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October 2023: Journal of Medical Primatology
Melina Castilho de Souza Balbueno, Jéssica Amâncio Martins, Soraya Kezam Malaga, Juliana Forato, Cidéli de Paula Coelho
Dilated cardiomyopathy (DCM) is a disease of the heart muscle diagnosed by alterations resulting from ventricular systolic dysfunction with enlargement of the heart chambers, which is still underdiagnosed in non-human primates. This report is the first case of the DCM phenotype diagnosed by echocardiography and confirmed by necropsy in Callithrix penicillata.
September 25, 2023: Journal of Medical Primatology
Jason P Dufour, Carolina Allers, Faith Schiro, Kathrine P Falkenstein, Kayleigh K Gregoire, Colin D Glover, Alayna N Chamel, Adrienne Woods, Jonah P Phillippi, Taylor M Gideon, Amitinder Kaur
BACKGROUND: Fine-needle aspiration (FNA) has been reported since 1912 beginning with the use of trocars and other specialized instruments that were impractical. Since then, FNA has proven to be a successful alternative technique to excisional biopsy for some assays despite a few limitations. METHODS: In this study, we compared four different techniques for FNA in rhesus macaques by evaluating total live cells recovered and cell viability using a standard 6 mL syringe and 1...
September 15, 2023: Journal of Medical Primatology
Jennifer A Manuzak, Ronald S Veazey
No abstract text is available yet for this article.
September 6, 2023: Journal of Medical Primatology
James Z Curlin, Kimberly Schmitt, Leila Remling-Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina
HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.
September 1, 2023: Journal of Medical Primatology
James Z Curlin, Kimberly Schmitt, Leila Remling-Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina
HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4+ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.
September 1, 2023: Journal of Medical Primatology
Lisa C Corewyn, Mary A Kelaita, Jenny Nollman, Isabel Hagnauer, Kinndle Blanco-Peña, Robert G Lessnau, Jonathan B Clayton, Robin Shields-Cutler, Kari Brossard Stoos
BACKGROUND: Alouatta palliata palliata are an ecologically flexible howler monkey subspecies that has recently been relisted as Endangered. Populations are declining through much of the subspecies' range, including at our study site at La Pacifica, Costa Rica. Our objectives were to screen blood hematology and biochemistry samples collected from this wild population to elucidate their baseline health. METHODS: We collected blood samples from 38 adult individuals from across the study site and analyzed 13 hematology and 14 biochemistry parameters...
September 1, 2023: Journal of Medical Primatology
Soraya Kezam Malaga, Melina Castilho de Souza Balbueno, Jéssica Amâncio Martins, Leonardo Dourado da Costa, Maria Luiza de Sousa Barbosa, Cidéli de Paula Coelho
Reports of sarcomas in nonhuman primates are scarce and, specifically, primary hepatic sarcomas are rare, as in humans. This is the first report of an aggressive hepatic fibrosarcoma in a young adult Callithrix jacchus. The final postmortem diagnosis was obtained by means of immunohistochemical analysis, which confirmed the tumor histogenesis.
August 29, 2023: Journal of Medical Primatology
Fanny A Granat, Catherine Trumel, Jean-Pierre D Braun, Nathalie H Bourgès-Abella
Most errors in clinical pathology originate in the preanalytical phase, which includes all steps from the preparation of animals and equipment to the collection of the specimen and its management until analyzed. Blood is the most common specimen collected in nonhuman primates. Other specimens collected include urine, saliva, feces, and hair. The primary concern is the variability of blood hematology and biochemistry results due to sampling conditions with the effects of capture, restraint, and/or anesthesia...
August 23, 2023: Journal of Medical Primatology
Joanna V Z Echenique, Anderson H Gris, Laura J Camargo, Cíntia De Lorenzo, Marianna Bertolini, Franscisca M S Barbosa, Moira Ansolch, Cláudio W Canal, Welden Panziera, Saulo P Pavarini, Luciana Sonne
BACKGROUND: Simplexvirus humanalpha1 (HuAHV-1) are common anthropozoonosis reported in marmosets but rare in howler monkeys (Alouatta sp.). METHODS: Necropsy of two brown-howler monkeys (A. caraya) and one red-howler monkey (A. guariba clamitans) from different zoo collections were performed. Fragments of all organs were examined through microscopy. Samples were submitted to IHC for Simplexvirus humanalpha 2 (HuAHV-2) [sin. Herpesvirus simplex type 2] and PCR...
August 21, 2023: Journal of Medical Primatology
Gyu-Seo Bae, Eun-Su Jeon, Hee Chang Son, Philyong Kang, Kyung Seob Lim, Eun-Ha Hwang, Green Kim, Seung Ho Baek, You Jung An, Gyu Young Shim, Young Min Woo, YuJin Kim, Taehwan Oh, Seok-Hwan Kim, JungJoo Hong, Bon-Sang Koo
Acute gastric dilatation (AGD) is one of the most prevalent and life-threatening diseases in nonhuman primates worldwide. However, the etiology of this syndrome has not been determined. Recently, sudden death occurred in a 7-year-old female cynomolgus monkey with a history of fecal microbiota transplantation using diarrheic stools. The monkey had undergone surgery previously. On necropsy, gastric dilatation and rupture demonstrated a tetrad arrangement on histopathologic examination. On 16S rRNA sequencing, a high population of Clostridium ventriculi was identified in the duodenum adjacent to stomach but not in the colon...
