Alex Junior Souza de Souza, Victor Lopes da Silva, Lilian Rose Marques de Sá
A free-ranging brown howler monkey (Atelidae: Alouatta guariba clamitans) was necropsied and a mediastinal T-cell lymphoma and esophageal dilation were diagnosed. The case report may contribute to the differential diagnosis of neoplastic and esophageal lesions in non-human primates and highlighted the importance of surveillance of cancer in wildlife.
July 26, 2023: Journal of Medical Primatology
Diego Celdran-Bonafonte, Kathryn A O'Connell, Katalin M Gothard, Iman Ghaderi, David Besselsen, Cynthia J Doane
Dolichocolon (redundant colon) is an underdiagnosed cause of severe constipation in humans. The clinical presentation reported here in a rhesus macaque closely resembles that of intestinal adenocarcinoma, the most common neoplasia in macaques. Dolichocolon should be considered in differential diagnosis of macaques with anorexia, weight loss, and constipation.
July 21, 2023: Journal of Medical Primatology
Victor N Rivas, Yu Ueda, Joshua A Stern
BACKGROUND: Diastolic dysfunction in humans is an age-related process with an overrepresentation in women. In rhesus macaques (Macaca mulatta), the incidence and predictors of diastolic dysfunction have yet to be reported. METHODS: Data from routine echocardiographic evaluations on clinically healthy rhesus macaques was obtained and used for univariate, bivariate, hypothesis testing, and linear regression statistical analyses interrogating differences and predictors of diastolic function...
July 17, 2023: Journal of Medical Primatology
Hilton Klein, Barry L Levinson, Steven L Leary, Glenn Dobson
BACKGROUND: A novel buprenorphine (BUP) extended-release formulation (BUP-XR) produced as a lipid-encapsulated, low viscosity BUP suspension for subcutaneous (SC) injection to control pain was evaluated for pharmacokinetics and safety in four adult male cynomolgus monkeys. METHODS: Each animal was given 0.2 mg/kg reformulated BUP-XR SC. Clinical observations were made during the course of the study. Blood samples were obtained from each animal before BUP-XR administration, 6, 24, 48, 72, and 96 h post-BUP-XR injection...
July 11, 2023: Journal of Medical Primatology
Rafaela Magalhães Barros, Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Líria Queiroz Luz Hirano, Giane Regina Paludo, Márcio Botelho de Castro
After fatal traumatic injuries, three urbanized free-ranging marmosets developed a milky white or pink-white thoracic alkaline effusion with high specific gravity, triglyceride levels, and predominance of small lymphocytes. Chylothorax is an uncommon thoracic fluid accumulation in animals and humans and has not been reported in free-ranging non-human primates.
July 2, 2023: Journal of Medical Primatology
Sarah Kezar, Natalie W Fowlkes, Martha E Hensel
Tumors of the skin and subcutaneous tissues are uncommon in marmosets. In this report, we describe the gross, histopathology, and immunohistochemical findings of a nerve sheath tumor that arose in the left forearm of an adult female marmoset (Callthrix jacchus).
June 20, 2023: Journal of Medical Primatology
Chelsea E Anderson, Jonathan H Tzu, Elizabeth E Hammond
A 41-year-old male vasectomized, zoo-housed chimpanzee (Pan troglodytes) presented with progressive visual deficits due to bilateral cataract formation. Phacoemulsification and lenticular implant were performed by a veterinary and human board-certified ophthalmologist team in a field setting. Post-operative healing occurred without complication, and the patient returned to the troop with improved vision.
June 19, 2023: Journal of Medical Primatology
David F Conga, Amanda A Figueiredo, Ana Sílvia S Ribeiro, Andrea M Bezerra, Washington L A Pereira
We report two cases of disseminated hyperinfection by filariae in free-living primates Saimiri sciureus and Saguinus niger from eastern Amazon. Histopathological examination showed the presence of Dipetalonema gracile microfilariae in blood, liver, lungs, spleen, small intestine, kidney, brain, liver, and adults in peritoneal thoracic cavity.
