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Journals Japanese Journal of Clinical O...

Japanese Journal of Clinical Oncology

https://read.qxmd.com/read/38391203/prognostic-evaluation-of-the-ki-67-labeling-system-in-histological-grading-of-non-small-round-cell-sarcoma-a-supplementary-analysis-of-a-randomized-controlled-trial-jcog1306
#1
JOURNAL ARTICLE
Shintaro Sugita, Kazuhiro Tanaka, Yoshinao Oda, Takayuki Nojima, Naomi Konishi, Ryunosuke Machida, Ryosuke Kita, Haruhiko Fukuda, Toshifumi Ozaki, Tadashi Hasegawa
BACKGROUND: Soft tissue sarcoma (STS) has various histological types and is rare, making it difficult to evaluate the malignancy of each histological type. Thus, comprehensive histological grading is most important in the pathological examination of STS. The Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grading system is most commonly used in daily pathological analysis of STS. Among the FNCLCC grading system parameters, mitotic count is a key morphological parameter reflecting the proliferative activity of tumor cells, although its reproducibility may be lacking...
February 22, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38376811/development-and-validation-of-a-nomogram-for-radiation-induced-hepatic-toxicity-after-intensity-modulated-radiotherapy-for-hepatocellular-carcinoma-a-retrospective-study
#2
JOURNAL ARTICLE
Qiaoyuan Wu, Yudan Wang, Yuxin Wei, Zhengqiang Yang, Kai Chen, Jianxu Li, Liqing Li, Tingshi Su, Shixiong Liang
OBJECTIVE: This study aimed to construct a nomogram to predict radiation-induced hepatic toxicity in patients with hepatocellular carcinoma treated with intensity-modulated radiotherapy. METHODS: This study reviewed the clinical characteristics and dose-volume parameters of 196 patients with hepatocellular carcinoma. Radiation-induced hepatic toxicity was defined as progression of the Child-Pugh score caused by intensity-modulated radiotherapy. Factors relevant to radiation-induced hepatic toxicity were selected using receiver operating characteristic and univariate logistic analysis...
February 19, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38376792/cost-effectiveness-of-surveillance-intervals-after-curative-resection-of-colorectal-cancer
#3
JOURNAL ARTICLE
Yuji Takayama, Shunsuke Tsukamoto, Yozo Kudose, Yasuyuki Takamizawa, Konosuke Moritani, Minoru Esaki, Yukihide Kanemitsu, Ataru Igarashi
BACKGROUND: Major guidelines consistently recommend 5 years of postoperative surveillance for patients with colorectal cancer. However, they differ in their recommendations for examination intervals and whether they should vary according to disease stage. Furthermore, there are no reports on the cost-effectiveness of the different surveillance schedules. The objective of this study is to identify the most cost-effective surveillance intervals after curative resection of colorectal cancer...
February 19, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38369557/a-population-based-validation-of-the-igcccg-update-consortium-for-survival-in-metastatic-non-seminoma-testis-cancer
#4
JOURNAL ARTICLE
Reha-Baris Incesu, Simone Morra, Lukas Scheipner, Francesco Barletta, Andrea Baudo, Cristina Cano Garcia, Stefano Tappero, Mattia Luca Piccinelli, Zhe Tian, Fred Saad, Shahrokh F Shariat, Ottavio de Cobelli, Carlo Terrone, Felix K H Chun, Luca Carmignani, Alberto Briganti, Sascha Ahyai, Nicola Longo, Derya Tilki, Markus Graefen, Pierre I Karakiewicz
BACKGROUND: In 2021, the International Germ Cell Cancer Collaborative Group (IGCCCG) Update Consortium reported improved overall survival (OS) rates in a modern cohort of metastatic non-seminoma testis cancer patients within each of the IGCCCG prognosis groups (96% in good vs. 89% in intermediate vs. 67% in poor), compared to the previous IGCCCG publication (92% in good vs. 80% in intermediate vs. 48% in poor). We hypothesized that a similar survival improvement may apply to a contemporary North-American population-based cohort of non-seminoma testis cancer patients...
