially be exposed to humans via the food chain, thus understanding its toxic effects and enantioselective bioaccumulation is crucial. In this study, toxicokinetics, bioaccumulation, tissue distribution and enantiomeric profiles of sulfoxaflor in rats were investigated through single oral exposure and 28-days continuous exposure experiment. Sulfoxaflor mainly accumulated in liver and kidney, and the (-)-2R,3R-sufloxaflor and (-)-2S,3R-sufloxaflor had higher enrichment than their enantiomers in rats...
April 16, 2024: Chemosphere