June 17, 2023: Journal of Medical Primatology
Rahmat Yusni, Silmi Mariya, Uus Saepuloh, Sela S Mariya, Huda S Darusman
BACKGROUND: Cell culture is the proliferation of a cell population in vitro by isolating from the original tissue or growing from existing ones. One essential source is the monkey kidney cell cultures which have an essential role in biomedical study. This is due to the significant homology between the human and macaque genomes making these useful for cultivating human viruses, especially enteroviruses, and growing vaccines. METHODS: This study developed cell cultures derived from the kidney of Macaca fascicularis (Mf) and validated its gene expression...
June 9, 2023: Journal of Medical Primatology
Taeho Kwon, Hong-Yi Xiang, Xiao-Ya Xing, Peng Jiang, Shuai-Yang Sun, Hu-Nan Sun, Ying-Hao Han
BACKGROUND: Simian immunodeficiency virus (SIV) infection in rhesus macaques (Macaca mulatta) can lead to the development of SIV encephalitis (SIVE), which is closely related to human immunodeficiency virus (HIV)-induced dementia. METHODS: This was done by analyzing SIV and SIVE encephalitis in infected M. mulatta hippocampus samples from two microarray data sets, identifying two groups of common differentially expressed genes and predicting associated protein interactions...
June 5, 2023: Journal of Medical Primatology
Rafael H de Souza Siragusi, Sheila C Rahal, Anneke Moresco, Jeana P da Silva, Maria J Mamprim, Eduardo B Mayrink Cardoso
BACKGROUND: Radiographic measurements are a useful tool to assess skeletal health and development in primates. This study aimed to perform radiographic measurements of hind limbs in capuchin monkeys. METHODS: Twelve Sapajus spp. were used; ten adults and two sub-adults, nine females and three males. RESULTS AND CONCLUSIONS: The pelvimetry showed that the pelvic inlet area presented mean values of 7.63, 10.23, and 5.43 cm2 for adult males, adult females, and sub-adult females, respectively...
June 5, 2023: Journal of Medical Primatology
Jeffrey S Frankel, Kristin L Gardiner, Angela K Brice, Lisa Hagan, Timothy J Manzi, Leah Makaron
A cynomolgus macaque presented with right hindlimb lameness as well as crepitus and decreased passive range of motion of the right coxal joint. Radiography and histopathology were consistent with avascular necrosis of the femoral head. This case is the first published report of this condition in a cynomolgus macaque.
May 29, 2023: Journal of Medical Primatology
Ana Petak, Jadranko Boras, Ingeborg Bata, Ivana Ilić, Marko Hohšteter, Ivan-Conrado Šoštarić-Zuckermann
BACKGROUND: Symmetrical alopecia is a common symptom of endocrine and autoimmune diseases, which are rarely manifested with pruritus. Increased levels of stress in primates have been presented with increased levels of pruritus and alopecia appearance. METHODS: A pruritic and alopecic disease was investigated in a group of tufted capuchin monkeys (N = 12), but due to ethical reasons, four random animals were further investigated by numerous diagnostic methods...
April 28, 2023: Journal of Medical Primatology
Clarissa Helena Santana, Laice Alves da Silva, Nayara Ferreira de Paula, Lucas Dos Reis de Souza, Ayisa Rodrigues Oliveira, Daniel Oliveira Dos Santos, Herlandes Penha Tinoco, Carlyle Mendes Coelho, Ângela Tinoco Pessanha Ribeiro Gonçalves, Rodrigo Otávio Silveira Silva, Tatiane Alves da Paixão, Renato Lima Santos
Chylothorax is the accumulation of lymph in the thoracic cavity, and it has never been reported in neotropical primates. An emperor tamarin died and at necropsy chylothorax associated with pulmonary compressive atelectasis was diagnosed. Idiopathic chylothorax can be a cause of respiratory insufficiency and death in tamarins.
