journal
https://read.qxmd.com/read/38084001/utilizing-non-human-primate-models-to-combat-recent-covid-19-sars-cov-2-and-viral-infectious-disease-outbreaks
#1
REVIEW
Taeho Kwon
In recent times, global viral outbreaks and diseases, such as COVID-19 (SARS-CoV-2), Zika (ZIKV), monkeypox (MPOX), Ebola (EBOV), and Marburg (MARV), have been extensively documented. Swiftly deciphering the mechanisms underlying disease pathogenesis and devising vaccines or therapeutic interventions to curtail these outbreaks stand as paramount imperatives. Amidst these endeavors, animal models emerge as pivotal tools. Among these models, non-human primates (NHPs) hold a position of particular importance. Their proximity in evolutionary lineage and physiological resemblances to humans render them a primary model for comprehending human viral infections...
December 11, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/38083993/first-detection-of-rift-valley-fever-virus-antibodies-in-non-human-primates-in-cameroon
#2
JOURNAL ARTICLE
Jean Thierry Ebogo-Belobo, Serge Alain Sadeuh-Mba, Gwladys Monamele Chavely, Martin H Groschup, Wilfred Fon Mbacham, Richard Njouom
We tested for Rift Valley fever virus (RVFV) from at least 15 species of non-human primates. RVFV IgG/IgM antibodies were detected in 3.7% (2 out of 53) of chimpanzees (Pan troglodytes) and in 1.4% (1 out of 72) of unidentified non-human primate species. This study was the first investigation of RVFV in monkeys in Cameroon.
December 11, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/38083989/combined-untargeted-and-targeted-lipidomics-approaches-reveal-potential-biomarkers-in-type-2-diabetes-mellitus-cynomolgus-monkeys
#3
JOURNAL ARTICLE
Chao-Yang Tian, Qun-Hui Yang, Hai-Zhou Lv, Feng Yue, Fei-Fan Zhou
BACKGROUND: The significantly increasing incidence of type 2 diabetes mellitus (T2DM) over the last few decades triggers the demands of T2DM animal models to explore the pathogenesis, prevention, and therapy of the disease. The altered lipid metabolism may play an important role in the pathogenesis and progression of T2DM. However, the characterization of molecular lipid species in fasting serum related to T2DM cynomolgus monkeys is still underrecognized. METHODS: Untargeted and targeted LC-mass spectrometry (MS)/MS-based lipidomics approaches were applied to characterize and compare the fasting serum lipidomic profiles of T2DM cynomolgus monkeys and the healthy controls...
December 11, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/38009978/retrospective-study-of-the-mortality-of-the-vieira-s-titi-monkey-plecturocebus-vieirai-at-the-sorocaba-zoo-brazil
#4
JOURNAL ARTICLE
Maraya Lincoln Silva, Mayara Grego Caiaffa, André Luiz Mota da Costa, Eduardo Ferreira-Machado, Ticiana Brasil Ervedosa, Pedro Enrique Navas-Suárez, Juliana Mariotti Guerra, Flora Nogueira Matos, Cássia Regina Ramos Gonzaga, Natália Coelho Couto de Azevedo Fernandes, Rodrigo Hidalgo Friciello Teixeira
BACKGROUND: The Vieira's titi monkey (Plecturocebus vieirai) was recently described and characterized as endemic to Brazil. According to the IUCN red list, this species is classified as critically endangered (CR). At the date of the publication of this manuscript, there are no published data on the health aspects of this species. METHODS: For this study, the necropsy, and histopathological data of the mortality of P. vieirai at Sorocaba Zoo (São Paulo, Brazil) were collected and analyzed...
November 27, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/38374540/role-and-ethics-of-cynomolgus-monkey-macaca-fascicularis-blastoids-in-primate-developmental-biology-research
#5
REVIEW
Taeho Kwon
This review on cynomolgus monkey (Macaca fascicularis) blastoids discusses a breakthrough in modeling early non-human primate embryogenesis, offering insights into embryonic development and implantation processes. It acknowledges ethical challenges and animal welfare considerations in developmental biology, suggests potential applications in human reproductive medicine, and highlights the need for ongoing ethical and technical refinement.
April 2024: Journal of Medical Primatology
https://read.qxmd.com/read/38353252/radiographically-guided-femoral-neck-osteosynthesis-with-cannulated-compressive-titanium-screw-and-anti-rotational-component-in-a-brown-howler-monkey-alouatta-guariba-clamitans
#6
Inácio Bernhardt Rovaris, Jacqueline Meyer, Paola Antunes Rodrigues, Lívia Eichenberg Surita, Roberta Picoli, Fábio Trindade Dutra de Almeida Filho, Eduardo Raposo Monteiro, Marcelo Meller Alievi
A Brown Howler Monkey presented with a femoral neck fracture was successfully treated with a cannulated compressive screw and an anti-rotational component inserted with radiographically guided technique. Complete bone consolidation and functional recovery were observed 9 weeks after the surgery, and the monkey was released to his place of origin.