February 17, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38366664/quantification-of-eosinophilic-area-and-its-potential-molecular-feature-in-clear-cell-renal-cell-carcinoma
#5
JOURNAL ARTICLE
Nengqiao Wen, Xiaomin Li, Jiangli Lu, Lu Pan, Ping Yang, Yijun Zhang, Keming Chen, Yun Cao
OBJECTIVE: Previous studies have acknowledged the presence of eosinophilic cytoplasm in clear cell renal cell carcinoma, yet the precise quantification method and potential molecular attributes in clear cell renal cell carcinoma remain elusive. This study endeavours to precisely quantify the eosinophilic attribute and probe into the molecular mechanisms governing its presence in clear cell renal cell carcinoma. METHODS: Data from cohorts of clear cell renal cell carcinoma patients who underwent nephrectomy, comprising The Cancer Genome Atlas cohort (n = 475) and Sun Yat-sen University Cancer Center cohort (n = 480), were aggregated to assess the eosinophilic attribute...
February 15, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38366663/gastric-type-adenocarcinoma-of-the-uterine-cervix-clinical-features-and-future-directions
#6
JOURNAL ARTICLE
Hiroshi Nishio, Risa Matsuda, Takashi Iwata, Wataru Yamagami
The concept of gastric-type mucinous carcinoma of the uterine cervix (GAS) has been accepted worldwide because of its aggressive clinical behaviour and the absence of high-risk human papilloma virus infection. The World Health Organization (WHO) 2020 classification divides cervical tumours into two categories: human papilloma virus-associated and human papilloma virus-independent. Hence, GAS is now classified as an human papilloma virus-independent gastric type. Because clinical studies have reported that GAS is refractory to conventional treatments such as chemotherapy and radiotherapy, especially at an advanced stage, and has aggressive features with widespread dissemination to unusual sites, such as the omentum, peritoneum and distant organs, it is urgent to establish new treatment strategies by comparing the molecular profiles of human papilloma virus-associated adenocarcinomas...
February 15, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38366353/correction-to-quality-of-life-but-not-cachexia-definitions-are-associated-with-overall-survival-in-women-with-cervical-cancer-a-strobe-compliant-cohort-study
#7
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38364442/extraneuraxial-pancreatic-hemangioblastoma-in-a-patient-with-tuberous-sclerosis
#8
JOURNAL ARTICLE
Rachel L Perez, Kevin J Wu, Ba D Nguyen
No abstract text is available yet for this article.
February 13, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38346918/fdg-pet-ct-findings-of-breast-metastasis-from-lung-adenocarcinoma
#9
JOURNAL ARTICLE
Inci Uslu Biner, Gulsah Safak Orkan, Ulku Yilmaz
No abstract text is available yet for this article.
February 12, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38342589/recent-progress-in-chemoradiotherapy-for-oesophageal-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Kotoe Oshima, Takahiro Tsushima, Yoshinori Ito, Ken Kato
Oesophageal squamous cell carcinoma is a common malignancy worldwide. Definitive chemoradiotherapy is the standard treatment for patients with resectable stage oesophageal squamous cell carcinoma who cannot undergo surgery, as well as those with locally advanced unresectable oesophageal squamous cell carcinoma. However, it has several disadvantages such as poor survival, radiation-related toxicities and severe and lethal complications related to salvage treatment for residual or recurrent disease. Numerous clinical trials on chemoradiotherapy have been conducted to confirm the optimal combination of irradiation and chemotherapy...
