journal
https://read.qxmd.com/read/38197395/lesions-and-viral-antigen-distribution-in-bald-eagles-red-tailed-hawks-and-great-horned-owls-naturally-infected-with-h5n1-clade-2-3-4-4b-highly-pathogenic-avian-influenza-virus
#21
JOURNAL ARTICLE
Arno Wünschmann, Dana Franzen-Klein, Mia Torchetti, Michele Confeld, Michelle Carstensen, Victoria Hall
An epidemic of highly pathogenic avian influenza (HPAI) began in North America in the winter of 2021. The introduced Eurasian H5N1 clade 2.3.4.4b virus subsequently reassorted with North American avian influenza strains. This postmortem study describes the lesions and influenza A virus antigen distribution in 3 species of raptors, including bald eagles ( Haliaeetus leucocephalus , n = 6), red-tailed hawks ( Buteo jamaicensis , n = 9), and great horned owls ( Bubo virginianus , n = 8), naturally infected with this virus strain based on positive reverse transcriptase polymerase chain reaction and sequencing results from oropharyngeal swabs...
January 10, 2024: Veterinary Pathology
https://read.qxmd.com/read/38197394/swine-models-in-translational-research-and-medicine
#22
REVIEW
David K Meyerholz, Eric R Burrough, Nicole Kirchhof, Douglas J Anderson, Kristi L Helke
Swine are increasingly studied as animal models of human disease. The anatomy, size, longevity, physiology, immune system, and metabolism of swine are more like humans than traditional rodent models. In addition, the size of swine is preferred for surgical placement and testing of medical devices destined for humans. These features make swine useful for biomedical, pharmacological, and toxicological research. With recent advances in gene-editing technologies, genetic modifications can readily and efficiently be made in swine to study genetic disorders...
January 10, 2024: Veterinary Pathology
https://read.qxmd.com/read/38193450/pyrethroid-associated-nephrotoxicity-in-channel-catfish-ictalurus-punctatus-and-blue-catfish-i-furcatus-at-a-public-aquarium
#23
JOURNAL ARTICLE
Justin M Stilwell, Sean M Perry, Lora Petrie-Hanson, Rachel Sheffler, John P Buchweitz, Alexa J Delaune
Over the course of an approximately 11-month period, an outdoor, freshwater, mixed species, recirculating, display system at a public aquarium experienced intermittent mortalities of channel catfish ( Ictalurus punctatus ) and blue catfish ( I. furcatus) . Catfish acutely presented for abnormal buoyancy, coelomic distention, and protein-rich coelomic effusion. Gross lesions typically involved massive coelomic distension with protein-rich effusion, generalized edema, and gastric hemorrhage and edema. Microscopically, primary lesions included renal tubular necrosis, gastric edema with mucosal hemorrhages, and generalized edema...
January 9, 2024: Veterinary Pathology
https://read.qxmd.com/read/38251685/image-challenge-in-veterinary-pathology-answers-paraneoplastic-syndromes
#24
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 2024: Veterinary Pathology
https://read.qxmd.com/read/37650249/outbreak-of-epizootic-hemorrhagic-disease-in-captive-reindeer-rangifer-tarandus
#25
JOURNAL ARTICLE
Emma H Torii, Arno Wünschmann, Mia Kim Torchetti, Leo Koster, Albert van Geelen, Randy Atchison, Anne Rivas
In September 2020, an outbreak of epizootic hemorrhagic disease occurred in captive reindeer ( Rangifer tarandus ) and was associated with neurological signs and mortality. Four reindeer died or were euthanized after acute illness over a 12-day period. Affected reindeer displayed abnormal behavior, neurologic signs, lethargy, and/or lameness. The most consistent gross finding was dark red streaks throughout the adrenal gland cortices (4/4). One animal had acute hemorrhage involving the subcutis and skeletal muscles over the ventrolateral body wall and back, and abomasal serosa...