April 2024: Journal of Medical Primatology
https://read.qxmd.com/read/38345331/immunohistochemical-characterization-of-integrin-alfa-6-in-uterus-and-cervix-of-the-cynomolgus-monkeys-macaca-fascicularis-with-mfpv3-infection
#7
JOURNAL ARTICLE
Dyah Setyawaty, Silmi Mariya, Silvia A Prabandari, Ditte Rahbaek Boilessen, Peter Johannes Holst, Huda Shalahudin Darusman
BACKGROUND: Cervical cancer is an abnormal growth of cervical tissue epithelial cells due to persistent human papilloma virus (HPV) infection. Cynomolgus monkeys (Macaca fascicularis) can be naturally and spontaneously infected with M. fascicularis Papillomavirus Type 3 (MfPV3), a virus that is phylogenetically closely related to human oncogenic HPV (HPV-16 and HPV-34), and therefore a potentially beneficial for modeling HPV disease. This study aims to evaluate the expression of the integrin alpha 6 (ITGα6) receptor in cynomolgus monkeys spontaneously infected with MfPV3, which this receptor also found in human infected with HPV...
February 2024: Journal of Medical Primatology
https://read.qxmd.com/read/38345330/a-reliable-and-cost-effective-protocol-for-creating-bilirubin-cerebral-palsy-model-in-rhesus-macaque
#8
JOURNAL ARTICLE
Yong Zhu, Yanan Xiong, Xiaoyan Xu, Jin Zhang, Haiyang Tong, Hongyi Yang, Xia Niu, Xiaming Shi, Jiulai Tang, Jinhua Li
BACKGROUND: Cerebral palsy is a severe motor disability in childhood that poses challenges for children, families, and society. Rhesus macaques are the preferred animals for cerebral palsy model, but surgical excision of motor cortex has low success rate and high cost. In this work, we created cerebral palsy rhesus macaque models by intrathecal injection of bilirubin. METHODS: The puncture point for injection was identified as the intervertebral disc space two, located below the intersection of the iliac crest line and the posterior median line...
February 2024: Journal of Medical Primatology
https://read.qxmd.com/read/37990472/whole-exome-sequencing-analysis-of-patent-ductus-arteriosus-in-a-japanese-macaque-macaca-fuscata
#9
Young-Jin Jang, Byung-Yong Park, Hyun-Jin Tae, Jeoungha Sim, Dongchoon Ahn
We performed whole-exome sequencing using a human exome capture kit to analyze the potential genetic factors related to patent ductus arteriosus in Japanese macaques. Compared with the reference sequences of other primates, we identified potential missense variants in five genes: ADAM15, AZGP1, CSPG4, TNFRSF13B, and EPOR.
November 21, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37985948/vulvar-squamous-cell-carcinoma-in-a-captive-female-chimpanzee-a-case-report
#10
JOURNAL ARTICLE
Aide Alpízar, Raul Fajardo, José Simón Martínez, Cesar Ortega
A necropsy was performed on a 43-year-old female zoo chimpanzee, with cancer in the vulvar and perivulvar region. She was diagnosed with squamous cell carcinoma, the presence of this tumor in domestic animals and non-human primates is very rare in the vulvar region and there were no previous reports found on it in chimpanzee, due to which this report contributes to the knowledge on chimpanzee pathologies.
November 20, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37946549/comparing-different-strategies-to-reduce-hepatocellular-damage-in-obese-common-marmosets-callithrix-jacchus
#11
JOURNAL ARTICLE
Mallory Gwendolyn Brown, Laine Elizabeth Feller, John Gregory Trupkiewicz, Eric Kenneth Hutchinson, Jessica Marie Izzi
BACKGROUND: Obesity in common marmosets (Callithrix jacchus) can lead to various liver pathologies. In other species, reduced caloric intake and weight loss improve prognosis, and, often, hepatoprotectants are used to halt or reverse hepatocellular damage from fat deposition in the liver. There are no published therapies for reducing hepatocellular damage in obese marmosets. METHODS: Fifteen obese marmosets were used to evaluate the ability of caloric restriction and pharmacologic therapy (S-adenosylmethionine + milk thistle extract, or SMT), alone and combined, to reduce elevated liver enzymes...
November 9, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37908039/effects-of-atipamezole-on-selected-physiologic-parameters-in-cynomolgus-macaques-macaca-fascicularis
#12
JOURNAL ARTICLE
K Schwartz, M Zhang, B Franco, K Jampachaisri, R M Cotton, M K Huss, K M Fisher, C Darian-Smith, P Sharp, L Pablo, C Pacharinsak
BACKGROUND: Atipamezole, an α-2 adrenergic receptor antagonist, reverses the α-2 agonist anesthetic effects. There is a dearth of information on the physiological effects of these drugs in cynomolgus macaques (Macaca fascicularis). We assessed atipamezole's physiologic effects. We hypothesized atipamezole administration would alter anesthetic parameters. METHODS: Five cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0...