February 10, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336481/effects-of-hormone-receptor-status-on-patient-clinic-and-survival-in-her2-positive-breast-cancer
#11
JOURNAL ARTICLE
Mukaddes Yılmaz, Eda Erdiş, Mahmut Uçar, Necla Demir, Celal Alandağ, Birsen Yücel
BACKGROUND: In the current study, the effect of hormone receptor (HR) status on clinical and survival in early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer was investigated. METHODS: Two hundred ninety-one patients with HER2- positive were examined in two categories as HR-positive and HR-negative. RESULTS: Of these, 197 (68%) were HR-positive and 94 (32%) were HR-negative with a mean follow-up period of 68 ± 2...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336479/trends-in-endometrial-carcinoma-experience-of-a-single-institute-for-four-decades
#12
JOURNAL ARTICLE
Masayuki Yamaguchi, Naohisa Kushiya, Ryo Tamura, Nobumichi Nishikawa, Akira Kikuchi
OBJECTIVE: To determine the current prognosis of endometrial carcinoma in Japan by analyzing long-term trends in endometrial carcinoma at our hospital. METHODS: We divided 1463 patients with endometrial carcinoma who visited our hospital between 1984 and 2022 into group 1984-1991, group 1992-1999, group 2000-2006, group 2007-2014 and group 2015-2022. Trends were determined using the Jonckheere-Terpstra and Cochran-Armitage tests. Data were analyzed using Cox regression analysis...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336476/the-trajectory-of-prognostic-cognition-in-patients-with-advanced-cancer-is-the-traditional-advance-care-planning-approach-desirable-for-patients
#13
JOURNAL ARTICLE
Takaaki Hasegawa, Toru Okuyama, Tatsuo Akechi
Most patients with advanced cancer initially express a desire to be informed of their prognosis, and prognostic discussions between patients and their oncologists can trigger the subsequent trajectory of prognostic cognitions. On the continuum of prognostic cognition, including inaccurate/accurate prognostic awareness (awareness of incurability of cancer, terminal nature of illness or life expectancy) and prognostic acceptance (accepting one's prognosis), patients' perceptions of being informed of their prognosis by oncologists and patients' coping strategy for serious medical conditions regulate prognostic cognitions...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336473/do-the-general-public-get-cancer-statistics-a-questionnaire-survey-in-japan
#14
JOURNAL ARTICLE
Laureline Gatellier, Hadrien Charvat, Yuri Ito, Tomohiro Matsuda
OBJECTIVES: The public does not always understand key information conveyed by epidemiologists and statisticians. The purpose of this study was to understand the level of public access to, trust in, and comprehension of, cancer statistics through a population-based survey in Japan. METHODS: We used an online research method, requesting online responses to a 15-question questionnaire. The survey was sent to males and females aged 20 years and older, selected by sex, age and prefecture to match the national population proportions shown in the latest census...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336462/the-accuracy-and-characteristics-of-gastric-cancer-treatment-information-in-the-national-data-of-the-hospital-based-cancer-registry
#15
JOURNAL ARTICLE
Manami Fujishita, Naoki Sakakibara, Takahiro Higashi, Tomone Watanabe, Hiraku Kumamaru, Hiroaki Miyata
OBJECTIVE: The hospital-based cancer registry is used extensively for research to support cancer control activities by providing an overview of how cancer treatments are provided nationwide. This study aimed to shed light on the quality and characteristics of treatment data in the hospital-based cancer registry using the linked dataset on gastric cancer. METHODS: Using the nationally linked data of the hospital-based cancer registry and the health services utilization data, the treatment data in the hospital-based cancer registry for patients who were newly diagnosed with gastric cancer in 2016 and 2017 and received the first course of treatment at their own institutions were examined...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38336460/impact-of-frailty-on-cancer-related-fatigue-and-quality-of-life-in-outpatients-with-prostate-cancer-a-cross-sectional-study-of-patient-reported-outcomes
#16
JOURNAL ARTICLE
Yoichiro Tohi, Takuma Kato, Tomoko Honda, Yu Osaki, Yohei Abe, Hirohito Naito, Yuki Matsuoka, Homare Okazoe, Rikiya Taoka, Nobufumi Ueda, Mikio Sugimoto
OBJECTIVE: To investigate the prevalence of frailty and its effects on cancer-related fatigue and quality of life among patients with prostate cancer. METHODS: In this cross-sectional study, questionnaires were administered to 254 outpatients who visited the Department of Urology at Kagawa University Hospital for prostate cancer; finally, 108 outpatients were analyzed. Frailty, cancer-related fatigue and quality of life were assessed using the G8 screening tool, Japanese version of the Brief Fatigue Inventory and Japanese version of the Short Form 8 Health Survey, respectively...