March 2024: Veterinary Pathology
https://read.qxmd.com/read/38031757/image-challenge-in-veterinary-pathology
#26
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Veterinary Pathology
https://read.qxmd.com/read/38031756/image-challenge-in-veterinary-pathology-answers-ultrastructural-pathology
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 2024: Veterinary Pathology
https://read.qxmd.com/read/38146917/characterization-of-cutaneous-lesions-caused-by-natural-tick-infestation-in-cattle
#28
JOURNAL ARTICLE
Stella Maris P Melo, Igor R Santos, Bruno A Almeida, Luciana Sonne, Welden Panziera, David Driemeier, Saulo P Pavarini
Although tick infestation is a significant health problem in livestock, there are limited studies on the dermatopathological aspects of natural tick infestation in cattle. This study aimed to describe the gross and histologic aspects of cutaneous lesions caused by tick infestation in cattle. Thirteen cases were selected based on necropsy data from a 10-year retrospective study. Predispositions were observed in beef cattle ( P = .049) and the Angus breed ( P = .012), and lesions occurred mainly in the fall ( P = ...
December 26, 2023: Veterinary Pathology
https://read.qxmd.com/read/38140953/epizootic-of-enterocolitis-and-clostridial-overgrowth-in-nsg-and-nsg-related-mouse-strains
#29
JOURNAL ARTICLE
Justin D Arthur, Jeannie L Mullen, Francisco A Uzal, Claude M Nagamine, Kerriann M Casey
While the immunodeficient status of NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) and NSG-related mice provides utility for numerous research models, it also results in increased susceptibility to opportunistic pathogens. Over a 9-week period, a high rate of mortality was reported in a housing room of NSG and NSG-related mice. Diagnostics were performed to determine the underlying etiopathogenesis. Mice submitted for evaluation included those found deceased ( n = 2), cage mates of deceased mice with or without diarrhea ( n = 17), and moribund mice ( n = 8)...
December 23, 2023: Veterinary Pathology
https://read.qxmd.com/read/38140946/highly-pathogenic-avian-influenza-virus-h5n1-infection-in-skua-and-gulls-in-the-united-kingdom-2022
#30
JOURNAL ARTICLE
Fabian Z X Lean, Marco Falchieri, Natalia Furman, Glen Tyler, Caroline Robinson, Paul Holmes, Scott M Reid, Ashley C Banyard, Ian H Brown, Catherine Man, Alejandro Núñez
The reemergence of the highly pathogenic avian influenza virus (HPAIV) subtype H5N1 in the United Kingdom in 2021-2022 has caused unprecedented epizootic events in wild birds and poultry. During the summer of 2022, there was a shift in virus transmission dynamics resulting in increased HPAIV infection in seabirds, and consequently, a profound impact on seabird populations. To understand the pathological impact of HPAIV in seabirds, we evaluated the virus antigen distribution and associated pathological changes in the tissues of great skua ( Stercorarius skua , n = 8), long-tailed skua ( Stercorarius longicaudus , n = 1), European herring gull ( Larus argentatus , n = 5), and black-headed gull ( Chroicocephalus ridibundus , n = 4), which succumbed to natural infection of HPAIV during the summer of 2022...
December 23, 2023: Veterinary Pathology
https://read.qxmd.com/read/38098215/canine-follicular-cell-and-medullary-thyroid-carcinomas-immunohistochemical-characterization
#31
JOURNAL ARTICLE
Jana Jankovic, Eve Tièche, Martina Dettwiler, Kerstin Hahn, Stephanie Scheemaeker, Martin Kessler, Sylvie Daminet, Sven Rottenberg, Miguel Campos
Research on modulation of iodine uptake by thyroid cells could help improve radioiodine treatment of dogs with thyroid tumors. The aim of this study was to characterize the immunohistochemical expression of thyroid transcription factor-1 (TTF-1), thyroglobulin, thyrotropin receptor (TSHR), sodium iodide symporter (NIS), pendrin, thyroid peroxidase (TPO), vimentin, and Ki-67 in follicular cell thyroid carcinomas (FTCs) and medullary thyroid carcinomas (MTCs), and to compare protein expression between FTC causing hyperthyroidism and FTC of euthyroid dogs...