October 31, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37849073/a-protocol-for-creating-endometriosis-in-rhesus-macaques-macaca-mulatta
#13
JOURNAL ARTICLE
Ov D Slayden, Fangzhou Luo, Lauren D Martin D V M
BACKGROUND: Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual endometrium. Macaques are the preferred model for pharmaceutical development, but the complex anatomy of the macaque cervix makes the baboon method impractical. In this work, we sought to validate a surgical approach for creating endometriosis in macaques...
October 17, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37849072/cytokine-storm-syndrome-after-anti-thymoglobulin-infusion-in-a-cynomolgus-monkey-with-systemic-lymphadenopathy-caused-by-follicular-hyperplasia-a-case-report
#14
Chang Gok Woo, Jong-Min Kim
Nonhuman primates are widely used in transplantation research as preclinical xeno- or allo-transplantation models. Rabbit anti-thymoglobulin (ATG) is often used for T-cell depletion as an immunosuppressant. T-cell depletion can cause a secondary cytokine storm syndrome that can be minimized/prevented by a prophylactic administration of systemic corticosteroids and antihistamines. We report a case of death due to CSS in a cynomolgus monkey with follicular hyperplasia-induced systemic lymphadenopathy after ATG administration...
October 17, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37807223/effect-of-age-and-sex-on-hematological-and-biochemical-parameters-in-chinese-rhesus-monkeys-macaca-mulatta-anesthetized-with-ketamine
#15
JOURNAL ARTICLE
Gaohong Zhu, Xuedan Liu, Jiaojiao Feng, Yun Deng, Yijiang Li, Qionglin Ma, Lilin Chen, Yulin Su, An Ping, Fei Xie, Tinghua Wang, Longbao Lv
OBJECTIVE: Rhesus monkeys are increasingly used in biomedical research, which makes their hematological and biochemical parameters increasingly important in preclinical research. Since age and sex can influence blood parameters, establishing reference intervals for such parameters based on age and sex becomes along with identifying the effect of age and sex on those parameters. METHODS: A total of 1385 healthy Chinese rhesus monkeys (548 males and 837 females) anesthetized with ketamine were selected and segregated by age (six groups) and sex...
October 8, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37787178/hydrotherapy-in-two-black-tufted-marmosets-callithrix-penicillata-with-metabolic-bone-disease-case-reports-2018-2020
#16
Letícia Prata Juliano Dimatteu Telles, Matheus Rabello de Figuereido Carvalho Krüger Martins, Júlia Vieira Herter, Líria Querioz Luz Hirano
Integrative medicine has gained space in veterinary medicine and hydrotherapy is mainly used as an adjunct on the treatment of neurological and musculoskeletal diseases. Use of this therapeutic modality in wild animals has seldom been reported. This article describes the use of hydrotherapy in two Callithrix penicillata patients with metabolic bone disease.
October 3, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37724462/39th-annual-symposium-on-nonhuman-primate-models-for-aids
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
October 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37747073/dilated-cardiomyopathy-phenotype-in-callithrix-penicillata-e-geoffroy-1812-case-report
#18
Melina Castilho de Souza Balbueno, Jéssica Amâncio Martins, Soraya Kezam Malaga, Juliana Forato, Cidéli de Paula Coelho
Dilated cardiomyopathy (DCM) is a disease of the heart muscle diagnosed by alterations resulting from ventricular systolic dysfunction with enlargement of the heart chambers, which is still underdiagnosed in non-human primates. This report is the first case of the DCM phenotype diagnosed by echocardiography and confirmed by necropsy in Callithrix penicillata.
September 25, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37712216/comparison-of-fine-needle-aspiration-techniques
#19
JOURNAL ARTICLE
Jason P Dufour, Carolina Allers, Faith Schiro, Kathrine P Falkenstein, Kayleigh K Gregoire, Colin D Glover, Alayna N Chamel, Adrienne Woods, Jonah P Phillippi, Taylor M Gideon, Amitinder Kaur
BACKGROUND: Fine-needle aspiration (FNA) has been reported since 1912 beginning with the use of trocars and other specialized instruments that were impractical. Since then, FNA has proven to be a successful alternative technique to excisional biopsy for some assays despite a few limitations. METHODS: In this study, we compared four different techniques for FNA in rhesus macaques by evaluating total live cells recovered and cell viability using a standard 6 mL syringe and 1...
September 15, 2023: Journal of Medical Primatology
https://read.qxmd.com/read/37674272/introduction
#20
JOURNAL ARTICLE
Jennifer A Manuzak, Ronald S Veazey
No abstract text is available yet for this article.
September 6, 2023: Journal of Medical Primatology
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