February 9, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38323684/mirtazapine-versus-megestrol-acetate-in-treatment-of-anorexia-cachexia-in-advanced-cancer-patients-a-randomized-double-blind-trial
#17
JOURNAL ARTICLE
Iftekhar Hossain Chowdhury, Md Sayedur Rahman, Md Najmul Kabir Chowdhury, Yeasmin Jahan Afroze, Masuma Tabassum, Muhammad Marnush, Nusrat Zerin
OBJECTIVE: Cancer-related anorexia-cachexia comprises one of the most common syndromes of advanced cancer patients. The management of cancer-related anorexia-cachexia is a great challenge in clinical practice. There are no definite practice guidelines yet for the prevention and treatment of cancer-related anorexia-cachexia. This study is considered to find out whether there is any role of mirtazapine in the improvement of anorexia in cancer patients. METHODS: A total of 80 cancer-anorexia patients were enrolled...
February 6, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38323655/effectiveness-of-opioid-switching-for-dyspnea-and-its-predictors-in-cancer-patients-a-single-center-retrospective-observational-study
#18
JOURNAL ARTICLE
Yoshihiro Yamamoto, Shion Tanaka, Katsuhiko Matsuura, Seiji Yamamoto, Kimihiko Urano, Junya Okita, Eisuke Kato, Takuya Odagiri, Yuko Deguchi
BACKGROUND: Morphine is the most used opioid for dyspnea, but other opioids such as oxycodone and fentanyl are increasingly used, and opioid switching to these is sometimes undertaken. No studies have verified the effectiveness of opioid switching for relief of dyspnea. We retrospectively investigated the effectiveness of opioid switching for dyspnea and its predictors. METHODS: All patients with opioid switching for dyspnea during hospitalization at Komaki City Hospital from January 2019 to August 2022 were included...
February 6, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38305663/real-world-data-on-the-comprehensive-genetic-profiling-test-for-japanese-patients-with-metastatic-castration-resistant-prostate-cancer
#19
JOURNAL ARTICLE
Dai Koguchi, Hideyasu Tsumura, Ken-Ichi Tabata, Soichiro Shimura, Takefumi Satoh, Masaomi Ikeda, Akinori Watanabe, Tsutomu Yoshida, Jiichiro Sasaki, Kazumasa Matsumoto, Masatsugu Iwamura
OBJECTIVE: comprehensive genomic profiling test has been covered by Japanese health insurance since June 2019. However, no real-world data on the test have been reported with a focus on Japanese patients with prostate cancer. METHODS: we retrospectively reviewed the data of 45 consecutive patients with metastatic castration-resistant prostate cancer, who underwent the comprehensive genomic profiling tests at Kitasato University Hospital between August 2019 and December 2022...
February 1, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38305451/determination-of-enzalutamide-long-term-safety-and-efficacy-for-castration-resistant-prostate-cancer-patients-after-combined-anti-androgen-blockade-followed-by-alternative-anti-androgen-therapy-a-multicenter-prospective-delc-study
#20
JOURNAL ARTICLE
Akira Nagahara, Motohide Uemura, Mototaka Sato, Wataru Nakata, Masao Tsujihata, Tetsuya Takao, Soichi Matsumura, Kensaku Nishimura, Shingo Takada, Toshichika Iwanishi, Yasuyuki Kobayashi, Yu Ishizuya, Tsuyoshi Takada, Koichi Okada, Hitoshi Inoue, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takeshi Ujike, Kazutoshi Fujita, Norio Nonomura
BACKGROUND: Alternative anti-androgen therapy has been widely used as a first-line treatment for castration-resistant prostate cancer, and it may affect treatment outcome of subsequent agents targeting the androgen receptor axis. We conducted the prospective observational DELC (Determination of Enzalutamide Long-term safety and efficacy for Castration-resistant prostate cancer patients after combined anti-androgen blockade followed by alternative anti-androgen therapy) study to evaluate the efficacy of enzalutamide in patients with castration-resistant prostate cancer who underwent prior combined androgen blockade with bicalutamide and then alternative anti-androgen therapy with flutamide...
February 1, 2024: Japanese Journal of Clinical Oncology
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