December 14, 2023: Veterinary Pathology
https://read.qxmd.com/read/38088189/diagnostic-challenge-in-veterinary-pathology-detection-of-braf-v595e-mutation-in-a-dog-with-follicular-cystitis-and-flat-urothelial-lesion-with-atypia
#32
JOURNAL ARTICLE
James K Chambers, Naohiro Takahashi, Shizuka Kato, Yuko Hashimoto, Yuko Goto-Koshino, Kazuyuki Uchida
No abstract text is available yet for this article.
December 13, 2023: Veterinary Pathology
https://read.qxmd.com/read/38018088/naturally-acquired-equine-parvovirus-hepatitis-is-associated-with-a-wide-range-of-hepatic-lesions-in-horses
#33
JOURNAL ARTICLE
Mason C Jager, Eunju Choi, Joy E Tomlinson, Gerlinde Van de Walle
Equine parvovirus-hepatitis (EqPV-H) is the causative agent of Theiler's disease, or severe acute hepatic necrosis, in horses. However, it is poorly understood whether EqPV-H is associated with other histologic findings in horses with clinical liver disease. The objective of this study was to examine the prevalence and severity of EqPV-H infections in diagnostic liver samples. Archived formalin-fixed, paraffin-embedded (FFPE) liver samples ( n = 98) from Cornell University and University of California, Davis, collected between 2007 and 2022 were evaluated for 15 individual histologic features and by EqPV-H in situ hybridization...
November 29, 2023: Veterinary Pathology
https://read.qxmd.com/read/38018125/neoplasia-in-an-assurance-population-of-puerto-rican-crested-toads-peltophryne-lemur
#34
JOURNAL ARTICLE
Sierra M Imanse, Caitlin E Burrell, Sarah A Cannizzo, Tara S Reilly, Kimberly L Rainwater, Martha A Delaney
Disease monitoring of amphibian assurance populations is an important buffer against ongoing global extinctions. This study documents a high incidence of neoplasia in a zoo-managed assurance population of Puerto Rican crested toads ( Peltophryne lemur ; PRCTs). Over 5 years, neoplasia was diagnosed in 17/49 (35%) submitted adult PRCTs and was the cause of death or euthanasia in 13/17 (72%). Most toads were male (16/17; 94%) and 6 to 11-years-old (average 8.1 years). Notably, seven toads (41%) had multiple neoplasms...
November 28, 2023: Veterinary Pathology
https://read.qxmd.com/read/38006226/aneurysm-associated-with-vascular-wall-degeneration-in-bearded-dragons-pogona-vitticeps
#35
JOURNAL ARTICLE
Joaquín Ortega, Jeanette Wyneken, Michael M Garner
This study describes the clinical, gross, and histologic findings in 17 cases of aneurysms in bearded dragons ( Pogona vitticeps ). The clinical presentation ranged from incidental to sudden and unexpected death. The affected vasculature was predominantly arterial; however, based on the topographical locations of the lesions, gross structure, and drainage, some veins were likely involved. Magnetic resonance imaging and computerized tomography scans of 1 animal showed a large aneurysm of the internal carotid artery extending from near its aortic origin into the caudal head...
November 25, 2023: Veterinary Pathology
https://read.qxmd.com/read/38006213/diversity-of-mutations-in-the-dystrophin-gene-and-details-of-muscular-lesions-in-porcine-dystrophinopathies
#36
JOURNAL ARTICLE
Yumiko Kamiya, Naoyuki Aihara, Takanori Shiga, Noriyuki Horiuchi, Junichi Kamiie
During meat inspections in pigs, dystrophinopathies are among the muscle lesions targeted for disposal. In this study, the authors examined the lesions and the distribution of dystrophin expression in 25 pigs with dystrophinopathy. In addition, complementary deoxyribonucleic acid (cDNA) sequencing and western blotting were performed in 6 of the 25 cases, all of which were characterized by degeneration, necrosis, and fat replacement of muscle fibers. Comparing the results of immunohistochemistry with anti-dystrophin antibodies that recognized at different sites in the protein, the authors noted that the loss of dystrophin expression was most pronounced in the C-terminus-recognizing antibody (19/25 cases)...