August 15, 2023: Journal of Medical Primatology
Nelson Broche, Vanessa Gris, Naoko Suda-Hashimoto, Keiko Mouri, Takako Miyabe-Nishiwaki, Juri Suzuki, Michael A Huffman
BACKGROUND: Previous studies suggest that housing relocation may be stressful for captive non-human primates. Our study investigated the stress levels of Japanese macaques during a housing relocation by measuring their daily fecal cortisol metabolites, which are often used as an indicator of stress. METHODS: Ten adult Japanese macaques, single-housed for research purposes, were relocated to a new facility. Fecal samples were collected daily for 7 days. Cortisol metabolite concentrations were determined via enzyme immunoassay...
July 31, 2023: Journal of Medical Primatology
Suryo Saputro, Uus Saepuloh, Huda Shalahudin Darusman, Wahyu Putriyani, Permanawati, Ellis Dwi Ayuningsih, Silvia Arin Prabandari, Dyah Setyawati, Joko Pamungkas
BACKGROUND: Klebsiella pneumoniae infection in nonhuman primates has been widely reported and causes significant morbidity and mortality. Animal deaths occur routinely at the Primate Research Center of IPB University. The results of necropsy and culture suggested a K. pneumoniae infection. METHODS: A mass health assessment of Cynomolgus monkeys (n = 429) was carried out by physical examination and molecular targeting K. pneumoniae (n = 96), family of Coronaviridae (n = 148) and Paramyxoviridae (n = 148)...
July 31, 2023: Journal of Medical Primatology
Alex Junior Souza de Souza, Victor Lopes da Silva, Lilian Rose Marques de Sá
A free-ranging brown howler monkey (Atelidae: Alouatta guariba clamitans) was necropsied and a mediastinal T-cell lymphoma and esophageal dilation were diagnosed. The case report may contribute to the differential diagnosis of neoplastic and esophageal lesions in non-human primates and highlighted the importance of surveillance of cancer in wildlife.
July 26, 2023: Journal of Medical Primatology
Diego Celdran-Bonafonte, Kathryn A O'Connell, Katalin M Gothard, Iman Ghaderi, David Besselsen, Cynthia J Doane
Dolichocolon (redundant colon) is an underdiagnosed cause of severe constipation in humans. The clinical presentation reported here in a rhesus macaque closely resembles that of intestinal adenocarcinoma, the most common neoplasia in macaques. Dolichocolon should be considered in differential diagnosis of macaques with anorexia, weight loss, and constipation.
July 21, 2023: Journal of Medical Primatology
Victor N Rivas, Yu Ueda, Joshua A Stern
BACKGROUND: Diastolic dysfunction in humans is an age-related process with an overrepresentation in women. In rhesus macaques (Macaca mulatta), the incidence and predictors of diastolic dysfunction have yet to be reported. METHODS: Data from routine echocardiographic evaluations on clinically healthy rhesus macaques was obtained and used for univariate, bivariate, hypothesis testing, and linear regression statistical analyses interrogating differences and predictors of diastolic function...
July 17, 2023: Journal of Medical Primatology
Hilton Klein, Barry L Levinson, Steven L Leary, Glenn Dobson
BACKGROUND: A novel buprenorphine (BUP) extended-release formulation (BUP-XR) produced as a lipid-encapsulated, low viscosity BUP suspension for subcutaneous (SC) injection to control pain was evaluated for pharmacokinetics and safety in four adult male cynomolgus monkeys. METHODS: Each animal was given 0.2 mg/kg reformulated BUP-XR SC. Clinical observations were made during the course of the study. Blood samples were obtained from each animal before BUP-XR administration, 6, 24, 48, 72, and 96 h post-BUP-XR injection...
July 11, 2023: Journal of Medical Primatology
Rafaela Magalhães Barros, Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Líria Queiroz Luz Hirano, Giane Regina Paludo, Márcio Botelho de Castro
After fatal traumatic injuries, three urbanized free-ranging marmosets developed a milky white or pink-white thoracic alkaline effusion with high specific gravity, triglyceride levels, and predominance of small lymphocytes. Chylothorax is an uncommon thoracic fluid accumulation in animals and humans and has not been reported in free-ranging non-human primates.
July 2, 2023: Journal of Medical Primatology
Sarah Kezar, Natalie W Fowlkes, Martha E Hensel
Tumors of the skin and subcutaneous tissues are uncommon in marmosets. In this report, we describe the gross, histopathology, and immunohistochemical findings of a nerve sheath tumor that arose in the left forearm of an adult female marmoset (Callthrix jacchus).
June 20, 2023: Journal of Medical Primatology
Chelsea E Anderson, Jonathan H Tzu, Elizabeth E Hammond
A 41-year-old male vasectomized, zoo-housed chimpanzee (Pan troglodytes) presented with progressive visual deficits due to bilateral cataract formation. Phacoemulsification and lenticular implant were performed by a veterinary and human board-certified ophthalmologist team in a field setting. Post-operative healing occurred without complication, and the patient returned to the troop with improved vision.
June 19, 2023: Journal of Medical Primatology
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