April 28, 2023: Journal of Medical Primatology
Akiko Takenaka, Juri Suzuki, Hiroyuki Tanaka, Kumiko Hibino, Yoshiro Kamanaka, Shin Nakamura, Fusako Mitsunaga, Yoshi Kawamoto, Mayumi Morimoto, Seitaro Aisu, Takayoshi Natsume
BACKGROUND: A rhesus macaque with the fourth highest plasma cholesterol (CH) levels of 501 breeding macaques was identified 22 years ago. Seven offspring with gene mutations causing hypercholesterolemia were obtained. METHODS: Activity of low-density lipoprotein receptor (LDLR), plasma CH levels and mRNA expression levels of LDLR were measured after administration of 0.1% (0.27 mg/kcal) or 0.3% CH. RESULTS: Activity of p. (Cys82Tyr) of LDLR was 71% and 42% in the heterozygotes and a homozygote, respectively...
April 26, 2023: Journal of Medical Primatology
Gessiane Pereira da Silva, Thyago Habner de Souza Pereira, Josi Teixeira de Melo, Aline Amaral Imbeloni, Rafael do Santos de Andrade, Maria Vivina Barros Monteiro, Frederico Ozanan Barros Monteiro, Rafaela S C Takeshita
BACKGROUND: Evaluation of blood parameters in captive non-human primates (NHPs) is crucial for monitoring their health and ensuring that their environment meets their physiological requirements. METHODS: We performed hemogram, serum biochemistry, and parasitological exams in 20 howler monkeys and 21 capuchin monkeys. RESULTS: In both species, over 50% of the individuals presented at least one parasite. There was a negative effect of age on red blood cell (RBC), white blood cell, platelets, total protein, globulin, and alkaline phosphatase, and a positive effect on the A:G ratio, gamma-glutamyl transferase, and mean platelet volume (MPV)...
April 20, 2023: Journal of Medical Primatology
Bárbara C S Meireles, Beatriz Goldschmidt, Gabriel M Leal, Fabiano Dias, Natalia F Cordeiro, Paulo R F Filho, Marllus L Barros
Congenital digital defects, particularly adactyly and oligodactyly, have been reported frequently in humans, however, their occurrence in rhesus monkeys is rare, mainly in the hind limbs. We present here for the first time, two female rhesus monkeys with unilateral congenital toe defects with metatarsal involvement. One showing adactyly and the other oligodactyly. In this report, we present the clinical/radiological details of these cases as well as discuss the risk factors possibly involved, such as contact with pesticides and genetic factors...
April 16, 2023: Journal of Medical Primatology
Seraina Luzia Meister, Taina Susanna Kaiponen, Fabia Wyss, Christian Wenker, Nicola Balmelli, Llorenç Grau Roma
Univentricular heart malformations are rarely described in the veterinary literature. This case report describes a single-inlet univentricular heart with persistent truncus arteriosus as a cause of death of a captive-bred, 2-day-old, female Sumatran orangutan (Pongo abelii), a critically endangered species.
April 2023: Journal of Medical Primatology
Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Bong-Seok Song, Won Seok Choi, Yeung Bae Jin, Jae-Won Huh, Sun-Uk Kim, Bo-Woong Sim
BACKGROUND: Melatonin is a multifunctional hormone synthesized in the pineal gland and peripheral reproductive tissues that regulates many biological processes. There is increasing evidence for a role of melatonin in oocyte maturation and embryonic development in various mammals. However, no study has reported evidence for the existence of melatonergic system, such as melatonin synthesis enzymes, melatonin membrane receptors, or melatonin binding sites in non-human primate cumulus-oocyte complexes (COCs)...
March 27, 2023: Journal of Medical Primatology
André Luis de Souza Teixeira, Welington Bandeira da Silva, Liana Villela de Gouvêa, Guilherme Nunes de Souza, Nádia Regina Pereira Almosny, Nayro Xavier de Alencar
The mean serum value of adiponectin in captive Aotus sp. is 541.99 ng/mL ± 73.05. There is no influence of sex or age, but there is a moderate positive correlation between body weight and adiponectin levels in males.
March 21, 2023: Journal of Medical Primatology
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