November 25, 2023: Veterinary Pathology
https://read.qxmd.com/read/37953600/a-new-genotype-of-hepatitis-a-virus-causing-transient-liver-enzyme-elevations-in-mauritius-origin-laboratory-housed-macaca-fascicularis
#37
JOURNAL ARTICLE
Lars Mecklenburg, Rebecca Ducore, Molly Boyle, Andrew Newell, Laura Boone, Joerg Luft, Annette Romeike, Ann-Kathrin Haverkamp, Keith Mansfield, Kelley A Penraat, J J Baczenas, Nick Minor, Shelby L O'Connor, David H O'Connor
Hepatitis A virus (HAV) infects humans and nonhuman primates, typically causing an acute self-limited illness. Three HAV genotypes have been described so far for humans, and three genotypes have been described for nonhuman primates. We observed transiently elevated liver enzymes in Mauritius-origin laboratory-housed macaques in Germany and were not able to demonstrate an etiology including HAV by serology and polymerase chain reaction (PCR). HAV is a rare pathogen in cynomolgus macaques, and since all employees were routinely vaccinated against HAV, it was not a part of the routine vaccination and screening program...
November 12, 2023: Veterinary Pathology
https://read.qxmd.com/read/37937724/equine-sarcoids-a-clinicopathologic-study-of-49-cases-with-mitotic-count-and-clinical-type-predictive-of-recurrence
#38
JOURNAL ARTICLE
Wilson Karalus, Supatsak Subharat, Geoff Orbell, Bernie Vaatstra, John S Munday
Sarcoids are common mesenchymal neoplasms of horses. Although there are few studies in which sarcoids have been followed over a long period of time, sarcoids are considered locally invasive and have been reported to frequently recur following surgical excision. Currently, no histological features have been identified to predict which sarcoids will recur after excision. The present study comprised 49 sarcoids for which histology sections were available and in which the recurrence status of the case was known...
November 8, 2023: Veterinary Pathology
https://read.qxmd.com/read/37921009/overview-of-the-veterinary-cancer-guidelines-and-protocols-group-s-developing-reporting-and-validating-histologic-tumor-grading-systems
#39
LETTER
F Yvonne Schulman, Christof A Bertram, Donald J Meuten, Frances M Moore, Giancarlo Avallone, Alexander Bartel, Pompei Bolfa, Melinda Camus, James K Chambers, Michael J Dark, Nick Dervisis, Melanie J Dobromylskyj, Taryn A Donovan, Robert A Foster, Paula M Krimer, Andrew Miller, Milan Milovancev, Paola Roccabianca, Laura E Selmic, Geoff A Wood
No abstract text is available yet for this article.
November 3, 2023: Veterinary Pathology
https://read.qxmd.com/read/37920996/pdl1-immunohistochemistry-in-canine-neoplasms-validation-of-commercial-antibodies-standardization-of-evaluation-and-scoring-systems
#40
JOURNAL ARTICLE
Luisa Vera Muscatello, Francesca Gobbo, Giancarlo Avallone, Micaela Innao, Cinzia Benazzi, Giulia D'Annunzio, Donatella Romaniello, Massimo Orioles, Mattia Lauriola, Giuseppe Sarli
Immuno-oncology research has brought to light the paradoxical role of immune cells in the induction and elimination of cancer. Programmed cell death protein 1 (PD1), expressed by tumor-infiltrating lymphocytes, and programmed cell death ligand 1 (PDL1), expressed by tumor cells, are immune checkpoint proteins that regulate the antitumor adaptive immune response. This study aimed to validate commercially available PDL1 antibodies in canine tissue and then, applying standardized methods and scoring systems used in human pathology, evaluate PDL1 immunopositivity in different types of canine tumors...
November 3, 2023: Veterinary Pathology
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